With　regard　to　the　high　lipophilicity　of　the　trifluoromethylthio　group　(CF3S-),　there　is　a　growing　interest　in　the　development　of　efficient　methods　for　the　incorporation　of　CF3S　moiety　onto　organic　molecules.　In　this　review,　recent　advances　in　trifluoromethylthiolation　using　nucleophilic　trifluoromethylthiolating　reagents　are　discussed,　highlighting　some　of　the　most　intriguing　examples　of　the　synthesis　of　trifluoromethylthio-containing　compounds　using　novel　reagents.　(C)　2016　Elsevier　Ltd.　All　rights　reserved.