With　regard　to　the　high　lipophilicity　of　the　trifluoromethylthio　group　(CF　3　S-),　there　is　a　growing　interest　in　the　development　of　efficient　methods　for　the　incorporation　of　CF　3　S　moiety　onto　organic　molecules.　In　this　review,　recent　advances　in　trifluoromethylthiolation　using　nucleophilic　trifluoromethylthiolating　reagents　are　discussed,　highlighting　some　of　the　most　intriguing　examples　of　the　synthesis　of　trifluoromethylthio-containing　compounds　using　novel　reagents.　©　2016　Elsevier　Ltd.　All　rights　reserved.