The　research　describes　an　intelligent　electrocardiogram　(ECG)　acquisition　system　with　low　power　and　low　data　loss　features.　The　system　is　constructed　with　ADS129X,　MSP430X,　CC254X　Bluetooth　low　energy　(BLE)　with　low　power　wireless　communication　protocol　and　smart　phone　for　the　ECG　display.　Two　architectures,　namely,　with　and　without　the　microprocessor　(MPU)　and　hinted　handoff　mechanism　algorithm,　are　used　to　verify　the　data　transmission　loss　between　the　BLE　and　the　smart　phone.　The　system　not　only　employed　low-power　solution　but　also　added　full　handshake　and　hinted　handoff　to　achieve　complete　synchronization　and　accurate　transmission　reliability.　The　MPU　method　definitely　enhanced　the　ECG　packet　loss　rate　and　power　saving　rate　to　0.63%　and　49.78%,　respectively.