Pyridinic-N　configurations　and　intrinsic　defects　on　nanocarbons　have　been　regarded　as　potentially　active-sites　for　the　oxygen　reduction　reaction　(ORR).　In　this　work,　a　facile　strategy　is　demonstrated　to　achieve　pyridinic-N　dominated　porous　carbon　nanosheets　with　edge-enriched　defective　nature　through　the　selection　of　the　bio-precursor　guanine　as　C/N　sources.　It　is　able　to　achieve　high　contents　of　pyridinicN　dominated　(48.1%　from　gross　N)　species　and　the　few-layers　carbon　architectures　with　hierarchical　porosity　by　a　template-free　carbonization　method.　These　2D　carbon　structures　are　of　low　cost,　scalable　and　economically　attractive　while　based　on　renewable　and　highly　abundant　resources.　As　a　result,　the　optimized　catalyst　delivers　a　significantly　enhanced　electrocatalytic　performance　for　ORR　under　wide　range　of　pH　from　alkaline　to　acid,　i.　e.　possessing　a　30　mV　more　positive　half-wave　potential　(0.885　V)　than　Pt/C　(0.855　V)　catalyst　in　0.1M　KOH,　and　very　close　activities　to　Pt/C　in　0.1M　PBS　and　0.1M　HClO4　solution.　This　ORR　performance　is　attributed　to　the　synergistic　effects　of　unique　graphene-like　architecture,　high　porosity,　and　coexistences　of　high　contents　of　pyridinic-　N　species　and　abundant　edge/defect　sites.　(C)　2019　Elsevier　Ltd.　All　rights　reserved.