Thermal　barrier　coating　is　a　high-temperature　protective　technology　widely　used　in　industrial　gas　turbines.　However,　the　failure　of　coating　peeling　because　of　the　generation　of　thermally　grown　oxide　(TGO)　at　the　interface　during　service　hinders　its　further　application.　In　this　study,　Raman　spectroscopy　and　wedge　indentation　are　used　to　determine　the　TGO　residual　stress　and　the　interface　energy　release　rate,　respectively.　The　effect　of　TGO　on　the　interfacial　fracture　toughness　during　the　growth　process　was　discussed.　Raman　spectroscopy　test　results　show　that　the　residual　stress　of　TGO　is　about　0.5　GPa.　Wedge　indentation　test　results　illustrate　that　high-temperature　heat　treatment　could　accelerate　the　interface　degradation　of　thermal　barrier　coatings.　Stress　analysis　and　test　research　demonstrate　that　the　microcracks　induced　by　compressive　stress　of　TGO　will　propagate　with　increasing　heating　time,　ending　with　failure　of　barrier　coatings.