On-demand　delivery　of　drug　to　deep　tumor　tissues　with　long-term　tumor　retention　has　directly　influence　on　therapeutic　efficiency　and　prognosis　of　patients,　which　still　remains　challenge　in　cancer　therapy.　Here　we　introduce　metallo-supramolecular　nanoflowers　through　multi-drugs　and　metal　coordination　effect　for　near-infrared　(NIR)　or　acidic-triggered　multi-drugs　release,　long-term　accumulation　at　tumor　tissues　and　NIR-II　fluorescence　imaging-guided　photo-chemotherapy.　The　nanoflowers　(refer　to　ICG　EDOX)　are　constructed　by　(-)-epigallocatechin-3-gallate　(EGCG),　Cu2+　ions,　indocyanine　green　(ICG)　and　doxorubicin　hydrochloride　(DOX)　through　coordination　effect,　ox-ox　stacking　and　hydrophobic　force.　Due　to　strong　intermolecular　interaction,　the　ICG　EDOX　is　superior　stable　in　physiological　conditions,　while　releases　DOX/ICG　on-demand　upon　the　acidic/NIR　laser　irradiation.　Moreover,　ICG　EDOX　could　penetrate　deep　tumor　tissues　with　ultralong　tumor　retention　(＞　8　d)　by　microvesicle　(MVs)-mediated　intercellular　interaction.　Irradiated　by　808　nm　laser,　the　higher　NIR-II　fluorescence　signal　from　ICG　EDOX　in　tumors　can　effectively　guide　local　phototherapy,　and　the　synergistic　therapeutic　efficiency　of　nanoflowers　with　completely　elimination　of　tumors　is　achieved　in　comparison　with　DOX　or　DOX/ICG　treated　4T1-bearing　mice.　Overall,　the　excellent　therapeutic　effect　of　nanoflowers　may　hold　great　promise　for　the　clinic　translation.