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学者姓名：陈岚岚
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Accurate differentiation of benign and malignant breast tumors is paramount for establishing schemes of breast cancer treatment and prognosis. Here we report a near-infrared (NIR) fluorescence probe (YF-1) with the overexpressed cathepsin C (CTSC) in metastatic breast tumors as the detecting substrate. This probe allows accurate identification of malignant tumor tissue specimens among tumor tissue specimens with unknown properties in a blind study. Importantly, a series of visible to NIR CTSC-activated fluorescence probes based on the same strategy realize effective identification of malignant tumor tissues, suggesting that CTSC could be the specific identification substrate of malignant breast tumors. Furthermore, a hydrophilic PEG moiety is coupled into YF-1, producing another CTSC-activated NIR probe (YF-2). YF-2 has excellent tumor-targeting capability, enabling the visualization of lung-metastatic breast tumors. The excellent detection accuracy and construction versatility of CTSC probes pave the way for preoperative diagnosis of malignant breast tumors.
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| GB/T 7714 | Zuo, Shan , Li, Yanhua , Chen, Yushi et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker [J]. | SCIENCE ADVANCES , 2025 , 11 (14) . |
| MLA | Zuo, Shan et al. "Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker" . | SCIENCE ADVANCES 11 . 14 (2025) . |
| APA | Zuo, Shan , Li, Yanhua , Chen, Yushi , Jiang, Gangwei , Zhou, Zhixuan , Ren, Tian-Bing et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker . | SCIENCE ADVANCES , 2025 , 11 (14) . |
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Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization of treatment plans, and minimization of side effects. Tracking the mitochondrial DNA (mtDNA) repair process helps to assess tumor radiosensitivity as mtDNA repair determines the fate of the cell under radiation-induced mtDNA damage. However, current probes developed to monitor levels of DNA repair enzymes suffered from complex synthesis, uncontrollable preparation, limited tumor selectivity, and poor organelle-targeting ability. Especially, the correlation between mtDNA repair activity and inherent radiosensitivity of tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) for in situ monitoring of the activity of the mtDNA repair enzyme and evaluating tumor radiosensitivity. TPP-Apt-tFNA consists of a DNA tetrahedral framework precisely modified with three functional modules on each of the three vertexes, that is, the tumor cell-targeting aptamer, the mitochondrion-targeting moiety, and the apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by tumor cells, the nanoprobe targeted the mitochondrion and specifically recognized APE1 to activate fluorescence, allowing the observation of mtDNA repair activity. The nanoprobe showed elevated APE1 levels in the mitochondria of tumor cells under oxidative stress. Moreover, the nanoprobe enabled the illumination of different levels of APE1-mediated mtDNA repair activity in different cell cycle phases. Furthermore, using the nanoprobe in vitro and in vivo, we found that tumor cells with high activity of mtDNA repair, which allowed them to recover from radiation-induced mtDNA lesions, had low sensitivity to radiation and an unsatisfactory radiotherapy outcome. Our work provides a new imaging tool for exploring the roles of mtDNA repair activity in diverse biological processes and for guiding tumor radiation treatment.
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| GB/T 7714 | Chen, Lanlan , Lai, Jingjing , Dong, Siqi et al. Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (1) : 382-391 . |
| MLA | Chen, Lanlan et al. "Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity" . | ANALYTICAL CHEMISTRY 97 . 1 (2025) : 382-391 . |
| APA | Chen, Lanlan , Lai, Jingjing , Dong, Siqi , Liu, Wenjun , Zhang, Ximei , Yang, Huanghao . Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity . | ANALYTICAL CHEMISTRY , 2025 , 97 (1) , 382-391 . |
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Traditional responsive fluorescent probes are predominantly restricted to qualitative biomarker detection, incapable of delivering real-time quantitative analysis or spatial mapping of protease activity in vivo, which is essential for elucidating disease progression. To overcome this, a ratiometric second near-infrared region (NIR-II) fluorescent (FL) probe (DCNP@IR-806) was developed by conjugating caspase-3-specific peptide substrates and sensitizer molecules (IR-806) to lanthanide-doped down-conversion nanoparticles (DCNP). DCNP@IR-806 achieves single-channel emission at 1550 nm under dual excitation, facilitating self-calibrated quantification and real-time monitoring of activated caspase-3 in vivo. Radiotherapy induces tumor cell apoptosis, thereby activating caspase-3, which subsequently triggers a ratiometric NIR-II FL signal change of DCNP@IR-806. The ratiometric signal demonstrates a linear correlation with caspase-3 concentration, achieving a detection limit of 9.96 U mL-1. Then, an early efficacy assessment system capable of predicting radiotherapy outcomes within 12 h post-treatment was constructed, markedly expediting evaluation compared to traditional methods that require weeks. This rapid, precise, and user-friendly assessment facilitates timely optimization of therapeutic regimens to enhance efficacy while minimizing side effects. This platform represents a significant advancement in precision oncology by transitioning from qualitative imaging to in situ quantitative biomarker tracking.
Keyword ：
Bioimaging Bioimaging Biosensing Biosensing Enzyme Enzyme Nanoprobe Nanoprobe Radiotherapy Radiotherapy
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| GB/T 7714 | Wu, Ying , Wang, Qian , Zhu, Kang et al. Quantitative Tracking of Apoptotic Caspase-3 In Vivo for Early Evaluation of Radiation Therapy Efficacy [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (34) . |
| MLA | Wu, Ying et al. "Quantitative Tracking of Apoptotic Caspase-3 In Vivo for Early Evaluation of Radiation Therapy Efficacy" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 34 (2025) . |
| APA | Wu, Ying , Wang, Qian , Zhu, Kang , Zheng, Liting , Li, Qingqing , Huang, Wei et al. Quantitative Tracking of Apoptotic Caspase-3 In Vivo for Early Evaluation of Radiation Therapy Efficacy . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (34) . |
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Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective and personalized cancer treatments. However, the requirement of high doses of X-ray irradiation to break chemical bonds for drug release limits the application of radiotherapy-induced prodrug activation in clinics. Recent advances in nanomaterials offer a promising approach for radiotherapy sensitization as well as integrating multiple modalities for improved therapy outcomes. In particular, the catalytic radiosensitization that utilizes electrons and energy generated by nanomaterials upon X-ray irradiation has demonstrated excellent potential for enhanced radiotherapy. In this Review, we summarize the design principles of X-ray-responsive chemical bonds for controlled drug release, strategies for catalytic radiosensitization, and recent progress of X-ray-responsive nanoradiosensitizers for enhanced radiotherapy by integration with chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy, and immunotherapy. Finally, we discuss the challenges of X-ray-responsive nanoradiosensitizers heading toward possible clinical translation. We expect that emerging strategies based on radiotherapy-triggered drug release will facilitate a frontier in accurate and effective cancer therapy in the near future.
Keyword ：
combined therapy combined therapy nanomaterials nanomaterials radiosensitive radiosensitive radiotherapy radiotherapy X-ray responsivedrug release X-ray responsivedrug release
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| GB/T 7714 | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun et al. Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) : 14801-14821 . |
| MLA | Jiang, Renfeng et al. "Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release" . | ACS APPLIED MATERIALS & INTERFACES 17 . 10 (2025) : 14801-14821 . |
| APA | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun , Chen, Lanlan , Yang, Huanghao . Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) , 14801-14821 . |
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Helicobacter Pylori infection is drawing increasing attentions in public health, especially the drug resistance problems induced by Single-Nucleotide Variants (SNV). Diagnosis of H. Pylori remains challenging for its requirement in selectivity and sensitivity. Herein an initial check-reexamination strategy is designed for analysis of H. Pylori DNA and SNV. At the first stage, target DNA with all genotypes is captured to form a Y-shaped structure, resulting in an electrochemiluminescence (ECL) signal recovered from quenched states. Then Cas9 assisted cleavage processes are followed to cut off the Y-shaped structure, resulting in corresponding signal decrease. By means of these two stages with different selectivity, both the total amount of H. Pylori DNA and the ratio of SNV can be clarified. To expand its capacity, a large-scale screening assay is carried out on chip. Array detection improves the reliability and the following PCA analysis confirms the otherness. This approach improved the work efficiency and reduced the cost, which may offer an appealing option for the prevention and cure of H. pylori infections in the future.
Keyword ：
CRISPR/Cas9 CRISPR/Cas9 Electrochemiluminescence Electrochemiluminescence Helicobacter pylori Helicobacter pylori Single-nucleotide variants Single-nucleotide variants
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| GB/T 7714 | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan et al. An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
| MLA | Hu, Shanwen et al. "An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants" . | SENSORS AND ACTUATORS B-CHEMICAL 398 (2024) . |
| APA | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan , Deng, Yuhang , Chen, Lanlan . An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
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Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However, traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial micro-compartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme (glucose oxidase/chloroperoxidase) and three-enzyme (invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.
Keyword ：
bacterial microcompartment bacterial microcompartment biocatalysis biocatalysis biomimetics biomimetics chemical warfare agent chemical warfare agent Pickering emulsion Pickering emulsion
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| GB/T 7714 | Xu, Xiao , Xie, Wenqi , Wu, Ting et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) : 3039-3049 . |
| MLA | Xu, Xiao et al. "Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions" . | SCIENCE CHINA-CHEMISTRY 67 . 9 (2024) : 3039-3049 . |
| APA | Xu, Xiao , Xie, Wenqi , Wu, Ting , Chen, Chen , Chen, Xiaoning , Yang, Yuheng et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) , 3039-3049 . |
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本研究建立了一种利用催化发夹自组装反应阵列对多种微生物进行联合检测的新方法.该方法采用双靶点策略,第一个靶点为原核生物 16S rRNA的一段保守序列,用于初步判定原核生物,第二个靶点分别为大肠埃希氏菌、单核增生李斯特菌、金黄色葡萄球菌的特异性序列,用于确证微生物种类.双靶点识别后,释放引发链触发催化发夹自组装反应,循环打开带有FAM荧光基团和猝灭基团标记的发夹探针,产生荧光信号.优化反应条件,评价信号的稳定性后,建立对靶标序列检测的工作曲线,通过荧光信号实现对多种微生物的鉴定和定量检测,并建立检测阵列.本方法在靶标浓度为3～50 nmol/L范围内具有良好的线性关系,检出限为0.001 nmol/L.在阵列检测中,本方法能够有效区分3种目标微生物,为多种病原微生物的同时检测提供了新的技术思路.
Keyword ：
催化发夹自组装 催化发夹自组装 病原微生物 病原微生物 阵列检测 阵列检测
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| GB/T 7714 | 黄敏芳 , 庄妙慧 , 张习梅 et al. 基于催化发夹自组装的多种病原微生物阵列检测 [J]. | 中国口岸科学技术 , 2024 , 6 (9) : 70-77 . |
| MLA | 黄敏芳 et al. "基于催化发夹自组装的多种病原微生物阵列检测" . | 中国口岸科学技术 6 . 9 (2024) : 70-77 . |
| APA | 黄敏芳 , 庄妙慧 , 张习梅 , 陈岚岚 . 基于催化发夹自组装的多种病原微生物阵列检测 . | 中国口岸科学技术 , 2024 , 6 (9) , 70-77 . |
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Zero-dimensional (0D) halide perovskites have garnered significant interest due to their novel properties in optoelectronic and energy applications. However, the mechanisms underlying their phase transformations and fluorescence properties remain poorly understood. In this study, we have synthesized a micron-scale 0D perovskite observable under confocal laser scanning microscopy (CLSM). This approach enables us to trace the phase transformation process from 0D to three-dimensional (3D) structures, offering a deeper understanding of the underlying mechanisms. Remarkably, we discovered that this in situ transformation is highly sensitive to water, allowing for label-free fluorescent analysis of trace amounts of water in organic solvents through the phase transformation process. Additionally, we have designed a reusable paper strip for humidity analysis leveraging this sensitivity as an application of the micron scale material. Our findings not only elucidate the physicochemical properties of perovskites but also expand the potential of halide perovskite materials in analytical chemistry.
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| GB/T 7714 | Xie, Lili , Qiu, Haiyan , Chen, Yuxin et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications [J]. | RSC ADVANCES , 2024 , 14 (48) : 35490-35497 . |
| MLA | Xie, Lili et al. "Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications" . | RSC ADVANCES 14 . 48 (2024) : 35490-35497 . |
| APA | Xie, Lili , Qiu, Haiyan , Chen, Yuxin , Lu, Yingxue , Chen, Yanyan , Chen, Lanlan et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications . | RSC ADVANCES , 2024 , 14 (48) , 35490-35497 . |
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MicroRNA-21 (MiR-21) has been confirmed to be upregulated in tumors, and its abnormal expression is closely associated with tumor occurrence. However, the traditional imaging methods are limited to qualitative imaging of miR-21, and no effective strategy has been developed for monitoring its concentration in vivo during cancer initiation and progression. Herein, a biosensor is created utilizing a NIR-II ratiometric fluorescent nanoprobe to quantitatively monitor dynamic alterations in miR-21 levels in vivo. The nanoprobe (termed DCNP@DNA2@IR806) is constructed by introducing IR806 as a donor and down-conversion nanoparticles (DCNP) as the acceptor, using DNA as linkers. Upon miR-21-responsive initiation of the nanoprobe, the 1550 nm fluorescent signal of DCNP stimulated by a 808 nm laser (F1550, 808Ex) increased because of the close proximity of IR806 to the DCNP and the subsequent non-radiative energy transfer (NRET). Meanwhile, the 1550 nm fluorescent signal of DCNP stimulated by a 980 nm laser (F1550, 980Ex) remained stable because of the absence of NRET. This ratiometric NIR-II fluorescent signal has been confirmed to be a reliable indicator of miR-21 concentration in vivo. The strategy holds promise for further enhancing the understanding of microRNAs-based molecular mechanisms underlying cancer progression, laying a foundation for the early diagnosis of microRNAs-related diseases. A miR-21-activated ratiometric NIR-II fluorescence nanoprobe (DCNP@DNA2@IR806) for early diagnosis and real-time monitoring of miR-21 levels during cancer initiation and progression via enhanced ratiometric fluorescence signals in vivo. The content of activated miR-21 is positively correlated with tumor volume in the development of tumors. image
Keyword ：
biosensors biosensors initiation and progression initiation and progression microRNA-21 microRNA-21 nanoprobes nanoprobes NIR-II fluorescence imaging NIR-II fluorescence imaging
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| GB/T 7714 | Zheng, Liting , Wu, Ying , Wang, Qian et al. Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (45) . |
| MLA | Zheng, Liting et al. "Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression" . | ADVANCED FUNCTIONAL MATERIALS 34 . 45 (2024) . |
| APA | Zheng, Liting , Wu, Ying , Wang, Qian , Du, Wei , Chen, Lanlan , Song, Jibin et al. Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (45) . |
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Background: Cell surface enzymes are important proteins that play essential roles in controlling a wide variety of biological processes, such as cell-cell adhesion, recognition and communication. Dysregulation of enzyme- catalyzed processes is known to contribute to numerous diseases, including cancer, cardiovascular diseases and neurodegenerative disease. From the perspective of drug discovery and development, there is a growing interest in detecting the cell surface enzyme activity, propelled by the arising need for innovative diagnostic and therapeutic approaches to address various health conditions. Results: In this review, we focus on advances in chemical strategies for the detection of cell surface enzyme activity. Firstly, this comprehensive review delves into the diverse landscape of cell surface enzymes, detailing their structural features and diverse biological functions. Various enzyme families on the cell surface are examined in depth, elucidating their roles in cellular homeostasis and signaling cascades. Subsequently, various biosensors, including electrochemical biosensors, optical biosensors and dual-mode biosensors, used for detecting the cell surface enzyme activity are described. Exemplars are provided to illustrate the mechanisms, limit of detection and prospective applications of these different biosensors. Furthermore, this review unravels the intricate interplay between cell surface enzymes and cellular physiology, contributing to the development of novel diagnostic and therapeutic strategies for various diseases. In the end, the review provides insights into the ongoing challenges and future prospects associated with the detection of cell surface enzyme activity. Significance: Detecting cell surface enzyme activity holds pivotal significance in biomedical research, offering valuable insights into cellular physiology and disease pathology. Understanding enzyme activity aids in eluci- dating signaling pathways, drug interactions and disease mechanisms. This knowledge informs the development of diagnostic tools and therapeutic interventions targeting various ailments, from cancer to neurodegenerative disease. Additionally, it contributes to the advancement of drug screening and personalized medicine approaches.
Keyword ：
Cell surface enzyme Cell surface enzyme Chemical strategies Chemical strategies Dual-mode biosensors Dual-mode biosensors Electrochemical biosensors Electrochemical biosensors Optical biosensors Optical biosensors
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| GB/T 7714 | Zhou, Zhilan , Chen, Tingting , Zhu, Yingdi et al. Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1332 . |
| MLA | Zhou, Zhilan et al. "Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity" . | ANALYTICA CHIMICA ACTA 1332 (2024) . |
| APA | Zhou, Zhilan , Chen, Tingting , Zhu, Yingdi , Chen, Lanlan , Li, Juan . Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity . | ANALYTICA CHIMICA ACTA , 2024 , 1332 . |
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