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学者姓名：黄立勤
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Abstract ：
Cine imaging serves as a vital approach for non-invasive assessment of cardiac functional parameters. The imaging process of Cine cardiac MRI is inherently slow, necessitating the acquisition of data at multiple time points within each cardiac cycle to ensure adequate temporal resolution and motion information. Over prolonged data acquisition and during motion, Cine images can exhibit image degradation, leading to the occurrence of artifacts. Conventional image reconstruction methods often require expert knowledge for feature selection, which may result in information loss and suboptimal outcomes. In this paper, we employ a data-driven deep learning approach to address this issue. This approach utilizes supervised learning to compare data with different acceleration factors to full-sampled spatial domain data, training a context-aware network to reconstruct images with artifacts. In our model training strategy, we employ an adversarial approach to make the reconstructed images closer to ground truth. We incorporate loss functions based on adversarial principles and introduce image quality assessment as a constraint. Our context-aware model efficiently accomplishes artifact removal and image reconstruction tasks.
Keyword ：
Cine MRI Cine MRI Context Encoder Context Encoder Deep Learning Deep Learning Generative Adversarial Networks Generative Adversarial Networks Image Reconstruction Image Reconstruction
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| GB/T 7714 | Zhang, Weihua , Tang, Mengshi , Huang, Liqin et al. A Context-Encoders-Based Generative Adversarial Networks for Cine Magnetic Resonance Imaging Reconstruction [J]. | STATISTICAL ATLASES AND COMPUTATIONAL MODELS OF THE HEART. REGULAR AND CMRXRECON CHALLENGE PAPERS, STACOM 2023 , 2024 , 14507 : 359-368 . |
| MLA | Zhang, Weihua et al. "A Context-Encoders-Based Generative Adversarial Networks for Cine Magnetic Resonance Imaging Reconstruction" . | STATISTICAL ATLASES AND COMPUTATIONAL MODELS OF THE HEART. REGULAR AND CMRXRECON CHALLENGE PAPERS, STACOM 2023 14507 (2024) : 359-368 . |
| APA | Zhang, Weihua , Tang, Mengshi , Huang, Liqin , Li, Wei . A Context-Encoders-Based Generative Adversarial Networks for Cine Magnetic Resonance Imaging Reconstruction . | STATISTICAL ATLASES AND COMPUTATIONAL MODELS OF THE HEART. REGULAR AND CMRXRECON CHALLENGE PAPERS, STACOM 2023 , 2024 , 14507 , 359-368 . |
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Neural networks have found widespread application in medical image registration, although they typically assume access to the entire training dataset during training. In clinical scenarios, medical images of various anatomical targets, such as the heart, brain, and liver, may be obtained successively with advancements in imaging technologies and diagnostic procedures. The accuracy of registration on a new target may degrade over time, as the registration models become outdated due to domain shifts occurring at unpredictable intervals. In this study, we introduce a deep registration model based on continual learning to mitigate the issue of catastrophic forgetting during training with continuous data streams. To enable continuous network training, we propose a dynamic memory system based on a density-based clustering algorithm to retain representative samples from the data stream. Training the registration network on these representative samples enhances its generalization capabilities to accommodate new targets within the data stream. We evaluated our approach using the CHAOS dataset, which comprises multiple targets, such as the liver, left kidney, and spleen, to simulate a data stream. The experimental findings illustrate that the proposed continual registration network achieves comparable performance to a model trained with full data visibility.
Keyword ：
continual learning continual learning Data models Data models dynamic memory dynamic memory Heuristic algorithms Heuristic algorithms Liver Liver Medical diagnostic imaging Medical diagnostic imaging Registration network Registration network Streams Streams Task analysis Task analysis Training Training
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| GB/T 7714 | Ding, Wangbin , Sun, Haoran , Pei, Chenhao et al. Multi-Organ Registration With Continual Learning [J]. | IEEE SIGNAL PROCESSING LETTERS , 2024 , 31 : 1204-1208 . |
| MLA | Ding, Wangbin et al. "Multi-Organ Registration With Continual Learning" . | IEEE SIGNAL PROCESSING LETTERS 31 (2024) : 1204-1208 . |
| APA | Ding, Wangbin , Sun, Haoran , Pei, Chenhao , Jia, Dengqiang , Huang, Liqin . Multi-Organ Registration With Continual Learning . | IEEE SIGNAL PROCESSING LETTERS , 2024 , 31 , 1204-1208 . |
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Unsupervised domain adaptation(UDA) aims to mitigate the performance drop of models tested on the target domain, due to the domain shift from the target to sources. Most UDA segmentation methods focus on the scenario of solely single source domain. However, in practical situations data with gold standard could be available from multiple sources (domains), and the multi-source training data could provide more information for knowledge transfer. How to utilize them to achieve better domain adaptation yet remains to be further explored. This work investigates multi-source UDA and proposes a new framework for medical image segmentation. Firstly, we employ a multi-level adversarial learning scheme to adapt features at different levels between each of the source domains and the target, to improve the segmentation performance. Then, we propose a multi-model consistency loss to transfer the learned multi-source knowledge to the target domain simultaneously. Finally, we validated the proposed framework on two applications, i.e., multi-modality cardiac segmentation and cross-modality liver segmentation. The results showed our method delivered promising performance and compared favorably to state-of-the-art approaches.
Keyword ：
Domain adaptation Domain adaptation medical image segmentation medical image segmentation multi-source multi-source unsupervised learning unsupervised learning
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| GB/T 7714 | Pei, Chenhao , Wu, Fuping , Yang, Mingjing et al. Multi-Source Domain Adaptation for Medical Image Segmentation [J]. | IEEE TRANSACTIONS ON MEDICAL IMAGING , 2024 , 43 (4) : 1640-1651 . |
| MLA | Pei, Chenhao et al. "Multi-Source Domain Adaptation for Medical Image Segmentation" . | IEEE TRANSACTIONS ON MEDICAL IMAGING 43 . 4 (2024) : 1640-1651 . |
| APA | Pei, Chenhao , Wu, Fuping , Yang, Mingjing , Pan, Lin , Ding, Wangbin , Dong, Jinwei et al. Multi-Source Domain Adaptation for Medical Image Segmentation . | IEEE TRANSACTIONS ON MEDICAL IMAGING , 2024 , 43 (4) , 1640-1651 . |
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Given the diversity of medical images, traditional image segmentation models face the issue of domain shift. Unsupervised domain adaptation (UDA) methods have emerged as a pivotal strategy for cross modality analysis. These methods typically utilize generative adversarial networks (GANs) for both image-level and feature-level domain adaptation through the transformation and reconstruction of images, assuming the features between domains are well-aligned. However, this assumption falters with significant gaps between different medical image modalities, such as MRI and CT. These gaps hinder the effective training of segmentation networks with cross-modality images and can lead to misleading training guidance and instability. To address these challenges, this paper introduces a novel approach comprising a cross-modality feature alignment sub-network and a cross pseudo supervised dual-stream segmentation sub-network. These components work together to bridge domain discrepancies more effectively and ensure a stable training environment. The feature alignment sub-network is designed for the bidirectional alignment of features between the source and target domains, incorporating a self-attention module to aid in learning structurally consistent and relevant information. The segmentation sub-network leverages an enhanced cross-pseudo-supervised loss to harmonize the output of the two segmentation networks, assessing pseudo-distances between domains to improve the pseudo-label quality and thus enhancing the overall learning efficiency of the framework. This method's success is demonstrated by notable advancements in segmentation precision across target domains for abdomen and brain tasks.
Keyword ：
cross modality segmentation cross modality segmentation cross pseudo supervision cross pseudo supervision feature alignment feature alignment unsupervised domain adaptation unsupervised domain adaptation
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| GB/T 7714 | Yang, Mingjing , Wu, Zhicheng , Zheng, Hanyu et al. Cross-Modality Medical Image Segmentation via Enhanced Feature Alignment and Cross Pseudo Supervision Learning [J]. | DIAGNOSTICS , 2024 , 14 (16) . |
| MLA | Yang, Mingjing et al. "Cross-Modality Medical Image Segmentation via Enhanced Feature Alignment and Cross Pseudo Supervision Learning" . | DIAGNOSTICS 14 . 16 (2024) . |
| APA | Yang, Mingjing , Wu, Zhicheng , Zheng, Hanyu , Huang, Liqin , Ding, Wangbin , Pan, Lin et al. Cross-Modality Medical Image Segmentation via Enhanced Feature Alignment and Cross Pseudo Supervision Learning . | DIAGNOSTICS , 2024 , 14 (16) . |
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Parkinson's disease (PD) is a serious neurological disease. Many studies have preseted regions of interest such as substantia nigra (SN) for PD detection from magnetic resonance imaging (MRI). However, the SN is not the only region with remarkable tissue changes in PD MRIs. Patients with Prodromal Parkinson's Disease usually present with non-motor symptoms, and the associated brain regions may show varying degrees of damage on imaging. Therefore, exploring PD-related regions from whole-brain MRI is essential. In this study, we proposed an interpretable PD detection framework, including PD classification and feature region visualization. Specifically, we constructed a 3D ResNet model that could detect PD from whole-brain MRIs and discover other brain regions related to PD through 3D Gradient-weighted Class Activation Mapping (Grad-CAM) and Unified Parkinson's Disease Rating Scale (UPDRS). We obtained T1-Weighted MRIs from the Parkinson's Progression Markers Initiative (PPMI) database. The average classification accuracy of the 5-fold cross-validation and held-out dataset reached 96.1% and 94.5%, respectively. In addition, we used the 3D Grad-CAM framework to extract the weight of the feature map and obtain visual interpretation. The heat map highlighted the regions that were crucial for PD classification and found significant differences between PD and HC in frontal lobe related to linguistic semantic disorders. The UPDRS scores of PD and HC on the linguistic semantic function items were also remarkably different. Combined with previous studies, this work verified the significance of the frontal lobe and proved that the correlation between the frontal lobe and the pathogenesis of PD was explanatory.
Keyword ：
3D ResNet 3D ResNet Frontal lobe Frontal lobe Grad-CAM Grad-CAM MRI MRI Parkinson's diseases Parkinson's diseases Semantics Semantics
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| GB/T 7714 | Yang, Mingjing , Huang, Xianbin , Huang, Liqin et al. Diagnosis of Parkinson's disease based on 3D ResNet: The frontal lobe is crucial [J]. | BIOMEDICAL SIGNAL PROCESSING AND CONTROL , 2023 , 85 . |
| MLA | Yang, Mingjing et al. "Diagnosis of Parkinson's disease based on 3D ResNet: The frontal lobe is crucial" . | BIOMEDICAL SIGNAL PROCESSING AND CONTROL 85 (2023) . |
| APA | Yang, Mingjing , Huang, Xianbin , Huang, Liqin , Cai, Guoen . Diagnosis of Parkinson's disease based on 3D ResNet: The frontal lobe is crucial . | BIOMEDICAL SIGNAL PROCESSING AND CONTROL , 2023 , 85 . |
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针对基于传统非刚性医学图像配准的心脏超声序列图像配准方法缺乏自动性及配准速度慢、准确率较低的问题,将基于深度学习的医学图像配准算法应用于心脏超声序列图像配准,通过引入通道注意力机制,构建由注意力机制模块、Unet卷积神经网络模块及空间转换模块STN构成的配准模型.实验选取不同的相似性损失函数和平滑损失函数,对比VoxelMorph配准模型,相关配准性能指标都有不同程度的改进,DICE指标提升0.42％,MI指标提升2.5％,SSIM提升3.7％,NRMSE减小9％,表明配准模型的有效性.从配准效果及配准时间分析,配准模型基本可以满足心脏超声序列图像配准的实时性需求,具有一定的临床应用价值.
Keyword ：
Unet卷积神经网络 Unet卷积神经网络 医学图像配准 医学图像配准 心脏超声序列图像 心脏超声序列图像 深度学习 深度学习 通道注意力 通道注意力
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| GB/T 7714 | 兰其斌 , 黄立勤 . 基于注意力机制无监督心脏超声序列图像配准 [J]. | 福州大学学报（自然科学版） , 2023 , 51 (1) : 41-48 . |
| MLA | 兰其斌 et al. "基于注意力机制无监督心脏超声序列图像配准" . | 福州大学学报（自然科学版） 51 . 1 (2023) : 41-48 . |
| APA | 兰其斌 , 黄立勤 . 基于注意力机制无监督心脏超声序列图像配准 . | 福州大学学报（自然科学版） , 2023 , 51 (1) , 41-48 . |
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Quickly extracting road networks from high-resolution remote sensing images is crucial in mapping, urban planning, and GIS databases updating. Semi-automatic road extraction, as the main method of road surveying and mapping, is a labor-intensive task. In order to reduce the cost of manual intervention and improve extraction efficiency, this paper proposes a fast road centerline extraction algorithm based on geodesic distance field. First, the optimal circular template is proposed to automatically estimated the road width and adjust the manual seeds to road center based on the morphological gradient map, and the road saliency map is calculated according to the local color features inside the templates. Second, we propose the soft road center kernel density based on road saliency map which overcomes the difficulty of threshold presetting of road segmentation in traditional road center kernel density estimation. Most importantly, a geodesic distance field is proposed to quickly extract the geodesic curve between two consecutive seeds, which dramatically increase the efficiency of our algorithm. Finally, we introduce the mean filter into our scheme to smooth the road centerlines. Extensive experiments and quantitative comparisons show that the proposed algorithm can greatly reduce manual intervention without losing much accuracy, and significantly improve the efficiency of road extraction. Furthermore, the proposed algorithm takes almost the same time to extract any length of road centerline given fixed image size, and no hyperparameters need to be set. The algorithm behaves good experience in human-computer interaction. © 2023 SinoMaps Press. All rights reserved.
Keyword ：
Curve fitting Curve fitting Efficiency Efficiency Extraction Extraction Geodesy Geodesy Human computer interaction Human computer interaction Mapping Mapping Remote sensing Remote sensing Roads and streets Roads and streets
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| GB/T 7714 | Lian, Renbao , Zhang, Zhenmin , Liao, Yipeng et al. A quick road centreline extraction method from remote sensing images combining with geodesic distance field and curve smoothing [J]. | Acta Geodaetica et Cartographica Sinica , 2023 , 52 (8) : 1317-1329 . |
| MLA | Lian, Renbao et al. "A quick road centreline extraction method from remote sensing images combining with geodesic distance field and curve smoothing" . | Acta Geodaetica et Cartographica Sinica 52 . 8 (2023) : 1317-1329 . |
| APA | Lian, Renbao , Zhang, Zhenmin , Liao, Yipeng , Zou, Changzhong , Huang, Liqin . A quick road centreline extraction method from remote sensing images combining with geodesic distance field and curve smoothing . | Acta Geodaetica et Cartographica Sinica , 2023 , 52 (8) , 1317-1329 . |
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Myocardial pathology segmentation (MyoPS) is critical for the risk stratification and treatment planning of myocardial infarction (MI). Multi-sequence cardiac magnetic resonance (MS-CMR) images can provide valuable information. For instance, balanced steady-state free precession cine sequences present clear anatomical boundaries, while late gadolinium enhancement and T2-weighted CMR sequences visualize myocardial scar and edema of MI, respectively. Existing methods usually fuse anatomical and pathological information from different CMR sequences for MyoPS, but assume that these images have been spatially aligned. However, MS-CMR images are usually unaligned due to the respiratory motions in clinical practices, which poses additional challenges for MyoPS. This work presents an automatic MyoPS framework for unaligned MS-CMR images. Specifically, we design a combined computing model for simultaneous image registration and information fusion, which aggregates multi-sequence features into a common space to extract anatomical structures (i.e., myocardium). Consequently, we can highlight the informative regions in the common space via the extracted myocardium to improve MyoPS performance, considering the spatial relationship between myocardial pathologies and myocardium. Experiments on a private MS-CMR dataset and a public dataset from the MYOPS2020 challenge show that our framework could achieve promising performance for fully automatic MyoPS.
Keyword ：
multi-sequence car-diac magnetic resonance multi-sequence car-diac magnetic resonance Myocardial pathology Myocardial pathology registration registration segmentation segmentation
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| GB/T 7714 | Ding, Wangbin , Li, Lei , Qiu, Junyi et al. Aligning Multi-Sequence CMR Towards Fully Automated Myocardial Pathology Segmentation [J]. | IEEE TRANSACTIONS ON MEDICAL IMAGING , 2023 , 42 (12) : 3474-3486 . |
| MLA | Ding, Wangbin et al. "Aligning Multi-Sequence CMR Towards Fully Automated Myocardial Pathology Segmentation" . | IEEE TRANSACTIONS ON MEDICAL IMAGING 42 . 12 (2023) : 3474-3486 . |
| APA | Ding, Wangbin , Li, Lei , Qiu, Junyi , Wang, Sihan , Huang, Liqin , Chen, Yinyin et al. Aligning Multi-Sequence CMR Towards Fully Automated Myocardial Pathology Segmentation . | IEEE TRANSACTIONS ON MEDICAL IMAGING , 2023 , 42 (12) , 3474-3486 . |
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Background: With the wide application of CT scanning, the separation of pulmonary arteries and veins (A/V) based on CT images plays an important role for assisting surgeons in preoperative planning of lung cancer surgery. However, distinguishing between arteries and veins in chest CT images remains challenging due to the complex structure and the presence of their similarities. Methods: We proposed a novel method for automatically separating pulmonary arteries and veins based on vessel topology information and a twin-pipe deep learning network. First, vessel tree topology is constructed by combining scale-space particles and multi-stencils fast marching (MSFM) methods to ensure the continuity and authenticity of the topology. Second, a twin-pipe network is designed to learn the multiscale differences between arteries and veins and the characteristics of the small arteries that closely accompany bronchi. Finally, we designed a topology optimizer that considers interbranch and intrabranch topological relationships to optimize the results of arteries and veins classification. Results: The proposed approach is validated on the public dataset CARVE14 and our private dataset. Compared with ground truth, the proposed method achieves an average accuracy of 90.1% on the CARVE14 dataset, and 96.2% on our local dataset. Conclusions: The method can effectively separate pulmonary arteries and veins and has good generalization for chest CT images from different devices, as well as enhanced and noncontrast CT image sequences from the same device.
Keyword ：
Chest CT images Chest CT images Preoperative planning Preoperative planning Pulmonary artery-vein segmentation Pulmonary artery-vein segmentation Topology reconstruction Topology reconstruction Twin-pipe network Twin-pipe network
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| GB/T 7714 | Pan, Lin , Yan, Xiaochao , Zheng, Yaoyong et al. Automatic pulmonary artery-vein separation in CT images using a twin-pipe network and topology reconstruction [J]. | PEERJ COMPUTER SCIENCE , 2023 , 9 . |
| MLA | Pan, Lin et al. "Automatic pulmonary artery-vein separation in CT images using a twin-pipe network and topology reconstruction" . | PEERJ COMPUTER SCIENCE 9 (2023) . |
| APA | Pan, Lin , Yan, Xiaochao , Zheng, Yaoyong , Huang, Liqin , Zhang, Zhen , Fu, Rongda et al. Automatic pulmonary artery-vein separation in CT images using a twin-pipe network and topology reconstruction . | PEERJ COMPUTER SCIENCE , 2023 , 9 . |
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Background: Automatic pulmonary artery-vein separation has considerable importance in the diagnosis and treatment of lung diseases. However, insufficient connectivity and spatial inconsistency have always been the problems of artery-vein separation. Methods: A novel automatic method for artery-vein separation in CT images is presented in this work. Specifically, a multi-scale information aggregated network (MSIA-Net) including multi-scale fusion blocks and deep supervision, is proposed to learn the features of artery-vein and aggregate additional semantic information, respectively. The proposed method integrates nine MSIA-Net models for artery-vein separation, vessel segmentation, and centerline separation tasks along with axial, coronal, and sagittal multi-view slices. First, the preliminary artery-vein separation results are obtained by the proposed multi-view fusion strategy (MVFS). Then, centerline correction algorithm (CCA) is used to correct the preliminary results of artery- vein separation by the centerline separation results. Finally, the vessel segmentation results are utilized to reconstruct the artery-vein morphology. In addition, weighted cross-entropy and dice loss are employed to solve the class imbalance problem. Results: We constructed 50 manually labeled contrast-enhanced computed CT scans for five-fold cross -validation, and experimental results demonstrated that our method achieves superior segmentation perfor-mance of 97.7%, 85.1%, and 84.9% on ACC, Pre, and DSC, respectively. Additionally, a series of ablation studies demonstrate the effectiveness of the proposed components. Conclusion: The proposed method can effectively solve the problem of insufficient vascular connectivity and correct the spatial inconsistency of artery-vein.
Keyword ：
Centerline correction Centerline correction CT images CT images Multi-scale information aggregated Multi-scale information aggregated Pulmonary artery-vein separation Pulmonary artery-vein separation
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| GB/T 7714 | Pan, Lin , Li, Zhaopei , Shen, Zhiqiang et al. Learning multi-view and centerline topology connectivity information for pulmonary artery-vein separation [J]. | COMPUTERS IN BIOLOGY AND MEDICINE , 2023 , 155 . |
| MLA | Pan, Lin et al. "Learning multi-view and centerline topology connectivity information for pulmonary artery-vein separation" . | COMPUTERS IN BIOLOGY AND MEDICINE 155 (2023) . |
| APA | Pan, Lin , Li, Zhaopei , Shen, Zhiqiang , Liu, Zheng , Huang, Liqin , Yang, Mingjing et al. Learning multi-view and centerline topology connectivity information for pulmonary artery-vein separation . | COMPUTERS IN BIOLOGY AND MEDICINE , 2023 , 155 . |
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