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学者姓名：陈星伟
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Abstract ：
高校实验室是科技创新和人才培养的摇篮,科学的实验室管理方式能够充分发挥实验室功能,也是提高教学质量,完成实验任务的根本保障。在结合实验室工作实际情况的基础上,借鉴国内外科研院所实验室建设经验,分析了高校实验室管理工作中的问题和不足,从实验室信息化建设、开放实验室建设、实验室安全建设等方面探讨实验室的管理方法和管理模式。以提高实验室管理效率,更好地服务于教学科研工作,为聚力福州大学“双一流”建设提供实验室支持。
Keyword ：
信息化 信息化 实验室安全 实验室安全 实验平台 实验平台 设备共享 设备共享
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| GB/T 7714 | 何春娴 , 陈星伟 , 林珍珍 et al. 高校实验平台管理模式探索 [J]. | 实验室科学 , 2024 , 27 (01) : 182-184,188 . |
| MLA | 何春娴 et al. "高校实验平台管理模式探索" . | 实验室科学 27 . 01 (2024) : 182-184,188 . |
| APA | 何春娴 , 陈星伟 , 林珍珍 , 丁正新 . 高校实验平台管理模式探索 . | 实验室科学 , 2024 , 27 (01) , 182-184,188 . |
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Abstract ：
本发明公开了一种羧基酞菁锌‑阿霉素偶联物及其制备方法和应用，属于光敏剂和药物制备领域。羧基酞菁锌‑阿霉素偶联物的结构式如下：(Ⅰ)、(Ⅱ)、(Ⅲ)或(Ⅳ)。该化合物是新型光敏药物，且为具有光动力治疗和化疗双重效应的抗癌药物。同时，产物组成单一、结构明确，制备工艺简单。
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| GB/T 7714 | 黄剑东 , 陈星伟 , 郑巧凤 et al. 一种羧基酞菁锌-阿霉素偶联物及其制备和应用 : CN201610134923.5[P]. | 2016/3/10 . |
| MLA | 黄剑东 et al. "一种羧基酞菁锌-阿霉素偶联物及其制备和应用" : CN201610134923.5. | 2016/3/10 . |
| APA | 黄剑东 , 陈星伟 , 郑巧凤 , 柯美荣 . 一种羧基酞菁锌-阿霉素偶联物及其制备和应用 : CN201610134923.5. | 2016/3/10 . |
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Abstract ：
Two new tetra- or di--substituted zinc(II) phthalocyanines 5 and 6 have been prepared through a side-strapped method. In the molecules, the adjacent benzene rings of the phthalocyanine core are linked at -position through a triethylene glycol bridge to form a hybrid aza-/oxa-crown ether. The tetra--substituted phthalocyanine 5 shows an eclipsed self-assembly property in CH2Cl2 and the effect on the di--substituted analogue 6 is significantly weakened. Furthermore, the crown ethers of these compounds can selectively complex with Fe3+ or Cu2+ ion in DMF, leading to formation of J-aggregated nano-assemblies, which can be disaggregated in the presence of some organic or inorganic ligands, such as triethylamine, tetramethylethylenediamine, CH3COO-, or OH-. In addition, both compounds are efficient singlet oxygen generators with the singlet oxygen quantum yields (phi) of 0.54-0.74 in DMF relative to unsubstituted zinc(II) phthalocyanine (phi=0.56). They exhibit photodynamic activities toward HepG2 human hepatocarcinoma cells, but the compound 6, which has more than 40-fold lower IC50 value (0.08M) compared to the analogue 5 (IC50=3.31M), shows remarkablely higher in vitro photocytotoxicity due to its significantly higher cellular uptake and singlet oxygen generation efficiency. The results suggest that these compounds can serve as promising multifunctional materials both in (opto)electronic field and photodynamic therapy.
Keyword ：
crown compounds crown compounds J aggregation J aggregation metal ions metal ions photodynamic therapy photodynamic therapy phthalocyanines phthalocyanines
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| GB/T 7714 | Chen, Xing-Wei , Ke, Mei-Rong , Li, Xing-Shu et al. Synthesis, Supramolecular Behavior, and In Vitro Photodynamic Activities of Novel Zinc(II) Phthalocyanines "Side-strapped" with Crown Ether Bridges [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2013 , 8 (12) : 3063-3070 . |
| MLA | Chen, Xing-Wei et al. "Synthesis, Supramolecular Behavior, and In Vitro Photodynamic Activities of Novel Zinc(II) Phthalocyanines "Side-strapped" with Crown Ether Bridges" . | CHEMISTRY-AN ASIAN JOURNAL 8 . 12 (2013) : 3063-3070 . |
| APA | Chen, Xing-Wei , Ke, Mei-Rong , Li, Xing-Shu , Lan, Wen-Liang , Zhang, Miao-Fen , Huang, Jian-Dong . Synthesis, Supramolecular Behavior, and In Vitro Photodynamic Activities of Novel Zinc(II) Phthalocyanines "Side-strapped" with Crown Ether Bridges . | CHEMISTRY-AN ASIAN JOURNAL , 2013 , 8 (12) , 3063-3070 . |
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Keyword ：
光动力 光动力 合成 合成 抗癌 抗癌 酞菁 酞菁
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| GB/T 7714 | 陈星伟 , 李兴淑 , 张妙芬 et al. α位取代酞菁化合物的合成及活性研究 [C] //全国第十六届大环化学暨第八届超分子化学学术讨论会论文集 . 2012 : 325-325 . |
| MLA | 陈星伟 et al. "α位取代酞菁化合物的合成及活性研究" 全国第十六届大环化学暨第八届超分子化学学术讨论会论文集 . (2012) : 325-325 . |
| APA | 陈星伟 , 李兴淑 , 张妙芬 , 黄剑东 . α位取代酞菁化合物的合成及活性研究 全国第十六届大环化学暨第八届超分子化学学术讨论会论文集 . (2012) : 325-325 . |
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