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学者姓名：张芳
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Abstract ：
鱼油富含二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)等ω-3多不饱和脂肪酸,对心血管疾病防治具有积极作用,其功效与品质直接关联.随着消费者对鱼油质量安全需求的日趋增长,快速检测技术的发展与应用对鱼油生产过程监控及其产品品质保障具有重要意义.光谱与物质的组成及含量密切相关,通过分析物质的光谱特征,获取能够反映其分子结构的信息,从而实现对化合物的定性、定量检测.相比传统化学检测方法,光谱技术具有高效、无损、无需过多前处理及绿色环保等优势,在鱼油品质检测方面具有一定的应用及开发前景.文章阐述了近红外、中红外和拉曼光谱技术及其在鱼油品质检测中的应用原理,归纳了建立光谱预测模型的常规步骤,介绍了几种用于光谱信息预处理、模型校正的化学计量学方法,梳理了近年来国内外基于这三种光谱技术在鱼油营养成分(脂肪酸、磷脂、虾青素等)、理化指标(酸价、过氧化值、碘值等)和掺假分析等品质检测方面的应用研究,并探讨了现代化光谱技术结合化学计量学在鱼油品质快速无损检测的应用前景及存在问题,以期实现从实验室研究扩展到实际生产检测,从而促进我国鱼油产业的健康发展.
Keyword ：
中红外光谱 中红外光谱 化学计量学 化学计量学 拉曼光谱 拉曼光谱 近红外光谱 近红外光谱 鱼油 鱼油
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| GB/T 7714 | 马湖伊杉 , 潘南 , 林振宇 et al. 振动光谱技术在鱼油品质检测中的应用研究进展 [J]. | 光谱学与光谱分析 , 2025 , 45 (2) : 301-311 . |
| MLA | 马湖伊杉 et al. "振动光谱技术在鱼油品质检测中的应用研究进展" . | 光谱学与光谱分析 45 . 2 (2025) : 301-311 . |
| APA | 马湖伊杉 , 潘南 , 林振宇 , 陈晓婷 , 吴靖娜 , 张芳 et al. 振动光谱技术在鱼油品质检测中的应用研究进展 . | 光谱学与光谱分析 , 2025 , 45 (2) , 301-311 . |
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Rationale: In recent years, ephedrine psychoactive substances have attracted much attention due to their prevalence in water bodies and potential threat to aquatic ecosystems. Psychoactive substances have been considered as a new type of environmental pollutant due to their unpredictable potential risks to the behavior and nervous system of non-target organisms. A rapid, sensitive, selective, and robust method for the quantification of three ephedrine psychoactive substances in sewage is needed. Methods: An ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous determination of three ephedrine psychoactive substances in water. The optimal processing conditions were determined by optimizing the chromatography—mass spectrometry and solid-phase extraction (SPE) conditions (e.g., the SPE column, sample pH, washing, and elution), and the treatment conditions were determined; this was achieved via positive ion scanning in multiple reaction monitoring mode. Poly-Sery MCX was selected as the extraction column, with samples loaded at pH 3. And 4-mL solution of 2% formic acid (FA) aqueous solution was used as the eluent; the target compounds were eluted with 5 mL of 5% NH4OH in acetonitrile (ACN) solution. The best results were obtained when the residue was resolubulization in ACN after nitrogen evaporation. Results: The developed UPLC-MS/MS showed a good linear relationship in the range of 0–50.00 μg/L, with determination coefficients (R2) greater than 0.9990. The detection limit and quantitation limit were 0.05–0.10 and 0.20–0.50 μg/L, respectively. Recovery rates of the target compounds in blank sewage at three different concentrations ranged from 92.37% to 106.31%, with relative standard deviations (RSDs) of 0.77%–4.83% (n = 7). Conclusions: This method has been successfully applied to the analysis of surface water and domestic sewage, and the samples were processed stably, indicating that the method is practical for the determination of ephedrine psychoactive drugs in water bodies. © 2024 John Wiley & Sons Ltd.
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| GB/T 7714 | Xu, Y. , Yang, F. , Ye, H. et al. Determination of three ephedrine psychoactive substances in sewage using solid-phase extraction–ultra-performance liquid chromatography–tandem mass spectrometry [J]. | Rapid Communications in Mass Spectrometry , 2024 , 38 (20) . |
| MLA | Xu, Y. et al. "Determination of three ephedrine psychoactive substances in sewage using solid-phase extraction–ultra-performance liquid chromatography–tandem mass spectrometry" . | Rapid Communications in Mass Spectrometry 38 . 20 (2024) . |
| APA | Xu, Y. , Yang, F. , Ye, H. , Tang, Q. , Chen, Y. , Gao, Z. et al. Determination of three ephedrine psychoactive substances in sewage using solid-phase extraction–ultra-performance liquid chromatography–tandem mass spectrometry . | Rapid Communications in Mass Spectrometry , 2024 , 38 (20) . |
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Bacterial infection of wounds is one of great concern to patients, and rapid and correct detection of bacterial infection is crucial to ensure accurate diagnosis and early intervention. Based on the principle that glucose can only be consumed by live bacteria, a fluorescent biosensor was constructed to detect four kinds of common infectious bacteria (Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) in skin wounds, taking advantage of magnetic bead-aptamer for recognizing, sorting and enrichment, platinum nanoparticles for signal amplification. The linear detection range of AB, EC, PA and SA were 27- 8 x 106 CFU/mL, 10- 2.5 x 107 CFU/mL, 34- 2.5 x 107 CFU/mL and 10- 1.0 x 107 CFU/mL, respectively, and the limits of detection were 27 CFU/mL, 10 CFU/mL, 34 CFU/mL and 2 CFU/mL. Furthermore, all target bacteria in samples containing 8 x 108 CFU/mL of other interfering bacteria have been successfully identified and quantified. The proposed method was also successfully applied to the detection of bacterial infection in skin wounds of mouse and human, including the detection of separate bacterial infection as well as a coinfection. The recovery of this method was in the range of 90.161- 109.961%. Thus, this proposed method can be a promising candidate for rapid and convenient evaluation of infectious bacteria in point-of-care settings.
Keyword ：
Aptamer Aptamer Bacterial infection Bacterial infection Fluorescent biosensor Fluorescent biosensor Platinum nanoparticles Platinum nanoparticles Wound Wound
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| GB/T 7714 | Gao, Lanmei , Zheng, Houbing , Hu, Yuanlong et al. Fluorescent biosensor based on MB-APT combined with Pt NPs for the detection of infectious bacteria in mouse and human wounds [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 393 . |
| MLA | Gao, Lanmei et al. "Fluorescent biosensor based on MB-APT combined with Pt NPs for the detection of infectious bacteria in mouse and human wounds" . | SENSORS AND ACTUATORS B-CHEMICAL 393 (2023) . |
| APA | Gao, Lanmei , Zheng, Houbing , Hu, Yuanlong , Zhong, Yi , Jiang, Linhai , Wu, Yuanzi et al. Fluorescent biosensor based on MB-APT combined with Pt NPs for the detection of infectious bacteria in mouse and human wounds . | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 393 . |
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Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles are known to be inherently unstable upon interaction with cell membranes in the physiological environment, thus potentially compromising their specific targeting against cancer cells. This flaw is addressed in the present work which reports a superstable micellar nanodelivery system as an amphiphilic copolymer self-assembled micelle composed of nucleic acid aptamer and polyvalent hydrophobic poly(maleic anhydride-alt-1-octadecene) (C18PMH). Using Ce6 as a drug model, these C18-aptamer micelles exhibit efficient tumor-targeting and -binding ability, facilitating the entry of Ce6 into targeted cells for photodynamic therapy. In addition, they can be loaded with other hydrophobic drugs and still demonstrate favorable therapeutic effects. As such, these C18-aptamer micelles can serve as a universal platform for loading multiple drugs, providing a safer and more effective solution for treating cancer.
Keyword ：
Aptamer micelles Aptamer micelles Self-assembly Self-assembly Specific cell recognition Specific cell recognition
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| GB/T 7714 | Chen, Ganghui , Mao, Dongsheng , Wang, Xuan et al. Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
| MLA | Chen, Ganghui et al. "Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery" . | JOURNAL OF NANOBIOTECHNOLOGY 21 . 1 (2023) . |
| APA | Chen, Ganghui , Mao, Dongsheng , Wang, Xuan , Chen, Jingqi , Gu, Chao , Huang, Shuqin et al. Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery . | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
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The combined contamination of multiple mycotoxins (MTs) is a matter of utmost concern, posing significant threats to both the economy stability and the well-being of humans and animals. Consequently, there is an urgent demand for highly sensitive and portable multiplex detection methods to effectively identify and quantify MTs. The primary objective of this paper is to provide a comprehensive overview of the methods to detect multiple MTs in agricultural products, including instrumental and biosensor approaches published in the last five years. Specifically, we emphasize detection methods for antibody (ab)- and aptamer (apt)-based biosensors, while undertaking a comparative analysis of their performance, particularly focusing on the sensitivity. Furthermore, this review proposes several promising technologies that can be leveraged in the future and outlines the challenges and prospects associated with achieving rapid, accurate, and intelligent detection of MTs.
Keyword ：
Agriculture products Agriculture products Antibody Antibody Aptamer Aptamer Multiplex detection Multiplex detection Mycotoxin Mycotoxin
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| GB/T 7714 | Wei, Chencheng , Wang, Handong , Li, Gaozheng et al. Multiplex detection methods for mycotoxins in agricultural products: A systematic review [J]. | FOOD CONTROL , 2023 , 158 . |
| MLA | Wei, Chencheng et al. "Multiplex detection methods for mycotoxins in agricultural products: A systematic review" . | FOOD CONTROL 158 (2023) . |
| APA | Wei, Chencheng , Wang, Handong , Li, Gaozheng , Li, Jianhua , Zhang, Fang , Wu, Yuezhong et al. Multiplex detection methods for mycotoxins in agricultural products: A systematic review . | FOOD CONTROL , 2023 , 158 . |
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Much progress has been made in the biosensor area with the prosperity and development of nucleic acid nanotechnology and molecular biology. Especially, the advances made in dynamic DNA nanotechnology and the increasing sophistication of toehold-mediated strand displacement reactions have put new energy into nucleic acid-based biosensor designs. The exposure of the gene-editing ability of clustered regularly interspaced short palindromic repeats (CRISPR) associated proteins (Cas) has also greatly revolutionized the way nucleic acid can be operated in biosensing systems, providing versatile strategies for signal handling. Hence, in this review, we will discuss the application of these two technologies as the expanded tools for nucleic acid-based biosensors and focus on their strategies governing signal trans-duction. Besides, technologies like DNA computing and deep learning approaches which flashed in nucleic acid biosensors very recently are also discussed in the perspective and outlook part.(c) 2023 Elsevier B.V. All rights reserved.
Keyword ：
Biosensor Biosensor Cas system Cas system CRISPR CRISPR DNA DNA DNA dynamic nanotechnology DNA dynamic nanotechnology Toehold strand displacement Toehold strand displacement
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| GB/T 7714 | Zhang, Fang , Chen, Ganghui , Gao, Chenshan et al. Updated toolkits for nucleic acid-based biosensors [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2023 , 159 . |
| MLA | Zhang, Fang et al. "Updated toolkits for nucleic acid-based biosensors" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 159 (2023) . |
| APA | Zhang, Fang , Chen, Ganghui , Gao, Chenshan , Huang, Shuqin , Mahu, Yishan , Luo, Fang et al. Updated toolkits for nucleic acid-based biosensors . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2023 , 159 . |
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Salmonella is one of four key global causes of diarrhea, and in humans, it is generally contracted through the consumption of contaminated food. It is necessary to develop an accurate, simple, and rapid method to monitor Salmonella in the early phase. Herein, we developed a sequence-specific visualization method based on loop-mediated isothermal amplification (LAMP) for the detection of Salmonella in milk. With restriction endonuclease and nicking endonuclease, amplicons were produced into single-stranded triggers, which further promoted the generation of a G-quadruplex by a DNA machine. The G-quadruplex DNAzyme possesses peroxidase-like activity and catalyzes the color development of 2,2'-azino-di-(3-ethylbenzthiazoline sulfonic acid) (ABTS) as the readouts. The feasibility for real samples analysis was also confirmed with Salmonella spiked milk, and the sensitivity was 800 CFU/mL when observed with the naked eye. Using this method, the detection of Salmonella in milk can be completed within 1.5 h. Without the involvement of any sophisticated instrument, this specific colorimetric method can be a useful tool in resource-limited areas.
Keyword ：
colorimetric detection colorimetric detection DNA machine DNA machine G-quadruplex G-quadruplex loop-mediated isothermal amplification loop-mediated isothermal amplification sequence-specific sequence-specific
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| GB/T 7714 | Zeng, Huan , Huang, Shuqin , Chen, Yunong et al. Label-Free Sequence-Specific Visualization of LAMP Amplified Salmonella via DNA Machine Produces G-Quadruplex DNAzyme [J]. | BIOSENSORS-BASEL , 2023 , 13 (5) . |
| MLA | Zeng, Huan et al. "Label-Free Sequence-Specific Visualization of LAMP Amplified Salmonella via DNA Machine Produces G-Quadruplex DNAzyme" . | BIOSENSORS-BASEL 13 . 5 (2023) . |
| APA | Zeng, Huan , Huang, Shuqin , Chen, Yunong , Chen, Minshi , He, Kaiyu , Fu, Caili et al. Label-Free Sequence-Specific Visualization of LAMP Amplified Salmonella via DNA Machine Produces G-Quadruplex DNAzyme . | BIOSENSORS-BASEL , 2023 , 13 (5) . |
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Rapid and accurate detection of Salmonella is extremely important to ensure food safety. Combining nucleic acid amplification with CRISPR/Cas12a can realize sensitive and specific detection of foodborne pathogens. However, present CRISPR/Cas-based methods mainly depend on fluorophore and quencher dual-labeled ssDNA as the reporter, which brings in high cost and steric hindrance. Herein, a new signal output format has been developed. The method takes advantage of graphene oxide adsorbing FAM-ssDNA and quenching the fluorescent emission while CRISPR/Cas12a recovering the fluorescent emission by trans-cleaving the FAM-ssDNA. Factors affecting the performance of the sensor have been optimized, and it is shown that the oligonucleotide of 12 nt with the fluorophore modified at the 3 ' end displays the highest signal to noise ratio. The signal output method has been combined with recombinase polymerase amplification for detection of Salmonella and presents consistent specificity and sensitivity (5 x 101 copies) as real-time PCR. By replacing the dual-labeled ssDNA reporter with FAM-ssDNA and GO, this signal output method saves similar to 65% cost. Notably, this method does not require a real-time thermal cycler or any other sophisticated instrument. Besides pathogens, this easy and convenient method can also be extended to detect other targets.
Keyword ：
CRISPR/Cas12a CRISPR/Cas12a Fluorescent recovery Fluorescent recovery Graphene oxide Graphene oxide Salmonella Salmonella Visual detection Visual detection
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| GB/T 7714 | Wang, Liu , Bai, Linlin , Wang, Hongmei et al. Graphene oxide assisting the visual detection of Salmonella by CRISPR/ Cas12a [J]. | MICROCHEMICAL JOURNAL , 2023 , 191 . |
| MLA | Wang, Liu et al. "Graphene oxide assisting the visual detection of Salmonella by CRISPR/ Cas12a" . | MICROCHEMICAL JOURNAL 191 (2023) . |
| APA | Wang, Liu , Bai, Linlin , Wang, Hongmei , He, Kaiyu , Wang, Rui , Wang, Qiang et al. Graphene oxide assisting the visual detection of Salmonella by CRISPR/ Cas12a . | MICROCHEMICAL JOURNAL , 2023 , 191 . |
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Food packaging plays a vital role in the food supply chain by acting as an additional layer to protect against food contamination, but the main function of traditional conventional packaging is only to isolate food from the outside environment, and cannot provide related information about food spoilage. Intelligent packaging can feel, inspect, and record external or internal changes in food products to provide further information about food quality. Importantly, intelligent packaging indicators will account for a significant proportion of the food industry's production, with promising application potential. In this review, we mainly summarize and review the upcoming progress in the classification, preparation, and application of food packaging indicators. Equally, the feasibility of 3D printing in the preparation of intelligent food packaging indicators is also discussed in detail, as well as the limitations and future directions of smart food packaging. Taken together, the information supported in this paper provides new insights into monitoring food spoilage and food quality.
Keyword ：
3D printing 3D printing color color food packaging food packaging indicator indicator spoilage spoilage
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| GB/T 7714 | Ma, Yuchen , Yang, Wei , Xia, Yujie et al. Properties and Applications of Intelligent Packaging Indicators for Food Spoilage [J]. | MEMBRANES , 2022 , 12 (5) . |
| MLA | Ma, Yuchen et al. "Properties and Applications of Intelligent Packaging Indicators for Food Spoilage" . | MEMBRANES 12 . 5 (2022) . |
| APA | Ma, Yuchen , Yang, Wei , Xia, Yujie , Xue, Wenshuang , Wu, Haixia , Li, Zhanming et al. Properties and Applications of Intelligent Packaging Indicators for Food Spoilage . | MEMBRANES , 2022 , 12 (5) . |
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Food allergy has been a serious public health problem around the world. Its prevention relies heavily on the effective avoidance of any contaminated food, making clear and accurate detection very important. LAMP is one of the most potent methods for allergen rapid detection. However, its current colorimetric readouts usually have low color contrast and narrow color variation range. Thus, here we proposed a strategy based on color evolution to enlarge the variation range as well as the contrast to improve its suitability for naked-eye observation. By simply blending two commonly used color change processes during amplification, a wider color variation window, and a near contrast color change, purple-to-green with a hues difference of 10 were obtained. Three important allergens (walnuts, hazelnuts, and peanuts) were tested with a comparable sensitivity towards fluo-rescent real-time LAMP. Its feasibility for practical use has also been studied. This simple but effective strategy provides a new idea for the colorimetric detection of LAMP amplicons and can be applied to various fields.
Keyword ：
Color blending Color blending Color evolution Color evolution Food allergen Food allergen Loop-mediated isothermal amplification Loop-mediated isothermal amplification Visual detection Visual detection
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| GB/T 7714 | Zhang, Fang , Gao, Chenshan , Bai, Linlin et al. Dual-color blending based visual LAMP for food allergen detection: A strategy with enlarged color variation range and contrast [J]. | FOOD CHEMISTRY-X , 2022 , 13 . |
| MLA | Zhang, Fang et al. "Dual-color blending based visual LAMP for food allergen detection: A strategy with enlarged color variation range and contrast" . | FOOD CHEMISTRY-X 13 (2022) . |
| APA | Zhang, Fang , Gao, Chenshan , Bai, Linlin , Chen, Yiquan , Liang, Shuying , Lv, Xucong et al. Dual-color blending based visual LAMP for food allergen detection: A strategy with enlarged color variation range and contrast . | FOOD CHEMISTRY-X , 2022 , 13 . |
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