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学者姓名：郑琤
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Abstract ：
Peroxynitrite (ONOO-) is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO- optical imaging probes are still hampered by high background/autofluorescence (fluorescence probe), short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein, we report a facile method to prepare an activatable chemiluminescence probe (PPA-PEG) with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a (PPA), a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly(ethylene glycol) (4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles (namely PPA-PEG nanoprobe) in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPA-PEG was successfully applied to image cellular ONOO- changes, as well as the endogenous ONOO- changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma (HCC) tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio (SBR). Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.
Keyword ：
chemiluminescence chemiluminescence inflammation inflammation pyropheophorbide-a pyropheophorbide-a reactive nitrogen species reactive nitrogen species tumor tumor
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| GB/T 7714 | Ke, Jianmei , Ding, Lei , Lian, Ronggui et al. Activatable chemiluminescence probe based on four-arm PEG-conjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite [J]. | SCIENCE CHINA-CHEMISTRY , 2025 , 68 (5) : 2125-2137 . |
| MLA | Ke, Jianmei et al. "Activatable chemiluminescence probe based on four-arm PEG-conjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite" . | SCIENCE CHINA-CHEMISTRY 68 . 5 (2025) : 2125-2137 . |
| APA | Ke, Jianmei , Ding, Lei , Lian, Ronggui , Zheng, Cheng , Li, Wenjun , Zheng, Aixian et al. Activatable chemiluminescence probe based on four-arm PEG-conjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite . | SCIENCE CHINA-CHEMISTRY , 2025 , 68 (5) , 2125-2137 . |
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介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究。本实验基于氧化还原反应和配位反应合成Cu(I)配合物，采用薄层色谱法判断合成反应进程，运用配位滴定法测定其铜含量，利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度。本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作，同时体现了发光金属配合物这一科研热点，探究物质结构与性质的关系。通过本实验的实践，学生在巩固所学实验知识和实验技能的同时，训练了运用所学知识解决实际问题的综合能力，有利于学生初步建立科学的思维方式和研究能力。
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜(I)配合物 铜(I)配合物 铜含量分析 铜含量分析
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 [J]. | 大学化学 , 2024 , 39 (07) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验" . | 大学化学 39 . 07 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 . | 大学化学 , 2024 , 39 (07) , 322-329 . |
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Abstract ：
介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究.本实验基于氧化还原反应和配位反应合成Cu(Ⅰ)配合物,采用薄层色谱法判断合成反应进程,运用配位滴定法测定其铜含量,利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度.本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作,同时体现了发光金属配合物这一科研热点,探究物质结构与性质的关系.通过本实验的实践,学生在巩固所学实验知识和实验技能的同时,训练了运用所学知识解决实际问题的综合能力,有利于学生初步建立科学的思维方式和研究能力.
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜含量分析 铜含量分析 铜(Ⅰ)配合物 铜(Ⅰ)配合物
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 [J]. | 大学化学 , 2024 , 39 (7) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究" . | 大学化学 39 . 7 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 . | 大学化学 , 2024 , 39 (7) , 322-329 . |
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Photodynamic therapy (PDT) is a promising cancer treatment modality with advantages of minimal in-vasiveness, repeatable therapy, and mild systemic toxicity. However, the limited bioavailability of photo -sensitizer (PS), tumor hypoxia, and the presence of antiapoptotic proteins in cancer cells, has hampered the efficiency of PDT. To address these limitations, herein, we developed a hyaluronic acid (HA) based nanosystem (HA-Ce6-Hemin@DNA-Protamine NPs, HCH@DP) loaded with chlorin e6 (Ce6, as PS), hemin (as mimetic catalase) and antisense oligonucleotide (ASO) of B-cell lymphoma 2 (Bcl-2) anti-apoptosis protein via a simple electrostatic self-assembly method for enhanced PDT of hypoxic solid tumors. The HCH@DP can target deliver the PS and ASO to tumor cells via cancer cell overexpressed HA receptors (i.e., CD44 or RHAMM). The Ce6 was released from HA-ss-Ce6 (HSC conjugates) after the reaction of cleavable disulfide bond with glutathione (GSH), which recovered the fluorescence and phototoxicity of Ce6 upon laser irradiation. Meanwhile, the catalase-mimicking hemin (degradation of HA-eda-hemin by hyaluronidase) decomposed the tumor overdressed endogenous H2O2 to oxygen, which relieved tumor hypoxia and further overcome hypoxia-associated resistance of PDT. Furthermore, the inhibition of Bcl-2 expression by Bcl-2 ASO also greatly improved the cellular sensitivity to PDT. Both in vitro and in vivo results showed the tumor cell targeting ability, hypoxia relief and significantly enhanced antitumor PDT efficacy of HCH@DP for hypoxic tumor cells upon laser irradiation. Thus, by improving the target delivery of PS and ASO, relieving tumor hypoxia, and down-regulation of anti-apoptotic proteins, this HCH@DP nanosystem achieved enhanced PDT efficiency against hypoxic tumors. In general, our work provided a promising strategy to increase the utilization of key components (PS and oxygen) of PDT and the cell sensitivity to PDT by targeting co-delivery PS and oligonucleotides to tumor cells via a biocompatible HA based carrier, thereby achieving efficiently PDT treatment of hypoxic solid tumors with potential transla-tion possibility.Statement of significance The efficiency of PDT against solid tumor is severely restricted by the limited bioavailability of photo -sensitizer, tumor hypoxia, and the presence of antiapoptotic proteins in cancer cells. Herein, we have developed an activatable hyaluronic acid (HA) based nanosystem (HA-Ce6-Hemin@DNA-Protamine NPs, HCH@DP) via a simple electrostatic self-assembly method for PDT treatment of hypoxic solid tumors. The HCH@DP enabled to target co-delivery of photosensitizer and antisense oligonucleotide to tumor cells, overcoming tumor hypoxia through in situ oxygen production and improving cellular sensitivity by efficiently reducing anti-apoptosis effect of cancer cells for synergistically enhancing PDT efficiency. This work suggests a promising strategy to develop small molecule drug and oligonucleotides co-delivery nanoplatforms for efficiently PDT treatment of hypoxic solid tumor. (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keyword ：
Antisense oligonucleotide Antisense oligonucleotide Hyaluronic acid Hyaluronic acid Hypoxia Hypoxia Synergistic PDT Synergistic PDT Tumor microenvironment Tumor microenvironment
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| GB/T 7714 | Wu, Yanni , Ding, Lei , Zheng, Cheng et al. Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors [J]. | ACTA BIOMATERIALIA , 2022 , 153 : 419-430 . |
| MLA | Wu, Yanni et al. "Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors" . | ACTA BIOMATERIALIA 153 (2022) : 419-430 . |
| APA | Wu, Yanni , Ding, Lei , Zheng, Cheng , Li, Hongsheng , Wu, Ming , Sun, Yupeng et al. Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors . | ACTA BIOMATERIALIA , 2022 , 153 , 419-430 . |
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Abstract ：
从命题思路、试题内容及特点和结果分析等3个方面对第11届全国大学生化学实验邀请赛的理论试题进行讨论分析和总结,同时对化学实验教学的改革提出几点思考和建议,以期促进高校化学实验教学的改革和创新。
Keyword ：
化学实验邀请赛 化学实验邀请赛 实验教学改革 实验教学改革 实验理论试题 实验理论试题
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| GB/T 7714 | 郑琤 , 魏巧华 , 汤儆 et al. 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 [J]. | 化学教育(中英文) , 2021 , 42 (06) : 61-64 . |
| MLA | 郑琤 et al. "从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考" . | 化学教育(中英文) 42 . 06 (2021) : 61-64 . |
| APA | 郑琤 , 魏巧华 , 汤儆 , 游毅 . 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 . | 化学教育(中英文) , 2021 , 42 (06) , 61-64 . |
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Abstract ：
从命题思路、试题内容及特点和结果分析等3个方面对第11届全国大学生化学实验邀请赛的理论试题进行讨论分析和总结,同时对化学实验教学的改革提出几点思考和建议,以期促进高校化学实验教学的改革和创新.
Keyword ：
化学实验邀请赛 化学实验邀请赛 实验教学改革 实验教学改革 实验理论试题 实验理论试题
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| GB/T 7714 | 郑琤 , 魏巧华 , 汤儆 et al. 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 [J]. | 化学教育 , 2021 , 42 (6) : 61-64 . |
| MLA | 郑琤 et al. "从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考" . | 化学教育 42 . 6 (2021) : 61-64 . |
| APA | 郑琤 , 魏巧华 , 汤儆 , 游毅 . 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 . | 化学教育 , 2021 , 42 (6) , 61-64 . |
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Polynucleotide kinase (PNK) is an important DNA damage repair-related enzyme and also a promising therapeutic target in various diseases. Here, we developed a dual amplified sensing strategy based on the combination of terminal deoxynucleotidyl transferase (TdT) and CRISPR-Cas12a for high selective and sensitive detection of PNK activity in cell lysates and also inhibitor screening. In this sensing system, the PNK converted the 3'-phosphate DNA to 3'-hydroxy DNA, and then the TdT catalyzed to add a long poly-adenine (poly (A)) at the 3' OH terminus DNA (as first amplified step). The produced poly (A) tail acted as activator to trigger the Cas12a trans-cleavage (non-target) activity to cleave reporter probes for fluorescence detection (as second amplified step). The dual amplified steps lead to a synergetic signal amplification effect for sensitive detection of PNK activity. The developed sensing platform enable detect PNK activity with linear range from 0 to 1 U/mL and a direct detection limit of 5 x 10(-4) U/mL. It was also successfully used for PNK inhibitor screening and PNK activity detection in cell extracts even at a single-cell level. The efficient dual amplified method can broaden the CRISPR/Cas-based sensing systems in other bio-/chem-analysis fields.
Keyword ：
CRISPR-Cas12a CRISPR-Cas12a Dephosphorylation Dephosphorylation DNA damage repair DNA damage repair Polynucleotide kinase Polynucleotide kinase Terminal deoxynucleotidyl transferase Terminal deoxynucleotidyl transferase
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| GB/T 7714 | Zhang, Xiaolong , Zheng, Cheng , Ding, Lei et al. CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 330 . |
| MLA | Zhang, Xiaolong et al. "CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity" . | SENSORS AND ACTUATORS B-CHEMICAL 330 (2021) . |
| APA | Zhang, Xiaolong , Zheng, Cheng , Ding, Lei , Wu, Yanni , Xu, Haipo , Sun, Yupeng et al. CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity . | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 330 . |
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MoO2 is a promising anode material for lithium-ion batteries, however, the lithiation of bulk MoO2 is usually limited to addition-type reaction at room temperature, and the conversion reaction is hindered because of the sluggish kinetics. Herein, a nanocomposite of MoO2 embedded in nitrogen-doped carbon (MoO2/NC) is synthesized through the in situ thermolysis of an organic molybdenum complex MoO2(acac)(phen) (acac = acetylacetone, phen = 1,10-Phenanthroline). Owing to the fact that [MoO2](2+) can be strongly chelated by phen, the molybdenum source in the MoO2(acac)(phen) precursor is highly dispersed, leading to the formation of ultra-small MoO2 nanoparticles in the nanocomposite, which can facilitate the conversion reaction. Moreover, the NC matrix can guarantee a high electrical conductivity and effectively accommodate the volume changes triggered by the conversion reaction. Consequently, the MoO2/NC nanocomposite exhibits outstanding electrochemical properties, including large reversible capacity of 950 mA h g(-1) at 0.1 A g(-1), high-rate capability of 605 mA h g(-1) at 2 A g(-1), and excellent cycling stability over 500 cycles as an anode material for lithium-ion batteries. (C) 2021 Elsevier Inc. All rights reserved.
Keyword ：
Electrochemical properties Electrochemical properties Lithium-ion batteries Lithium-ion batteries MoO2 nanoparticles MoO2 nanoparticles Nanocomposite Nanocomposite Nitrogen-doped carbon Nitrogen-doped carbon Organic molybdenum complex derivation Organic molybdenum complex derivation
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| GB/T 7714 | Zheng, Cheng , Wu, Weixin , Deng, Qixin et al. Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance [J]. | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2021 , 592 : 33-41 . |
| MLA | Zheng, Cheng et al. "Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance" . | JOURNAL OF COLLOID AND INTERFACE SCIENCE 592 (2021) : 33-41 . |
| APA | Zheng, Cheng , Wu, Weixin , Deng, Qixin , Li, Yafeng , Wei, Mingdeng . Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance . | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2021 , 592 , 33-41 . |
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Lithiated transition metal oxide cathode materials that combine oxygen-anion redox [O-2(-)/(O-2)(n-)] with cation redox offer substantial capacities and higher voltage than cathodes without oxygen redox, but oxygen-anion redox is usually accompanied by the formation of peroxo or superoxo species that may cause oxygen release. To clarify the relationship between the oxygen release and peroxide and superoxide dimers without the complication of transition-metal redox, we performed density functional theory calculations to study the layered Li8SnO6 cathode because it has only oxygen-anion redox during delithiation. Features with O-O distances of similar to 1.5 angstrom (corresponding to the formation of a peroxide) were observed at 75% lithium concentration, and further delithiation to 62.5% lithium concentration shortened the O-O bond distance to similar to 1.3 angstrom (corresponding to the formation of superoxide). The solely anionic oxygen redox stabilizes the delithiated structure of Li8-xSnO6, and it does not cause structural disorder or release oxygen gas. Ab initio molecular dynamics calculations in the supercell at 300 K indicate that oxygen dimerization may occur at 75% lithium concentration. On the (0001) surface with a high lithium concentration (98%), oxygen dimerization is unfavorable. The calculations by HSE06 show that oxygen redox in Li8SnO6 offers an initial voltage (vs Li/Li+) greater than 4.2 V. The GGA+U calculations indicate that the Li+-polaron in Li95Sn12O72 migrates with a migration barrier of only 0.43 eV. This work also quantifies a solely anionic oxygen redox mechanism in Li8SnO6, and it provides a deeper understanding of anionic oxygen redox in Li-excess oxide cathode materials.
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| GB/T 7714 | Luo, Ningjing , Hou, Zhufeng , Zheng, Cheng et al. Anionic Oxygen Redox in the High-Lithium Material Li8SnO6 [J]. | CHEMISTRY OF MATERIALS , 2021 , 33 (3) : 834-844 . |
| MLA | Luo, Ningjing et al. "Anionic Oxygen Redox in the High-Lithium Material Li8SnO6" . | CHEMISTRY OF MATERIALS 33 . 3 (2021) : 834-844 . |
| APA | Luo, Ningjing , Hou, Zhufeng , Zheng, Cheng , Zhang, Yongfan , Stein, Andreas , Huang, Shuping et al. Anionic Oxygen Redox in the High-Lithium Material Li8SnO6 . | CHEMISTRY OF MATERIALS , 2021 , 33 (3) , 834-844 . |
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金属纳米团簇具有独特的超小尺寸和光、磁、催化等性能,以及优异的生物相容性等特征,在生物医学研究中备受关注.但其存在发光效率偏低、活体代谢速度较快等问题.为此介绍近几年通过合成优化和发光调控等方法提高金属纳米团簇的检测与成像灵敏度和肿瘤诊疗能力的研究进展.探究金属纳米团簇的肾代谢和生物酶催化性能;开发具有精确原子数、高效生物相容性和肿瘤靶向性的金属纳米团簇;突破其近红外发光量子产率限制,提高光声-磁共振造影等性能,将是未来该领域研究的重要方向.
Keyword ：
生物传感 生物传感 生物成像 生物成像 肿瘤治疗 肿瘤治疗 金属纳米团簇 金属纳米团簇
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| GB/T 7714 | 郑琤 , 李诗华 , 宋晓荣 . 金属纳米团簇在生物医学领域的研究进展 [J]. | 福州大学学报（自然科学版） , 2020 , 48 (3) : 395-403 . |
| MLA | 郑琤 et al. "金属纳米团簇在生物医学领域的研究进展" . | 福州大学学报（自然科学版） 48 . 3 (2020) : 395-403 . |
| APA | 郑琤 , 李诗华 , 宋晓荣 . 金属纳米团簇在生物医学领域的研究进展 . | 福州大学学报（自然科学版） , 2020 , 48 (3) , 395-403 . |
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