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学者姓名：黄锥良
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Aim: This study aimed to investigate post-marketing adverse events (AEs) of interleukin-6 (IL-6) inhibitors, and to explore risk factors for death. Method: Disproportionality analyses were conducted on adverse event cases of IL-6 inhibitors reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from the time of drug launch until the fourth quarter of 2023. Univariate and multivariate logistic regression analyses were carried out utilizing patient-related clinical information, and prediction models for IL-6 inhibitor-related mortality risk were developed by incorporating patient age and weight factors. Results: A total of 63,445 reports were retrieved, with the majority of known age groups falling between 18 and 64 years. Most reports were submitted by consumers and physicians, predominantly from the United States. Tocilizumab was associated with AEs such as drug intolerance and infection, while sarilumab showed symptoms of pain and condition aggravated. Siltuximab was linked to disease progression and thrombocytopenia. The median time to AEs with IL-6 inhibitors was 74 days (interquartile range [IQR] 10-311), mostly occurring within 1 month. Factors such as age, propionic acid derivative, infections and infestations, nervous system disorders, and immune system disorders were independent risk factors for deaths related to IL-6 inhibitor use (p < 0.05). The mortality risk prediction model demonstrated good discriminatory power and clinical applicability in both the training set (AUC 0.6968) and the validation set (AUC 0.7502). Conclusion: Our postmarketing pharmacovigilance analysis revealed the types and incidence of AEs related to IL-6 inhibitors. Column line diagrams may be useful for clinical assessment of the occurrence of death and have high clinical utility.
Keyword ：
adverse event adverse event FAERS FAERS IL-6 inhibitor IL-6 inhibitor risk profile risk profile signal mining signal mining
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| GB/T 7714 | Fang, Meilin , Li, Jinglin , Zhuang, Boyang et al. Analysis of Predictors of Adverse Events and Mortality Risk Associated With IL-6 Inhibitors: A Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database [J]. | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS , 2025 , 2025 (1) . |
| MLA | Fang, Meilin et al. "Analysis of Predictors of Adverse Events and Mortality Risk Associated With IL-6 Inhibitors: A Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database" . | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 2025 . 1 (2025) . |
| APA | Fang, Meilin , Li, Jinglin , Zhuang, Boyang , Liang, Weijie , Wang, Ling , Wang, Cunze et al. Analysis of Predictors of Adverse Events and Mortality Risk Associated With IL-6 Inhibitors: A Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database . | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS , 2025 , 2025 (1) . |
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This paper introduces an efficient and accurate interpolator for NURBS (non-uniform rational B-spline) curves, addressing the challenge of regulating feedrate under machining accuracy and dynamic constraints, particularly at sensitive corners. A recursive matrix representation and polynomial conversion are utilized to enhance the computation of NURBS curve intermediate points and derivatives. An improved adaptive planning method is presented to adjust the feedrate at sensitive corners, ensuring that chord error and dynamic constraints are met. The method integrates linear acceleration and deceleration stages to mitigate abrupt changes in acceleration and jerk. Additionally, a prediction-correction scheme-based interpolator is developed, employing an asynchronous mechanism to improve computational efficiency. The proposed method's effectiveness and correctness are validated through simulation tests and machining experiments.
Keyword ：
feedrate planning feedrate planning interpolation interpolation NURBS curve NURBS curve prediction-correction scheme prediction-correction scheme sensitive corner sensitive corner
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| GB/T 7714 | Huang, Zhuiliang , Chen, Jianxiong . An Interpolator for a Non-Uniform Rational B-Spline Curve with a High Efficiency and Accuracy Using Polynomial Representations [J]. | ACTUATORS , 2024 , 13 (11) . |
| MLA | Huang, Zhuiliang et al. "An Interpolator for a Non-Uniform Rational B-Spline Curve with a High Efficiency and Accuracy Using Polynomial Representations" . | ACTUATORS 13 . 11 (2024) . |
| APA | Huang, Zhuiliang , Chen, Jianxiong . An Interpolator for a Non-Uniform Rational B-Spline Curve with a High Efficiency and Accuracy Using Polynomial Representations . | ACTUATORS , 2024 , 13 (11) . |
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Data envelopment analysis is a data-driven tool for building a composite index. Fare et al. (1995) proposed an attribute-incorporated data envelopment analysis where a Malmquist productivity index including attributes was formulated. The attribute-incorporated Malmquist productivity index was decomposed into quality change, efficiency change, and technical change. However, this attribute-incorporated Malmquist productivity index may yield incorrect results due to the fact that its separable multiplier only considers the reference technology and ignores the corresponding period data. This current paper proposes a revised decomposition version of the attribute-incorporated Malmquist productivity index. In addition, we propose an aggregate quality change model which is extended from Fare et al. (1995), where subjective quality and objective quality are considered at the same time. The aggregate quality change model is useful for measuring changes in the quality of life. An application in this paper shows that, within quality attributes, subjective quality of life has a more significant impact on the overall urban quality of life than objective quality of life.
Keyword ：
Data envelopment analysis Data envelopment analysis Malmquist productivity index Malmquist productivity index Quality change Quality change Subjective quality of life Subjective quality of life
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| GB/T 7714 | Huang, Zhui-Liang , Hwang, Shiuh-Nan . Decomposition of quality changes: Focusing on subjective quality of life [J]. | OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE , 2024 , 131 . |
| MLA | Huang, Zhui-Liang et al. "Decomposition of quality changes: Focusing on subjective quality of life" . | OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE 131 (2024) . |
| APA | Huang, Zhui-Liang , Hwang, Shiuh-Nan . Decomposition of quality changes: Focusing on subjective quality of life . | OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE , 2024 , 131 . |
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面对物流产业的飞速发展与转型升级，该文基于新工科建设背景，针对福州大学物流工程专业硕士人才培养面临的挑战、存在的问题及物流工程专业硕士的学科特点，确立了“新工科、卓越、创新、创业”的物流工程专业硕士人才培养目标，通过多学科交叉融合，探索新的人才培养体系、培养机制、培养路径和实践教学模式，有效推动物流工程专业硕士教育教学内涵式发展。
Keyword ：
人才培养 人才培养 教学改革 教学改革 新工科 新工科 物流工程 物流工程
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| GB/T 7714 | 黄锥良 , 吴鹏 , 李艺全 . 新工科背景下物流工程专业硕士人才培养的创新实践——以福州大学为例 [J]. | 海峡科学 , 2023 , 5 (12) : 182-186 . |
| MLA | 黄锥良 et al. "新工科背景下物流工程专业硕士人才培养的创新实践——以福州大学为例" . | 海峡科学 5 . 12 (2023) : 182-186 . |
| APA | 黄锥良 , 吴鹏 , 李艺全 . 新工科背景下物流工程专业硕士人才培养的创新实践——以福州大学为例 . | 海峡科学 , 2023 , 5 (12) , 182-186 . |
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Abstract ：
面对物流产业的飞速发展与转型升级,该文基于新工科建设背景,针对福州大学物流工程专业硕士人才培养面临的挑战、存在的问题及物流工程专业硕士的学科特点,确立了"新工科、卓越、创新、创业"的物流工程专业硕士人才培养目标,通过多学科交叉融合,探索新的人才培养体系、培养机制、培养路径和实践教学模式,有效推动物流工程专业硕士教育教学内涵式发展.
Keyword ：
人才培养 人才培养 教学改革 教学改革 新工科 新工科 物流工程 物流工程
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| GB/T 7714 | 黄锥良 , 吴鹏 , 李艺全 . 新工科背景下物流工程专业硕士人才培养的创新实践 [J]. | 海峡科学 , 2023 , (12) : 182-186 . |
| MLA | 黄锥良 et al. "新工科背景下物流工程专业硕士人才培养的创新实践" . | 海峡科学 12 (2023) : 182-186 . |
| APA | 黄锥良 , 吴鹏 , 李艺全 . 新工科背景下物流工程专业硕士人才培养的创新实践 . | 海峡科学 , 2023 , (12) , 182-186 . |
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Facing competition from manufacturers' online direct channels, how retailers make sales channel decisions to increase consumer stickiness has become the core concern of the industry and academia. Empirical research showed that delivery lead time is a key factor that affects consumers' preference for online channels. To analyze the impact of consumer delivery time preference on channel selection and pricing strategy of retailers, consumer delivery lead time preference function was improved from a linear function to an exponential function and consumer demand under the mixed dual-channel supply chain of manufacturer and retailer was derived. Then, the Stackelberg game models under different channel strategies of retailer were established and solved. Results show that consumer preference for delivery lead time has four implications on the channel decision of retailers under manufacturer encroachment in the dual-channel supply chain. First, the dual retail channels strategy is the optimal choice for retailers, and the profit margins that a retailer obtains from dual retail channels supply chain and single online retail channel supply chain will increase as consumers' delivery lead time preference coefficient increases. Second, the optimal pricing of online retail channel and offline retail channel is positively related to consumers' delivery lead time preference coefficient. By contrast, the optimal pricing of online direct channel is negatively related to consumers' delivery lead time preference coefficient. Third, the optimal pricing of online retail channel is higher than that of offline retail and online direct channels. Fourth, a retailer and a manufacturer can adopt a compensation-based whole price contract to address the conflict brought about by the optimal channel choice of the retailer. This study introduces consumer delivery lead time preference into retailer channel decision making and provides a theoretical reference for retailer's mixed channel construction in practice. (C) 2020 CPE, University of Maribor. All rights reserved.
Keyword ：
Channel coordination Channel coordination Channel selection Channel selection Consumer preference Consumer preference Delivery lead time preference Delivery lead time preference Dual-channel Dual-channel Supply chain Supply chain
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| GB/T 7714 | Hu, Y. S. , Zeng, L. H. , Huang, Z. L. et al. Optimal channel decision of retailers in the dual-channel supply chain considering consumer preference for delivery lead time [J]. | ADVANCES IN PRODUCTION ENGINEERING & MANAGEMENT , 2020 , 15 (4) : 453-466 . |
| MLA | Hu, Y. S. et al. "Optimal channel decision of retailers in the dual-channel supply chain considering consumer preference for delivery lead time" . | ADVANCES IN PRODUCTION ENGINEERING & MANAGEMENT 15 . 4 (2020) : 453-466 . |
| APA | Hu, Y. S. , Zeng, L. H. , Huang, Z. L. , Cheng, Q. . Optimal channel decision of retailers in the dual-channel supply chain considering consumer preference for delivery lead time . | ADVANCES IN PRODUCTION ENGINEERING & MANAGEMENT , 2020 , 15 (4) , 453-466 . |
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This paper studies a production and distribution problem in a supply chain of perishable electronic products, where the firm determines the production-distribution policies under different production modes and carbon emission regulation. In order to maximize the firm's profit, the mixed integer optimization models with time constraints are proposed under carbon trading mechanism. The models are solved by Lingo11.0 to obtain the optimal production and distribution quantities under three production modes, i.e., MTS (Make to Stock), MTO (Make to Order, and partially delayed mode. Finally, numerical experiments are provided to compare the optimal production-distribution policies under the three production modes. The result shows that the partially delayed mode can effectively meet the time requirements of the large market demand by production scale effect, which is the best choice for the supply chain of the perishable electronic products.
Keyword ：
Carbon trading mechanism Carbon trading mechanism Perishable electronic products Perishable electronic products Production-distribution network Production-distribution network
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| GB/T 7714 | Huang Zhui-liang , Zhang Lei , Yang Cheng-hu . Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism [C] . 2019 : 677-682 . |
| MLA | Huang Zhui-liang et al. "Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism" . (2019) : 677-682 . |
| APA | Huang Zhui-liang , Zhang Lei , Yang Cheng-hu . Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism . (2019) : 677-682 . |
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Abstract ：
This paper studies a production and distribution problem in a supply chain of perishable electronic products, where the firm determines the production-distribution policies under different production modes and carbon emission regulation. In order to maximize the firm's profit, the mixed integer optimization models with time constraints are proposed under carbon trading mechanism. The models are solved by Lingo11.0 to obtain the optimal production and distribution quantities under three production modes, i.e., MTS (Make to Stock), MTO (Make to Order, and partially delayed mode. Finally, numerical experiments are provided to compare the optimal production-distribution policies under the three production modes. The result shows that the partially delayed mode can effectively meet the time requirements of the large market demand by production scale effect, which is the best choice for the supply chain of the perishable electronic products. © 2019 IEEE.
Keyword ：
Carbon Carbon Electronics industry Electronics industry Emission control Emission control Integer programming Integer programming Supply chains Supply chains
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| GB/T 7714 | Zhui-Liang, Huang , Lei, Zhang , Cheng-Hu, Yang . Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism [C] . 2019 . |
| MLA | Zhui-Liang, Huang et al. "Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism" . (2019) . |
| APA | Zhui-Liang, Huang , Lei, Zhang , Cheng-Hu, Yang . Optimal Production-distribution Polices of Perishable Electronic Products under Carbon Trading mechanism . (2019) . |
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The sample machined with the polygonal path is a common feature in a micro laser-cutting machine. It brings a difficult problem in feedrate planning when the machining accuracy is limited to the scale of sub-micrometer. In this paper, the transition feedrate at the node point is determined by the dynamic capacity of a machine. Then, the jerk-limited feedrate planning is introduced to adjust the feedrate in a smooth manner. The feedrate profile is transferred into the discrete shape for the sampling mechanism of the interpolator in a CNC controller. Moreover, a two-step feedrate planning is proposed to handle the problem that, there exists a distance error, as the line segment is not divisible by the step calculated by feedrate and sample cycle. Firstly, the control parameters, namely, the command feedrate, acceleration and jerk in different stage of the feedrate profile, are estimated by the jerk-limited feedrate planning. Then, a correction scheme is developed to slightly regulate the control parameters. It aims to compensate the distance error caused by the discretization in the process of interpolation. Meanwhile, the proposed method is discussed in two cases according to the length of the line segment. The method of direct adjustment is applied to handle the situation where a line segment is long enough; otherwise, the method of numerical estimation will take the place. Finally, a simulation analysis is presented to demonstrate the performance of the proposed method in feedrate planning. Then, machining experiments are conducted on the self-developed micro laser-cutting machine to verify the effeteness of proposed method.
Keyword ：
Error compensation Error compensation Feedrate planning Feedrate planning Micro laser-cutting machine Micro laser-cutting machine Polygonal path Polygonal path
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| GB/T 7714 | Huang, Zhuiliang , Chen, Jianxiong , Tu, Yiliu . A two-step feedrate planning of polygonal path for micro laser-cutting machines [J]. | INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY , 2019 , 103 (9-12) : 4135-4145 . |
| MLA | Huang, Zhuiliang et al. "A two-step feedrate planning of polygonal path for micro laser-cutting machines" . | INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 103 . 9-12 (2019) : 4135-4145 . |
| APA | Huang, Zhuiliang , Chen, Jianxiong , Tu, Yiliu . A two-step feedrate planning of polygonal path for micro laser-cutting machines . | INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY , 2019 , 103 (9-12) , 4135-4145 . |
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以创新型人才培养为目标,针对仓储订单拣选虚拟仿真实验课程,明确提出实验教学目标和实验内容,自主开发构建了能与实验内容高度相融合的仓储分拣虚拟仿真实验平台,引入新的"演示-设计-验证"的实验教学方式,从而有效培养学生的创新思维能力和解决实际问题的能力.
Keyword ：
仓储订单拣选 仓储订单拣选 仿真实验 仿真实验 创新人才培养 创新人才培养 物流实验教学 物流实验教学
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| GB/T 7714 | 黄锥良 , 叶翀 , 李艺全 . 仓储订单拣选虚拟仿真实验教学改革与实践——以创新型人才培养为目标 [J]. | 中国轻工教育 , 2018 , (6) : 64-70 . |
| MLA | 黄锥良 et al. "仓储订单拣选虚拟仿真实验教学改革与实践——以创新型人才培养为目标" . | 中国轻工教育 6 (2018) : 64-70 . |
| APA | 黄锥良 , 叶翀 , 李艺全 . 仓储订单拣选虚拟仿真实验教学改革与实践——以创新型人才培养为目标 . | 中国轻工教育 , 2018 , (6) , 64-70 . |
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