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学者姓名：张岑
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Abstract ：
Using copper-ionophores to translocate extracellular copper into mitochondria is a clinically validated anticancer strategy that has been identified as a new type of regulated cell death termed "cuproptosis." This study reports a mitochondria-targeting Cu(I) complex, Cu(I)Br(PPh3)(3) (CBP), consisting of a cuprous ion coordinated by three triphenylphosphine moieties and a Br atom. CBP exhibited antitumor and antimetastatic efficacy in vitro and in vivo by specifically targeting mitochondria instigating mitochondrial dysfunction. The cytotoxicity of CBP could only be reversed by a copper chelator rather than inhibitors of the known cell death, indicating copper-dependent cytotoxicity. Furthermore, CBP induced the oligomerization of lipoylated proteins and the loss of Fe-S cluster proteins, consistent with characteristic features of cuproptosis. Additionally, CBP induced remarkable intracellular generation of reactive oxygen species (ROS) through a Fenton-like reaction, indicating a complex antitumor mechanism. This is a proof-of-concept study exploiting the antitumor activity and mechanism of the Cu(I)-based mitochondria-targeting therapy.
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| GB/T 7714 | Xu, Siyu , Hao, Yashuai , Xu, Xinyi et al. Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex [J]. | JOURNAL OF MEDICINAL CHEMISTRY , 2024 , 67 (10) : 7911-7920 . |
| MLA | Xu, Siyu et al. "Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex" . | JOURNAL OF MEDICINAL CHEMISTRY 67 . 10 (2024) : 7911-7920 . |
| APA | Xu, Siyu , Hao, Yashuai , Xu, Xinyi , Huang, Lu , Liang, Yuqiong , Liao, Jia et al. Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex . | JOURNAL OF MEDICINAL CHEMISTRY , 2024 , 67 (10) , 7911-7920 . |
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Abstract ：
As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which is different from other regulated cell death forms morphologically, biochemically, and immunologically. Ferroptosis is regulated by iron metabolism, lipid metabolism, and antioxidant defense systems as well as various transcription factors and related signal pathways. Emerging evidence has highlighted that ferroptosis is associated with many physiological and pathological processes, including cancer, neurodegeneration diseases, cardiovascular diseases, and ischemia/reperfusion injury. Noncoding RNAs are a group of functional RNA molecules that are not translated into proteins, which can regulate gene expression in various manners. An increasing number of studies have shown that noncoding RNAs, especially miRNAs, lncRNAs, and circRNAs, can interfere with the progression of ferroptosis by modulating ferroptosis-related genes or proteins directly or indirectly. In this review, we summarize the basic mechanisms and regulations of ferroptosis and focus on the recent studies on the mechanism for different types of ncRNAs to regulate ferroptosis in different physiological and pathological conditions, which will deepen our understanding of ferroptosis regulation by noncoding RNAs and provide new insights into employing noncoding RNAs in ferroptosis-associated therapeutic strategies.
Keyword ：
circRNAs circRNAs ferroptosis ferroptosis iron metabolism iron metabolism lipid peroxidation lipid peroxidation lncRNAs lncRNAs miRNAs miRNAs ncRNAs ncRNAs
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| GB/T 7714 | Zheng, Xiangnan , Zhang, Cen . The Regulation of Ferroptosis by Noncoding RNAs [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (17) . |
| MLA | Zheng, Xiangnan et al. "The Regulation of Ferroptosis by Noncoding RNAs" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 17 (2023) . |
| APA | Zheng, Xiangnan , Zhang, Cen . The Regulation of Ferroptosis by Noncoding RNAs . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (17) . |
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Abstract ：
Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, and immunologically distinct from other regulated cell death forms. Ferroptosis is regulated by iron metabolism, lipid metabolism, anti-oxidant defense systems, as well as various signal pathways. Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms. Emerging evidence demonstrated that hypoxia regulates ferroptosis in certain cell types and conditions. In this review, we summarize the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in physiological and pathological conditions, which may contribute to the numerous diseases therapies.
Keyword ：
ferroptosis ferroptosis hypoxia hypoxia hypoxia-inducible factors hypoxia-inducible factors iron metabolism iron metabolism lipid peroxidation lipid peroxidation
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| GB/T 7714 | Zheng, Xiangnan , Liang, Yuqiong , Zhang, Cen . Ferroptosis Regulated by Hypoxia in Cells [J]. | CELLS , 2023 , 12 (7) . |
| MLA | Zheng, Xiangnan et al. "Ferroptosis Regulated by Hypoxia in Cells" . | CELLS 12 . 7 (2023) . |
| APA | Zheng, Xiangnan , Liang, Yuqiong , Zhang, Cen . Ferroptosis Regulated by Hypoxia in Cells . | CELLS , 2023 , 12 (7) . |
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