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学者姓名：韩霄
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This article has been retracted: please see Elsevier policy on Article Correction, Retraction and Removal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Authors. The authors of the above-mentioned article have requested its retraction following concerns raised about Fig. 9g, where apparent overlap of regions in two panels was identified. Upon review, the authors confirmed that they inadvertently used images from different fields of the same sample during the preparation of the manuscript. The authors have contacted the journal to express their desire to retract the article to maintain scientific integrity. In light of this request, the editors of Carbohydrate Polymers have decided to proceed with the retraction. © 2025
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| GB/T 7714 | Zhang, Y. , Chen, W. , Feng, W. et al. Retraction notice to “Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation” [Carbohydrate Polymers 314 (2023) 120937] (Carbohydrate Polymers (2023) 314, (S0144861723004022), (10.1016/j.carbpol.2023.120937)) [未知]. |
| MLA | Zhang, Y. et al. "Retraction notice to “Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation” [Carbohydrate Polymers 314 (2023) 120937] (Carbohydrate Polymers (2023) 314, (S0144861723004022), (10.1016/j.carbpol.2023.120937))" [未知]. |
| APA | Zhang, Y. , Chen, W. , Feng, W. , Fang, W. , Han, X. , Cheng, C. . Retraction notice to “Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation” [Carbohydrate Polymers 314 (2023) 120937] (Carbohydrate Polymers (2023) 314, (S0144861723004022), (10.1016/j.carbpol.2023.120937)) [未知]. |
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INTRODUCTION Viral hepatitis, caused by various hepatitis viruses, is a global health threat leading to chronic liver disease, hepatic cirrhosis, hepatic failure, and hepatocellular carcinoma. Smoking, a known risk factor for numerous chronic diseases, has been implicated in the pathogenesis of viral hepatitis. However, understanding the relationship between smoking and viral hepatitis is complex due to the presence of confounding factors and the potential for reverse associations. METHODS We utilized Mendelian randomization (MR) analysis to explore the potential association between smoking behavior and viral hepatitis. In this study, SNPs were utilized as instrumental variables in a Mendelian randomization framework to examine the relationship between smoking behavior and viral hepatitis risk. To ensure the accuracy of the experiment, our data were sourced from large-scale genome-wide association studies (GWAS) and analyzed using a series of methods, such as inverse variance weighting (IVW) and leave-one-out analysis. RESULTS The MR analysis revealed significant positive associations between SNPs related to smoking initiation, status, and cessation, and the risk of viral hepatitis. The IVW method demonstrated a consistent rightward shift of the effect estimates, indicating a potential increase in viral hepatitis risk associated with smoking exposure. Smoking initiation, status, and cessation were associated with increased odds of viral hepatitis by 2.17-fold (95% CI: 1.45-3.24, p=0.00015), 2.93-fold (95% CI: 1.58-5.41, p=0.00061), and 5.30-fold (95% CI: 2.05-13.70, p=0.00057), respectively. The leave-one-out analysis further validated the robustness of our model, with minor SNP-specific deviations observed. CONCLUSIONS Our study presents strong associations between smoking behavior and an elevated risk of viral hepatitis, highlighting the need for further investigation into this potential connection. These findings underscore the importance of smoking cessation in liver disease management and inform public health strategies aimed at reducing the burden of viral hepatitis.
Keyword ：
analysis analysis association association behavior behavior intervention strategies intervention strategies Mendelian Mendelian public health public health randomization randomization smoking smoking viral hepatitis viral hepatitis
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| GB/T 7714 | Lin, Birong , Ma, Huaxi , Lin, Yan et al. Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach [J]. | TOBACCO INDUCED DISEASES , 2025 , 23 . |
| MLA | Lin, Birong et al. "Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach" . | TOBACCO INDUCED DISEASES 23 (2025) . |
| APA | Lin, Birong , Ma, Huaxi , Lin, Yan , Lin, Ting , Han, Xiao , Lin, Minghua et al. Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach . | TOBACCO INDUCED DISEASES , 2025 , 23 . |
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RNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species-dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu+)-containing disulfide assembled siRNA (Gu+-siRNA), demonstrating remarkable species independence and efficient systemic gene silencing across different plant species. Our results indicate that this approach effectively utilizes the plant vascular system to deliver siRNA, enabling long-distance gene silencing across both monocot and dicot plants, such as rice and Arabidopsis. By applying this method, we successfully targeted and silenced key genes like STM, WER, MYB23, GD1, EIL1, and EIL2, which regulate plant development and enhance salt tolerance. This delivery system significantly expands the application of RNAi technology across different plants, serving as a valuable tool for advancing agricultural biotechnology, enhancing crop resistance, and improving agricultural productivity, while aligning with global goals for sustainable food production and crop improvement.
Keyword ：
long-distance movement long-distance movement nanoparticle nanoparticle RNA interference RNA interference systematically deliver systematically deliver thiolated thiolated
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| GB/T 7714 | Lin, Shujin , Zhang, Qian , Bai, Shiyan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles [J]. | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) : 1165-1177 . |
| MLA | Lin, Shujin et al. "Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles" . | PLANT BIOTECHNOLOGY JOURNAL 23 . 4 (2025) : 1165-1177 . |
| APA | Lin, Shujin , Zhang, Qian , Bai, Shiyan , Yang, Liwen , Qin, Guannan , Wang, Liyuan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles . | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) , 1165-1177 . |
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Pumpkin rootstock is commonly used to graft cucurbit crops, improving their ability to withstand stress. While the significance of systemic signals from rootstocks to scions is recognized, the role of root-to-shoot transported mRNAs remains understudied. Cucumber plants often face growth and productivity limitations due to low temperatures. To shed light on the enhancement of chilling tolerance in grafted cucumber scions by pumpkin-derived mRNAs, we revisit the metabolomic and transcriptomic dataset from the cucumber/pumpkin heterograft under chilling condition. We identify pumpkin Ketol-acid reductoisomerase 1 (CmoKARI1) as the key mobile mRNA that specifically travels from pumpkin rootstock to cucumber scion upon early chilling stress. Overexpressing CmoKARI1 results in increased isoleucine level and chilling tolerance in both cucumber and Arabidopsis. The increased isoleucine is further used to synthesize JA-Ile conjugates, activating JA-Ile signaling and enabling heterografts to weather low temperatures. This study represents the instance of a unidirectional mobile mRNA triggered by specific environmental cues.
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| GB/T 7714 | Zhang, Miao , Liu, Wenqian , Wang, Cuicui et al. Root-to-shoot mobile mRNA CmoKARI1 promotes JA-Ile biosynthesis to confer chilling tolerance in grafted cucumbers [J]. | NATURE COMMUNICATIONS , 2025 , 16 (1) . |
| MLA | Zhang, Miao et al. "Root-to-shoot mobile mRNA CmoKARI1 promotes JA-Ile biosynthesis to confer chilling tolerance in grafted cucumbers" . | NATURE COMMUNICATIONS 16 . 1 (2025) . |
| APA | Zhang, Miao , Liu, Wenqian , Wang, Cuicui , Lin, Shujin , Chen, Ying , Cui, Heran et al. Root-to-shoot mobile mRNA CmoKARI1 promotes JA-Ile biosynthesis to confer chilling tolerance in grafted cucumbers . | NATURE COMMUNICATIONS , 2025 , 16 (1) . |
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A new nanoparticles-based sensing platform was designed for high-through electrochemical immunoassay of ferritin (FET) biomarker on a magneto-controlled microfluidic device by using anti-FET capture antibody-conjugated magnetic sensing probes. Thionine-doped calcium carbonate (CaCO3) nanoparticles labeled with anti-FET detection antibodies were utilized as the recognition elements. Introduction of target FET caused the sandwich-type immunoreaction between two antibodies. The formed immunocomplexes were attached onto magnetic microfluidic sensing interface through an external magnet. Subsequently, the carried CaCO3 nanoparticles were dissolved under acidic conditions to release the doped thionine molecules with redox activity. The thionine-based voltammetric signals increased with the increment of target FET levels within the linear range 0.01-100 ng mL-1. The limit of detection was 7.9 pg mL-1 FET. Good analytical properties such as selectivity, reproducibility, and accuracy were achieved with the nanoparticles-based magnetic electrochemical immunoassay. More significantly, the magnetic microfluidic electrochemical immunoassay provides new opportunities for rapid, simple, and cost-effective serum sample analysis.
Keyword ：
Calcium carbonate with redox activity Calcium carbonate with redox activity Electrochemical immunoassay Electrochemical immunoassay Ferritin biomarker Ferritin biomarker High-throughput analysis High-throughput analysis Magnetic beads Magnetic beads Magnetic microfluidic device Magnetic microfluidic device Square-wave voltammetry Square-wave voltammetry
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| GB/T 7714 | Lin, Shaofeng , Lin, Ting , Xu, Haipeng et al. Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device [J]. | MICROCHIMICA ACTA , 2025 , 192 (5) . |
| MLA | Lin, Shaofeng et al. "Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device" . | MICROCHIMICA ACTA 192 . 5 (2025) . |
| APA | Lin, Shaofeng , Lin, Ting , Xu, Haipeng , Li, Haining , Zhang, Wenwen , Wu, Chenyu et al. Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device . | MICROCHIMICA ACTA , 2025 , 192 (5) . |
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Saccharomyces cerevisiae predominantly ferments sugar to ethanol, irrespective of the presence of oxygen, which is known as the Crabtree-effect. Traditional methods rely on static controls of glycolytic flux to make S. cerevisiae Crabtree-negative, which are not favorable for future biomanufacturing applications. Considering native metabolic pathways typically harness dynamic regulatory networks, we therefore aim to develop an alternative strategy using dynamic regulation of the yeast central metabolism to generate Crabtree-negative S. cerevisiae. We report that manipulating a single step at sugar phosphorylation can alter the mode of yeast metabolism with an attenuated Crabtree-effect. By implementing catabolite-regulated sugar phosphorylation, the diauxic shift in budding yeast was effectively reduced. The Crabtree-attenuated metabolism in the engineered yeast was confirmed by multidimensional characterizations such as cell morphology, the measurements of sugar utilization rate and ethanol production, and transcriptomics. In addition, we demonstrated that the Crabtree-attenuated metabolism could substantially improve the mitochondrial synthesis of short branched-chain fatty acids from amino acid catabolism, and allow the synthesis and accumulation of retinaldehyde. Taken together, we present for the first time that manipulation of sugar phosphorylation can alter the mode of yeast metabolism, and the synthetic Crabtree-attenuated yeast factory established here might serve as a non-fermentative biomanufacturing chassis.
Keyword ：
Biosynthesis Biosynthesis Crabtree-effect Crabtree-effect Saccharomyces cerevisiae Saccharomyces cerevisiae Sugar phosphorylation Sugar phosphorylation Synthetic biology Synthetic biology
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| GB/T 7714 | Fan, Cong , Fan, Jian , Chen, Haofeng et al. Switching the yeast metabolism via manipulation of sugar phosphorylation [J]. | METABOLIC ENGINEERING , 2025 , 89 : 76-85 . |
| MLA | Fan, Cong et al. "Switching the yeast metabolism via manipulation of sugar phosphorylation" . | METABOLIC ENGINEERING 89 (2025) : 76-85 . |
| APA | Fan, Cong , Fan, Jian , Chen, Haofeng , Lin, Shujin , Zhang, Danli , Song, Jingya et al. Switching the yeast metabolism via manipulation of sugar phosphorylation . | METABOLIC ENGINEERING , 2025 , 89 , 76-85 . |
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Interleukin-6 (IL-6) protects neurons by inhibiting the expression of factors related to neuronal injury in nervous headache patients. The development of rapid and sensitive IL-6 detection methods will be very advantageous for easing the pain of such patients. In this work, an immobilization-free immunodetection method is explored for the voltammetric screening of IL-6 in serum samples from nervous headache patients. Initially, methylene-blue-encapsulated liposomes (MBLS) labeled with anti-IL-6 detection antibodies are confined in an anti-IL-6 capture antibody-coated microplate through a sandwich-type immunoreaction, and subsequently subjected to lysis treatment. After that, the lytic solution is transferred into a detection cell including a Nafion-modified working electrode. Methylene blue molecules with positive charge are captured on the negatively charged Nafion membrane, thus generating a voltammetric signal. The voltammetric peak currents are relative to the amount of IL-6 in the solution. Under optimized experimental situations, MBLS-based split-type electrochemical sensing protocols have acceptable voltammetric currents for IL-6 from 0.01 to 100 pg mL-1, and allow screening at a concentration of IL-6 as low as 9.1 fg mL-1. The batch-to-batch coefficients of variation were <= 11.95%. Good anti-interference capability was achieved against other biomolecules. Seven human serum specimens and two diluted serum samples including IL-6 obtained from nervous headache patients were determined by MBLS-based electrochemical immunoassay, and achieved well-matched results in comparison with those of the IL-6 ELISA protocol.
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| GB/T 7714 | Lin, Nan , Han, Xiao , Tian, Shuo et al. Methylene-blue-encapsulated liposome for immobilization-free electrochemical immunoassay of interleukin-6 from nervous headache [J]. | ANALYST , 2025 , 150 (11) : 2343-2349 . |
| MLA | Lin, Nan et al. "Methylene-blue-encapsulated liposome for immobilization-free electrochemical immunoassay of interleukin-6 from nervous headache" . | ANALYST 150 . 11 (2025) : 2343-2349 . |
| APA | Lin, Nan , Han, Xiao , Tian, Shuo , Tang, Dianping , Zhang, Danfeng . Methylene-blue-encapsulated liposome for immobilization-free electrochemical immunoassay of interleukin-6 from nervous headache . | ANALYST , 2025 , 150 (11) , 2343-2349 . |
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Polysaccharide hydrogels have emerged as pivotal wound dressings due to their inherent biocompatibility and extracellular matrix-mimicking properties. However, conventional systems employing permanent covalent or physical crosslinks suffer from irreversibility, poor self-repair capacity, and limited responsiveness that compromise clinical efficacy. To address these challenges, dynamic covalent bonding strategies have been innovatively integrated into polysaccharide networks, enabling unprecedented functionalities through reversible bond reconfiguration. These advanced hydrogels exhibit intelligent characteristics including self-healing, injectable adaptability, and stimulus-responsive drug release, achieved through precisely engineered imine, borate ester, disulfide, and other dynamic linkages, which allows the polysaccharide hydrogels to better adapt to different shapes of wounds and self-repair after damage to extend the life of the dressing. In this review, we summarize different types of dynamic covalently cross-linked polysaccharide hydrogels and their applications as wound dressings in wound repair, discuss the prospects of polysaccharide hydrogels based on dynamic covalent bonding, and address some of the associated limitations.
Keyword ：
Dynamic covalent bonding Dynamic covalent bonding Polysaccharide hydrogel Polysaccharide hydrogel Wound Dressings Wound Dressings Wound repair Wound repair
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| GB/T 7714 | Gao, Haibing , Wang, Zhen , Lin, Ting et al. Dynamic covalent bonding based polysaccharide hydrogels and their applications in wound dressings: A review [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 254 . |
| MLA | Gao, Haibing et al. "Dynamic covalent bonding based polysaccharide hydrogels and their applications in wound dressings: A review" . | COLLOIDS AND SURFACES B-BIOINTERFACES 254 (2025) . |
| APA | Gao, Haibing , Wang, Zhen , Lin, Ting , Zhang, Guolong , Han, Xiao , Cheng, Cui . Dynamic covalent bonding based polysaccharide hydrogels and their applications in wound dressings: A review . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 254 . |
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Aim: Type 2 diabetes mellitus (T2DM) is one of the most common diseases, and epigenetic modification N6-methyladenosine (m(6)A) is essential for transcriptional modulation involved in its development. However, the precise role and landscape of transcriptome-wide m(6)A alterations in molecular adaptations after physical exercise have yet to be fully elucidated. Methods: Four-week-old male C57BL/6J mice received a high-fat diet (HFD) for 12 weeks to establish a diabetic state, and HFD mice were simultaneously subjected to physical exercise (HFD + EX). The hepatic RNA m(6)A methylome was examined, the conjoint MeRIP-seq and RNA-seq was performed, and the exercise-modulated genes were confirmed. Results: Physical exercise significantly ameliorates liver metabolic disorder and triggers a dynamic change in hepatic RNA m(6)A. By analyzing the distribution of m(6)A in transcriptomes, an abundance of m(6)A throughout mRNA transcripts and a pattern of conserved m(6)A after physical exercise was identified. It is noteworthy that conjoint MeRIP-seq and RNA-seq data revealed that both differentially methylated genes and differentially expressed genes were enriched in all stages of the PI3K-Akt signaling pathway, in particular the upstream nodes of this pathway, which are considered a valuable therapeutic target for T2DM. Moreover, in vivo and in vitro analyses showed that exercise-mediated methyltransferase Rbm15 positively regulated the expression of two upstream genes (Itga3 and Fgf21) in an m(6)A-dependent manner. Conclusion: These findings highlight the pivotal role of the exercise-induced m(6)A epigenetic network and contribute insights into the intricate epigenetic mechanism underlying insulin signaling.
Keyword ：
PI3K-Akt signaling PI3K-Akt signaling RNA m(6)A modification RNA m(6)A modification transcriptome transcriptome type 2 diabetes mellitus type 2 diabetes mellitus
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| GB/T 7714 | Cong, Chen , Jiang, Cai , Lin, Ting et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise [J]. | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
| MLA | Cong, Chen et al. "Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise" . | ACTA PHYSIOLOGICA 240 . 6 (2024) . |
| APA | Cong, Chen , Jiang, Cai , Lin, Ting , Hu, Yue , Wu, Huijuan , Xiang, Qing et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise . | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
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The immune system plays a crucial role in the ageing process. As individuals age, significant alterations in the immune system experiences occur, marked by a decline in immune cell count, compromised immune function, and decreased immune regulation across various immune organs. These changes collectively weaken the capacity to combat diseases and infections, highlighting the vulnerability that accompanies ageing. Exercise is a potent intervention that profoundly influences holistic well-being and disease mitigation, with a notable emphasis on immune modulation. In general, regular moderate exercise holds significant potential to enhance immune defense mechanisms and metabolic well-being by augmenting the circulation and activation of immune cells. However, some exercise modalities would trigger detrimental effects on the immune system. It can be seen that the regulatory responses of various immune organs to diverse exercise patterns are different. This review aims to examine the immunological responses elicited by exercise across various immune organs, including the lymph nodes, spleen, bone marrow, and thymus, to underscore the nuanced interplay between exercise patterns and the immune organ. This underscores the importance of customizing exercise interventions to optimize immune function across the lifespan.
Keyword ：
Ageing Ageing Exercise Exercise Immune organs Immune organs Immune response Immune response
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| GB/T 7714 | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu et al. Exercise-induced adaptive response of different immune organs during ageing [J]. | AGEING RESEARCH REVIEWS , 2024 , 102 . |
| MLA | Zhou, Huanghao et al. "Exercise-induced adaptive response of different immune organs during ageing" . | AGEING RESEARCH REVIEWS 102 (2024) . |
| APA | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu , Wu, Huijuan , Hu, Yue , Chen, Cong et al. Exercise-induced adaptive response of different immune organs during ageing . | AGEING RESEARCH REVIEWS , 2024 , 102 . |
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