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学者姓名：陈秋水
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Abstract ：
Next-generation sequencing (NGS) technologies have achieved remarkable success in both biological research and clinical applications. However, in recent years, performance improvements have slowed due to fundamental limitations imposed by Poiseuille fluid dynamics in flow cells, which we overcome using Couette flow. Here we show NGS by roll-to-roll fluidics (r2r-fl), a cost-effective approach compatible with flexible biochip sizes. r2r-fl is a practical implementation of plane Couette flow, with up to 85-fold lower reagent consumption (US$0.16 per gigabase pair), rinsing times under 2 s and a reduction in paired-end 100-base pair sequencing turnaround from days to less than 12 h. The method maintains over 99.9% precision and 99.3% sensitivity of single nucleotide polymorphisms in the human genome, 99.9% mapping rate for Escherichia coli, and minimal nucleotide substitutions, deletions or insertions in the severe acute respiratory syndrome coronavirus 2 alpha strain. By lowering cost and time, r2r-fl enables rapid, scalable NGS for pathogen detection, cancer diagnostics and genetic disease profiling.
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| GB/T 7714 | Qin, Yanzhe , Koehler, Stephan A. , Ling, Yunyan et al. Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics [J]. | NATURE METHODS , 2025 , 22 (8) . |
| MLA | Qin, Yanzhe et al. "Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics" . | NATURE METHODS 22 . 8 (2025) . |
| APA | Qin, Yanzhe , Koehler, Stephan A. , Ling, Yunyan , Yu, Shiqiang , Zhang, Yongjie , Luo, Jie et al. Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics . | NATURE METHODS , 2025 , 22 (8) . |
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Precise control over the release of light energy, distinct from conventional thermal energy management, poses significant challenges in luminescent technologies. This study pioneers organic above-room-temperature thermoluminescent materials using radical pairs as energy storage centers (ESCs), enabling controlled light energy release from multi-hour afterglows to microsecond-scale explosive bursts, accelerating the energy release rate by up to 1.8 x 108 times. Notably, the unique transannular interactions between sulfur and oxygen in thianthrene oxides facilitate a thermally driven back electron transfer (BET) process based on radical pairs, central to the energy storage and release mechanism. Due to this BET process, these materials precisely modulate luminescence and exhibit robust stability, maintaining luminescence for 4 h in boiling water and storing energy in air for over six months. These findings advance organic thermoluminescence, highlight the significance of BET processes in various domains, and set new performance benchmarks for luminescent materials under extreme conditions.
Keyword ：
back electron transfer back electron transfer high-temperature stability high-temperature stability organic thermoluminescence organic thermoluminescence persistent luminescence persistent luminescence radical pairs radical pairs X-ray imaging X-ray imaging
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| GB/T 7714 | Wang, Yunsheng , Wang, Liwei , Li, Aisen et al. Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow [J]. | ADVANCED MATERIALS , 2025 . |
| MLA | Wang, Yunsheng et al. "Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow" . | ADVANCED MATERIALS (2025) . |
| APA | Wang, Yunsheng , Wang, Liwei , Li, Aisen , Li, Nan , Cao, Yalei , Wang, Xiaoze et al. Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow . | ADVANCED MATERIALS , 2025 . |
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X-ray-induced photodynamic therapy offers substantial promise for treating deep-seated tumors, but it is still limited by highly inefficient energy transfer processes and the stringent requirements for scintillators with high luminescence quantum yield and significant singlet-triplet intersystem crossing ratios. Herein, we describe X-ray-induced electron-dynamic therapy (X-eDT), which obviates the need for intersystem crossing by exposing nonluminescent hafnium-silica nanoparticles to X-rays, to generate high-energy electrons that can sensitize lower-lying triplet states of various photosensitizers. Our approach strongly induced the production of singlet oxygen (6.18-fold) in vitro even at lower X-ray doses, and in mice it strongly inhibited the growth of xenografts derived from liver, breast, or colon cancer cell lines (CDX), and growth of patient-derived xenografts (PDX) of hepatocellular carcinoma. In these CDX preclinical systems, X-eDT was not only effective against the irradiated xenograft but also against untreated xenografts in the same animal, and these abscopal effects involved enhanced tumor infiltration by CD4+T cells, CD8+T cells, and IFN-gamma-polarized M1 macrophages within the tumor microenvironment. X-eDT even stimulated the production of memory T cells that inhibited rechallenges after treatment. These findings suggest that X-eDT can be effective against primary and metastatic tumors as well as tumor recurrence, which makes it much more powerful than conventional X-PDT.
Keyword ：
abscopal effect abscopal effect immunity immunity metastatic cancer metastatic cancer radiosensitizer radiosensitizer radiotherapy radiotherapy X-ray-induced electron-dynamic therapy X-ray-induced electron-dynamic therapy
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| GB/T 7714 | Zhang, Da , Chen, Qingjing , Zhang, Junrong et al. Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy [J]. | ACS NANO , 2025 , 19 (17) : 16775-16793 . |
| MLA | Zhang, Da et al. "Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy" . | ACS NANO 19 . 17 (2025) : 16775-16793 . |
| APA | Zhang, Da , Chen, Qingjing , Zhang, Junrong , Xing, Xiaohua , Zhou, Yang , Ou, Xiangyu et al. Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy . | ACS NANO , 2025 , 19 (17) , 16775-16793 . |
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Flexible scintillator screens characterized by high spatial resolution, low cost, and a simple fabrication process are in significant demand for applications in medical diagnosis and industrial detection. Here, we have demonstrated a new Mn2+-doped two-dimensional (2D) Ruddlesden-Popper type perovskite, (4-tert-butylbenzylamine)(2)PbBr4:Mn, serving as a highly efficient scintillator candidate. Doping with Mn2+ induces a spin-forbidden internal transition (T-4(1g) -> (6)A(1g)) that enhances the energy-transfer efficiency from the strongly bound excitons of the host material to the d electrons of the Mn2+ ions, ultimately leading to intense orange-red emission. This process enhances the photoluminescence quantum yield of (4-tert-butylbenzylamine)(2)PbBr4 (1) and decreases its self-absorption. Therefore, at the optimal Mn2+-doping concentration, 1:8.4%Mn2+ demonstrates a high light yield of 21,532 Ph/MeV and a low detection limit of 198.19 nGy(air) s(-1), exceeding the performance of a commercial bismuth germanium oxide (BGO) scintillator. Furthermore, we combined ultrafine powders of 1:8.4%Mn2+ with poly(dimethylsiloxane) to fabricate flexible scintillator films. With the optimal film thickness and mass percentage of 1:8.4%Mn2+, the scintillator films achieve their maximum spatial resolution of 17.3 lp mm(-1). The above results indicate that the exceptional flexible scintillation imaging performance of 1:8.4%Mn2+ effectively addresses the shortcomings of current commercial scintillators, thereby providing a new option for the scintillator family.
Keyword ：
2D perovskite 2D perovskite flexible scintillator screen flexible scintillator screen imaging imaging Mn2+ doping Mn2+ doping scintillator scintillator
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| GB/T 7714 | Rong, Hao , Xu, Xinqi , Yao, Jia-Yu et al. High-Resolution Flexible X-ray Imaging in a Two-Dimensional Mn2+-Doped Perovskite Scintillator [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (16) : 24137-24145 . |
| MLA | Rong, Hao et al. "High-Resolution Flexible X-ray Imaging in a Two-Dimensional Mn2+-Doped Perovskite Scintillator" . | ACS APPLIED MATERIALS & INTERFACES 17 . 16 (2025) : 24137-24145 . |
| APA | Rong, Hao , Xu, Xinqi , Yao, Jia-Yu , Fan, Qingshun , Zhang, Haoyu , Xu, Haojie et al. High-Resolution Flexible X-ray Imaging in a Two-Dimensional Mn2+-Doped Perovskite Scintillator . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (16) , 24137-24145 . |
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The hypoxic tumor microenvironment (TME), inadequate penetration depth of Vis/NIR light, and lack of sustaining reactive oxygen species (ROS) production capability of photosensitizers pose significant obstacles to the widespread clinic applications of photodynamic therapy (PDT). Herein, we developed a "persistent type I X-PDT" platform to simultaneously overcome these three limitations. Such a nanoplatform could generate efficient ROS (center dot OH and O2 center dot-) under X-ray irradiation in both normoxic and hypoxic environments. The ROS production persists in tumor cells for more than 4 h, even after the X-ray source is removed. Notably, the persistent type I X-PDT does not increase the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) in tumor cells both in vitro and in vivo. Moreover, to further enhance the radiotherapy efficacy in hypoxic conditions, a Pt (IV) prodrug was also introduced, which can be reduced to cisplatin selectively in tumor cells, functioning not only as a chemodrug but also as a radiosensitizer.
Keyword ：
chemotherapy chemotherapy hypoxia hypoxia persistent X-PDT persistent X-PDT radiation therapy radiation therapy type I ROS type I ROS
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| GB/T 7714 | Cheng, Wei , He, Shuai , Chen, Qiushui et al. X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy [J]. | NANO LETTERS , 2025 , 25 (11) : 4549-4559 . |
| MLA | Cheng, Wei et al. "X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy" . | NANO LETTERS 25 . 11 (2025) : 4549-4559 . |
| APA | Cheng, Wei , He, Shuai , Chen, Qiushui , Song, Xiaorong , Lu, Chunhua , Yang, Huanghao . X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy . | NANO LETTERS , 2025 , 25 (11) , 4549-4559 . |
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Real-time, high-precision X-ray imaging is of critical importance in a wide range of applications, from medical diagnostics to security screening. While lanthanide luminescent materials are among the most commonly used scintillators, achieving a combination of large-area scalability, rapid response, and optimal performance remains challenging. Herein, a perovskite-inspired cerium halide nanocrystal scintillator is presented with a remarkable photoluminescence quantum yield approaching unity and a fast radiative recombination rate of approximate to 29 ns. By leveraging these promising characteristics, large-area X-ray imaging is demonstrated with a spatial resolution of 12.21 lp mm-1 and an ultra-low detection limit of 11.2 nGy s-1, alongside applications in dynamic imaging. Based on these paternal nanocrystals, the versatile spectral tunability through halide alloying and cation doping is further explored, offering a promising platform for future chemical and structural design toward advanced scintillations and other down-conversion applications.
Keyword ：
blue LED blue LED cerium based colloidal nanocrystals cerium based colloidal nanocrystals photoluminescence reversibility photoluminescence reversibility X-ray dynamic imaging X-ray dynamic imaging
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| GB/T 7714 | Yang, Huifang , Zhao, Chaohui , Wang, Yanze et al. Sensitive and Fast X-Ray Scintillation with Perovskite-Inspired Cerium Halide Nanocrystals [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (27) . |
| MLA | Yang, Huifang et al. "Sensitive and Fast X-Ray Scintillation with Perovskite-Inspired Cerium Halide Nanocrystals" . | ADVANCED FUNCTIONAL MATERIALS 35 . 27 (2025) . |
| APA | Yang, Huifang , Zhao, Chaohui , Wang, Yanze , Xu, Xinqi , Chen, Gaoyu , Zhao, Denglin et al. Sensitive and Fast X-Ray Scintillation with Perovskite-Inspired Cerium Halide Nanocrystals . | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (27) . |
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Broadband emissive perovskites are next-generation materials for solid-state lighting and radiative detection. However, white-emitting perovskites are generally synthesized by regulating B/X sites, while not enough attention is paid to the A-site, which is thought to hardly affect the band-edge structures and optoelectronic properties. Here, a series of Sb3+-doped In-based 0D halide perovskite derivatives are described with various organoammonium cations in A-sites. Warm-white light emitting across the visible spectrum (450-850 nm), large Stokes shifts, and high photoluminescence quantum yields are easily tunable by molecularly tailoring A-site cations. These features enable a light yield up to 60976 Photons/MeV as X-ray scintillator, and a detection limit of 90 nGyair/s that is approximate to 60 times lower than the medical requirement. It is proved that A-site plays a critical role in determining the degree of distortion of polyhedra, which influences the broadband photoluminescence and self-trapped exciton (STE) dominates the emission process. Moreover, for the first time, via the incorporation of 2,6-dimethylpiperazine, a mixed A-site regulating strategy produces a standard white-light emission, which originates from the blue-light and yellow-light related to various STE emission centers. It is foreseen that this strategy highlights the expanded role of A-site and the importance of rethinking A-sites in perovskites. Efficient and tunable broadband warm-white emission is achieved by engineering the A-site organoammonium cations in Sb-doped In-based 0D perovskite derivatives, with visible light emitting, large Stokes shift, high photoluminescence yield, and X-ray scintillation. For the first time, a standard white-light emission is realized by a mixed A-site regulation strategy by the incorporation of another functional organic amine cation.image
Keyword ：
A-site A-site broadband photoluminescence broadband photoluminescence halide perovskites halide perovskites white-light emission white-light emission X-ray scintillator X-ray scintillator
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| GB/T 7714 | Huang, Hanlin , Yang, Yalin , Qiao, Shuoyan et al. Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (8) . |
| MLA | Huang, Hanlin et al. "Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission" . | ADVANCED FUNCTIONAL MATERIALS 34 . 8 (2024) . |
| APA | Huang, Hanlin , Yang, Yalin , Qiao, Shuoyan , Wu, Xiaodong , Chen, Zheyan , Chao, Yu et al. Accommodative Organoammonium Cations in A-Sites of Sb―In Halide Perovskite Derivatives for Tailoring BroadBand Photoluminescence with X-Ray Scintillation and White-Light Emission . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (8) . |
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The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging. However, scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge. In this study, we report an efficient method to synthesize ligand-free, lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method. The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration. Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators. We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method, a spatial resolution of 24.9 lp/mm for X-ray imaging. Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.
Keyword ：
Afterglow Afterglow Microscintillators Microscintillators NaLuF4:Tb3+ NaLuF4:Tb3+ X-ray detector X-ray detector X-ray luminescence imaging X-ray luminescence imaging
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| GB/T 7714 | Jiang, Hao , Chen, Qihao , Wang, Hongyu et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
| MLA | Jiang, Hao et al. "Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging" . | CHINESE CHEMICAL LETTERS 35 . 3 (2024) . |
| APA | Jiang, Hao , Chen, Qihao , Wang, Hongyu , Wu, Tingting , Gong, Jianwei , Zhang, Zhenzhen et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging . | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
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With the increasing demands of X-ray detection and medical diagnosis, organic scintillators with intense and tunable X-ray excited emission have been becoming important. To guarantee the X-ray absorption, heavy atoms were widely added in reported organic scintillators, which led to emission quenching. In this work, we propose a new strategy to realize organic scintillators through the host-guest doping strategy. Then the X-ray absorption centers (host) and emission centers (guest) are separated. Under X-ray excitation, these materials displayed intense and readily tunable emissions ranging from green (520 nm) to near infrared (NIR) regions (682 nm). Besides, the relationship between the X-ray absorption and spatial arrangement of the heavy atoms in the host matrix was also revealed. The potential application of these wide-range color tunable organic host-guest scintillators in X-ray imaging were demonstrated. This work provides a new feasible strategy for constructing high-performance organic scintillators with tunable luminescence properties. A new strategy to achieve organic scintillators through constructing host-guest doping system was demonstrated. When doping guest materials with different triplet state energy levels, readily tunable emissions ranging from green (520 nm) to near infrared (NIR) regions (682 nm) were achieved under X-ray excitation. The developed system also enabled color-tunable NIR X-ray imaging and provided a convenient visualization tool for X-ray radiography.image
Keyword ：
Host-Guest Doping Systems Host-Guest Doping Systems Organic NIR Scintillator Organic NIR Scintillator Organic Scintillator Organic Scintillator Wide-Range Color-Tunable Wide-Range Color-Tunable X-Ray Imaging X-Ray Imaging
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| GB/T 7714 | Wang, Hailan , Peng, Chenxi , Chen, Minghong et al. Wide-Range Color-Tunable Organic Scintillators for X-Ray Imaging Through Host-Guest Doping [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (3) . |
| MLA | Wang, Hailan et al. "Wide-Range Color-Tunable Organic Scintillators for X-Ray Imaging Through Host-Guest Doping" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 3 (2024) . |
| APA | Wang, Hailan , Peng, Chenxi , Chen, Minghong , Xiao, Yuxin , Zhang, Tiantian , Liu, Xiaowang et al. Wide-Range Color-Tunable Organic Scintillators for X-Ray Imaging Through Host-Guest Doping . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (3) . |
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Photodynamic therapy (PDT) as an emerging therapeutic method has drawn much attention in the treatment field for cancer. Photosensitizer, which can convert photon energy into cytotoxic species under light irradiation, is the core component in PDT. The design of photosensitizers still faces problems of light absorption, targeting, penetration and oxygen dependence. With the rapid progress of material science, various photosensitizers have been developed to produce cytotoxic species for treatment of tumor with high selectivity, safety, and noninvasiveness. Besides, the applications of photosensitizers have been expanded to diverse cancer treatments such as drug release, optogenetics and immune checkpoint blockade. In this review, we summarize the recent advances of photosensitizers in various therapeutic methods for cancer. Prevailing challenges and further prospects associated with photosensitizers are also discussed. Explore the groundbreaking realm of cancer therapy with our comprehensive study on the mechanism and applications of photosensitizer-mediated light-controlled cancer therapy. Uncover the intricate workings and diverse applications of this innovative approach, clarify the future of targeted and controlled cancer treatment. image
Keyword ：
Drug Delivery Drug Delivery Optogenetics Optogenetics Photodynamic Therapy Photodynamic Therapy Photosensitizer Photosensitizer X-rays X-rays
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| GB/T 7714 | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen et al. Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
| MLA | Chen, Minle et al. "Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy" . | CHEMISTRY-AN ASIAN JOURNAL 19 . 11 (2024) . |
| APA | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen , Chen, Qiushui , Yang, Huanghao . Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy . | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
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