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学者姓名：张进
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Abstract ：
Conductive organohydrogels with flexibility and biocompatibility have attracted extensive attention in bioelectronic devices. However, poor mechanical properties and crack propagation resistance have severely limited their applications. Herein, strong, tough, and ionically conductive organogels (ICOs) with outstanding fatigue resistance are prepared based on simultaneous construction of dense cross-linked polymer network with numerous crystalline domains and ionically conductive network during the solvent exchange. ICOs show excellent mechanical properties with tensile strength and elongation at break as high as 16.7 +/- 0.9 MPa and 1112.4 +/- 120.3%, respectively. Moreover, the fracture energy and fatigue threshold can reach 34.0 +/- 4.7 KJ/m(2) and 561.3 +/- 59.6 J/m(2), respectively, exhibiting outstanding crack resistant properties. ICOs with antifreezing performance are used for strain sensing with a linear working strain up to 80% and superior cycling stability, and the ICO strain sensor can monitor various body motions. The mechanically strong and antifatigue organogels show promising applications in flexible and smart electronics even in extreme environments.
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| GB/T 7714 | Wang, Yuqing , Wu, Yongchuan , Liu, Yuntao et al. Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors [J]. | ACS MATERIALS LETTERS , 2024 , 6 (4) : 1140-1150 . |
| MLA | Wang, Yuqing et al. "Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors" . | ACS MATERIALS LETTERS 6 . 4 (2024) : 1140-1150 . |
| APA | Wang, Yuqing , Wu, Yongchuan , Liu, Yuntao , Wu, Haidi , Xiao, Wei , Zhang, Hechuan et al. Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors . | ACS MATERIALS LETTERS , 2024 , 6 (4) , 1140-1150 . |
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Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification or functionalization has emerged as a promising approach. These tailored nanovaccines not only enhance antigen presentation, but also effectively modulate immunosuppression within the tumor microenvironment. Specifically, they are distinguished by their diverse sizes, shapes, charges, structures, and unique physicochemical properties, along with targeting ligands. These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells. This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications, offering insights into their future development and role in cancer immunotherapy.
Keyword ：
Customized structure Customized structure Enhanced cancer immunotherapy Enhanced cancer immunotherapy Nanovaccines Nanovaccines Prophylactic and therapeutic applications Prophylactic and therapeutic applications Tailored-ligand Tailored-ligand
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| GB/T 7714 | Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang et al. Engineering customized nanovaccines for enhanced cancer immunotherapy [J]. | BIOACTIVE MATERIALS , 2024 , 36 : 330-357 . |
| MLA | Guo, Jinyu et al. "Engineering customized nanovaccines for enhanced cancer immunotherapy" . | BIOACTIVE MATERIALS 36 (2024) : 330-357 . |
| APA | Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang , Qiu, Ting , Zhang, Jin , Yang, Huanghao . Engineering customized nanovaccines for enhanced cancer immunotherapy . | BIOACTIVE MATERIALS , 2024 , 36 , 330-357 . |
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Hydrogel coatings of catheters have attracted extensive attention in the field of medical devices due to its hydrophilicity and softness, while scarcities of Janus adhesion, adaptive antibacterial property, and real-time disease monitoring restricted their clinical translational applications. Herein, a novel hydrogel coating with water-responsive Janus adhesion and acidity-triggered transformation was fabricated for antibacterial treatment and fluorescence diagnosis of catheters-associated infections. First, a sufficient adhesion strength of 44.6 ± 1.9 kPa effectively prevented shedding of the hydrogel coating during catheterization, and meanwhile a super-lubricated layer with an extremely-low coefficient of friction of about 0.03 was formed to reduce friction pain in an aqueous microenvironment. Furthermore, size and fluorescence intensity of chitosan/bovine serum albumin-gold nanoparticles within the hydrogel were varied with pH due to acidity-triggered transformation, where an adaptive release of antibacterial nanoparticles was achieved to reduce biofilms formation and alleviate inflammation degree synergistically. More importantly, such antibacterial treatment was monitored in real-time dependent on an on–off variation of fluorescence intensity. Overall, amounts of in-vitro and in-vivo results performed in rabbit urinary tract infection model and porcine tracheal intubation model fully suggested our newly-synthesized hydrogel coating on universal medical devices showed a promising potential for integrated diagnosis and treatment of catheters-associated infections. © 2024 Elsevier B.V.
Keyword ：
Adhesion Adhesion Catheters Catheters Diagnosis Diagnosis Fluorescence Fluorescence Friction Friction Hydrogels Hydrogels Nanoparticles Nanoparticles
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| GB/T 7714 | Liu, Yanyun , Li, Ming , Zheng, Ying et al. Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis [J]. | Chemical Engineering Journal , 2024 , 481 . |
| MLA | Liu, Yanyun et al. "Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis" . | Chemical Engineering Journal 481 (2024) . |
| APA | Liu, Yanyun , Li, Ming , Zheng, Ying , Liu, Changhua , Cao, Yang , Guo, Wei et al. Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis . | Chemical Engineering Journal , 2024 , 481 . |
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Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.
Keyword ：
bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy
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| GB/T 7714 | Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 . |
| MLA | Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 . |
| APA | Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 . |
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Structural engineering is an appealing means to modulate osteogenesis without the intervention of exogenous cells or therapeutic agents. In this work, a novel 3D scaffold with anisotropic micropores and nanotopographical patterns is developed. Scaffolds with oriented pores are fabricated via the selective extraction of water-soluble polyethylene oxide from its poly(epsilon-caprolactone) co-continuous mixture and uniaxial stretching. The plate apatite-like lamellae are subsequently hatched on the pore walls through surface-induced epitaxial crystallization. Such a unique geometric architecture yields a synergistic effect on the osteogenic capability. The prepared scaffold leads to a 19.2% and 128.0% increase in the alkaline phosphatase activity of rat bone mesenchymal stem cells compared to that of the scaffolds with only oriented pores and only nanotopographical patterns, respectively. It also induces the greatest upregulation of osteogenic-related gene expression in vitro. The cranial defect repair results demonstrate that the prepared scaffold effectively promotes new bone regeneration, as indicated by a 350% increase in collagen I expression in vivo compared to the isotropic porous scaffold without surface nanotopology after implantation for 14 weeks. Overall, this work provides geometric motifs for the transduction of biophysical cues in 3D porous scaffolds, which is a promising option for tissue engineering applications. This study presents a 3D scaffold featuring anisotropic micropores and nanotopographical patterns to modulate osteogenesis. The scaffold, fabricated through selective extraction, uniaxial stretching, and surface-induced epitaxial crystallization, possesses a unique geometric architecture, which significantly enhances bone mesenchymal stem cell proliferation and osteogenic differentiation, leading to effective cranial defect repair and promising implications for tissue engineering applications. image
Keyword ：
co-continuous structure co-continuous structure hierarchical oriented scaffolds hierarchical oriented scaffolds nanotopographical patterns nanotopographical patterns osteogenesis osteogenesis uniaxial stretching uniaxial stretching
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| GB/T 7714 | Wei, Xin , Chen, Jiaxin , Shen, Hui-Yuan et al. Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (17) . |
| MLA | Wei, Xin et al. "Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation" . | ADVANCED HEALTHCARE MATERIALS 13 . 17 (2024) . |
| APA | Wei, Xin , Chen, Jiaxin , Shen, Hui-Yuan , Jiang, Kai , Ren, Haohao , Liu, Yao et al. Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (17) . |
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Spinal cord injury (SCI) often results in irreversible loss of sensory and motor functions, and most SCIs are incurable with current medical practice. One of the hardest challenges in treating SCI is the development of a dysfunctional pathological microenvironment, which mainly comprises excessive inflammation, deposition of inhibitory molecules, neurotrophic factor deprivation, glial scar formation, and imbalance of vascular function. To overcome this challenge, implantation of functional biomaterials at the injury site has been regarded as a potential treatment for modulating the dysfunctional microenvironment to support axon regeneration, remyelination at injury site, and functional recovery after SCI. This review summarizes characteristics of dysfunctional pathological microenvironment and recent advances in biomaterials as well as the technologies used to modulate inflammatory microenvironment, regulate inhibitory microenvironment, and reshape revascularization microenvironment. Moreover, technological limitations, challenges, and future prospects of functional biomaterials to promote efficient repair of SCI are also discussed. This review will aid further understanding and development of functional biomaterials to regulate pathological SCI microenvironment.
Keyword ：
Axon regeneration Axon regeneration Dysfunctional pathological microenvironment Dysfunctional pathological microenvironment Functional biomaterials Functional biomaterials Functional recovery Functional recovery Spinal cord injury Spinal cord injury
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| GB/T 7714 | Ma, Dezun , Fu, Changlong , Li, Fenglu et al. Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury [J]. | BIOACTIVE MATERIALS , 2024 , 39 : 521-543 . |
| MLA | Ma, Dezun et al. "Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury" . | BIOACTIVE MATERIALS 39 (2024) : 521-543 . |
| APA | Ma, Dezun , Fu, Changlong , Li, Fenglu , Ruan, Renjie , Lin, Yanming , Li, Xihai et al. Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury . | BIOACTIVE MATERIALS , 2024 , 39 , 521-543 . |
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Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in -vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual -stimuli responsive release, synergistic therapy strategy, and real -time monitoring. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amphiphilic iridium complex Amphiphilic iridium complex NIR/GSH dual-responsiveness NIR/GSH dual-responsiveness Photoacoustic imaging Photoacoustic imaging Synergistic tumor therapy Synergistic tumor therapy Transferrin targeting Transferrin targeting
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| GB/T 7714 | Guo, Jinyu , Lin, Yandai , He, Shaohua et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| MLA | Guo, Jinyu et al. "Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | CHINESE CHEMICAL LETTERS 35 . 9 (2024) . |
| APA | Guo, Jinyu , Lin, Yandai , He, Shaohua , Chen, Yueqing , Li, Fenglu , Ruan, Renjie et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
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Traditional hepatocellular carcinoma-chip models lack the cell structure and microenvironments necessary for high pathophysiological correlation, leading to low accuracy in predicting drug efficacy and high production costs. This study proposed a decellularized hepatocellular carcinoma-on-a-chip model to screen anti-tumor nanomedicine. In this model, human hepatocellular carcinoma (HepG2) and human normal liver cells (L02) were co-cultured on a three-dimensional (3D) decellularized extracellular matrix (dECM) in vitro to mimic the tumor microenvironments of human hepatocellular carcinoma in vivo. Additionally, a smart nanomedicine was developed by encapsulating doxorubicin (DOX) into the ferric oxide (Fe3O4)-incorporated liposome nanovesicle (NLV/Fe+DOX). NLV/Fe+DOX selectively killed 78.59% ± 6.78% of HepG2 cells through targeted delivery and synergistic chemo-chemodynamic-photothermal therapies, while the viability of surrounding L02 cells on the chip model retained high, at over 90.0%. The drug efficacy tested using this unique chip model correlated well with the results of cellular and animal experiments. In summary, our proposed hepatocellular carcinoma-chip model is a low-cost yet accurate drug-testing platform with significant potential for drug screening. © 2024 Elsevier B.V.
Keyword ：
Decellularized extracellular matrix Decellularized extracellular matrix Drug screening Drug screening Hepatocellular carcinoma-on-a-chip model Hepatocellular carcinoma-on-a-chip model Multi-functional nanomedicine Multi-functional nanomedicine Synergistic tumor therapy Synergistic tumor therapy
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| GB/T 7714 | Chen, Y. , Lin, G. , Wang, Z. et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip [J]. | Biosensors and Bioelectronics , 2024 , 264 . |
| MLA | Chen, Y. et al. "Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip" . | Biosensors and Bioelectronics 264 (2024) . |
| APA | Chen, Y. , Lin, G. , Wang, Z. , He, J. , Yang, G. , Lin, Z. et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip . | Biosensors and Bioelectronics , 2024 , 264 . |
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| GB/T 7714 | Liu, Zongtai , Zhang, Jin , Fu, Changfeng et al. Osteoimmunity-regulating biomaterials promote bone regeneration [J]. | ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES , 2023 , 18 (1) . |
| MLA | Liu, Zongtai et al. "Osteoimmunity-regulating biomaterials promote bone regeneration" . | ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 18 . 1 (2023) . |
| APA | Liu, Zongtai , Zhang, Jin , Fu, Changfeng , Ding, Jianxun . Osteoimmunity-regulating biomaterials promote bone regeneration . | ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES , 2023 , 18 (1) . |
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MXene-decorated textile composites have attracted tremendous attention, due to their possible applications in wearable sensing electronics. However, the easy oxidation, low strain sensitivity and poor water-proof performance restrict the applications of MXene-based smart textiles. Here, we developed a flexible and hydrophobic polymer nanofibrous composite with a screw-like structure by assembling MXene nanosheets onto a prestretched polyurethane (PU) nanofiber surface and subsequent fluorination treatment. The thin hydrophobic fluorosilane layer can greatly prevent the MXene shell from being oxidized and simultaneously endow the nanofiber composite with good hemostatic performance. The wrinkled MXene shell with the screw-like structure enhances the sensitivity of MXene@PU nanofiber composite (HMPU) toward strain, and the hydrophobic strain sensor exhibits a high gauge factor (324.4 in the strain range of 85-100%), and can detect different human movements. In virtue of its excellent water-proof performance, HMPU can function normally in corrosive and underwater conditions. In addition, the resistance of HMPU exhibits a negative temperature coefficient; thus, HMPU shows potential for monitoring temperature and providing a temperature alarm. The multifunctional HMPU shows broad application prospects in smart wearable electronics.
Keyword ：
MXene nanosheets MXene nanosheets Nanofibrous composite Nanofibrous composite Strain sensor Strain sensor Temperature alarm Temperature alarm
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| GB/T 7714 | Xiao, Wei , Chen, Yutong , Pan, Gaoxing et al. Hydrophobic, Hemostatic and Durable Nanofiber Composites with a Screw-Like Surface Architecture for Multifunctional Sensing Electronics [J]. | ADVANCED FIBER MATERIALS , 2023 , 5 (6) : 2040-2054 . |
| MLA | Xiao, Wei et al. "Hydrophobic, Hemostatic and Durable Nanofiber Composites with a Screw-Like Surface Architecture for Multifunctional Sensing Electronics" . | ADVANCED FIBER MATERIALS 5 . 6 (2023) : 2040-2054 . |
| APA | Xiao, Wei , Chen, Yutong , Pan, Gaoxing , Yan, Jun , Zhang, Jin , Gao, Jiefeng . Hydrophobic, Hemostatic and Durable Nanofiber Composites with a Screw-Like Surface Architecture for Multifunctional Sensing Electronics . | ADVANCED FIBER MATERIALS , 2023 , 5 (6) , 2040-2054 . |
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