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学者姓名：宋继彬
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Abstract ：
Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.
Keyword ：
bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy
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| GB/T 7714 | Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 . |
| MLA | Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 . |
| APA | Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 . |
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The external quantum efficiency (EQE) enhancement of different sized GaN micro-light-emitting diodes (mu LEDs) by using localized surface plasmons (LSPs) have been studied. Silver nanoparticles (Ag NPs) are attached to the sidewalls of mu LEDs by spin-coating so as to be effectively coupled with the multiple quantum well (MQW) of mu LEDs and generate the LSPs. In the mu LEDs with 20 x 20 mu m2 large mesas, the LSPs can effectively inhibit the efficiency droop. Compared to the mu LED samples without the LSPs coupling, the EQE has been enhanced by about 8% at a high current density of 20,000 A/cm2. This work confirms the effectiveness of the LSPs technology in improving the mu LED performances, which is originally practiced only on the basal faces of conventional LEDs.
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| GB/T 7714 | Du, Zaifa , Sun, Jie , Feng, Hongjuan et al. Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling [J]. | APPLIED PHYSICS B-LASERS AND OPTICS , 2024 , 130 (3) . |
| MLA | Du, Zaifa et al. "Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling" . | APPLIED PHYSICS B-LASERS AND OPTICS 130 . 3 (2024) . |
| APA | Du, Zaifa , Sun, Jie , Feng, Hongjuan , Tang, Penghao , Guo, Weiling , Han, Kai et al. Efficiency enhancement of micro-light-emitting diode with shrinking size by localized surface plasmons coupling . | APPLIED PHYSICS B-LASERS AND OPTICS , 2024 , 130 (3) . |
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Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in -vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual -stimuli responsive release, synergistic therapy strategy, and real -time monitoring. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amphiphilic iridium complex Amphiphilic iridium complex NIR/GSH dual-responsiveness NIR/GSH dual-responsiveness Photoacoustic imaging Photoacoustic imaging Synergistic tumor therapy Synergistic tumor therapy Transferrin targeting Transferrin targeting
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| GB/T 7714 | Guo, Jinyu , Lin, Yandai , He, Shaohua et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| MLA | Guo, Jinyu et al. "Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | CHINESE CHEMICAL LETTERS 35 . 9 (2024) . |
| APA | Guo, Jinyu , Lin, Yandai , He, Shaohua , Chen, Yueqing , Li, Fenglu , Ruan, Renjie et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
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Surface-enhanced Raman scattering (SERS) is a feasible and ultra-sensitive method for biomedical imaging and disease diagnosis. SERS is widely applied to in vivo imaging due to the development of functional nanoparticles encoded by Raman active molecules (SERS nanoprobes) and improvements in instruments. Herein, the recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed. Various SERS substrates that have been successfully used for in vivo imaging are described. Then, the applications of SERS imaging in cancer detection and in vivo intraoperative guidance are summarized. The role of highly sensitive SERS biosensors in guiding the detection and prevention of diseases is discussed in detail. Moreover, its role in the identification and resection of microtumors and as a diagnostic and therapeutic platform is also reviewed. Finally, the progress and challenges associated with SERS active materials, equipment, and clinical translation are described. The present evidence suggests that SERS could be applied in clinical practice in the future.
Keyword ：
biosensing biosensing diagnosis diagnosis Raman mapping Raman mapping self-assembly self-assembly surface-enhanced Raman scattering surface-enhanced Raman scattering
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| GB/T 7714 | Li, Qingqing , Huo, Hongqi , Wu, Ying et al. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing [J]. | ADVANCED SCIENCE , 2023 , 10 (8) . |
| MLA | Li, Qingqing et al. "Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing" . | ADVANCED SCIENCE 10 . 8 (2023) . |
| APA | Li, Qingqing , Huo, Hongqi , Wu, Ying , Chen, Lanlan , Su, Lichao , Zhang, Xuan et al. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing . | ADVANCED SCIENCE , 2023 , 10 (8) . |
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Background Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation of absorption in the NIR-II window, leading to poor effect of PTT. It remains a great challenge to gain photothermal agents with strong and characteristic absorption in NIR-II regions. To overcome this problem, based on carbon dots (CDs)-mediated growth strategy, we proposed a simple and feasible approach to prepare plasmonic gold nanodendrites (AuNDs) with NIR-II absorption to enhance the therapeutic effect of PTT.Results By rationally regulating the size and branch length of AuNDs, the AuNDs exhibited a broadband absorption from 300 to 1350 nm, with two characteristic absorption peaks located at 1077 and 1265 nm. The AuNDs demonstrated desired optical photothermal conversion efficiency (38.0%), which was further applied in NIR-II photoacoustic imaging (PAI) and PTT in human colon cancer cells (HCT 116)-tumor-bearing mice model. The tumor cells could be effectively eliminated in vivo under 1064 nm laser irradiation by the guidance of PAI.Conclusions We reported a simple but powerful synthetic method to obtain the unique AuNDs with strong and characteristic absorption peaks in the NIR-II window. This study provides a promising solution to tuning the growth of nanoparticles for bioimaging and phototherapy in the NIR-II window.
Keyword ：
Carbon dots Carbon dots Gold nanodendrites Gold nanodendrites Photoacoustic imaging Photoacoustic imaging Photothermal therapy Photothermal therapy Second near-infrared window Second near-infrared window
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| GB/T 7714 | Liu, Guoyong , Wang, Shuxian , Wang, Shumin et al. Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
| MLA | Liu, Guoyong et al. "Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy" . | JOURNAL OF NANOBIOTECHNOLOGY 21 . 1 (2023) . |
| APA | Liu, Guoyong , Wang, Shuxian , Wang, Shumin , Wu, Rongrong , Li, Hui , Zha, Menglei et al. Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy . | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
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Radiotherapy (RT) is an effective and widely applied cancer treatment strategy in clinic. However, it usually suffers from radioresistance of tumor cells and severs side effects of excessive radiation dose. Therefore, it is highly significant to improve radiotherapeutic performance and monitor real-time tumor response, achieving precise and safe RT. Herein, an X-ray responsive radio-pharmaceutical molecule containing chemical radiosensitizers of diselenide and nitroimidazole (BBT-IR/Se-MN) is reported. BBT-IR/Se-MN exhibits enhanced radiotherapeutic effect via a multifaceted mechanisms and self-monitoring ROS levels in tumors during RT. Under X-ray irradiation, the diselenide produces high levels of ROS, leading to enhanced DNA damage of cancer cell. Afterwards, the nitroimidazole in the molecule inhibits the damaged DNA repair, offering a synergetic radiosensitization effect of cancer. Moreover, the probe shows low and high NIR-II fluorescence ratios in the absence and presence of ROS, which is suitable for precise and quantitative monitoring of ROS during sensitized RT. The integrated system is successfully applied for radiosensitization and the early prediction of in vitro and in vivo RT efficacy.
Keyword ：
Activatable Probe Activatable Probe Biosensor Biosensor NIR-II Fluorescence Imaging NIR-II Fluorescence Imaging Radiotherapy Radiotherapy X-Ray X-Ray
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| GB/T 7714 | Ge, Xiaoguang , Su, Lichao , Chen, Zhongxiang et al. A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2023 , 62 (29) . |
| MLA | Ge, Xiaoguang et al. "A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 62 . 29 (2023) . |
| APA | Ge, Xiaoguang , Su, Lichao , Chen, Zhongxiang , Zhu, Kang , Zhang, Xuan , Wu, Ying et al. A Radio-Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2023 , 62 (29) . |
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Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO2-Cu7S4) antimicrobial nanomotors with an intended Janus configuration through the overgrowth of copper rich Cu7S4 nanocrystals at only one high-curvature site of Au nanorods (Au NRs). These nanomotors were applied for photoacoustic imaging (PAI)-guided synergistic photothermal and photocatalytic treatment of bacterial infections. Both the photothermal performance and photocatalytic activity of the nanomotors are dramatically improved owing to the strong plasmon coupling between Au NRs and the Cu7S4 component and enhanced energy transfer. The motion behavior of nanomotors promotes transdermal penetration and enhances the matter-bacteria interaction. More importantly, the directional navigation and synergistic antimicrobial activity of the nanomotors could be synchronously driven by NIR-II light. The marriage of active motion and enhanced antibacterial activity resulted in the expected good antibacterial effects in an abscess infection mouse model.
Keyword ：
bacterial infections bacterial infections gold nanorod gold nanorod Janus nanoparticle Janus nanoparticle nanomotor nanomotor photoacoustic imaging photoacoustic imaging
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| GB/T 7714 | Liu, Luntao , Li, Shuqin , Yang, Kaiqiong et al. Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections [J]. | NANO LETTERS , 2023 , 23 (9) : 3929-3938 . |
| MLA | Liu, Luntao et al. "Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections" . | NANO LETTERS 23 . 9 (2023) : 3929-3938 . |
| APA | Liu, Luntao , Li, Shuqin , Yang, Kaiqiong , Chen, Zhongxiang , Li, Qingqing , Zheng, Liting et al. Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections . | NANO LETTERS , 2023 , 23 (9) , 3929-3938 . |
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The controllable assembly of nanoparticles significantly improves their biological effects in vivo. However, it is difficult to realize the assembly regulation of nanomaterials under complex physiological conditions. Herein, endogenous glutathione (GSH)-triggered vesicles with spatiotemporally confined aggregation of gold nanogapped nanoparticles (AuNNPs) within vesicles were developed. These vesicles had excellent photoacoustic (PA) imaging capability in the near-infrared second window (NIR-II) for precise localization of deep tumors, measuring tumor volume, and making deep tumors more sensitive to radiotherapy and chemodynamic therapy (CDT). The vesicles were prepared via self-assembly of MnO2-coated AuNNPs that were functionalized by phosphate-polystyrene and bovine serum albumin (AuNNP@MnO2 Ve@BSA). The MnO2 shell was etched when AuNNP@MnO2 Ve@BSA vesicle was exposed to GSH, the gap between intra-vesicular AuNNP@MnO2 NPs was reduced. This significantly enhanced the plasmonic coupling effect be-tween AuNNP@MnO2 NPs, giving it excellent NIR-II PA imaging capability, and thus can be used to delineate the boundary and volume of deep-seated tumors. Meanwhile, the Mn2+-mediated CDT released after the etching of the MnO2 shell interacted with GSH-responsive AuNNP@MnO2 Ve@BSA and significantly in-hibited tumor growth due to enhanced radiosensitization effect. This unique strategy provides new per-spectives and methods for designing and applying biomedical nanomaterials.& COPY; 2023 Published by Elsevier Ltd.
Keyword ：
NIR-II NIR-II Photoacoustic imaging Photoacoustic imaging Radiosensitizer Radiosensitizer Self-assembly Self-assembly X-ray X-ray
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| GB/T 7714 | Su, Lichao , Tang, Huaiding , Liao, Naishun et al. Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit [J]. | NANO TODAY , 2023 , 50 . |
| MLA | Su, Lichao et al. "Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit" . | NANO TODAY 50 (2023) . |
| APA | Su, Lichao , Tang, Huaiding , Liao, Naishun , Chen, Zhongxiang , Li, Hang , Ge, Xiaoguang et al. Spatiotemporally confined assembly of radiosensitizers for synergistic radio-chemodynamic therapy on deep tumor of rabbit . | NANO TODAY , 2023 , 50 . |
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X-ray-induced afterglow and radiodynamic therapy tackle the tissue penetration issue of optical imaging and phototherapy. However, inorganic nanophosphors used in this therapy have their radio afterglow dynamic function as always on, limiting the detection specificity and treatment efficacy. Here we report organic luminophores (IDPAs) with near-infrared afterglow and O-1(2) production after X-ray irradiation for cancer theranostics. The in vivo radio afterglow of IDPAs is >25.0 times brighter than reported inorganic nanophosphors, whereas the radiodynamic production of O-1(2) is >5.7 times higher than commercially available radio sensitizers. The modular structure of IDPAs permits the development of a smart molecular probe that only triggers its radio afterglow dynamic function in the presence of a cancer biomarker. Thus, the probe enables the ultrasensitive detection of a diminutive tumour (0.64 mm) with superb contrast (tumour-to-background ratio of 234) and tumour-specific radiotherapy for brain tumour with molecular precision at low dosage. Our work reveals the molecular guidelines towards organic radio afterglow agents and highlights new opportunities for cancer radio theranostics.
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| GB/T 7714 | Huang, Jingsheng , Su, Lichao , Xu, Cheng et al. Molecular radio afterglow probes for cancer radiodynamic theranostics [J]. | NATURE MATERIALS , 2023 , 22 (11) . |
| MLA | Huang, Jingsheng et al. "Molecular radio afterglow probes for cancer radiodynamic theranostics" . | NATURE MATERIALS 22 . 11 (2023) . |
| APA | Huang, Jingsheng , Su, Lichao , Xu, Cheng , Ge, Xiaoguang , Zhang, Ruiping , Song, Jibin et al. Molecular radio afterglow probes for cancer radiodynamic theranostics . | NATURE MATERIALS , 2023 , 22 (11) . |
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Ultrasmall gold nanoclusters (AuNCs) are emerging as promising luminescent nanoprobes for bioimaging due to their fantastic photoluminescence (PL) and renal-clearable ability. However, it remains a great challenge to design them for in vivo sensitive molecular imaging in desired tissues. Herein, we have developed a strategy to tailor the PL and biofate of near-infrared II (NIR-II)emitting AuNCs via ligand anchoring for improved bioimaging. By optimizing the ligand types in AuNCs and using Er3+-doped lanthanide (Ln) nanoparticles as models, core-satellite Ln@AuNCs assemblies were rationally constructed, which enabled 2.5-fold PL enhancement of AuNCs at 1100 nm and prolonged blood circulation compared to AuNCs. Significantly, Ln@AuNCs with dual intense NIR-II PL (from AuNCs and Er3+) can effectively accumulate in the liver for ratiometric NIR-II imaging of H2S, facilitated by H2S-mediated selective PL quenching of AuNCs. We have then demonstrated the real-time imaging evaluation of liver delivery efficacy and dynamics of two H2S prodrugs. This shows a paradigm to visualize liver H2S delivery and its prodrug screening in vivo. Note that Ln@AuNCs are body-clearable via the hepatobiliary excretion pathway, thus reducing potential long-term toxicity. Such findings may propel the engineering of AuNC nanoprobes for advancing in vivo bioimaging analysis.
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| GB/T 7714 | Li, Shihua , Ma, Qiuping , Wang, Chenlu et al. Near-Infrared II Gold Nanocluster Assemblies with Improved Luminescence and Biofate for In Vivo Ratiometric Imaging of H2S [J]. | ANALYTICAL CHEMISTRY , 2022 , 94 (5) : 2641-2647 . |
| MLA | Li, Shihua et al. "Near-Infrared II Gold Nanocluster Assemblies with Improved Luminescence and Biofate for In Vivo Ratiometric Imaging of H2S" . | ANALYTICAL CHEMISTRY 94 . 5 (2022) : 2641-2647 . |
| APA | Li, Shihua , Ma, Qiuping , Wang, Chenlu , Yang, Kaidong , Hong, Zhongzhu , Chen, Qiushui et al. Near-Infrared II Gold Nanocluster Assemblies with Improved Luminescence and Biofate for In Vivo Ratiometric Imaging of H2S . | ANALYTICAL CHEMISTRY , 2022 , 94 (5) , 2641-2647 . |
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