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学者姓名:邵敬伟

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Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects SCIE
期刊论文 | 2024 , 269 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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Abstract :

The existing therapies for cancer are not remote satisfactory due to drug-resistance in tumors that are malignant. There is a pressing necessity to take a step forward to develop innovative therapies that can complement current ones. Multiple investigations have demonstrated that ferroptosis therapy, a non-apoptotic modality of programmed cell death, has tremendous potential in face of multiple crucial events, such as drug resistance and toxicity in aggressive malignancies. Recently, ferroptosis at the crosswalk of chemotherapy, materials science, immunotherapy, tumor microenvironment, and bionanotechnology has been presented to elucidate its therapeutic feasibility. Given the burgeoning progression of ferroptosis-based nanomedicine, the newest advancements in this field at the confluence of ferroptosis-inducers, nanotherapeutics, along with tumor microenvironment are given an overview. Here, the signaling pathways of ferroptosis-related were first talked about briefly. The emphasis discussion was placed on the pharmacological mechanisms and the nanodrugs design of ferroptosis inducing agents based on multiple distinct metabolism pathways. Additionally, a comprehensive overview of the action mechanisms by which the tumor microenvironment influences ferroptosis was elaborately descripted. Finally, some limitations of current researches and future research directions were also deliberately discussed to provide details about therapeutic avenues for ferroptosis-related diseases along with the design of anti-drugs.

Keyword :

Ferroptosis Ferroptosis Nanodrug design Nanodrug design Pathway Pathway Pharmacological mechanism Pharmacological mechanism Tumor microenvironment Tumor microenvironment

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GB/T 7714 Yu, Shijing , Tong, Lingwu , Shen, Jiangwen et al. Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects [J]. | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , 2024 , 269 .
MLA Yu, Shijing et al. "Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects" . | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 269 (2024) .
APA Yu, Shijing , Tong, Lingwu , Shen, Jiangwen , Li, Chenglei , Hu, Yongshan , Feng, Keke et al. Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects . | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , 2024 , 269 .
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Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis SCIE
期刊论文 | 2024 , 660 , 257-276 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
WoS CC Cited Count: 4
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Abstract :

The heterogeneity of hepatocellular carcinoma (HCC) and the complexity of the tumor microenvironment (TME) pose challenges to efficient drug delivery and the antitumor efficacy of combined or synergistic therapies. Herein, a metal-coordinated carrier-free nanodrug (named as USFe3+ LA NPs) was developed for ferroptosis-mediated multimodal synergistic anti-HCC. Natural product ursolic acid (UA) was incorporated to enhance the sensitivity of tumor cells to sorafenib (SRF). Surface decoration of cell penetration peptide and epithelial cell adhesion molecule aptamer facilitated the uptake of USFe3+ LA NPs by HepG2 cells. Meanwhile, Fe3+ ions could react with intracellular hydrogen peroxide, generating toxic hydroxyl radical (& sdot;OH) for chemodynamical therapy (CDT) and amplified ferroptosis by cystine/glutamate antiporter system (System Xc  ), which promoted the consumption of glutathione (GSH) and inhibited the expression of glutathione peroxidase 4 (GPX4). Notably, these all-in-one nanodrugs could inhibit tumor metastasis and induced immunogenic cell death (ICD). Last but not least, the nanodrugs demonstrated favorable biocompatibility, augmenting the immune response against the programmed death-ligand 1 (PD-L1) by increasing cytotoxic T cell infiltration. In vivo studies revealed significant suppression of tumor growth and distant metastasis. Overall, our work introduced a novel strategy for applications of metalcoordinated co-assembled carrier-free nano-delivery system in HCC combination therapy, especially in the realms of cancer metastasis prevention and immunotherapy.

Keyword :

Chemodynamical therapy Chemodynamical therapy Ferroptosis Ferroptosis Immunotherapy Immunotherapy Metal -coordinated nanoplatform Metal -coordinated nanoplatform Synergistic chemotherapy Synergistic chemotherapy

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GB/T 7714 Zhao, Rui-Rui , Wu, Ju-Hong , Li, Jin -Yu et al. Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis [J]. | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2024 , 660 : 257-276 .
MLA Zhao, Rui-Rui et al. "Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis" . | JOURNAL OF COLLOID AND INTERFACE SCIENCE 660 (2024) : 257-276 .
APA Zhao, Rui-Rui , Wu, Ju-Hong , Li, Jin -Yu , Lu, Yu-sheng , Shao, Jing -Wei . Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis . | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2024 , 660 , 257-276 .
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Advancements in the synthesis of carbon dots and their application in biomedicine Scopus
其他 | 2024 , 255
SCOPUS Cited Count: 1
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Abstract :

As a sort of fluorescent carbon nanomaterial with a particle size of less than 10 nm, carbon dots (CDs) have their own merits of good dispersibility in water, stable optical properties, strong chemical inertness, stable optical properties, and good biosecurity. These excellent peculiarities facilitated them like sensing, imaging, medicine, catalysis, and optoelectronics, making them a new star in the field of nanotechnology. In particular, the development of CDs in the fields of chemical probes, imaging, cancer therapy, antibacterial and drug delivery has become a hot topic in current research. Although the biomedical applications in CDs have been demonstrated in many research articles, a systematic summary of their role in biomedical applications is scarce. In this review, we introduced the basic information of CDs in detail, including synthesis approaches of CDs as well as their favorable properties including photoluminescence and low cytotoxicity. Subsequently, the application of CDs in the field of biomedicine was emphasized. Finally, the main challenges and research prospects of CDs in this field were proposed, which might provide some detailed information in designing new CDs in this promising biomedical field. © 2023

Keyword :

Bioimaging Bioimaging Cancer therapy Cancer therapy Carbon dots Carbon dots Chemical probe Chemical probe Drug delivery Drug delivery

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GB/T 7714 Xu, J. , Huang, B.-B. , Lai, C.-M. et al. Advancements in the synthesis of carbon dots and their application in biomedicine [未知].
MLA Xu, J. et al. "Advancements in the synthesis of carbon dots and their application in biomedicine" [未知].
APA Xu, J. , Huang, B.-B. , Lai, C.-M. , Lu, Y.-S. , Shao, J.-W. . Advancements in the synthesis of carbon dots and their application in biomedicine [未知].
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Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib SCIE
期刊论文 | 2024 , 234 | COLLOIDS AND SURFACES B-BIOINTERFACES
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Both ursolic acid (UA) and sorafenib (Sora) have been generally utilized in cancer treatment, and the combination of the two has also shown a good anti-tumor effect. However, single-agent therapy for Hepatocellular carcinoma (HCC) has the disadvantages of multi-drug resistance, poor water solubility and low bioavailability, and the application of traditional nanocarrier materials is limited due to their low drug loading and low carrierrelated toxicity. Therefore, we prepared US NPs with different proportions of UA and Sora by solvent exchange method for achieving synergistic HCC therapy. US NPs had suitable particle size, good dispersibility and storage stability, which synergistically inhibited the proliferation of HepG2 cells, SMMC7721 cells and H22 cells. In addition, we also proved that US NPs were able to suppress the migration of HepG2 cells and SMMC7721 cells and reduce the adhesion ability and colony formation ability of these cells. According to the results, US NPs could degrade the membrane potential of mitochondrial, participate in cell apoptosis, and synergistically induce autophagy. Collectively, the carrier-free US NPs provide new strategies for HCC treatment and new ideas for the development of novel nano-drug delivery systems containing UA and Sora.

Keyword :

Co-assembly Co-assembly Sorafenib Sorafenib Synergistic therapy Synergistic therapy Ursolic acid Ursolic acid

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GB/T 7714 Tong, Ling-Wu , Le, Jing-Qing , Song, Xun-Huan et al. Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2024 , 234 .
MLA Tong, Ling-Wu et al. "Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib" . | COLLOIDS AND SURFACES B-BIOINTERFACES 234 (2024) .
APA Tong, Ling-Wu , Le, Jing-Qing , Song, Xun-Huan , Li, Cheng-Lei , Yu, Shi-Jing , Lin, Ying-Qi et al. Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2024 , 234 .
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A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma SCIE
期刊论文 | 2024 , 482 | CHEMICAL ENGINEERING JOURNAL
WoS CC Cited Count: 2
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Abstract :

Ferroptosis, an emerging cell death mode discovered in recent decades, is characterized by lipid peroxidation during cell death, usually manifested as iron accumulation. However, the forthright delivery of iron species will cause adverse detrimental effects such as anaphylactic reactions in routine tissues. So far, studies on cellular ferroptosis by employing bio-derived nanomaterials have rarely been acquired. Herein, we reported carbon dots (CDs)-based biocompatible enzymes with negligible toxicity from a representative hepatoprotective triterpenoid natural product ursolic acid (UA) with acknowledged antitumor activity. We observed that CDs presented distinct GSH oxidase-like characteristics and then contributed ferroptosis of carcinoma cells by interfering with the GPX4-catalyzed lipid repair system. After the CDs were assembled with UA, the obtained denoted as UCDs integrated multi-model therapy into one, resulting in enhanced therapeutic efficacy, reduced adverse effects, and optimized clinical outcomes. In vivo, the UCDs hysterically inhibited tumor growth in hepatoma H22-bearing mice with inconsequential toxicity. Exceptionally, UCDs enlisted a large number of tumor-infiltrating immune cells, including T cells, NK cells, and macrophages in H22 tumor-bearing mice, consequently transforming "cold" into "hot" tumors to activate systemic anti-tumor immune responses. Meanwhile, UCDs could also awfully suppress the H22-LUC tumor growth in orthotopic xenograft mouse models. Collectively, our research commends that the drug delivery systems based on natural-products-derived CDs can function as biocompatible enzymes for antitumor treatment and may facilitate the advancement of nanotechnology-based immunotherapeutics. It is extremely anticipated that such ferroptosis-like designing in nano-catalytic medicine would be favorable for future development in cancer-therapeutic regimens.

Keyword :

Ferroptosis Ferroptosis Hepatocellular carcinoma Hepatocellular carcinoma Nanozyme Nanozyme Tumor immune microenvironment Tumor immune microenvironment

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GB/T 7714 Lai, Chun-Mei , Xu, Jia , Zhang, Bing -Chen et al. A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma [J]. | CHEMICAL ENGINEERING JOURNAL , 2024 , 482 .
MLA Lai, Chun-Mei et al. "A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma" . | CHEMICAL ENGINEERING JOURNAL 482 (2024) .
APA Lai, Chun-Mei , Xu, Jia , Zhang, Bing -Chen , He, Shao-Hua , Shao, Jing-Wei . A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma . | CHEMICAL ENGINEERING JOURNAL , 2024 , 482 .
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Multifunctional Theranostic 2D Vanadium Carbidel for Enhanced Cancer Immunotherapy SCIE
期刊论文 | 2024 | ADVANCED FUNCTIONAL MATERIALS
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The application of 2D MXene materials in the biomedical field has been widely explored. Apart from excellent photothermal properties, their role in modulating various immune cells and overcoming immune-suppressive tumor microenvironments is waiting to be discovered. In this work, a novel multifunctional 2D vanadium carbide is constructed that degrades in situ in the tumor microenvironment. Various characterizations and first-principles calculations indicated that V4C3 nanosheets exhibit excellent light absorption and photothermal conversion capabilities in the NIR-II biological window. The photothermal and X-ray absorption properties of V4C3 nanosheets enabled dual-modal photoacoustic imaging/computerized tomography (PA/CT) imaging functionality. The V4C3 nanosheets in the tumor microenvironment decomposed under the effect of H2O2 and GSH, triggering a Fenton-like reaction. The photothermal ablation and reactive oxygen species (ROS) generation capabilities enabled V4C3 nanosheets to convert cold tumors into hot ones (macrophage: M2 -> M1) and induce reactions like immunogenic cell death (ICD). Dendritic cell (DC) cells matured under the ICD stimulation, which promoted T cell activation, reduced Treg cells and thus effectively enhanced tumor immunotherapy. The multiple properties including imaging, photothermal, enzyme-driven, and immune functions enable V4C3 nanosheets to ablate tumors effectively. This study provides an example for the research of the multifunctional exploration and application of MXene in biomedicine filed. The novel multifunctional 2D vanadium carbide (V4C3) MXene nanosheets in question can be degraded in situ in the tumor microenvironment, which show superior photothermal tumor ablation ability in the NIR-II biological window. Its ability to trigger ICD reaction can significantly enhance tumor immunotherapy. image

Keyword :

dual-mode imaging dual-mode imaging immunotherapy immunotherapy in situ degradation in situ degradation photothermal therapy photothermal therapy vanadium carbide vanadium carbide

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GB/T 7714 Feng, Keke , Li, Chenglei , Xiong, Rui et al. Multifunctional Theranostic 2D Vanadium Carbidel for Enhanced Cancer Immunotherapy [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 .
MLA Feng, Keke et al. "Multifunctional Theranostic 2D Vanadium Carbidel for Enhanced Cancer Immunotherapy" . | ADVANCED FUNCTIONAL MATERIALS (2024) .
APA Feng, Keke , Li, Chenglei , Xiong, Rui , Lin, Yingqi , Cui, Zhou , Tu, Yifan et al. Multifunctional Theranostic 2D Vanadium Carbidel for Enhanced Cancer Immunotherapy . | ADVANCED FUNCTIONAL MATERIALS , 2024 .
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Current application and future perspective of CRISPR/cas9 gene editing system mediated immune checkpoint for liver cancer treatment Scopus
期刊论文 | 2024 , 35 (40) | Nanotechnology
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Liver cancer, which is well-known to us as one of human most prevalent malignancies across the globe, poses a significant risk to live condition and life safety of individuals in every region of the planet. It has been shown that immune checkpoint treatment may enhance survival benefits and make a significant contribution to patient prognosis, which makes it a promising and popular therapeutic option for treating liver cancer at the current time. However, there are only a very few numbers of patients who can benefit from the treatment and there also exist adverse events such as toxic effects and so on, which is still required further research and discussion. Fortunately, the clustered regularly interspaced short palindromic repeat/CRISPR-associated nuclease 9 (CRISPR/Cas9) provides a potential strategy for immunotherapy and immune checkpoint therapy of liver cancer. In this review, we focus on elucidating the fundamentals of the recently developed CRISPR/Cas9 technology as well as the present-day landscape of immune checkpoint treatment which pertains to liver cancer. What’s more, we aim to explore the molecular mechanism of immune checkpoint treatment in liver cancer based on CRISPR/Cas9 technology. At last, its encouraging and powerful potential in the future application of the clinic is discussed, along with the issues that already exist and the difficulties that must be overcome. To sum up, our ultimate goal is to create a fresh knowledge that we can utilize this new CRISPR/Cas9 technology for the current popular immune checkpoint therapy to overcome the treatment issues of liver cancer. © 2024 IOP Publishing Ltd.

Keyword :

CRISPR/Cas9 CRISPR/Cas9 immune checkpoint immune checkpoint immunotherapy immunotherapy liver cancer liver cancer

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GB/T 7714 Tong, L.-W. , Hu, Y.-S. , Yu, S.-J. et al. Current application and future perspective of CRISPR/cas9 gene editing system mediated immune checkpoint for liver cancer treatment [J]. | Nanotechnology , 2024 , 35 (40) .
MLA Tong, L.-W. et al. "Current application and future perspective of CRISPR/cas9 gene editing system mediated immune checkpoint for liver cancer treatment" . | Nanotechnology 35 . 40 (2024) .
APA Tong, L.-W. , Hu, Y.-S. , Yu, S.-J. , Li, C.-L. , Shao, J.-W. . Current application and future perspective of CRISPR/cas9 gene editing system mediated immune checkpoint for liver cancer treatment . | Nanotechnology , 2024 , 35 (40) .
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Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy Scopus CSCD
期刊论文 | 2024 , 14 (7) , 3205-3217 | Acta Pharmaceutica Sinica B
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Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade (ICB) monotherapy. However, combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted delivery. Herein, based on a universal triterpene template and the anticancer active agent ursolic acid (UA), a cytomembrane-coated biomimetic delivery nanoplatform (UR@M) prepared by the self-assembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma (HCC) treatment. UR@M showed enhanced tumor accumulation in vivo with homologous tumor targeting, and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target effects. UA activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway, which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of PD-L1. The strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor regression. Overall, the UA-templated strategy “killed three birds with one stone” by establishing a self-assembly nanosystem, inducing tumor cell death, and promoting synergistic immunostimulation for HCC treatment. © 2024

Keyword :

Biomimetic nanoplatform Biomimetic nanoplatform CRISPR/Cas9 CRISPR/Cas9 Gene therapy Gene therapy Hepatocellular carcinoma Hepatocellular carcinoma Immune checkpoint blockade Immune checkpoint blockade Immunotherapy Immunotherapy Self-assembly Self-assembly Ursolic acid Ursolic acid

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GB/T 7714 Zhang, B.-C. , Lai, C.-M. , Luo, B.-Y. et al. Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy [J]. | Acta Pharmaceutica Sinica B , 2024 , 14 (7) : 3205-3217 .
MLA Zhang, B.-C. et al. "Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy" . | Acta Pharmaceutica Sinica B 14 . 7 (2024) : 3205-3217 .
APA Zhang, B.-C. , Lai, C.-M. , Luo, B.-Y. , Shao, J.-W. . Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy . | Acta Pharmaceutica Sinica B , 2024 , 14 (7) , 3205-3217 .
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A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma SCIE
期刊论文 | 2023 , 123 , 330-341 | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
WoS CC Cited Count: 1
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Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually becomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystem containing hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolic acid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepato-cellular carcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to the sensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyanine green. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and amelio-rate the tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drug delivery system was expected to effectively reduce the resistance of traditional treatment methods against tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinoma treatment.(c) 2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Keyword :

Chemo-photo therapy Chemo-photo therapy Hemoglobin Hemoglobin Hepatocellular carcinoma Hepatocellular carcinoma Hypoxia Hypoxia Self-assembly Self-assembly

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GB/T 7714 Le, Jing-Qing , Yang, Fang , Song, Xun-Huan et al. A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma [J]. | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 2023 , 123 : 330-341 .
MLA Le, Jing-Qing et al. "A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma" . | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 123 (2023) : 330-341 .
APA Le, Jing-Qing , Yang, Fang , Song, Xun-Huan , Feng, Ke-Ke , Tong, Ling-Wu , Yin, Meng-Die et al. A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma . | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY , 2023 , 123 , 330-341 .
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A erythrocyte-platelet hybrid membrane coated biomimetic nanosystem based on ginsenosides and PFH combined with ultrasound for targeted delivery in thrombus therapy SCIE
期刊论文 | 2023 , 229 | COLLOIDS AND SURFACES B-BIOINTERFACES
WoS CC Cited Count: 5
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Thrombus is one of the culprits for global health problems. However, most current antithrombotic drugs are limited by restricted targeting ability and a high risk of systemic bleeding. A hybrid cell membrane-coated biomimetic nanosystem (PM/RM@PLGA@P/R) was constructed in this paper to fulfil the targeted delivery of ginsenoside (Rg1) and perfluorohexane (PFH). Poly lactic-co-glycolic acid (PLGA) is used as carriers to coat Rg1 and PFH. Thanks to the camouflage of erythrocyte membrane (RM) and platelet membrane (PM), the nanosystem in question possesses remarkable features including immune escape and self-targeting. Therefore, a compact nano-core with PLGA@P/R was formed, with a hybrid membrane covering the surface of the core, forming a "core-shell" structure. With its "core-shell" structure, this nanoparticle fancifully combines the advantages of both PFH (the low-intensity focused ultrasound (LIFU)-responsive phase-change thrombolysis) and Rg1(the antioxidant, anti-inflammatory and anticoagulant abilities). Meanwhile, PM/RM@PLGA@P/R nanoparticles exhibits superior in-vitro performance in terms of ROS scavenging, anticoagulant activity and immune escape compared with those without cell membranes (PLGA@P/R). Furthermore, in the animal experiment in which the tail vein thrombosis model was established by injecting k-carrageenan, the combined treatment of LIFU and PM/ RM@PLGA@P/R showed a satisfactory antithrombotic efficiency (88.20 %) and a relatively higher biological safety level. This strategy provides new insights into the development of more effective and safer targeted biomimetic nanomedicines for antithrombotic treatments, possessing potential application in synergistic therapy field.

Keyword :

Biomimetic nanosystem Biomimetic nanosystem Ginsenoside Ginsenoside Perfluorohexane Perfluorohexane Thrombotic diseases Thrombotic diseases

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GB/T 7714 Yang, Ming-Yue , Tu, Yi-Fan , Feng, Ke-Ke et al. A erythrocyte-platelet hybrid membrane coated biomimetic nanosystem based on ginsenosides and PFH combined with ultrasound for targeted delivery in thrombus therapy [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2023 , 229 .
MLA Yang, Ming-Yue et al. "A erythrocyte-platelet hybrid membrane coated biomimetic nanosystem based on ginsenosides and PFH combined with ultrasound for targeted delivery in thrombus therapy" . | COLLOIDS AND SURFACES B-BIOINTERFACES 229 (2023) .
APA Yang, Ming-Yue , Tu, Yi-Fan , Feng, Ke-Ke , Yin, Meng-Die , Fang, Yi-Fan , Le, Jing-Qing et al. A erythrocyte-platelet hybrid membrane coated biomimetic nanosystem based on ginsenosides and PFH combined with ultrasound for targeted delivery in thrombus therapy . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2023 , 229 .
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