Query：
学者姓名：王莹淑
Refining：
Year
Type
Indexed by
Source
Complex
Co-
Language
Clean All
Abstract ：
Esophageal squamous cell carcinoma (ESCC) is a severe malignancy with high incidence and mortality rate in China, while the application of standard chemotherapeutic drugs for ESCC meets the barriers of high toxicity and multiple drug resistance (MDR). In recent years, the anticancer effects of artesunate (ART), a Chinese medicine monomer have gained extensive attentions due to its characteristics of low toxicity, high potency, and reversal of MDR. In this study, we develop the artesunate-loaded solid lipid nanoparticles (SLNART) to overcome the poor water solubility and bioavailability of ART, further improving the efficiency of ART on ESCC treatment. Especially mentioned, SLNART is shown to present marked inhibitory effects on ESCC development based on the induction of ferroptosis by two pathways included upregulating TFR to increase Fe2+ ions and inhibiting the AKT/mTOR signaling to downregulate GPX4. Collectively, this study is the first to pave a promising approach for ESCC therapy based on a strategy of developing SLNART to induce ferroptosis by mediating Fe2+ ions and AKT/ mTOR signaling.
Keyword ：
AKT/mTOR signaling AKT/mTOR signaling Artesunate Artesunate ESCC ESCC Ferroptosis Ferroptosis Solid lipid nanoparticles Solid lipid nanoparticles
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Xia, Yu , Tang, Yixin , Huang, Zhixin et al. Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/ mTOR signaling [J]. | CELLULAR SIGNALLING , 2024 , 117 . |
| MLA | Xia, Yu et al. "Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/ mTOR signaling" . | CELLULAR SIGNALLING 117 (2024) . |
| APA | Xia, Yu , Tang, Yixin , Huang, Zhixin , Ke, Nantian , Zheng, Yue , Zhuang, Wanzhen et al. Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/ mTOR signaling . | CELLULAR SIGNALLING , 2024 , 117 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Zinc-ion hybrid capacitors (ZIHC) demonstrate impressive charge-storage performance and intrinsic safety due to the inherited superiorities of aqueous rechargeable batteries and supercapacitors. However, the promotion of electrochemical performance is usually hindered by the cathode materials that fail to hold high energy density and rate capability of ZIHC. The optimization of porous carbon cathodes into a hierarchical structure is an efficient strategy to break the bottlenecks of ZIHC. Herein, a metal oxide space-confined strategy is proposed to build 3D graphene-like porous carbon nanosheets (3DPC) with doping of O and S heteroatoms by using low-cost aromatic hydrocarbons as precursors. It is found that the obtained 3DPC consists of micro-, mseo- and macropores and further delivers a high specific surface area of 2813 m2 g-1 with a total pore volume of 1.82 cm3 g- 1. Specifically, such a well-defined hierarchical porosity of 3DPC coupled with rich O and S heteroatoms enables sufficient multilevel ion transport channels and large accessible surface sites to capture the Zn2+ ions. As a proof of concept demonstration, the assembled aqueous ZIHC by employing the 3DPC cathode exhibits a desirable capacity of 194 mAh g-1 at 0.5 A g-1 with a superior rate capability of 53% at 30 A g-1 and excellent cycling stability of over 88% after 15000 cycles. Moreover, the remarkable electrochemical performance of the 3DPC cathode can be well-preserved in the case of a quasi-solid-state ZIHC device under various harsh bent states, highlighting the promising application in flexible and wearable energy storage.
Keyword ：
Aromatic hydrocarbons Aromatic hydrocarbons Hierarchical carbon nanosheets Hierarchical carbon nanosheets Multilevel ion channels Multilevel ion channels One-step pyrolysis One-step pyrolysis Zn-ion hybrid capacitors Zn-ion hybrid capacitors
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wang, Yingshu , Yang, Juan , Liu, Siyu et al. 3D graphene-like oxygen and sulfur-doped porous carbon nanosheets with multilevel ion channels for high-performance aqueous Zn-ion storage [J]. | CARBON , 2023 , 201 : 624-632 . |
| MLA | Wang, Yingshu et al. "3D graphene-like oxygen and sulfur-doped porous carbon nanosheets with multilevel ion channels for high-performance aqueous Zn-ion storage" . | CARBON 201 (2023) : 624-632 . |
| APA | Wang, Yingshu , Yang, Juan , Liu, Siyu , Che, Xiaogang , He, Songjie , Liu, Zhibin et al. 3D graphene-like oxygen and sulfur-doped porous carbon nanosheets with multilevel ion channels for high-performance aqueous Zn-ion storage . | CARBON , 2023 , 201 , 624-632 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
One-pot synthesis of urea [(NH2)(2)CO] from easily available small molecules, that is, N-2, CO2, and H2O, is an extremely attractive but very challenging reaction. 2D-CdS@3D-BiOBr composites with S-scheme heterojunctions are constructed via a facile hydrothermal technique followed by a self-assembly method and shown to be an excellent photocatalyst enabling the reduction of N-2 and CO2 with H2O to (NH2)(2)CO under visible light. The optimal 40%2D-CdS@3D-BiOBr sample shows up to 15 mu mol.g(-1).h(-1) total yield of NH3 and (NH2)(2)CO, of which (NH2)(2)CO accounts for 54%. The apparent quantum efficiency (AQE) is 3.93% for urea production. On the photocatalyst, urea is speculated to form by two possible chemical routes. One is direct photocatalytic synthesis. Both N-2 and CO2 molecules are activated by the Cd2+ ion of 2D-CdS and the oxygen defect of 3D-BiOBr at the edges of the heterojunction interface of 2D-CdS/3D-BiOBr, respectively. *HNCONH* is the key intermediate of the formation of (NH2)(2)CO molecules. The other is indirect synthesis by photocatalysis and then thermocatalysis. N-2 is reduced into NH3 and CO2 is reduced into CO on 2D-CdS by the photogenerated electrons and protons, and then the formed NH3 reacts with the reactant CO2 or the product CO to form (NH2)(2)CO by thermocatalysis on 2D-CdS. The former is dominant for urea synthesis. The work confirms that urea could be synthesized photocatalytically from cheap N-2, CO2, and H2O under visible light. A composite heterojunction semiconductor could be a prospective photocatalyst appropriate for the complex reaction.
Keyword ：
carbon dioxide carbon dioxide CdS@BiOBr composite CdS@BiOBr composite nitrogen nitrogen photocatalysis photocatalysis urea synthesis urea synthesis
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wang, Yingshu , Wang, Shuyue , Gan, Jiasi et al. Photocatalytic Coreduction of N-2 and CO2 with H2O to (NH2)(2)CO on 2D-CdS/3D-BiOBr [J]. | ACS SUSTAINABLE CHEMISTRY & ENGINEERING , 2023 , 11 (5) : 1962-1973 . |
| MLA | Wang, Yingshu et al. "Photocatalytic Coreduction of N-2 and CO2 with H2O to (NH2)(2)CO on 2D-CdS/3D-BiOBr" . | ACS SUSTAINABLE CHEMISTRY & ENGINEERING 11 . 5 (2023) : 1962-1973 . |
| APA | Wang, Yingshu , Wang, Shuyue , Gan, Jiasi , Shen, Jinni , Zhang, Zizhong , Zheng, Huidong et al. Photocatalytic Coreduction of N-2 and CO2 with H2O to (NH2)(2)CO on 2D-CdS/3D-BiOBr . | ACS SUSTAINABLE CHEMISTRY & ENGINEERING , 2023 , 11 (5) , 1962-1973 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Electrochemical ammonia synthesis has advantages over the conventional Haber-Bosch process in terms of environment friendliness, sustainability, and cleanliness. However, this process is facing challenges such as low ammonia yield and low Faraday efficiency due to the low solubility and the difficulty in activation of nitrogen in aqueous solutions. To overcome these limitations, finding a catalyst of high efficiency, stability, and selectivity is crucial. Inspired by the concept of noble metal doping and two-dimensional layered catalysts, we have designed a novel catalyst for nitrogen reduction by incorporating ruthenium into lanthanum sulfide. In this context, the inclusion of ruthenium serves to optimize the electron transfer interface, enhance the low conductivity of lanthanum sulfide, and increase the number of active sites. Furthermore, the synergistic effect between the ruthenium and lanthanum ions significantly improves the activity of the catalyst. As a catalyst for the N-2 reduction reaction (NRR), Ru/La2S3 demonstrates a superior NH3 formation rate of 19.40 mu g h(-1) mg(cat)(-1) and a faradaic efficiency of 7.77% at -0.5 V versus the reversible hydrogen electrode (RHE). These values are significantly higher compared to those of La2O3 (1.4%; 12.5 mu g h(-1) mg(cat)(-1)) and La2S3 (2.3%; 10.7 mu g h(-1) mg(cat)(-1)), and most reported values in this field.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yingshu, Wang , Hong, Wang , Yixin, Tang et al. Ru/La2S3 nanorods as an electrocatalyst for efficient N-2 fixation under ambient conditions [J]. | REACTION CHEMISTRY & ENGINEERING , 2023 , 8 (8) : 2011-2021 . |
| MLA | Yingshu, Wang et al. "Ru/La2S3 nanorods as an electrocatalyst for efficient N-2 fixation under ambient conditions" . | REACTION CHEMISTRY & ENGINEERING 8 . 8 (2023) : 2011-2021 . |
| APA | Yingshu, Wang , Hong, Wang , Yixin, Tang , Yu, Shu , Suying, Zhao , Lu, Hong et al. Ru/La2S3 nanorods as an electrocatalyst for efficient N-2 fixation under ambient conditions . | REACTION CHEMISTRY & ENGINEERING , 2023 , 8 (8) , 2011-2021 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明公开了一种气相光催化固氮反应的方法，其在气相条件下以氮气和水为反应物进行光催化固氮。其中反应物氮气充满整个反应器，打入反应器中的微量水以水蒸气的形式分散在反应器中，催化剂以滴片的方式制成催化剂板引入到反应器，反应物与催化剂是气固接触，反应过程中反应器封闭。本发明可以避免催化剂活性位点被水大量覆盖导致反应物氮气在催化剂上的吸附量少以及氮气一直鼓泡造成的反应物浪费和反应产物氨带出的问题。与现有光催化固氮反应方法相比，反应物更容易吸附在催化剂活性位点上，促进传质，有利于提高光催化固氮活性。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 王莹淑 , 王淑月 , 郑辉东 . 一种气相光催化固氮反应的方法 : CN202210296269.3[P]. | 2022-03-24 00:00:00 . |
| MLA | 王莹淑 et al. "一种气相光催化固氮反应的方法" : CN202210296269.3. | 2022-03-24 00:00:00 . |
| APA | 王莹淑 , 王淑月 , 郑辉东 . 一种气相光催化固氮反应的方法 : CN202210296269.3. | 2022-03-24 00:00:00 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The aspect ratio modulation in the alcoholysis process is highly significant for the production of high-quality sucralose. In this work, antisolvent crystallization (ASC) accompanied by preferred orientation was first adopted in the sucralose separation, based on which simultaneous modulations on aspect ratio, solubility, and stability have been realized. In detail, after the alcoholysis process in methanol, four antisolvents bearing different functional groups were used in ASC, i.e., isopentanol (IPN), isovaleraldehyde (IVD), isovaleric acid (IVA), and isobutyl propionate (IBP). To our interest, when IVA was used as the antisolvent, the highest separation efficiency (49.33%), fastest crystallizing rate (5.64%/h), lowest aspect ratio (1.55), and solubility (9.28 wt %) and good thermal stability (131.65 degrees C) of sucralose were achieved. Single crystal structures of sucralose using different antisolvents have been determined. Sucralose using IVA as the antisolvent exhibits the greatest molecular distortion and strongest intermolecular C-HCl hydrogen bonds; thus, the preferred growth along {002}/{011} directions has occurred and accounted for its lower aspect ratio, worse solubility, and better stability. The strongest methanolIVA interactions due to the presence of a carboxyl group can accelerate the formation of the emulsion, resulting in the fastest crystallizing rate. The antisolvent screening and the discovery about relative mechanisms will provide a theoretical guide for the production of high-quality sucralose.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Xu, Qiaoyan , Lv, Zhoulin , Chen, Xiaoping et al. Aspect Ratio Modulation of Sucralose through {002}/{011} Preferred Orientation in Antisolvent Crystallization [J]. | ACS OMEGA , 2023 , 8 (44) : 41145-41155 . |
| MLA | Xu, Qiaoyan et al. "Aspect Ratio Modulation of Sucralose through {002}/{011} Preferred Orientation in Antisolvent Crystallization" . | ACS OMEGA 8 . 44 (2023) : 41145-41155 . |
| APA | Xu, Qiaoyan , Lv, Zhoulin , Chen, Xiaoping , Li, Shaoheng , Huang, Changqi , Chen, Jingjing et al. Aspect Ratio Modulation of Sucralose through {002}/{011} Preferred Orientation in Antisolvent Crystallization . | ACS OMEGA , 2023 , 8 (44) , 41145-41155 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
本发明提供了一种蔗糖‑6‑乙酸酯脱酸提纯的方法，包括如下步骤：将蔗糖和醋酐酯化反应后生成的蔗糖‑6‑乙酸酯反应液输送至精馏塔中精馏浓缩，塔顶得到不含乙酸的DMF和水，塔底得到蔗糖‑6‑乙酸酯的浓缩液。向浓缩液中加入共晶溶剂，得到蔗糖‑6‑乙酸酯与乙酸的共晶体。将提纯后的蔗糖‑6‑乙酸酯共晶体固体用DMF进行溶解，再利用支撑液膜对蔗糖‑6‑乙酸酯溶液中的乙酸进行萃取，从而得到不含乙酸的高纯度蔗糖‑6‑乙酸酯，同时利用反萃取剂进行反萃，得到乙酸盐副产品。本发明完美解决了酯化反应液乙酸难脱除以及蔗糖‑6‑乙酸酯难提纯的问题，具有更高的工业运用价值。
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 揭会民 , 郑辉东 , 李浩宏 et al. 一种蔗糖-6-乙酸酯脱酸提纯的方法 : CN202310187287.2[P]. | 2023-03-02 00:00:00 . |
| MLA | 揭会民 et al. "一种蔗糖-6-乙酸酯脱酸提纯的方法" : CN202310187287.2. | 2023-03-02 00:00:00 . |
| APA | 揭会民 , 郑辉东 , 李浩宏 , 陈小平 , 陈晶晶 , 王莹淑 et al. 一种蔗糖-6-乙酸酯脱酸提纯的方法 : CN202310187287.2. | 2023-03-02 00:00:00 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
以过氧化叔丁醇为氧化剂,以钴(II)与含N配体为催化体系催化氧化2-乙基-3-甲基吡嗪(EMP),提出一种具有放大应用前景的2-乙酰基-3-甲基吡嗪绿色制备方法.考察了过渡金属催化剂的种类、配体种类、溶剂、温度等反应条件对催化氧化过程的影响,在最优反应条件下EMP转化率可达58.8%, 2-乙酰基-3-甲基吡嗪(AMP)选择性92.2%.研究了该反应体系催化氧化EMP的反应机理,建立了该反应的拟均相反应动力学模型.在以上实验基础上,对该反应体系进行了放大实验研究,结果表明该新方法具有较好的工业放大前景,但反应温度的控制是放大过程的关键因素.
Keyword ：
2-乙基-3-甲基吡嗪(EMP) 2-乙基-3-甲基吡嗪(EMP) 2-乙酰基-3-甲基吡嗪(AMP) 2-乙酰基-3-甲基吡嗪(AMP) 动力学 动力学 反应机理 反应机理 工艺放大 工艺放大 烯丙基氧化 烯丙基氧化
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈晶晶 , 王莹淑 , 余珺 et al. 钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法（英文） [J]. | 有机化学 , 2020 , 40 (01) : 78-86 . |
| MLA | 陈晶晶 et al. "钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法（英文）" . | 有机化学 40 . 01 (2020) : 78-86 . |
| APA | 陈晶晶 , 王莹淑 , 余珺 , 成佳佳 , 郑辉东 . 钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法（英文） . | 有机化学 , 2020 , 40 (01) , 78-86 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
以过氧化叔丁醇为氧化剂,以钴(Ⅱ)与含N配体为催化体系催化氧化2-乙基-3-甲基吡嗪(EMP),提出一种具有放大应用前景的2-乙酰基-3-甲基吡嗪绿色制备方法.考察了过渡金属催化剂的种类、配体种类、溶剂、温度等反应条件对催化氧化过程的影响,在最优反应条件下EMP转化率可达58.8%, 2-乙酰基-3-甲基吡嗪(AMP)选择性92.2%.研究了该反应体系催化氧化EMP的反应机理,建立了该反应的拟均相反应动力学模型.在以上实验基础上,对该反应体系进行了放大实验研究,结果表明该新方法具有较好的工业放大前景,但反应温度的控制是放大过程的关键因素.
Keyword ：
2-乙基-3-甲基吡嗪(EMP) 2-乙基-3-甲基吡嗪(EMP) 2-乙酰基-3-甲基吡嗪(AMP) 2-乙酰基-3-甲基吡嗪(AMP) 动力学 动力学 反应机理 反应机理 工艺放大 工艺放大 烯丙基氧化 烯丙基氧化
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 陈晶晶 , 王莹淑 , 余珺 et al. 钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法 [J]. | 有机化学 , 2020 , 40 (1) : 78-83 . |
| MLA | 陈晶晶 et al. "钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法" . | 有机化学 40 . 1 (2020) : 78-83 . |
| APA | 陈晶晶 , 王莹淑 , 余珺 , 成佳佳 , 郑辉东 . 钴(Ⅱ)催化2-乙基-3-甲基吡嗪绿色氧化方法 . | 有机化学 , 2020 , 40 (1) , 78-83 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A green and scalable oxidation of 2-ethyl-3-methylpyrazine (EMP) by tert-butylhydroperoxide was investigated with a catalytic system of cobalt(II) and N-containing ligand. The effects of catalyst, ligand, solvent and temperature were compared, and the catalysis system of cobalt(II) acetylacetonate and 2,2-bipyridine gave the highest selectivity. Mechanistic study of this catalysis system suggested that the oxidation of EMP followed a free radical oxidation pathway, and a homogeneous reaction kinetics model was established to calculate the reaction rate constant and activation energy. The scale-up of the oxidation system was performed to check the scalability of the oxidation reaction, and the temperature control of the system was the key part of the process.
Keyword ：
2-acetyl-3-methylpyrazine (AMP) 2-acetyl-3-methylpyrazine (AMP) 2-ethyl-3-methylpyrazine (EMP) 2-ethyl-3-methylpyrazine (EMP) allylic oxidation allylic oxidation kinetics kinetics reaction mechanism reaction mechanism scale-up scale-up
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen Jingjing , Wang Yingshu , Yu Jun et al. A Green and Scalable Cobalt(II)-Catalyzed Oxidation of 2-Ethyl-3-methylpyrazine [J]. | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2020 , 40 (1) : 78-83 . |
| MLA | Chen Jingjing et al. "A Green and Scalable Cobalt(II)-Catalyzed Oxidation of 2-Ethyl-3-methylpyrazine" . | CHINESE JOURNAL OF ORGANIC CHEMISTRY 40 . 1 (2020) : 78-83 . |
| APA | Chen Jingjing , Wang Yingshu , Yu Jun , Cheng Jiajia , Zheng Huidong . A Green and Scalable Cobalt(II)-Catalyzed Oxidation of 2-Ethyl-3-methylpyrazine . | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2020 , 40 (1) , 78-83 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
