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学者姓名：孟春
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目的 探究益景汤对早期糖尿病视网膜病变(DR)大鼠视网膜组织中微小RNA(miRNA)表达的影响,筛选出益景汤干预早期DR的靶点miRNA.方法 将20只2月龄雄性SD大鼠使用链脲佐菌素建立糖尿病大鼠模型,随机分为模型组(MG)和益景汤组(YJG),另将常规喂养的大鼠设为对照组(CG),每组10只.YJG组大鼠每日灌胃益景汤12.50 g/kg,CG、MG组大鼠灌胃等体积0.9%氯化钠注射液,均干预16周.给药完成后记录大鼠体质量,摘除双侧眼球剥离视网膜,提取总RNA,PCR扩增构建小RNA文库,采用高通量测序技术对该文库进行测序.对差异miRNA进行靶基因预测,并对靶基因进行基因本体论(GO)、Pathway分析,选择差异倍数较大的miRNA进行PCR验证.结果 (1)已知miRNA差异:筛选出644个已知miRNA,其中差异miRNA共59个.与CG组比较,MG组35个miRNA上调、6 个miRNA下调,YJG组20个miRNA上调、4个miRNA下调;与MG组比较,YJG组6个miRNA上调、13个miRNA下调,差异均有统计学意义(均P＜0.05);其中,1个上调miRNA,11个下调miRNA为益景汤干预DM大鼠后,3组共同差异性表达miRNA.(2)新发现miRNA差异:3组筛选出242个新发现的miRNA,其中差异miRNA共105个.与CG组比较,MG组50个miRNA上调,15个miRNA下调;与CG组比较,YJG组55个miRNA上调,20个miRNA下调;与MG组比较,YJG组16个miRNA上调,6个miRNA下调,差异均有统计学意义(均P＜0.05).(3)差异miRNA生物学功能和通路:差异基因主要涉及生物学过程方面的多种蛋白的转录调节;靶基因关联的通路主要是肿瘤相关的信号通路和糖脂代谢相关通路.(4)PCR验证:MG组大鼠视网膜miR-673-3p表达低于CG组,余11个miRNA表达均高于CG组;YJG组大鼠视网膜miR-673-3p、miR-23b-5p表达均高于MG组,余10个miRNA表达均低于MG组,差异均有统计学意义(均P＜0.05).除miR-23b-5p外,其余11个miRNA与上述RNA检测结果一致.结论 miR-673、miR-1、miR-133、miR-214、miR-23b、miR-31a、miR-451等可能是益景汤干预早期DR微血管损害的靶点miRNA.
Keyword ：
miRNA miRNA 益景汤 益景汤 糖尿病视网膜病变 糖尿病视网膜病变 靶点 靶点
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| GB/T 7714 | 王丽 , 邱心悦 , 孟春 et al. 益景汤对早期糖尿病视网膜病变大鼠视网膜miRNA表达的影响 [J]. | 中国中医眼科杂志 , 2024 , 34 (3) : 205-213 . |
| MLA | 王丽 et al. "益景汤对早期糖尿病视网膜病变大鼠视网膜miRNA表达的影响" . | 中国中医眼科杂志 34 . 3 (2024) : 205-213 . |
| APA | 王丽 , 邱心悦 , 孟春 , 刘光辉 . 益景汤对早期糖尿病视网膜病变大鼠视网膜miRNA表达的影响 . | 中国中医眼科杂志 , 2024 , 34 (3) , 205-213 . |
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The white rot fungus Cerrena unicolor 87613 has been previously shown to be a promising resource in laccase production, an enzyme with significant biotechnological applications. Conventional methods face technical challenges in improving laccase activity. Attempts are still being made to develop novel approaches for further enhancing laccase activity. This study aimed to understand the regulation of laccase activity in C. unicolor 87613 for a better exploration of the novel approach. Transcriptomic and metabolomic analyses were performed to identify key genes and metabolites involved in extracellular laccase activity. The findings indicated a strong correlation between the glutathione metabolism pathway and laccase activity. Subsequently, experimental verifications were conducted by manipulating the pathway using chemical approaches. The additive reduced glutathione (GSH) dose-dependently repressed laccase activity, while the GSH inhibitors (APR-246) and reactive oxygen species (ROS) inducer (H2O2) enhanced laccase activity. Changes in GSH levels could determine the intracellular redox homeostasis in interaction with ROS and partially affect the expression level of laccase genes in C. unicolor 87613 in turn. In addition, GSH synthetase was found to mediate GSH abundance in a feedback loop. This study suggests that laccase activity is negatively influenced by GSH metabolism and provides a theoretical basis for a novel strategy to enhance laccase activity by reprogramming glutathione metabolism at a specific cultivation stage.
Keyword ：
Cerrena unicolor Cerrena unicolor glutathione metabolism glutathione metabolism laccase activity laccase activity metabolome metabolome transcriptome transcriptome
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| GB/T 7714 | Zhang, Long-Bin , Qiu, Ting-Ting , Qiu, Xiu-Gen et al. Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613 [J]. | MICROBIOLOGY SPECTRUM , 2024 , 12 (2) . |
| MLA | Zhang, Long-Bin et al. "Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613" . | MICROBIOLOGY SPECTRUM 12 . 2 (2024) . |
| APA | Zhang, Long-Bin , Qiu, Ting-Ting , Qiu, Xiu-Gen , Yang, Wu-Wei-Jie , Ye, Xiu-Yun , Meng, Chun . Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613 . | MICROBIOLOGY SPECTRUM , 2024 , 12 (2) . |
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OBJECTIVE: To investigate the effects of emodin on alkali burn -induced corneal inflammation and neovascularization. METHODS: The ability of emodin to target vascular endothelial growth factor receptor 2 (VEGFR2) was predicted by molecular docking. The effects of emodin on the invasion, migration, and proliferation of human umbilical vein endothelial cells (HUVEC) were determined by cell counting kit -8, Transwell, and tube formation assays. Analysis of apoptosis was performed by flow cytometry. CD31 levels were examined by immunofluorescence. The abundance and phosphorylation state of VEGFR2, protein kinase B (Akt), signal transducer and activator of transcription 3 (STAT3), and P38 were examined by immunoblot analysis. Corneal alkali burn was performed on 40 mice. Animals were divided randomly into two groups, and the alkali -burned eyes were then treated with drops of either 10 mu M emodin or phosphate buffered saline (PBS) four times a day. Slit - lamp microscopy was used to evaluate inflammation and corneal neovascularization (CNV) in all eyes on Days 0, 7, 10, and 14. The mice were killed humanely 14 d after the alkali burn, and their corneas were removed and preserved at -80 celcius until histological study or protein extraction. RESULTS: Molecular docking confirmed that emodin was able to target VEGFR2. The findings revealed that emodin decreased the invasion, migration, angiogenesis, and proliferation of HUVEC in a dose -dependent manner. In mice, emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali burn. Compared to those of the PBS -treated group, lower VEGFR2 expression and CD31 levels were found in the emodin- treated group. Emodin dramatically decreased the expression of VEGFR2, p-VEGFR2, p-Akt, p-STAT3, and p -P38 in VEGF-treated HUVEC. CONCLUSION: This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and neovascularization. Emodin might be a promising new therapeutic option for corneal alkali burns.
Keyword ：
alkali burn alkali burn corneal inflammation corneal inflammation corneal neovascularisation corneal neovascularisation emodin emodin signal transduction signal transduction vascular endothelial growth factor receptor-2 vascular endothelial growth factor receptor-2
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| GB/T 7714 | Zheng, Xueying , Guo, Liang , Lai, Siyi et al. Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway [J]. | JOURNAL OF TRADITIONAL CHINESE MEDICINE , 2024 , 44 (2) : 268-276 . |
| MLA | Zheng, Xueying et al. "Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway" . | JOURNAL OF TRADITIONAL CHINESE MEDICINE 44 . 2 (2024) : 268-276 . |
| APA | Zheng, Xueying , Guo, Liang , Lai, Siyi , Li, Fengyue , Liang, Mingli , Liu, Wanting et al. Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway . | JOURNAL OF TRADITIONAL CHINESE MEDICINE , 2024 , 44 (2) , 268-276 . |
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目的:观察益景汤拮抗高糖诱导的体外血-视网膜内屏障(iBRB)模型基底膜(BM)损害及机制。方法:分离、培养大鼠内皮细胞(ECs)和视网膜微血管周细胞(RMPs)构建体外iBRB模型,随机分成低糖组、高糖组、米诺环素组、益景汤组,分别予25 mmol/L葡萄糖、60 mmol/L葡萄糖、60 mmol/L葡萄糖+10μg/mL米诺环素、60 mmol/L葡萄糖+10%益景汤含药血清干预,各组干预12 h后终止孵育。采用Western blot法检测各组BM相关蛋白[Ⅳ型胶原(collagenⅣ, CⅣ)、层黏连蛋白(laminin, LN)]及MMPs/TIMPs相关蛋白(MMP-2、MMP-3、MMP-9、TIMP-1、TIMP-2)的表达。结果:与低糖组相比,高糖组、米诺环素组、益景汤组CⅣ蛋白表达增加,高糖组、米诺环素组LN蛋白表达增加(均P<0.05)。益景汤及米诺环素能够抑制高糖诱导的CⅣ、LN蛋白表达增加,益景汤组、米诺环素组与高糖组相比具有差异(均P<0.05)。与低糖组相比,高糖组、米诺环素组MMP-2、MMP-3、MMP-9蛋白表达增加(均P<0.05)。益景汤能够抑制高糖诱导的MMP-2、MMP-3、MMP-9蛋白表达增加,益景汤组与高糖组相比具有差异(均P<0.05)。低糖组、高糖组、米诺环素组、益景汤组各组之间TIMP-1、TIMP-2表达未见明显差异(均P>0.05)。结论:益景汤可能通过调控MMP-2、MMP-3、MMP-9、CⅣ、LN的表达,干预高糖介导的BM重塑,抑制iBRB的损害,从而干预DR。
Keyword ：
MMPs/TIMPs MMPs/TIMPs 基底膜 基底膜 益景汤 益景汤 糖尿病视网膜病变 糖尿病视网膜病变 血-视网膜内屏障 血-视网膜内屏障
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| GB/T 7714 | 赖思艺 , 邱心悦 , 何建忠 et al. 益景汤调控MMPs/TIMPs相关分子拮抗高糖诱导的iBRB模型基底膜损害 [J]. | 国际眼科杂志 , 2024 , 24 (09) : 1387-1391 . |
| MLA | 赖思艺 et al. "益景汤调控MMPs/TIMPs相关分子拮抗高糖诱导的iBRB模型基底膜损害" . | 国际眼科杂志 24 . 09 (2024) : 1387-1391 . |
| APA | 赖思艺 , 邱心悦 , 何建忠 , 王航 , 孟春 , 刘光辉 . 益景汤调控MMPs/TIMPs相关分子拮抗高糖诱导的iBRB模型基底膜损害 . | 国际眼科杂志 , 2024 , 24 (09) , 1387-1391 . |
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Background: White-rot fungi are known to naturally produce high quantities of laccase, which exhibit commendable stability and catalytic efficiency. However, their laccase production does not meet the demands for industrial-scale applications. To address this limitation, it is crucial to optimize the conditions for laccase production. However, the regulatory mechanisms underlying different conditions remain unclear. This knowledge gap hinders the cost-effective application of laccases. Results: In this study, we utilized transcriptomic and metabolomic data to investigate a promising laccase producer, Cerrena unicolor 87613, cultivated with fructose as the carbon source. Our comprehensive analysis of differentially expressed genes (DEGs) and differentially abundant metabolites (DAMs) aimed to identify changes in cellular processes that could affect laccase production. As a result, we discovered a complex metabolic network primarily involving carbon metabolism and amino acid metabolism, which exhibited contrasting changes between transcription and metabolic patterns. Within this network, we identified five biomarkers, including succinate, serine, methionine, glutamate and reduced glutathione, that played crucial roles in co-determining laccase production levels. Conclusions: Our study proposed a complex metabolic network and identified key biomarkers that determine the production level of laccase in the commercially promising Cerrena unicolor 87613. These findings not only shed light on the regulatory mechanisms of carbon sources in laccase production, but also provide a theoretical foundation for enhancing laccase production through strategic reprogramming of metabolic pathways, especially related to the citrate cycle and specific amino acid metabolism. © The Author(s) 2024.
Keyword ：
Cerrena unicolor Cerrena unicolor Fructose Fructose Laccase production Laccase production Metabolic networks Metabolic networks Regulation mechanism Regulation mechanism White rot fungi White rot fungi
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| GB/T 7714 | Zhang, L.-B. , Xiu, X.-G. , Qiu, T.-T. et al. A complex metabolic network and its biomarkers regulate laccase production in white-rot fungus Cerrena unicolor 87613 [J]. | Microbial Cell Factories , 2024 , 23 (1) . |
| MLA | Zhang, L.-B. et al. "A complex metabolic network and its biomarkers regulate laccase production in white-rot fungus Cerrena unicolor 87613" . | Microbial Cell Factories 23 . 1 (2024) . |
| APA | Zhang, L.-B. , Xiu, X.-G. , Qiu, T.-T. , Cui, Z. , Zheng, Y. , Meng, C. . A complex metabolic network and its biomarkers regulate laccase production in white-rot fungus Cerrena unicolor 87613 . | Microbial Cell Factories , 2024 , 23 (1) . |
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为研究外源酶对陈年武夷岩茶挥发性成分的影响,运用气相色谱-质谱联用技术(gas chromatography-mass spectrometry,GC-MS)、感官评价和香气活性值(odor activity value,OAV)方法对酶处理后的武夷岩茶进行分析.GC-MS分析结果表明,纤维素酶、果胶酶、漆酶和β-葡萄糖苷酶质量比为2:1:2:3时有利于香气物质的释放,尤其对醇类、酯类及酮类香气物质释放贡献较大.感官评价和OAV值的结果表明,酶的添加能明显提高武夷岩茶的花香、甜香和木香,复合酶的处理效果最佳,其次是β-葡萄糖苷酶.经复合酶处理后己醛、2-己烯醛和(E,E)-2,4-己二烯醛等物质含量降低,OAV减小.上述研究表明,纤维素酶、果胶酶、漆酶、β-葡萄糖苷酶及其复合酶的添加均可明显改善陈年武夷岩茶香气品质.
Keyword ：
β-葡萄糖苷酶 β-葡萄糖苷酶 果胶酶 果胶酶 武夷岩茶 武夷岩茶 气相色谱-质谱法 气相色谱-质谱法 漆酶 漆酶 纤维素酶 纤维素酶 香气活性值 香气活性值
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| GB/T 7714 | 谢李玲 , 薛婉茹 , 李丹阳 et al. 外源酶对陈年武夷岩茶香气品质的改善作用 [J]. | 食品研究与开发 , 2023 , 44 (5) : 155-164 . |
| MLA | 谢李玲 et al. "外源酶对陈年武夷岩茶香气品质的改善作用" . | 食品研究与开发 44 . 5 (2023) : 155-164 . |
| APA | 谢李玲 , 薛婉茹 , 李丹阳 , 周惠媛 , 孟春 , 洪晶 . 外源酶对陈年武夷岩茶香气品质的改善作用 . | 食品研究与开发 , 2023 , 44 (5) , 155-164 . |
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•AIM: To observe the effect of soluble glycoprotein 130 (sgp130) on expression of p - STAT3 and vascular endothelial growth factor (VEGF) - A in retina of mice with diabetes mellitus (DM), and explore the possibility of sgp130 in interfering with inflammatory damage of diabetic retinopathy (DR). •METHODS: A total of 45 mice were randomly divided into normal group, DM group and sgp130 group. DM models were made in DM group and sgp130 group with streptozotocin. No special intervention was given to normal group and DM group, but sgp130 group was given intravitreal injection of 1.5mg/mL sgp130 2μ L at the 1 and 5wk. After 10wk, all the mice were sacrificed to assess the protein expression of interleukin 6 (IL - 6), p - STAT3 and VEGF- A in the retina. • RESULTS: The expressions of IL - 6, p - STAT3 and VEGF- A in retina of DM group were higher than those of normal group at 10wk (all P < 0.01). The expression of p - STAT3 and VEGF - A in sgp130 group were lower than those in DM group (all P< 0.01). • CONCLUSION: The sgp130 can selectively antagonize the trans signal transduction pathway of IL - 6, down - regulate the expression of downstream inflammatory factors VEGF- A, and it may be used in the intervention of retinal inflammatory damage related with IL- 6 in DM. © 2023 International Journal of Ophthalmology (c/o Editorial Office). All rights reserved.
Keyword ：
diabetic retinopathy diabetic retinopathy inflammation inflammation interleukin 6 interleukin 6 p - STAT3 p - STAT3 soluble glycoprotein 130(sgp130) soluble glycoprotein 130(sgp130) vascular endothelial growth factor-A(VEGF-A) vascular endothelial growth factor-A(VEGF-A)
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| GB/T 7714 | Liu, G.-H. , Shi, C.-X. , Hong, Y.-J. et al. Effects of soluble glycoprotein 130 on expression of p - STAT3 and vascular endothelial growth factor - A in retina of mice with diabetes mellitus; [sgp130 对糖尿病小鼠视网膜 p-STAT3 及 VEGF-A 表达的影响] [J]. | International Eye Science , 2023 , 23 (3) : 375-378 . |
| MLA | Liu, G.-H. et al. "Effects of soluble glycoprotein 130 on expression of p - STAT3 and vascular endothelial growth factor - A in retina of mice with diabetes mellitus; [sgp130 对糖尿病小鼠视网膜 p-STAT3 及 VEGF-A 表达的影响]" . | International Eye Science 23 . 3 (2023) : 375-378 . |
| APA | Liu, G.-H. , Shi, C.-X. , Hong, Y.-J. , Zheng, Y.-Z. , Wang, H. , Meng, C. . Effects of soluble glycoprotein 130 on expression of p - STAT3 and vascular endothelial growth factor - A in retina of mice with diabetes mellitus; [sgp130 对糖尿病小鼠视网膜 p-STAT3 及 VEGF-A 表达的影响] . | International Eye Science , 2023 , 23 (3) , 375-378 . |
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天然异胡椒醇作为一种植物来源香料，具有很高的经济价值。目前国内外还未见利用大肠杆菌工程菌株转化生产异胡椒醇的报道。【目的】构建工程菌，采用生物合成方法获得天然香料异胡椒醇。【方法】对来自胡椒薄荷的细胞色素P450家族的柠檬烯-3-羟化酶(LIM3H)基因PM2进行改造，截短LIM3H的N端疏水区，分别添加17α短肽或2B1短肽增加其亲水性，采用CO差示光谱法检测LIM3H活性；将N端疏水区截短后的来自拟南芥(Arabidopsis thaliana)的NADPH-细胞色素P450还原酶基因(trATR)和修饰后LIM3H基因(Modi-LIM3H)融合后表达，最终以柠檬烯为底物进行全细胞转化。【结果】3种N端修饰LIM3H基因均检测到LIM3H表达和异胡椒醇生成，其中17α短肽修饰后的蛋白表达量最高，异胡椒醇产量达到1.94 mg/L。【结论】本研究在大肠杆菌中增加外源LIM3H与ATR，成功催化柠檬烯生成异胡椒醇，为天然异胡椒醇的生产提供了新的方法。
Keyword ：
N端修饰 N端修饰 大肠杆菌 大肠杆菌 异胡椒醇 异胡椒醇 柠檬烯-3-羟化酶 柠檬烯-3-羟化酶
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| GB/T 7714 | 马文晓 , 陈弼致 , 孟春 et al. 在大肠杆菌中拓展合成途径合成异胡椒醇 [J]. | 微生物学报 , 2023 , 63 (03) : 1243-1253 . |
| MLA | 马文晓 et al. "在大肠杆菌中拓展合成途径合成异胡椒醇" . | 微生物学报 63 . 03 (2023) : 1243-1253 . |
| APA | 马文晓 , 陈弼致 , 孟春 , 王航 . 在大肠杆菌中拓展合成途径合成异胡椒醇 . | 微生物学报 , 2023 , 63 (03) , 1243-1253 . |
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目的 探讨益景汤对高糖环境中人脑微血管内皮细胞(HBMEC)形态及TGF-β1/Smads信号通路相关蛋白表达的影响.方法 取对数生长期的HBMEC分为空白组、血清组、模型组、含药组,空白组采用无血清培养基,血清组采用血清培养基,模型组采用40 mmol/L葡萄糖血清培养基,含药组采用益景汤含药血清+40 mmol/L葡萄糖培养基,各培养48 h.采用光镜观察4组细胞形态变化,Western blot检测4组晚期糖基化终末产物特异性受体(RAGE)、转化生长因子β1(TGF-β1)、同源物4重组蛋白(Smad4)以及纤维连接蛋白(fibronectin)、紧密连接蛋白5(claudin-5)、Ⅳ型胶原蛋白(collagen Ⅳ)的蛋白表达量.结果 空白组细胞稀疏,形态尚规则;血清组细胞形态规则,成簇生长,呈"铺路石"单层贴壁生长;模型组细胞不规则增大,细胞间隙增宽、数量变少,细胞碎片、悬浮死细胞增多;含药组细胞不规则形态减少、间隙变小、数量增多,细胞碎片、悬浮死细胞减少.与空白组及血清组比较,模型组claudin-5蛋白表达量均明显降低(P均＜0.05),RAGE、TGF-β1、Smad4、fibronectin和collagen Ⅳ蛋白表达量差异均无统计学意义(P均＞0.05);与模型组比较,含药组claudin-5蛋白表达量明显升高(P＜0.05),RAGE、TGF-β1、Smad4、fibronectin和collagen Ⅳ蛋白表达量差异均无统计学意义(P均＞0.05).结论益景汤能提高高糖环境中HBMEC的增殖活力,保护细胞形态,明显上调HBMEC的claudin-5蛋白表达,对保护人脑微血管正常结构,维持人血脑屏障正常通透性有一定意义.
Keyword ：
TGF-β1/Smads信号通路 TGF-β1/Smads信号通路 人脑微血管内皮细胞 人脑微血管内皮细胞 益景汤 益景汤 糖尿病 糖尿病
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| GB/T 7714 | 王丽 , 梁明丽 , 孟春 et al. 益景汤对高糖环境中人脑微血管内皮细胞形态和TGF-β1/Smads信号通路相关蛋白表达的影响 [J]. | 福建中医药 , 2023 , 54 (7) : 31-34 . |
| MLA | 王丽 et al. "益景汤对高糖环境中人脑微血管内皮细胞形态和TGF-β1/Smads信号通路相关蛋白表达的影响" . | 福建中医药 54 . 7 (2023) : 31-34 . |
| APA | 王丽 , 梁明丽 , 孟春 , 刘光辉 . 益景汤对高糖环境中人脑微血管内皮细胞形态和TGF-β1/Smads信号通路相关蛋白表达的影响 . | 福建中医药 , 2023 , 54 (7) , 31-34 . |
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目的:观察可溶性糖蛋白130(sgp130)对糖尿病(DM)小鼠视网膜p-STAT3及VEGF-A表达的影响,探讨sgp130防治糖尿病视网膜病变(DR)炎性损害的可能性.方法:小鼠45只被随机分为正常组、DM组和sgp130组.采用链脲佐菌素对DM组和sgp130组进行DM造模.正常组、DM组不做特殊干预,sgp130组在第1、5wk被给予1.5mg/mL sgp1302μL进行玻璃体腔注射治疗.10wk后处死所有小鼠,检查视网膜组织IL-6、p-STAT3、VEGF-A等蛋白的表达.结果:在第10wk时,DM组视网膜IL-6、p-STAT3、VEGF-A表达较正常组升高(均P<0.01).sgp130组p-STAT3、VEGF-A表达水平较DM组低(均P<0.01).结论:sgp130可以选择性拮抗IL-6反式信号传导通路,下调下游炎性因子VEGF-A的表达,可以用于干预DM引起的IL-6相关性视网膜炎性损害.
Keyword ：
p-STAT3 p-STAT3 可溶性糖蛋白130(sgp130) 可溶性糖蛋白130(sgp130) 炎症 炎症 白介素6 白介素6 糖尿病视网膜病变 糖尿病视网膜病变 血管内皮生长因子A(VEGF-A) 血管内皮生长因子A(VEGF-A)
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| GB/T 7714 | 刘光辉 , 史常旋 , 洪雅军 et al. sgp130对糖尿病小鼠视网膜p-STAT3及VEGF-A表达的影响 [J]. | 国际眼科杂志 , 2023 , 23 (3) : 375-378 . |
| MLA | 刘光辉 et al. "sgp130对糖尿病小鼠视网膜p-STAT3及VEGF-A表达的影响" . | 国际眼科杂志 23 . 3 (2023) : 375-378 . |
| APA | 刘光辉 , 史常旋 , 洪雅军 , 郑永征 , 王航 , 孟春 . sgp130对糖尿病小鼠视网膜p-STAT3及VEGF-A表达的影响 . | 国际眼科杂志 , 2023 , 23 (3) , 375-378 . |
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