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学者姓名：唐凤翔
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Abstract ：
Phthalocyanines (Pcs) are considered promising in cancer phototherapy. However, their maximum absorption wavelengths are only around 700 nm, which cannot allow deep tissue penetration and leads to poor therapeutic efficacy. To expand their clinical application, significantly shifting their absorption to longer wavelengths is urgently required. Dye J-aggregates exhibit a redshifted absorption relative to its monomer. However, Pc J-aggregates with enormous-redshifted and intense absorption is rarely reported, and little is known about the relationships between Pc structure and J-aggregation. Herein, such Pc J-aggregates are ingeniously conceived. With a yeast β-D-glucan-ursodeoxycholic acid conjugate as a potential tumor-associated macrophages (TAMs)-targeting carrier and 1-(4-carboxyethylphenoxy) zinc (II) phthalocyanine (Pc1) as a model, Pc1 J-aggregate nanoparticle (NanoPc1) is obtained via ultrasonication-aided emulsification-solvent evaporation technique. NanoPc1 displays strong absorption at 830 nm, with a 156 nm redshift. Further investigation on another twenty-four Pcs demonstrates that unsubstituted zinc (II) or magnesium (II) Pc and hydrophobic mono-substituted zinc (II) or magnesium (II) Pcs with mono-substituted phenoxy or phenylthio or naphthoxy as a substituent can readily form desired Pc J-aggregates with significant redshifts (140–165 nm). The other Pcs fail to form expected J-aggregates probably due to absence of central metals, steric hindrance on central metals (atoms), forming axial coordination on central metals, disorder tendency during self-assembly or hydrophilicity. The theoretical calculation indicates that Pc1 in its J-aggregates exhibits a spiral-like arrangement, and the reduction in the energy gap between HOMO and LUMO and variation of intermolecular π-π interaction caused by J-aggregate formation are responsible for the huge redshift. Additionally, using NanoPc1 as an exemplar, such Pc J-aggregate nanoparticles are substantiated to afford TAMs-targeted and efficient tri-modal imaging and photothermal therapy in a H22 mouse model. © 2024 Elsevier B.V.
Keyword ：
J-aggregate J-aggregate Large redshift Large redshift Multimodal phototheranostics Multimodal phototheranostics Phthalocyanine Phthalocyanine Yeast glucan Yeast glucan
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| GB/T 7714 | Tang, F. , Yu, H. , Huang, Y. et al. Phthalocyanine J-aggregate nanoparticles with enormous-redshifted and intense absorption: Potential structure-J-aggregation relationships and application in tumor-associated macrophages-targeted phototheranostics [J]. | Chemical Engineering Journal , 2024 , 496 . |
| MLA | Tang, F. et al. "Phthalocyanine J-aggregate nanoparticles with enormous-redshifted and intense absorption: Potential structure-J-aggregation relationships and application in tumor-associated macrophages-targeted phototheranostics" . | Chemical Engineering Journal 496 (2024) . |
| APA | Tang, F. , Yu, H. , Huang, Y. , Zhao, X. , Chen, Z. , Ma, H. et al. Phthalocyanine J-aggregate nanoparticles with enormous-redshifted and intense absorption: Potential structure-J-aggregation relationships and application in tumor-associated macrophages-targeted phototheranostics . | Chemical Engineering Journal , 2024 , 496 . |
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Abstract ：
A monolithic-based mixed-mode stationary phase was prepared for capillary electrochromatography via the fast photoinitiated polymerization of 2-methacryloyloxyethyl phosphorylcholine and polyhedral oligomeric silsesquioxane methacrylate (POSS-MA) monomers in the presence of crosslinker pentaerythritol triacrylate (PETA). Several copolymerization parameters, including the composition of monomers or porogens, ratio of crosslinkers to monomers, and polymerization time, were systematically optimized to tune the permeability and efficiency of monolithic columns. The morphologies and structures of the as-prepared monoliths were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, thermogravimetry and nitrogen adsorption/desorption analysis, indicating a typical POSS skeleton morphology with numerous mesopores on the monolith. Owing to the incorporation of zwitterionic functional groups and rigid POSS skeleton on the hybrid monolith, the resulting stationary phase exhibited both hydrophilic and electrostatic interactions, as well as good mechanical stability. Pressurized CEC separation of various kinds of polar compounds such as amides, nucleobases, nucleosides and benzoic acids, and polypeptide antibiotics was achieved by mixed-mode retention mechanisms including hydrophilic interaction chromatography (HILIC) and weak cation exchange chromatography (WCX) with a high column efficiency up to 93 500 plates per m (thiourea).
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| GB/T 7714 | Lei, Xiaoyun , Zhang, Bingyu , Zhang, Yi et al. In situ photoinitiated fabrication of phosphorylcholine-functionalized polyhedral oligomeric silsesquioxane hybrid monolithic column for mixed-mode capillary electrochromatography [J]. | ANALYST , 2022 , 147 (10) : 2253-2263 . |
| MLA | Lei, Xiaoyun et al. "In situ photoinitiated fabrication of phosphorylcholine-functionalized polyhedral oligomeric silsesquioxane hybrid monolithic column for mixed-mode capillary electrochromatography" . | ANALYST 147 . 10 (2022) : 2253-2263 . |
| APA | Lei, Xiaoyun , Zhang, Bingyu , Zhang, Yi , Huang, Ting , Tang, Fengxiang , Wu, Xiaoping . In situ photoinitiated fabrication of phosphorylcholine-functionalized polyhedral oligomeric silsesquioxane hybrid monolithic column for mixed-mode capillary electrochromatography . | ANALYST , 2022 , 147 (10) , 2253-2263 . |
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Photodynamic antifungal therapy is a promising treatment for increasing drug-resistant fungi. However, low physiological solubility and low fungi-affinity of most potential photosensitizers limits their therapeutic efficacy. To improve the water-solubility and photodynamic antifungal activity of zinc(II) phthalocyanine, two molecular-weight carboxymethyl chitosans (CMC1,50 kDa; CMC2,170 kDa) were herein respectively conjugated with 1-[4-(2-aminoethyl)phenoxy] zinc(II) phthalocyanine (ZnPcN) and further quaternized, and eight novel conjugates were obtained and characterized. Their photophysical and photochemical properties, cellular uptakes and in vitro photodynamic antifungal activities against Candida albicans have also been investigated. All the conjugates are less aggregated in water than ZnPcN. The low-molecular-weight CMC1-conjugated ZnPcN is more readily ingested and highly photoactive. Mainly due to its highest uptake by Candida cells, a conjugate of CMC1 and ZnPcN shows the highest photocytotoxicity with an IC90 value down to 0.72 mu M. Further quaternization decreases the photocytotoxicity. Additionally, the conjugates show special affinity to the mitochondria of C. albicans.
Keyword ：
Candida albicans Candida albicans Carboxymethyl chitosan Carboxymethyl chitosan Carboxymethyl chitosan-phthalocyanine conjugates Carboxymethyl chitosan-phthalocyanine conjugates Photodynamic antifungal therapy Photodynamic antifungal therapy Phthalocyanine Phthalocyanine Quaternization Quaternization
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| GB/T 7714 | Tang, Fengxiang , Gao, Fang , Xie, Wei et al. Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy [J]. | CARBOHYDRATE POLYMERS , 2020 , 235 . |
| MLA | Tang, Fengxiang et al. "Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy" . | CARBOHYDRATE POLYMERS 235 (2020) . |
| APA | Tang, Fengxiang , Gao, Fang , Xie, Wei , Li, Sicong , Zheng, Biyuan , Ke, Meirong et al. Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy . | CARBOHYDRATE POLYMERS , 2020 , 235 . |
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Tumor-associated macrophages (TAMs)-targeted photodynamic therapy (PDT) has dual-selectivity and hence is promising in cancer treatment. Since the scavenger receptor-A (SR-A) on TAMs can recognize polyanions, two molecular-weight sodium alginates (SA1, 41.2 kDa; SA2, 1231.5 kDa) were herein respectively conjugated with 1-[4-(2-aminoethyl) phenoxy] zinc (II) phthalocyanine (1) and two novel conjugates were obtained, characterized and evaluated for their TAMs-targeted PDT efficacy. The SA introduction makes 1 water-soluble, less aggregated and capable of emitting considerable fluorescence in water. Compared with 1, both conjugates, especially 1-SA1, can give higher selectivity and photocytotoxicity to SR-A-positive macrophages J774A.1 than SR-A-negative HepG2 cells. The in vivo biodistribution evaluation shows both conjugates can selectively accumulate at the tumor site and 1-SA1 owns higher tumor accumulation. 1-SA1 can achieve an 87 % tumor inhibition rate without observable systemic toxicity. These results reveal the great potential of SA as a carrier for conjugating anti-tumor drugs and 1-SA1 for TAMs-targeted PDT.
Keyword ：
Alginate Alginate Conjugate Conjugate Photodynamic therapy Photodynamic therapy Phthalocyanine Phthalocyanine Tumor-associated macrophage Tumor-associated macrophage Tumor-targeting therapy Tumor-targeting therapy
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| GB/T 7714 | Tang, Fengxiang , Xie, Wei , Li, Sicong et al. Alginate-zinc (II) phthalocyanine conjugates: Synthesis, characterization and tumor-associated macrophages-targeted photodynamic therapy [J]. | CARBOHYDRATE POLYMERS , 2020 , 240 . |
| MLA | Tang, Fengxiang et al. "Alginate-zinc (II) phthalocyanine conjugates: Synthesis, characterization and tumor-associated macrophages-targeted photodynamic therapy" . | CARBOHYDRATE POLYMERS 240 (2020) . |
| APA | Tang, Fengxiang , Xie, Wei , Li, Sicong , Hu, Qingyan , Zheng, Biyuan , Ke, Meirong et al. Alginate-zinc (II) phthalocyanine conjugates: Synthesis, characterization and tumor-associated macrophages-targeted photodynamic therapy . | CARBOHYDRATE POLYMERS , 2020 , 240 . |
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Abstract ：
工业药剂学作为制药工程专业的核心课程之一,在药学教育中发挥了重要作用.目前制药企业发展急需复合型人才,这就要求工业药剂学紧跟新形势,以学生为中心,以培养学生的综合素质和求知能力为目标开展教学改革.文章结合教学实际,通过优化教学内容、丰富教学手段、创新实验教学和建设多元课堂,对工业药剂学的教学进行了一些有益的改革探索和实践.
Keyword ：
多元课堂 多元课堂 工业药剂学 工业药剂学 教学改革 教学改革 核心课程 核心课程
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| GB/T 7714 | 万东华 , 高瑜 , 唐凤翔 et al. 制药工程专业核心课程工业药剂学的教学改革探索与实践 [J]. | 化工高等教育 , 2020 , 37 (1) : 104-109 . |
| MLA | 万东华 et al. "制药工程专业核心课程工业药剂学的教学改革探索与实践" . | 化工高等教育 37 . 1 (2020) : 104-109 . |
| APA | 万东华 , 高瑜 , 唐凤翔 , 黄剑东 . 制药工程专业核心课程工业药剂学的教学改革探索与实践 . | 化工高等教育 , 2020 , 37 (1) , 104-109 . |
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Abstract ：
生物化学实验是制药工程专业重要的专业课程之一,但在传统教学中,实验课程仅简单作为理论课程教学的补充,存在实验内容陈旧、教学方法单一、师资力量不足等问题.为了培养适应21世纪社会发展的复合型人才,近年来尝试从更新教学内容体系、在教学中引入科研课题、改进评估方法、拓展课外开放性实验、加强师资队伍建设等方面进行改革探索并取得一定成效,学生在参与科研综合训练项目、学科竞赛及大学生创新创业比赛等方面获得明显进步.
Keyword ：
制药工程专业 制药工程专业 生物化学实验 生物化学实验 课程建设 课程建设
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| GB/T 7714 | 邵敬伟 , 唐凤翔 , 郑允权 et al. 制药工程专业生物化学实验课程的建设与探索 [J]. | 生物学杂志 , 2020 , 37 (1) : 107-109 . |
| MLA | 邵敬伟 et al. "制药工程专业生物化学实验课程的建设与探索" . | 生物学杂志 37 . 1 (2020) : 107-109 . |
| APA | 邵敬伟 , 唐凤翔 , 郑允权 , 万东华 , 黄剑东 . 制药工程专业生物化学实验课程的建设与探索 . | 生物学杂志 , 2020 , 37 (1) , 107-109 . |
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A simple thiol-ene photopolymerization approach was developed for the rapid preparation of ionic liquid-functionalized hybrid monolithic column based on polyhedral oligomeric silsesquioxane (POSS). "One-pot" polymerization was realized in the UV-transparent fused-silica capillary by using octanethiol, 1-allyl-3-methylimidazolium hexafluorophosphate as functional monomers and methacryl-substituted POSS as a crosslinker. The thiol-vinyl-methacrylate ternary system uniquely exhibits a mixed step-chain growth polymerization regime that combining the thiol-ene reaction and free-radical reaction mechanisms, which provides a simple route to prepare novel POSS-based functionalized hybrid monoliths. The pore property, permeability, and electroosmotic flow (EOF) of the hybrid monoliths can be tailored by proper adjustment of the feeding composition and initiation condition. Morphologic and spectroscopic characterizations of monolithic columns clearly indicate that utilization of the photo-initiated approach in thiol-vinyl polymerization can generate a more homogeneous porous structure, smaller domain size and higher column efficiency (53,800-60,300 plates/m for alkylbenzenes) than the thermally-initiated one (32,800-49,300 plates/m). Significant improvements in mechanical stability, anti-swelling property and tailorability of hybrid polymer were achieved in a simple manner, owing to the photopolymerization of rigid nanoscale POSS units and imidazolium-based ionic liquids in ternary thiol-vinyl system for the first time. The resulting hybrid monolith possessed controllable EOFs at pH values from 2 to 10, and showed a multimode separation mechanism in capillary electrochromatography, including pi-pi interaction, ion exchange, electrophoretic migration, electrostatic and hydrophobic interaction. Satisfactory separation ability was achieved for the analysis of different types of small molecules. (C) 2019 Elsevier B.V. All rights reserved.
Keyword ：
Capillary electrochromatography Capillary electrochromatography Hybrid monoliths Hybrid monoliths Ionic liquids Ionic liquids Mixed step-chain growth photopolymerization Mixed step-chain growth photopolymerization Polyhedral oligomeric silsesquioxanes Polyhedral oligomeric silsesquioxanes Ternary thiol-ene system Ternary thiol-ene system
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| GB/T 7714 | Li, Minsheng , Lei, Xiaoyun , Huang, Yan et al. Ternary thiol-ene photopolymerization for facile preparation of ionic liquid-functionalized hybrid monolithic columns based on polyhedral oligomeric silsesquioxanes [J]. | JOURNAL OF CHROMATOGRAPHY A , 2019 , 1597 : 167-178 . |
| MLA | Li, Minsheng et al. "Ternary thiol-ene photopolymerization for facile preparation of ionic liquid-functionalized hybrid monolithic columns based on polyhedral oligomeric silsesquioxanes" . | JOURNAL OF CHROMATOGRAPHY A 1597 (2019) : 167-178 . |
| APA | Li, Minsheng , Lei, Xiaoyun , Huang, Yan , Guo, Yuan , Zhang, Bingyu , Tang, Fengxiang et al. Ternary thiol-ene photopolymerization for facile preparation of ionic liquid-functionalized hybrid monolithic columns based on polyhedral oligomeric silsesquioxanes . | JOURNAL OF CHROMATOGRAPHY A , 2019 , 1597 , 167-178 . |
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制药工艺学是制药工程专业一门重要的专业核心课程.针对传统的制药工艺学教学和考核方式难以促进学生毕业能力的达成,按照工程教育专业认证的成果导向教学理念,提出在制药工艺学教学中引入撰写化学类新药合成工艺进展性论文的研究性学习.通过对该研究性学习的学习内容、教师与学生的互动以及考核方式的精心组织与实施,取得了良好的实践效果.该研究性学习可对工程认证标准中的多项毕业要求进行支撑并促进学生毕业能力的提升.
Keyword ：
制药工艺学 制药工艺学 化学类新药 化学类新药 研究性学习 研究性学习 进展性论文 进展性论文
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| GB/T 7714 | 唐凤翔 , 郑允权 , 陈海军 et al. 基于成果导向教育的制药工艺学教学改革探索 [J]. | 药学教育 , 2019 , 35 (3) : 45-50 . |
| MLA | 唐凤翔 et al. "基于成果导向教育的制药工艺学教学改革探索" . | 药学教育 35 . 3 (2019) : 45-50 . |
| APA | 唐凤翔 , 郑允权 , 陈海军 , 黄剑东 . 基于成果导向教育的制药工艺学教学改革探索 . | 药学教育 , 2019 , 35 (3) , 45-50 . |
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瑞博西尼是一种有高度特异性细胞周期依赖性激酶CDK4/6双重抑制剂,用于治疗晚期或转移性乳腺癌.本文报道了迄令为止的瑞博西尼的合成工艺路线和其关键中间体7的合成工艺路线,并进行了相应的评价,指出了改进的方向.对所有合成工艺路线的分析表明,瑞博西尼的合成主要有两种途径,均为汇聚式,分别涉及两个关键中间体的合成.
Keyword ：
合成 合成 抗乳腺癌 抗乳腺癌 瑞博西尼 瑞博西尼
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| GB/T 7714 | 洪艺君 , 唐凤翔 . 新型抗乳腺癌药瑞博西尼的合成进展 [J]. | 海峡药学 , 2019 , 31 (4) : 47-51 . |
| MLA | 洪艺君 et al. "新型抗乳腺癌药瑞博西尼的合成进展" . | 海峡药学 31 . 4 (2019) : 47-51 . |
| APA | 洪艺君 , 唐凤翔 . 新型抗乳腺癌药瑞博西尼的合成进展 . | 海峡药学 , 2019 , 31 (4) , 47-51 . |
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Abstract ：
制药工程专业实验是制药工程专业人才培养过程中的重要实践环节.过去制药工程专业实验不足以支撑学生毕业能力的达成,近3年来基于工程教育专业认证的理念和要求,对制药工程专业实验课程内容和教学平台进行重新设计和建设并付诸实践.改革后的制药工程专业实验课程符合工程教育专业认证的要求,能促进学生多项毕业能力的达成,能培养学生解决复杂工程问题的能力,可为国内高校同专业实验教学提供有益借鉴.
Keyword ：
制药工程专业实验 制药工程专业实验 复杂工程问题 复杂工程问题 工程教育专业认证 工程教育专业认证
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| GB/T 7714 | 郑允权 , 唐凤翔 , 黄剑东 et al. 工程教育专业认证背景下制药工程专业实验课程改革 [J]. | 药学教育 , 2019 , 35 (5) : 60-64 . |
| MLA | 郑允权 et al. "工程教育专业认证背景下制药工程专业实验课程改革" . | 药学教育 35 . 5 (2019) : 60-64 . |
| APA | 郑允权 , 唐凤翔 , 黄剑东 , 许小平 , 万东华 , 郑碧远 et al. 工程教育专业认证背景下制药工程专业实验课程改革 . | 药学教育 , 2019 , 35 (5) , 60-64 . |
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