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学者姓名：刘树滔
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Abstract ：
透明质酸（HA）是一种新型食品功能性成分,具有良好的抗氧化和抗炎活性。目前市场供应的HA多为高分子量透明质酸（HMW-HA）,但是HMW-HA活性不如小分子量HA。因此,本文利用酶生物反应罐与平板式聚醚砜超滤膜分离组件组成的连续式酶解-膜分离耦合反应体系酶解HMW-HA,一次性制备了分子量分别约为35 kDa的低分子量透明质酸（LMW-HA）和400 Da的寡聚透明质酸（O-HA）,然后在体外和体内探究3种分子量的透明质酸的抗氧化和抗炎效果。结果表明这两种HA酶解产物均具有更高的清除DPPH自由基和羟自由基的能力,并且LMW-HA和O-HA能显著提高H
Keyword ：
抗氧化 抗氧化 抗炎 抗炎 透明质酸 透明质酸 酶膜耦合反应 酶膜耦合反应
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| GB/T 7714 | 刘俊辉 , 刘树滔 . 高分子量透明质酸酶解产物的抗氧化和抗炎活性研究 [C] //中国食品科学技术学会第二十一届年会 . 2024 . |
| MLA | 刘俊辉 等. "高分子量透明质酸酶解产物的抗氧化和抗炎活性研究" 中国食品科学技术学会第二十一届年会 . (2024) . |
| APA | 刘俊辉 , 刘树滔 . 高分子量透明质酸酶解产物的抗氧化和抗炎活性研究 中国食品科学技术学会第二十一届年会 . (2024) . |
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Abstract ：
透明质酸（HA）是一种非硫酸化糖胺聚糖，2021年获批为新食品原料后，引起食品科研人员与产业界的广泛兴趣。近年来，越来越多的研究显示，HA的生物活性根据其分子质量的不同，发挥促炎或抗炎、促细胞增殖或抗增殖作用。为了高效、精准地提高HA在食品中的应用价值，有必要根据分子质量的差异性，全面归纳总结HA在食品相关领域的研究进展。本文概述HA的应用开发进展，重点分析不同分子质量HA的制备方法、细胞功能、消化吸收特性，从维持稳态、缓解炎症两个维度分析HA对肠道的调节作用，以期促进HA在营养与健康产业的精准开发及应用。
Keyword ：
分子质量 分子质量 制备 制备 生物学功能 生物学功能 肠道 肠道 透明质酸 透明质酸
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| GB/T 7714 | 滕薇 , 刘树滔 , 吴金鸿 et al. 透明质酸的制备、功能特性及其调节肠道健康的研究进展 [J]. | 中国食品学报 , 2024 , 24 (07) : 401-413 . |
| MLA | 滕薇 et al. "透明质酸的制备、功能特性及其调节肠道健康的研究进展" . | 中国食品学报 24 . 07 (2024) : 401-413 . |
| APA | 滕薇 , 刘树滔 , 吴金鸿 , 张勇 . 透明质酸的制备、功能特性及其调节肠道健康的研究进展 . | 中国食品学报 , 2024 , 24 (07) , 401-413 . |
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To explore the formation pattern of 5-hydroxymethylfurfural (5-HMF) and the safety of dried longan during processing and storage, this study monitored the changes in 5-HMF content during drying and storage at different temperatures. The changes in the contents of reducing sugar, total acid and total free amino acid and browning degree during processing were determined and their correlation with 5-HMF content was analyzed. Moreover, the safety of dried longan was analyzed using in vitro simulated digestion experiments and a Caco-2 cell model. The results showed that as the drying temperature increased above 85 ℃, the 5-HMF content significantly increased (P © 2024 Chinese Chamber of Commerce. All rights reserved.
Keyword ：
Drying Drying
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| GB/T 7714 | Fang, Ronghui , Sang, Wanjing , Cheng, Qun et al. Effects of Drying, Storage Conditions and Simulated Digestion on the Content of 5-Hydroxymethylfurfural in Dried Longan [J]. | Food Science , 2024 , 45 (19) : 41-48 . |
| MLA | Fang, Ronghui et al. "Effects of Drying, Storage Conditions and Simulated Digestion on the Content of 5-Hydroxymethylfurfural in Dried Longan" . | Food Science 45 . 19 (2024) : 41-48 . |
| APA | Fang, Ronghui , Sang, Wanjing , Cheng, Qun , Liu, Shutao . Effects of Drying, Storage Conditions and Simulated Digestion on the Content of 5-Hydroxymethylfurfural in Dried Longan . | Food Science , 2024 , 45 (19) , 41-48 . |
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为探究龙眼干在加工、储存过程中5-羟甲基糠醛(5-hydroxymethylfurfural,5-HMF)的生成规律及安全性,测定不同温度干制、储存过程中龙眼干5-HMF含量的变化,以及干制过程中还原糖、总酸、总游离氨基酸和褐变度的变化,并分析各种变化之间的相关性;然后通过体外模拟消化实验及肠道上皮细胞模型对其进行安全性分析.结果表明:随着干制温度的上升,5-HMF在干制温度大于85 ℃时显著升高(P＜0.05),5-HMF含量与总酸含量和褐变度呈正相关,与总游离氨基酸及还原糖含量呈负相关;龙眼干在冷藏(4 ℃)、常温(25 ℃)、高温(37 ℃)储存条件下,5-HMF随储存时间延长先上升后下降,不同条件下的增长趋势不同,其中25 ℃条件下最快开始下降且总体含量较低;龙眼干中的5-HMF含量在口腔消化阶段短暂升高,在胃、肠消化阶段显著降低;龙眼干水提液能抑制5-HMF的吸收,且对于24 mmol/L 5-HMF的Caco-2细胞毒性有一定的抵消作用.结果说明,优化龙眼干的干制和储存条件能够降低5-HMF的含量;正常食用的情况下,人体消化道能降低龙眼干中5-HMF,提高其食用安全性.
Keyword ：
5-羟甲基糠醛 5-羟甲基糠醛 安全性 安全性 美拉德反应 美拉德反应 龙眼干 龙眼干
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| GB/T 7714 | 方榕辉 , 桑婉婧 , 程群 et al. 干制、储存条件及模拟消化对龙眼干中5-羟甲基糠醛含量的影响 [J]. | 食品科学 , 2024 , 45 (19) : 41-48 . |
| MLA | 方榕辉 et al. "干制、储存条件及模拟消化对龙眼干中5-羟甲基糠醛含量的影响" . | 食品科学 45 . 19 (2024) : 41-48 . |
| APA | 方榕辉 , 桑婉婧 , 程群 , 刘树滔 . 干制、储存条件及模拟消化对龙眼干中5-羟甲基糠醛含量的影响 . | 食品科学 , 2024 , 45 (19) , 41-48 . |
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Spices can improve the quality, color, flavor and taste of food, and at the same time have a variety of health care functions, which can be used to dispel cold, dehumidify, and dredge meridians. The purpose of this study is to develop a delicious and natural spice drink that can act on the meridians and collaterals by using licorice, cinnamon and ginger, which are sweet and warm in nature, as raw materials. Beverage formulation selection was determined by sensory evaluation by a sensory panel of 6-8 persons. The effect on the meridians was determined by observing the changes in the voltage of the subjects' meridians. The results showed that when the concentration of liquorice was 0 mg/ mL, the concentration of cinnamon was 1.5 mg/mL, and the concentration of ginger was 0.5 mg/mL, the sensory evaluation effect of the spice combination beverage was the best. And according to the measurement of the meridian voltage, the ginger-cassia group has the most prominent effect on the meridian voltage of the human body among the 7 different spice combinations (liquorice, cinnamon, ginger, liquorice-cinnamon, liquorice-ginger, ginger-cinnamon, and liquorice-ginger-cinnamon), can greatly improve the meridian voltage of liver, spleen and kidney meridians, showing that it has a special effect on liver, spleen and kidney meridians. © 2023 Chinese Institute of Food Science and Technology. All rights reserved.
Keyword ：
Beverages Beverages Humidity control Humidity control Sensory analysis Sensory analysis Sensory perception Sensory perception Water quality Water quality
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| GB/T 7714 | Luo, Yuanyuan , Guo, Jingke , Liu, Shutao et al. The Preparation of Spicy Beverage and Its Effect on the Human Body's Meridian Voltage [J]. | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (9) : 109-119 . |
| MLA | Luo, Yuanyuan et al. "The Preparation of Spicy Beverage and Its Effect on the Human Body's Meridian Voltage" . | Journal of Chinese Institute of Food Science and Technology 23 . 9 (2023) : 109-119 . |
| APA | Luo, Yuanyuan , Guo, Jingke , Liu, Shutao , Li, Henian , Li, Qiaoling , Wang, Mengtian . The Preparation of Spicy Beverage and Its Effect on the Human Body's Meridian Voltage . | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (9) , 109-119 . |
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Oxidative stress is generally considered inseparable from the development and exacerbation of ulcerative colitis (UC). Therefore, reducing oxidative stress has become a possible way to alleviate UC. In this study, the therapeutic effects of different doses of liposome-embedded superoxide dismutase (L-SOD) on mice with DSS-induced UC were systematically investigated. The results showed that L-SOD significantly attenuated the signs of colitis in mice, including colonic shortening, diarrhoea, bloody stools, and histopathological changes. L-SOD ameliorated DSS-induced oxidative damage, increased SOD, catalase (CAT), and glutathione (GSH) activities, and decreased malondialdehyde (MDA) levels. In addition, L-SOD ameliorated the inflammatory response by inhibiting the expression of myeloperoxidase (MPO) and pro-inflammatory cytokines and protected barrier function by promoting the expression of the tight junction proteins occludin and ZO-1 in the colon. Importantly, the results demonstrated a bell-shaped distribution of therapeutic effects relative to the administered dose, with an optimal dose of 150 000 U kg(-1). These results indicate that L-SOD has great potential as an ingredient in functional foods for the prevention and mitigation of UC.
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| GB/T 7714 | Zhang, Chi , Hu, Yujia , Yuan, Yi et al. Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction [J]. | FOOD & FUNCTION , 2023 , 14 (9) : 4392-4405 . |
| MLA | Zhang, Chi et al. "Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction" . | FOOD & FUNCTION 14 . 9 (2023) : 4392-4405 . |
| APA | Zhang, Chi , Hu, Yujia , Yuan, Yi , Guo, Jingke , Li, Henian , Li, Qiaoling et al. Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction . | FOOD & FUNCTION , 2023 , 14 (9) , 4392-4405 . |
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Ulcerative colitis (UC) is an idiopathic intestinal disease with an increasing incidence, and all the therapeutic drugs have different degrees of side effects. Studies have found that collagen peptide can relieve the symptoms of UC, and is safe and healthy. However, the current research is mainly limited to the prevention effect of UC, and there is still a lack of research on the therapeutic effect of UC. Eel skin is rich in collagen, but eel head is generally discarded in processing, resulting in a waste of resources. Meanwhile, there is a lack of research on eel skin collogen hydrolysates. In this study, collagen was extracted from eel skin and hydrolyzed in the hope of obtaining eel skin collagen hydrolysate (CH) with therapeutic effect on UC, so as to improve the utilization value of eel processing by-products. It was found that eel skin contained abundant collagen, accounting for 27.87% of the wet weight of the skin. The extracted collagen was of high purity and mainly type I collagen, and eel skin could be used as a high - quality source of collagen. Collagen was enzymatically hydrolyzed to obtain eel skin collagen hydrolysate (CH) with antioxidant activity, and CH was administered to DSS induced UC mouse model. The results showed that CH could safely and healthily reduce DAI score to 0 and improve colon status in UC Model mice compared with Positive control group and Model group. Pathological sections of colon tissue showed that CH could restore the integrity of mucosal epithelium and reduce inflammatory cell infiltration. Oxidative stress index of colon tissue showed that CH could reduce MDA content (0.75 nmol/mg protein) and MPO activity (0.11 U/g tissue) in colon tissue, and improve the antioxidant capacity of colon tissue and reduce oxidative stress level by increasing GSH content (22.92 umol/g pro) and activities of SOD (693.61 U/g pro), CAT (1.69 U/g pro) and GPx (141.29 U/g pro) antioxidant enzymes, so as to treat UC. © 2023 Chinese Institute of Food Science and Technology. All rights reserved.
Keyword ：
antioxidant antioxidant collagen collagen eel skin eel skin ulcerative colitis ulcerative colitis
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| GB/T 7714 | Li, H. , Hu, Y. , Zhang, C. et al. The Effect of Collagen Hydrolysate of Eel Skin on the Improvement of Colitis; [鳗鱼皮胶原蛋白水解物对结肠炎的改善作用] [J]. | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (4) : 96-105 . |
| MLA | Li, H. et al. "The Effect of Collagen Hydrolysate of Eel Skin on the Improvement of Colitis; [鳗鱼皮胶原蛋白水解物对结肠炎的改善作用]" . | Journal of Chinese Institute of Food Science and Technology 23 . 4 (2023) : 96-105 . |
| APA | Li, H. , Hu, Y. , Zhang, C. , Lin, J. , Guo, J. , Liu, S. . The Effect of Collagen Hydrolysate of Eel Skin on the Improvement of Colitis; [鳗鱼皮胶原蛋白水解物对结肠炎的改善作用] . | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (4) , 96-105 . |
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The chitosan-coated alginate gel particles (CS/SA) and chitosan-coated alginate-shellac gel particles (CS/SA/Lac) were constructed to serve as a potential oral delivery system to enhance the stability and activity of superoxide dismutase (SOD) in this study. The encapsulation efficiency (EE), enzyme activity retention ratio (ER), particle structure, and SOD release behavior, as well as the effect of shellac, were evaluated. The best formula is determined by the percentage of total effective activity (PTEA).The results showed that CS/SA prepared by 0.30 parts per thousand chitosan, 1.00% CaCl2, 2.00% sodium alginate (M/G = 1:1, Mw: 38,857 kDa), and gelation solution pH 5.50 had the best chitosan shell, the strongest gel structure and the maximum PTEA which was 10.75 +/- 1.45%. Based on the optimal formula, addition of shellac that formed shellac-Ca2+ microspheres in the gel network was averse to SOD encapsulation, but it significantly improved the stability of SOD in gastric conditions. By adding 15.00% shellac, the PTEA reached 16.30 +/- 1.64%. At optimal formulation, SOD encapsulated in CS/SA was completely released in the stimulated intestinal fluid and accumulative release enzyme activity (EA) was 966.62 +/- 103.75 (U) after 6 h. However, the CS/SA/Lac with a low swelling ratio only released SOD in stimulated colonic fluid and the EA value reached 1692.28 +/- 101.82 (U) after 1 h. These findings demonstrated that CS/SA and CS/SA/Lac were excellent candidates for SOD oral administration, which was useful in the food and biomedical industries for developing functional products containing SOD.
Keyword ：
Chitosan-coated alginate Chitosan-coated alginate Chitosan-coated alginate gel particles Chitosan-coated alginate gel particles Intestinal delivery Intestinal delivery shellac gel particles shellac gel particles Superoxide dismutase Superoxide dismutase
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| GB/T 7714 | Zhu, Zeliang , Yuan, Yi , Guo, Jingke et al. Encapsulation of SOD in chitosan-coated gel particles of alginate or mixture of alginate and shellac for targeted intestinal delivery [J]. | FOOD HYDROCOLLOIDS , 2023 , 142 . |
| MLA | Zhu, Zeliang et al. "Encapsulation of SOD in chitosan-coated gel particles of alginate or mixture of alginate and shellac for targeted intestinal delivery" . | FOOD HYDROCOLLOIDS 142 (2023) . |
| APA | Zhu, Zeliang , Yuan, Yi , Guo, Jingke , Luo, Xiaolin , Liu, Shutao , Miao, Song . Encapsulation of SOD in chitosan-coated gel particles of alginate or mixture of alginate and shellac for targeted intestinal delivery . | FOOD HYDROCOLLOIDS , 2023 , 142 . |
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溃疡性结肠炎（UC）是一种特发性肠道疾病，发病率不断上升，且治疗药物都存在不同程度的副作用。研究发现胶原蛋白肽可缓解UC症状，并且安全、健康。然而，目前研究主要局限于UC的预防作用，缺少对其治疗作用的研究。鳗鱼皮富含胶原蛋白，而鳗鱼头一般在加工中被丢弃，造成资源浪费，目前缺少对鳗鱼皮胶原蛋白水解物的研究。本研究尝试利用鳗鱼头中的鱼皮提取胶原蛋白并进行水解，希望得到对UC具有治疗作用的鳗鱼皮胶原蛋白水解物（CH），提高鳗鱼加工副产物的利用价值。研究发现鳗鱼皮所含胶原蛋白丰富，占鱼皮湿重的27.87%，纯度较高且主要为Ⅰ型胶原蛋白，可作为胶原蛋白的优质来源。对胶原蛋白进行酶解，得到具有抗氧化活性的CH，并给药UC模型小鼠，结果显示：与阳性对照和模型组相比，CH可以安全健康地降低UC模型小鼠的DAI评分至0，并改善结肠状态；结肠组织病理切片表明CH可以恢复黏膜上皮完整性，减轻炎性细胞浸润；结肠组织氧化应激指标表明CH可以降低结肠组织MDA含量（0.75 nmol/mg pro）和MPO活性（0.11 U/g tissue），并通过提高GSH含量（22.92 umol/g pro）和SOD(693.61 U/g pro)、CAT(1.69 U/g pro)、GPx(141.29U/g pro)3种抗氧化酶活性来提高结肠组织抗氧化能力，降低氧化应激水平，从而治疗UC。
Keyword ：
抗氧化 抗氧化 溃疡性结肠炎 溃疡性结肠炎 胶原蛋白 胶原蛋白 鳗鱼皮 鳗鱼皮
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| GB/T 7714 | 李鹤年 , 胡雨嘉 , 张弛 et al. 鳗鱼皮胶原蛋白水解物对结肠炎的改善作用 [J]. | 中国食品学报 , 2023 , 23 (04) : 96-105 . |
| MLA | 李鹤年 et al. "鳗鱼皮胶原蛋白水解物对结肠炎的改善作用" . | 中国食品学报 23 . 04 (2023) : 96-105 . |
| APA | 李鹤年 , 胡雨嘉 , 张弛 , 林婕 , 郭静科 , 刘树滔 . 鳗鱼皮胶原蛋白水解物对结肠炎的改善作用 . | 中国食品学报 , 2023 , 23 (04) , 96-105 . |
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Instant rice with added coarse grain (IR/CG) is a new type of coarse grain product which is self-heating and convenient to eat and has the nutritional value of coarse grains. However, its health effects are not clear yet. Therefore, in this study, the effect of IR/CG on glucose and lipid metabolism was explored in mice with type 2 diabetes mellitus (T2DM) induced by high fat diet (HFD) combined with intraperitoneal injection of streptozotocin. The mice were fed on HFD alone (model), its mixture with IR/CG in different ratios: 25% (low-dose IR/CG, IR/CG-L), 50% (medium-dose IR/CG, IR/CG-M), and 75% (high-dose IR/CG, IR/CG-H), IR/CG alone, or a basal diet (control). During the dietary intervention, the body mass, fasting blood glucose, food intake and glucose tolerance of the mice were measured. After the IR/CG intervention for four weeks, the organ coefficients were calculated, and the pathological changes in liver and pancreas tissues were examined by hematoxylin and eosin (HE) staining. Fasting insulin levels, blood glucose and lipid levels, and proinflammatory cytokines levels were determined. The experimental results showed that dietary supplementation of IR/CG improved blood glucose and lipid levels in T2DM mice to different extents, and this effect was more prominent in the IR/CG-H and IR/CG groups. In addition, IR/CG-H and IR/CG significantly mitigated insulin resistance, decreased insulin secretion, glucagon and HbA1c levels, and reduced oxidative stress injury and inflammatory cytokine levels in T2DM mice. By analyzing the organ index and pathological sections of liver and pancreas tissues, it was found that IR/CG intervention could effectively alleviate liver steatosis and partially restore the structure of the pancreatic islets in mice. Therefore, the substitution of high-fat diet by IR/CG has a significant effect on regulating blood glucose and lipids in T2DM mice, which can provide a theoretical basis for the development of self-heating rice products and functional foods with coarse-grain. © 2023 Chinese Chamber of Commerce. All rights reserved.
Keyword ：
blood glucose blood glucose instant rice with added coarse grain instant rice with added coarse grain type 2 diabetes mellitus type 2 diabetes mellitus
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| GB/T 7714 | Zhang, C. , Guo, J. , Hu, Y. et al. Effect of the Substitution of High-Fat Diet by Instant Rice with Added Coarse Grain on Glucose and Lipid Metabolism in Mice with Type 2 Diabetes Mellitus; [粗粮速食米替代高脂饮食对2型糖尿病小鼠糖脂代谢的影响] [J]. | Food Science , 2023 , 44 (9) : 96-103 . |
| MLA | Zhang, C. et al. "Effect of the Substitution of High-Fat Diet by Instant Rice with Added Coarse Grain on Glucose and Lipid Metabolism in Mice with Type 2 Diabetes Mellitus; [粗粮速食米替代高脂饮食对2型糖尿病小鼠糖脂代谢的影响]" . | Food Science 44 . 9 (2023) : 96-103 . |
| APA | Zhang, C. , Guo, J. , Hu, Y. , Wang, X. , Liu, S. . Effect of the Substitution of High-Fat Diet by Instant Rice with Added Coarse Grain on Glucose and Lipid Metabolism in Mice with Type 2 Diabetes Mellitus; [粗粮速食米替代高脂饮食对2型糖尿病小鼠糖脂代谢的影响] . | Food Science , 2023 , 44 (9) , 96-103 . |
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