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学者姓名：王群
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Abstract ：
Mitophagy is the selective degradation of mitochondria by autophagy, which is an important mitochondrial quality and quantity control process. During Drosophila metamorphosis, the degradation of midgut involves a large change in length and organization, which is mediated by autophagy. Here we noticed a cell-type specific mitochondria] clearance process that occurs in enterocytes (ECs), while most mitochondria remain in intestinal stem cells (ISCs) during metamorphosis. Although PINK]/PARKIN represent the canonical pathway for the elimination of impaired mitochondria in varied pathological conditions, their roles in developmental processes or normal physiological conditions have been less studied. To examine the potential contribution of PINK1 in developmental processes, we monitored the dynamic expression pattern of PINKI in the midgut development by taking advantage of a newly CRISPR/Cas9 generated knock-in fly strain expressing PINK1-mCherry fusion protein that presumably recapitulates the endogenous expression pattern of PINK1. We disclosed a spatiotemporal correlation between the expression pattern of PINKI and the mitochondrial clearance or persistence in ECs or ISCs respectively. By mosaic genetic analysis, we then demonstrated that PINK1 and PARKIN function epistatically to mediate the specific timely removal of mitochondria, and are involved in global autophagy in ECs during Drosophila midgut metamorphosis, with kinase-dead PINKI exerting dominant negative effects. Taken together, our studies concluded that the PINK1/PARKIN is crucial for timely cell-type specific mitophagy under physiological conditions and demonstrated again that Drosophila midgut metamorphosis might serve as an elegant in vivo model to study autophagy. (C) 2016 Elsevier Inc. All rights reserved.
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| GB/T 7714 | Liu, Yan , Lin, Jingjing , Zhang, Minjie et al. PINK1 is required for timely cell-type specific mitochondrial clearance during Drosophila midgut metamorphosis [J]. | DEVELOPMENTAL BIOLOGY , 2016 , 419 (2) : 357-372 . |
| MLA | Liu, Yan et al. "PINK1 is required for timely cell-type specific mitochondrial clearance during Drosophila midgut metamorphosis" . | DEVELOPMENTAL BIOLOGY 419 . 2 (2016) : 357-372 . |
| APA | Liu, Yan , Lin, Jingjing , Zhang, Minjie , Chen, Kai , Yang, Shengxi , Wang, Qun et al. PINK1 is required for timely cell-type specific mitochondrial clearance during Drosophila midgut metamorphosis . | DEVELOPMENTAL BIOLOGY , 2016 , 419 (2) , 357-372 . |
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Abstract ：
开展党的群众路线教育实践活动,要切实加强青年教师的马克思主义群众观点和党的群众路线教育.高校深入开展党的群众路线教育实践活动,要主动适应新形势新任务下加强和改进青年教师思想政治工作的现实要求,充分认识到加强和改进青年教师思想政治工作在群众路线教育实践活动中的重要性,在感情上贴近青年教师、利益上维护青年教师、作风上深入青年教师、工作上依靠青年教师,切实加强马克思主义群众观点,密切与青年教师的关系.
Keyword ：
思想政治工作 思想政治工作 青年教师 青年教师 马克思主义群众观 马克思主义群众观
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| GB/T 7714 | 王群 . 新形势下以马克思主义群众观加强和改进青年教师思想政治工作研究 [J]. | 广西教育学院学报 , 2014 , (5) : 130-132,151 . |
| MLA | 王群 . "新形势下以马克思主义群众观加强和改进青年教师思想政治工作研究" . | 广西教育学院学报 5 (2014) : 130-132,151 . |
| APA | 王群 . 新形势下以马克思主义群众观加强和改进青年教师思想政治工作研究 . | 广西教育学院学报 , 2014 , (5) , 130-132,151 . |
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Abstract ：
Deer antlers are well known for their regeneration and rapid growth. However, little is known about the genes that are involved in their development, especially the molecular mechanisms responsible for rapid growth. In the present study, we produced more than 41 million sequencing reads using the Illumina sequencing platform. These reads were assembled into 89,001 unique sequences (mean size: 450 bp), representing more than 58 times as many Sika deer sequences previously available in the NCBI database (as of Sep 15, 2011). Based on a similarity search with known proteins, we identified 40,088 sequences with a cut-off E value of 10(-5). Assembled sequences were then annotated using Gene ontology terms, Clusters of Orthologous Groups classifications, and Kyoto Encyclopedia of Genes and Genomes pathways. In addition, we found a number of highly expressed genes involved in the regulation of Sika deer antler rapid growth, including transcription factors, signaling molecules, and extracellular matrix proteins. Our data represent the most comprehensive sequence resource available for the deer antler and provide a basis for new research on deer antler molecular genetics and functional genomics.
Keyword ：
Antler tip Antler tip Chinese Sika deer Chinese Sika deer Gene expression Gene expression Rapid growth Rapid growth Transcriptome Transcriptome
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| GB/T 7714 | Yao, Baojin , Zhao, Yu , Wang, Qun et al. De novo characterization of the antler tip of Chinese Sika deer transcriptome and analysis of gene expression related to rapid growth [J]. | MOLECULAR AND CELLULAR BIOCHEMISTRY , 2012 , 364 (1-2) : 93-100 . |
| MLA | Yao, Baojin et al. "De novo characterization of the antler tip of Chinese Sika deer transcriptome and analysis of gene expression related to rapid growth" . | MOLECULAR AND CELLULAR BIOCHEMISTRY 364 . 1-2 (2012) : 93-100 . |
| APA | Yao, Baojin , Zhao, Yu , Wang, Qun , Zhang, Mei , Liu, Meichen , Liu, Hailong et al. De novo characterization of the antler tip of Chinese Sika deer transcriptome and analysis of gene expression related to rapid growth . | MOLECULAR AND CELLULAR BIOCHEMISTRY , 2012 , 364 (1-2) , 93-100 . |
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创业可以带动就业，预创业作为创业的预先准备阶段，其重要性不容忽视。“一个平台，四个层次”的预创业人才培养模型，即在一个预创业的平台上，分四个层次来培养创业人才，总体呈现一种金字塔的形状。这种人才培养模型符合时代发展和我国高等教育的要求，突破了当前大学生创业的瓶颈，优化了传统“订单式”人才培养模式，并且该模式可被快速复制，同时也是我国“创业型大学”建设的实践探索，是人才培养的一种新理念。
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| GB/T 7714 | 王群 . 预创业：高校创业型人才培养模式新探索 [J]. | 福州大学学报：哲学社会科学版 , 2010 , (1) . |
| MLA | 王群 . "预创业：高校创业型人才培养模式新探索" . | 福州大学学报：哲学社会科学版 1 (2010) . |
| APA | 王群 . 预创业：高校创业型人才培养模式新探索 . | 福州大学学报：哲学社会科学版 , 2010 , (1) . |
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Keyword ：
大学生社会实践活动 大学生社会实践活动 建构 建构 服务社会 服务社会 海峡西岸经济区 海峡西岸经济区 用人单位 用人单位 相结合 相结合 福州大学 福州大学 经济社会发展 经济社会发展 长效机制 长效机制 青年学生 青年学生
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| GB/T 7714 | 王群 . 建构大学生社会实践长效机制的探索 [J]. | 福建理论学习 , 2007 : 14-18 . |
| MLA | 王群 . "建构大学生社会实践长效机制的探索" . | 福建理论学习 (2007) : 14-18 . |
| APA | 王群 . 建构大学生社会实践长效机制的探索 . | 福建理论学习 , 2007 , 14-18 . |
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