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学者姓名：陈珠灵
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Abstract ：
Saccharides are a sort of ubiquitous and vital molecules within the whole life. However, the application of saccharides analysis with matrix -assisted laser desorption/ionization mass spectrometry (MALDI-MS) is restricted by their low ionization efficiency and the instability of the sialic acid fraction. Derivatization strategy based on nonreductive amination provides a good solution, however, this is often time consuming and may result in sample loss due to removal of excessive derivatization reagents. Herein, hydralazine (HZN) was utilized as a reactive matrix for labeling reducing saccharides directly on MALDI target which eliminated tedious sample preparation and avoided sample loss. After optimization, effective and reproducible on-MALDI-target derivatization of neutral and acidic saccharides was achieved in both positive and negative modes. Compared with 2,5-dihydroxybenzoic acid (DHB) and 9-aminoacridine (9 -AA), HZN improved the detection sensitivity of reducing saccharides and provided more abundant fragment ions in MS/MS analysis. Moreover, 26 kinds of neutral glycans and 5 kinds of sialic glycans were identified from ovalbumin (OVA) and bovine fetuin, respectively. Combined with the statistical models, this strategy could be used to distinguish and predict samples of 6 brands of beer, and discriminate 2 kinds of beer fermentation modes. In addition, HZN was applied for quantitative analysis of glucose in urine samples, and the obtained urine glucose concentrations of diabetic patients were consistent with the clinical test results, showing the potential of qualitative and quantitative analysis of reducing saccharides in complex samples. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Hydralazine Hydralazine On-MALDI-target derivatization On-MALDI-target derivatization Reactive matrix Reactive matrix Saccharides Saccharides
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| GB/T 7714 | Ouyang, Dan , Huang, Huan , He, Yanting et al. Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
| MLA | Ouyang, Dan et al. "Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides" . | CHINESE CHEMICAL LETTERS 35 . 5 (2024) . |
| APA | Ouyang, Dan , Huang, Huan , He, Yanting , Chen, Jiajing , Lin, Jiali , Chen, Zhuling et al. Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides . | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
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Abstract ：
A hollow microtubular covalent organic framework (denoted as TatDha-COF) was synthesized by solvothermal method for the enrichment and determination of quinones. The TatDha-COF showed large specific surface area (2057 m(2) g(-1)), good crystal structure, ordered pore size distribution (2.3 nm), stable chemical properties and good reusability. Accordingly, a simple and efficient method based on dispersive solid-phase extraction (d-SPE) and atmospheric pressure gas chromatography tandem mass spectrometry (APGC-MS/MS) was developed for the determination of quinones in complex samples. The established method demonstrated a wide liner range, good linearity (r > 0.9990), high enrichment factors (EFs, 24-69-folds) and low detection limits (LODs, 0.200-30.0 pg L-1, S/N >= 3). On this basis, the suggested method was successfully applied to sensitively detect the eight ultratrace quinones in mice plasma. Overall, the established method has provided a powerful tool for the enrichment and detection of ultratrace quinones in complex samples, presenting the promising application of TatDha-COF in sample pretreatment.
Keyword ：
APGC-MS/MS APGC-MS/MS Dispersive solid-phase extraction Dispersive solid-phase extraction Hollow microtubular covalent organic frameworks Hollow microtubular covalent organic frameworks Plasma analysis Plasma analysis Quinones Quinones
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| GB/T 7714 | Wang, Ran , Tong, Wei , Wu, Yijing et al. Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS [J]. | MICROCHIMICA ACTA , 2023 , 190 (2) . |
| MLA | Wang, Ran et al. "Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS" . | MICROCHIMICA ACTA 190 . 2 (2023) . |
| APA | Wang, Ran , Tong, Wei , Wu, Yijing , Chen, Zhuling , Lin, Zian , Cai, Zongwei . Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS . | MICROCHIMICA ACTA , 2023 , 190 (2) . |
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Constructing advanced substrates with excellent features is promising for sensitive surface-enhanced Raman spectroscopy (SERS) detection. Here a novel capillary monolithic 3D structural-substrate SERS platform with Au@cDNA@Ag@Cyanine 3-aptamer nanoparticles (Au@cDNA@Ag@Cy3-Apt NPs) was fabricated for rapid, highly specific profiling of ultra-trace Bisphenol A (BPA). The proposed SERS platform combined both in capillary SERS and aptamer-affinity recognition strategies, in which the superior SERS properties of Au-Ag NPs, aptamer selectivity, and the advantages of capillary monolith were integrated. A 3D hierarchically porous network was constructed in the monolithic column, which was endowed with rich hotspots for SERS, rapid sample permeation, and better analysis efficiency than most plane-shaped SERS modes. By varying the amount of Ag+ precursor, the Ag-shell thickness on SERS was finely tuned to guarantee Cy3 label in proximity to the plasmonic surface. Based on the biorecognition of aptamer, the selective identification of BPA occurred and exhibited a significant change in SERS intensity without obvious interference. As a result, the monolithic SERS platform featured facile operation, excellent specificity, and rapid analysis (10 min, much less than the solution based or planar substrate SERS modes). Ultra-high sensitivity and robust reproducibility for BPA analysis was achieved with a low limit of detection (LOD) at 9.12 x 10-4 ng/L. The feasibility of this SERS platform for monitoring BPA in water and milk samples was also validated. This work lights a new access to capillary monolithic SERS-sensing platform for ultrasensitive and specific analysis of BPA.
Keyword ：
3D structural-substrate 3D structural-substrate Aptasensor Aptasensor Bisphenol A Bisphenol A Monolith Monolith Surface-enhanced Raman spectroscopy Surface-enhanced Raman spectroscopy
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| GB/T 7714 | Li, Zhixin , Xie, Qian , Chi, Jinxin et al. Monolithic 3D structural-substrate SERS sensing platform for ultrasensitive and highly-specific analysis of trace bisphenol A [J]. | TALANTA , 2023 , 266 . |
| MLA | Li, Zhixin et al. "Monolithic 3D structural-substrate SERS sensing platform for ultrasensitive and highly-specific analysis of trace bisphenol A" . | TALANTA 266 (2023) . |
| APA | Li, Zhixin , Xie, Qian , Chi, Jinxin , Chen, Hui , Chen, Zhuling , Lin, Xucong et al. Monolithic 3D structural-substrate SERS sensing platform for ultrasensitive and highly-specific analysis of trace bisphenol A . | TALANTA , 2023 , 266 . |
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Analysis of cis-diol compounds is essential, because they play important roles in cosmetics, food, pharmaceuticals, and living organisms. Herein, we describe the development of a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to analyse cis-diol compounds. In this method, a 6-borono-1-methylquinoline-1-ium (BMQI) reactive matrix was designed for in situ derivatisation of cis-diol compounds based on the boronate affinity interaction between boronic acid and cis-diol groups. Compared to traditional commercial matrices and other boronic acid reagents, BMQI can significantly accelerate the desorption/ionisation process, improve reproducibility, exhibit free background interference, and enhance signal intensity in the analysis of various cis-diol compounds even for amounts as low as 1 nmol. The BMQI-assisted laser desorption/ionisation mass spectrometry (LDI-MS) was successfully applied to the rapid screening and identification of sugar alcohols in different sugar-free foods. This work provides an alternative method to the LDI-MS analysis of cis-diol-containing molecules, and the method can be extended to other food samples and biofluids.
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| GB/T 7714 | Chen, Jiajing , Huang, Huan , Ouyang, Dan et al. A reactive matrix for in situ chemical derivatisation and specific detection of cis-diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry [J]. | ANALYST , 2023 , 148 (21) : 5402-5406 . |
| MLA | Chen, Jiajing et al. "A reactive matrix for in situ chemical derivatisation and specific detection of cis-diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry" . | ANALYST 148 . 21 (2023) : 5402-5406 . |
| APA | Chen, Jiajing , Huang, Huan , Ouyang, Dan , Lin, Jiali , Chen, Zhuling , Cai, Zongwei et al. A reactive matrix for in situ chemical derivatisation and specific detection of cis-diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry . | ANALYST , 2023 , 148 (21) , 5402-5406 . |
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Phthalate esters (PAEs) are a typical group of endocrine-disrupting chemicals (EDCs) and widely found in the environment, which have attracted great concern due to the potential risks to environment and human health. It is urgent to develop a high-efficiency and high-sensitivity analytical approach for enrichment and determination of ultra-trace PAEs. Herein, magnetic covalent organic frameworks (Fe3O4@TAPB-DVA) were fabricated via a one-pot approach at room temperature and explored as a magnetic enrichment probe with high surface area (275.50 m(2)/g), good crystallinity, regular pore size distribution (3.1 nm) and outstanding saturation magnetization (26.5 emu/g). Accordingly, a simple and sensitive method based on magnetic solid-phase extraction (MSPE) combined with HPLC-MS/MS was established to detect ultra-trace PAEs from fine particulate matter (PM2.5) samples. The proposed method showed wide linear ranges (1-400 ng/L), good linearity (r > 0.9978) and high enrichment factors (EFs, 6.99-95.01 folds) with low detection limits (LODs) ranged from 0.01 to 0.5 ng/L (S/N >= 3). On this basis, the proposed method was substantially employed for sensitive detection of low-abundance PAEs from PM2.5 samples, suggesting the promising application of the Fe3O4@TAPB-DVA in sample enrichment. (C) 2022 Elsevier B.V. All rights reserved.
Keyword ：
Endocrine-disrupting chemicals Endocrine-disrupting chemicals Fine particulate matter Fine particulate matter Magnetic covalent organic frameworks Magnetic covalent organic frameworks Magnetic solid-phase extraction Magnetic solid-phase extraction Phthalate esters Phthalate esters
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| GB/T 7714 | Zhang, Shasha , Wang, Ran , Wu, Yijing et al. One-pot synthesis of magnetic covalent organic frameworks for highly efficient enrichment of phthalate esters from fine particulate matter [J]. | JOURNAL OF CHROMATOGRAPHY A , 2022 , 1667 . |
| MLA | Zhang, Shasha et al. "One-pot synthesis of magnetic covalent organic frameworks for highly efficient enrichment of phthalate esters from fine particulate matter" . | JOURNAL OF CHROMATOGRAPHY A 1667 (2022) . |
| APA | Zhang, Shasha , Wang, Ran , Wu, Yijing , Chen, Zhuling , Tong, Ping , He, Yu et al. One-pot synthesis of magnetic covalent organic frameworks for highly efficient enrichment of phthalate esters from fine particulate matter . | JOURNAL OF CHROMATOGRAPHY A , 2022 , 1667 . |
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Pyrite (FeS2) is known for one alternative to the promising anode materials for lithium-ion batteries (LIBs) on account of the low price, friendliness to environment and comparable higher theoretical capacity. Nonetheless, its long-term cycling performance is still not satisfied. In our present work, a FeS2@carbon composite coated with reduced graphene oxide (rGO) (rGO@FeS2@C) was synthesized to settle this problem. With the addition of rGO, the huge volume change was relieved and the big pulverization was also alleviated. When applied as the anode material for LIBs, the rGO@FeS2@C electrode could deliver outstanding electrochemical performance owing to its special structure. At 1 A g(-1), it could exhibit a high specific capacity of 820.7 mA h g(-1) after 300 cycles. Even if when the current density reaches to a higher degree of 5 A g(-1), rGO@FeS2@C could still exhibit a great specific capacity to 600.8 mA h g(-1) in the wake of 1100 cycles, which is one of the best results to FeS2 systems. In addition, we also compare its performance with the commercialized FeS2, further confirming the good electrochemical properties of rGO@FeS2@C.
Keyword ：
Electrochemical properties Electrochemical properties Lithium-ion batteries Lithium-ion batteries Pyrite Pyrite Reduced graphene oxide Reduced graphene oxide
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| GB/T 7714 | Yang, Rong , Wang, Cong , Li, Yafeng et al. Construction of FeS2@C coated with reduced graphene oxide as high-performance anode for lithium-ion batteries [J]. | JOURNAL OF ELECTROANALYTICAL CHEMISTRY , 2022 , 918 . |
| MLA | Yang, Rong et al. "Construction of FeS2@C coated with reduced graphene oxide as high-performance anode for lithium-ion batteries" . | JOURNAL OF ELECTROANALYTICAL CHEMISTRY 918 (2022) . |
| APA | Yang, Rong , Wang, Cong , Li, Yafeng , Chen, Zhuling , Wei, Mingdeng . Construction of FeS2@C coated with reduced graphene oxide as high-performance anode for lithium-ion batteries . | JOURNAL OF ELECTROANALYTICAL CHEMISTRY , 2022 , 918 . |
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Amyloid beta-peptide 1-42 (A beta 1-42) is one of the biomarkers of Alzheimer's disease, and its selective capture and quantitative detection are important for diagnosis and treatment of Alzheimer's disease. Herein, copper(II) ions-immobilized virus-like hollow covalent organic frameworks (V-HCOFs@Cu2+) were synthesized by a facile approach. The as-prepared V-HCOFs@Cu2+ showed unique morphology, ultrahigh specific surface (2552 m(2)/g), uniform mesoporous structure (3.2 nm), superior chemical stability and abundant binding sites. Based on these excellent properties, the V-HCOFs@Cu2+ could be adopted as an ideal enrichment probe for highly efficient capture of A beta 1-42, exhibiting high adsorption capacity (320 mg/g), and fast adsorption equilibration time (3 min). In addition, an attractive approach of the V-HCOFs@Cu2+-based matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was developed for the rapid screening and quantitative analysis of A beta 1-42 in human serum by using C-peptide as an internal standard, which exhibited low limit of detection (LOD, 0.2 fmol/mu L), and satisfactory recovery. This work provides an alternative solution for enrichment of biomarkers and also offers the potential applications of COFs in clinical analysis (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amyloid beta-peptide 1-42 Amyloid beta-peptide 1-42 Capture Capture Matrix-assisted laser desorption/ionization mass spectrometry Matrix-assisted laser desorption/ionization mass spectrometry Metal ion immobilization Metal ion immobilization Virus-like hollow covalent organic frameworks Virus-like hollow covalent organic frameworks
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| GB/T 7714 | Ma, Wende , Zhong, Chao , Lin, Juan et al. Copper(II) ions-immobilized virus-like hollow covalent organic frameworks for highly efficient capture and sensitive analysis of amyloid beta-peptide 1-42 by MALDI-MS [J]. | CHINESE CHEMICAL LETTERS , 2022 , 33 (12) : 5174-5179 . |
| MLA | Ma, Wende et al. "Copper(II) ions-immobilized virus-like hollow covalent organic frameworks for highly efficient capture and sensitive analysis of amyloid beta-peptide 1-42 by MALDI-MS" . | CHINESE CHEMICAL LETTERS 33 . 12 (2022) : 5174-5179 . |
| APA | Ma, Wende , Zhong, Chao , Lin, Juan , Chen, Zhuling , Li, Guorong , Tong, Wei et al. Copper(II) ions-immobilized virus-like hollow covalent organic frameworks for highly efficient capture and sensitive analysis of amyloid beta-peptide 1-42 by MALDI-MS . | CHINESE CHEMICAL LETTERS , 2022 , 33 (12) , 5174-5179 . |
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在分析化学实验教学基础上,引入光谱分析和数据处理,设计了用紫外-可见分光光度法测定铬黑T解离常数的实验.根据系列pH下铬黑T溶液的吸光度,利用ORIGIN进行数学拟合,推导出相应的数学模型,计算铬黑T水溶液的解离常数pKa1、pKa2、pKa3.实验方案简单高效,结果准确度高,可以拓展本科化学实验内容,深入理解酸碱解离过程,加强对仪器分析的认识和应用,培养学生实验设计、数据处理、拟合建模、推导判断的综合能力.
Keyword ：
紫外-可见分光光度法 紫外-可见分光光度法 解离常数 解离常数 铬黑T 铬黑T
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| GB/T 7714 | 孙瑞卿 , 许紫婷 , 陈珠灵 et al. 分光光度法测定铬黑T解离常数实验设计 [J]. | 大学化学 , 2022 , 37 (12) : 183-190 . |
| MLA | 孙瑞卿 et al. "分光光度法测定铬黑T解离常数实验设计" . | 大学化学 37 . 12 (2022) : 183-190 . |
| APA | 孙瑞卿 , 许紫婷 , 陈珠灵 , 林佳丽 . 分光光度法测定铬黑T解离常数实验设计 . | 大学化学 , 2022 , 37 (12) , 183-190 . |
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介绍一个由科研成果转化的分析化学综合设计性实验——纸基显色分析法测定白酒中硫离子的含量。硫离子与作为过氧化物模拟酶的四磺基酞菁铁(Fe(Ⅲ)TSPc)在酞菁环平面的轴向位置与中心铁原子配位,能进一步促进过氧链的断裂及高活性中间体高价铁氧正离子自由基的生成,导致3,3′,5,5′-四甲基联苯胺(TMB)氧化产物在纸基上显色加深。利用颜色强度与硫离子含量的关系,可实现对硫离子简单、快速、实时、可靠的检测。本实验综合运用化学、光学、计算机软件等技术,对实验室硬件要求低,易于推广,且实验操作难度适中,内容新颖,综合性强,有利于培养学生实验知识灵活运用的能力。
Keyword ：
3′ 3′ 5 5 5′-四甲基联苯胺纸基分析 5′-四甲基联苯胺纸基分析 硫离子四磺基酞菁铁3 硫离子四磺基酞菁铁3
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| GB/T 7714 | 林佳丽 , 林立超 , 陈珠灵 et al. 纸基显色分析法测定白酒中硫离子的含量——推荐一个分析化学综合设计性实验 [J]. | 化学教育(中英文) , 2021 , 42 (20) : 63-68 . |
| MLA | 林佳丽 et al. "纸基显色分析法测定白酒中硫离子的含量——推荐一个分析化学综合设计性实验" . | 化学教育(中英文) 42 . 20 (2021) : 63-68 . |
| APA | 林佳丽 , 林立超 , 陈珠灵 , 王建 . 纸基显色分析法测定白酒中硫离子的含量——推荐一个分析化学综合设计性实验 . | 化学教育(中英文) , 2021 , 42 (20) , 63-68 . |
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Abstract ：
结合仪器分析实验的特点和教学中存在的问题,阐述了虚拟仿真技术应用于仪器分析实验教学对线下实验的补充作用,并介绍了虚拟仿真实验教学在应对"停课不停学"等特殊状况的出色表现,通过问卷和互动反馈,准确评估学生的学习状况,指出虚拟仿真实验的局限性,提出线上虚拟仿真与线下课堂实验相结合的教学模式,促进仪器分析实验教学质量的提升。
Keyword ：
仪器分析实验 仪器分析实验 教学改革 教学改革 线上教学 线上教学 虚拟仿真 虚拟仿真
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| GB/T 7714 | 林佳丽 , 王建 , 陈珠灵 et al. 常态化疫情防控下的仪器分析实验教学实践的探讨 [J]. | 大学化学 , 2021 , 36 (09) : 10-17 . |
| MLA | 林佳丽 et al. "常态化疫情防控下的仪器分析实验教学实践的探讨" . | 大学化学 36 . 09 (2021) : 10-17 . |
| APA | 林佳丽 , 王建 , 陈珠灵 , 袁耀锋 . 常态化疫情防控下的仪器分析实验教学实践的探讨 . | 大学化学 , 2021 , 36 (09) , 10-17 . |
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