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学者姓名：杜蔚
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Abstract ：
Real-time monitoring the therapeutic process of sonodynamic therapy (SDT) is essential to optimize the treatment course in time and eventually improve the efficacy. The generation of singlet oxygen (1O2) is a quintessential characteristic of SDT, which permits non-invasive monitoring of SDT by real-time imaging of 1O2 inside the tumor. Nonetheless, the majority of probes are unable to measure 1O2 in real time because of its short half-life and strong oxidative capacity. Here, the study constructs a ratiometric nanoplatform (DTPI) utilizing two fluorescent probes and the sonosensitizer TiO2. The poisonous 1O2 generated by DTPI following ultrasonic (US) radiation efficiently destroys tumor cells. The structural disruption of fluorescent dye IR-1061 by 1O2 leads to a reduction in the DTPI fluorescence signal at 1100 nm, while US radiation has no impact on the fluorescence signal at 1550 nm. Thus, DTPI provides a precise and consistent reflection of the treatment efficacy at the tumor site, leveraging the ratiometric fluorescence signal and variations in oxygen content throughout the treatment process. This ratiometric-fluorescence-based reflection strategy establishes an effective and dependable platform for the real-time monitoring and assessment of the cancer therapeutic effect through ratiometric probes. The study develops a novel second near-infrared (NIR-II) ratiometric fluorescent nanoplatform for real-time monitoring and evaluating cancer sonodynamic therapy efficacy in vivo. image
Keyword ：
nanoplatform nanoplatform NIR-II NIR-II ratiometric fluorescent imaging ratiometric fluorescent imaging real-time monitoring and evaluating real-time monitoring and evaluating sonodynamic therapy sonodynamic therapy
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| GB/T 7714 | Yang, Kaiqiong , Tang, Huaiding , Zhang, Yiping et al. NIR-II Ratiometric Fluorescent Nanoplatform for Real-Time Monitoring and Evaluating Cancer Sonodynamic Therapy Efficacy [J]. | ADVANCED OPTICAL MATERIALS , 2024 , 12 (17) . |
| MLA | Yang, Kaiqiong et al. "NIR-II Ratiometric Fluorescent Nanoplatform for Real-Time Monitoring and Evaluating Cancer Sonodynamic Therapy Efficacy" . | ADVANCED OPTICAL MATERIALS 12 . 17 (2024) . |
| APA | Yang, Kaiqiong , Tang, Huaiding , Zhang, Yiping , Wu, Ying , Su, Lichao , Zhang, Xuan et al. NIR-II Ratiometric Fluorescent Nanoplatform for Real-Time Monitoring and Evaluating Cancer Sonodynamic Therapy Efficacy . | ADVANCED OPTICAL MATERIALS , 2024 , 12 (17) . |
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Plasmonic nanoparticles and their assemblies have been widely used in biosensing, optical imaging, and biomedicine over the past few decades. Especially in the field of radiotherapy, the physicochemical prop-erties of high-Z plasmonic nanomaterials endow them with the ability to sensitize radiotherapy. Compared with single particles, the assembled structure with tunable properties leads to versatile appli-cations in drug delivery and cancer treatment. In this review, we focus on plasmonic nanoparticles and their assemblies for cancer radiotherapy. First, the sensitization mechanism of plasmonic radiosensitizers is briefly introduced. Subsequently, the recent progress in cancer radiotherapy is systematically discussed according to the structure and shape classification. Finally, the current challenges and future perspectives in this field are also discussed in detail.(c) 2023 Elsevier B.V. All rights reserved.
Keyword ：
Assemblies Assemblies Optical imaging Optical imaging Plasmonic nanoparticles Plasmonic nanoparticles Radiosensitizer Radiosensitizer Radiotherapy Radiotherapy
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| GB/T 7714 | Wu, Ying , Zhu, Kang , Zhang, Xuan et al. Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy [J]. | ADVANCED DRUG DELIVERY REVIEWS , 2023 , 194 . |
| MLA | Wu, Ying et al. "Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy" . | ADVANCED DRUG DELIVERY REVIEWS 194 (2023) . |
| APA | Wu, Ying , Zhu, Kang , Zhang, Xuan , Du, Wei , Song, Jibin , Yang, Huanghao . Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy . | ADVANCED DRUG DELIVERY REVIEWS , 2023 , 194 . |
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Over the past few decades, pretargeted bioimaging has made significant contributions to disease diagnosis and the real-time visualization of biological processes. Notably, the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) has shown enormous potential in pretargeted bioimaging applications by capitalizing on its rapid kinetics, specific reactivity, biorthogonality and biocompatibility. To date, imaging probes based on the Tz-TCO click reaction have been extensively developed and widely used for pretargeted bioimaging applications. In this review, we focus on the Tz-TCO click reaction and summarize its applications in pretargeted bioimaging. Firstly, the fundamental principles for designing imaging probes based on the Tz-TCO click reaction are explained. Then, recent advances in imaging probes based on the Tz-TCO click reaction are discussed in detail. Finally, the current challenges and perspectives of the Tz-TCO click reaction in pretargeted bioimaging applications are presented. The Tz-TCO click reaction-based pretargeting bioimaging strategy involves two steps: (1) Enrichment of the first bioorthogonal component (Tz/TCO moiety) at targets of interest (TOI) by using a functional group-modified Tz/TCO moiety; (2) addition of the second bioorthogonal component (TCO/Tz motif) for the in situ Tz-TCO click reaction, which is accompanied by the acquisition of imaging signal at TOI.image
Keyword ：
IEDDA reaction IEDDA reaction imaging probe imaging probe pretargeted bioimaging pretargeted bioimaging Tz-TCO click reaction Tz-TCO click reaction
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| GB/T 7714 | Liao, Aihua , Du, Wei , Yang, Huanghao . The Inverse Electron Demand Diels-Alder Reaction Between Tetrazine and Trans-Cyclooctene for Pretargeted Bioimaging Applications [J]. | ANALYSIS & SENSING , 2023 , 4 (2) . |
| MLA | Liao, Aihua et al. "The Inverse Electron Demand Diels-Alder Reaction Between Tetrazine and Trans-Cyclooctene for Pretargeted Bioimaging Applications" . | ANALYSIS & SENSING 4 . 2 (2023) . |
| APA | Liao, Aihua , Du, Wei , Yang, Huanghao . The Inverse Electron Demand Diels-Alder Reaction Between Tetrazine and Trans-Cyclooctene for Pretargeted Bioimaging Applications . | ANALYSIS & SENSING , 2023 , 4 (2) . |
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Accurately quantifying microRNA levels in vivo is of great importance for cancer staging and prognosis. However, the low abundance of microRNAs and interference from the complex tumor microenvironment usually limit the real-time quantification of microRNAs in vivo. Herein, for the first time, we develop an ultrasensitive microRNA (miR)-21 activated ratiometric nanoprobe for quantification of the miR-21 concentration in vivo without signal amplification as well as dynamic tracking of its distribution. The core-satellite nanoprobe by miR-21 triggered in situ self-assembly was built on nanogapped gold nanoparticles (AuNNP probe) and gold nanoparticles (AuNP probe). The AuNP probe generated a photoacoustic (PA) signal and ratiometric SERS signal with the variation of miR-21, whereas the AuNNP probe served as an internal standard, enabling ratiometric SERS imaging of miR-21. The absolute concentration of miR-21 in MCF-7 tumor-bearing mice was quantified to be 83.8 +/- 24.6 pM via PA and ratiometric SERS imaging. Our strategy provides a powerful approach for the quantitative detection of microRNAs in vivo, providing a reference for the clinical treatment of cancer.
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| GB/T 7714 | Zheng, Liting , Li, Qingqing , Wu, Ying et al. Quantitative detection of microRNA-21 in vivo using in situ assembled photoacoustic and SERS nanoprobes [J]. | CHEMICAL SCIENCE , 2023 , 14 (47) : 13860-13869 . |
| MLA | Zheng, Liting et al. "Quantitative detection of microRNA-21 in vivo using in situ assembled photoacoustic and SERS nanoprobes" . | CHEMICAL SCIENCE 14 . 47 (2023) : 13860-13869 . |
| APA | Zheng, Liting , Li, Qingqing , Wu, Ying , Su, Lichao , Du, Wei , Song, Jibin et al. Quantitative detection of microRNA-21 in vivo using in situ assembled photoacoustic and SERS nanoprobes . | CHEMICAL SCIENCE , 2023 , 14 (47) , 13860-13869 . |
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Owing to the high sensitivity and high spatial resolution, fluorescence (FL) imaging has been widely applied for visualizing biological processes. To gain insight into molecular events on deeper tissues, photoacoustic (PA) imaging with better deep-tissue imaging capability can be incorporated to provide complementary visualization and quantitative information on the pathological status. However, the development of activatable imaging probes to achieve both FL and PAsignal amplification remains challenging because the enhancement oflight absorption in PA imaging often caused the quenching of FL signal.Herein, wefirst developed a caspase-3 enzyme activatable nanoprobe ofa nanogapped gold nanoparticle coated with AIE molecule INT20 andDEVD peptides (AuNNP@DEVD-INT20) for tumor FL and PAimaging and subsequent imaging-guided radiotherapy. The nanoprobecould interact with GSH and caspase-3 enzyme to liberate INT20 molecules, leading to AIE. Simultaneously, thein situself-assembly of AuNPs was achieved through the cross-linking reaction between the sulfhydryl and the maleimide, resulting in ratiometric PAimaging in tumor. Remarkably, the nanoprobe can generate richful ROS for cancer radiotherapy under X-ray irradiation. The platform not only achieves the aggregation-induced FL and PA signal enhancement but also provides a general strategy for imaging of various biomarkers, eventually benefiting precise cancer therapy.
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| GB/T 7714 | Yuan, Meng , Fang, Xiao , Wu, Ying et al. Activatable Nanoprobe with Aggregation-Induced Dual Fluorescence and Photoacoustic Signal Enhancement for Tumor Precision Imaging and Radiotherapy [J]. | ANALYTICAL CHEMISTRY , 2022 , 94 (12) : 5204-5211 . |
| MLA | Yuan, Meng et al. "Activatable Nanoprobe with Aggregation-Induced Dual Fluorescence and Photoacoustic Signal Enhancement for Tumor Precision Imaging and Radiotherapy" . | ANALYTICAL CHEMISTRY 94 . 12 (2022) : 5204-5211 . |
| APA | Yuan, Meng , Fang, Xiao , Wu, Ying , Xu, Yuanji , Feng, Hongjuan , Mu, Jing et al. Activatable Nanoprobe with Aggregation-Induced Dual Fluorescence and Photoacoustic Signal Enhancement for Tumor Precision Imaging and Radiotherapy . | ANALYTICAL CHEMISTRY , 2022 , 94 (12) , 5204-5211 . |
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Metformin is commonly used for clinical treatment of type-2 diabetes, but long-term or overdose intake of metformin usually causes selective upregulation of H2S level in the liver, resulting in liver injury. Therefore, tracking the changes of H2S content in the liver would contribute to the prevention and diagnosis of liver injury. However, in the literature, there are few reports on ratiometric PA molecular probes for H2S detection in drug-induced liver injury (DILI). Accordingly, here we developed a H2S-activated ratiometric PA probe, namely BDP-H2S, based Aza-BODIPY dye for detecting the H2S upregulation of metformin-induced liver injury. Due to the intramolecular charge transfer (ICT) effect, BDP-H2S exhibited a strong PA signal at 770 nm. Following the response to H2S, its ICT effect was recovered which showed a decrement of PA(7)(70) and an enhancement of PA(840). The ratiometric PA signal (PA(840)/PA(7)(70)) showed excellent H2S selectivity response with a low limit of detection (0.59 mu M). Bioimaging experiments demonstrated that the probe has been successfully used for ratiometric PA imaging of H2S in cells and metformin-induced liver injury in mice. Overall, the designed probe emerges as a powerful tool for noninvasive and accurate imaging of H2S level and tracking its distribution and variation in liver in-real time.
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| GB/T 7714 | Wu, Rongrong , Chen, Zhongxiang , Huo, Hongqi et al. Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging [J]. | ANALYTICAL CHEMISTRY , 2022 , 94 (30) : 10797-10804 . |
| MLA | Wu, Rongrong et al. "Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging" . | ANALYTICAL CHEMISTRY 94 . 30 (2022) : 10797-10804 . |
| APA | Wu, Rongrong , Chen, Zhongxiang , Huo, Hongqi , Chen, Lanlan , Su, Lichao , Zhang, Xuan et al. Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging . | ANALYTICAL CHEMISTRY , 2022 , 94 (30) , 10797-10804 . |
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Optical imaging in the second near-infrared (NIR-II, 900-1700 nm) window has been extensively investigated for bioimaging. However, a strong autofluorescence background from real-time excitation light significantly reduces the images' quality of NIR-II fluorescence (FL) imaging. To resolve this issue, a NIR-II self-luminous small molecule (CLPD) based on bioluminescence (BL) resonance energy transfer (BRET) mechanism is first developed. The reactive oxygen species (ROS) can trigger NIR-II BL and reduce the NIR-II FL signals of the CLPD simultaneously, enabling ROS-correlated ratiometric BL/FL imaging. CLPD is used for high-contrast NIR-II BL imaging of osteoarthritis as well as guiding the treatment process by ratiometric BL/FL imaging. Moreover, CLPD is applied for NIR-II BL imaging of tumor triggered by the generated ROS during PDT. A correlation between the ratiometric NIR-II BL/FL signal and tumor size is constructed, providing a trustworthy tool for early assessment of PDT effect. Overall, this study presents a novel NIR-II self-luminous small molecular probe for in vivo imaging and provides a strategy for design a self-evaluation system of therapeutic effect.
Keyword ：
activatable probes activatable probes bioluminescence bioluminescence biosensing biosensing in vivo bioimaging in vivo bioimaging NIR-II imaging NIR-II imaging
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| GB/T 7714 | Yuan, Meng , Fang, Xiao , Liu, Jianyong et al. NIR-II Self-Luminous Molecular Probe for In Vivo Inflammation Tracking and Cancer PDT Effect Self-Evaluating [J]. | SMALL , 2022 , 19 (11) . |
| MLA | Yuan, Meng et al. "NIR-II Self-Luminous Molecular Probe for In Vivo Inflammation Tracking and Cancer PDT Effect Self-Evaluating" . | SMALL 19 . 11 (2022) . |
| APA | Yuan, Meng , Fang, Xiao , Liu, Jianyong , Yang, Kaiqiong , Xiao, Shenggan , Yang, Sheng et al. NIR-II Self-Luminous Molecular Probe for In Vivo Inflammation Tracking and Cancer PDT Effect Self-Evaluating . | SMALL , 2022 , 19 (11) . |
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Real-time imaging of reactive oxygen species (ROS) during cisplatin chemotherapy of cancer is imperative to fully reveal their functions in the biological response to cisplatin. Currently, using a bioluminescent probe for real-time imaging of a specific ROS in vivo during cisplatin chemotherapy has not been achieved. Herein, three bioluminescent probes, F Probe, N Probe and P Probe were synthesized for real-time imaging of the primary ROS, O-2(center dot-). They all consisted of a bioluminescent emitter (D)-luciferin ((D)-LH2) and an O-2(center dot-)-recognition group, and their bioluminescent signal could be turned on in response to O-2(center dot-). In vitro results indicated that P Probe was the most suitable one among the three probes for detection of O-2(center dot-), with high sensitivity, excellent selectivity and stability. P Probe was then successfully applied for real-time imaging of O-2(center dot-) in both cancer cells and tumors during cisplatin chemotherapy. The imaging results demonstrated that O-2(center dot-) amount in cancer cells increased with the increasing dose of cisplatin, and that cisplatin-induced upregulation of O-2(center dot-) level in cancer cells was upstream of the cancer-killing pathway of cisplatin. We envision that P Probe may serve as an elucidative tool to further explore the role of O-2(center dot-) in cisplatin chemotherapy.
Keyword ：
Bioluminescence Bioluminescence Cancer chemotherapy Cancer chemotherapy Cisplatin Cisplatin Reactive oxygen species Reactive oxygen species Real-time imaging Real-time imaging Turn-on probe Turn-on probe
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| GB/T 7714 | Li, Qian , Chen, Zhongxiang , Su, Lichao et al. Constructing turn-on bioluminescent probes for real-time imaging of reactive oxygen species during cisplatin chemotherapy [J]. | BIOSENSORS & BIOELECTRONICS , 2022 , 216 . |
| MLA | Li, Qian et al. "Constructing turn-on bioluminescent probes for real-time imaging of reactive oxygen species during cisplatin chemotherapy" . | BIOSENSORS & BIOELECTRONICS 216 (2022) . |
| APA | Li, Qian , Chen, Zhongxiang , Su, Lichao , Wu, Ying , Du, Wei , Song, Jibin . Constructing turn-on bioluminescent probes for real-time imaging of reactive oxygen species during cisplatin chemotherapy . | BIOSENSORS & BIOELECTRONICS , 2022 , 216 . |
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Currently, drug-induced liver injury (DILI) has become a huge concern for the majority of modern medicine, whereas the diagnosis of DILI is still in its infancy due to the lack of appropriate methods. Herein, based on the fact that nitric oxide (NO) has been recognized as an early unifying, direct, and vital biomarker for DILI, we rationally designed and developed a NO-responsive ratiometric fluorescent nanoprobe DCNP@MPS@IR NO to quantitatively detect NO and monitor DILI in the second near-infrared (NIR-II) window. In the presence of NO, due to the conversion of IR NO into IR RA and excellent stability of the downconversion nanoparticle (DCNP), DCNP@MPS@IR NO could present a "Turn-On" fluorescence signal at 1050 nm under 808 nm excitation (F-1050 (Em,) (808) (Ex)) and an "Always-On" fluorescence signal at 1550 nm under 980 nm excitation (F-1550 Em,F- (980 Ex)), which led to a "Turn-On" ratiometric fluorescence signal F-1050( Em, 808 Ex)/F-1550 Em,F- 980 Ex. DCNP@MPS@IR NO was then successfully applied in vitro to selectively detect NO, at a linear concentration range of 0-100 mu M with a limit of detection of 0.61 mu M. In vivo results revealed that DCNP@MPS@IR was available to quantify NO in acetaminophen (APAP)-induced liver injury, monitor DILI, and screen an antidote for APAP through NIR-II ratiometric fluorescence imaging. We envision that our nanoprobe DCNP@MPS@IR NO might become a really useful biotechnology tool for visualizing and early diagnosis of drug-induced liver injury and revealing the mechanism of drug hepatotoxicity in the clinic in the near future.
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| GB/T 7714 | Bai, Feicheng , Du, Wei , Liu, Xia et al. A NO-Responsive Ratiometric Fluorescent Nanoprobe for Monitoring Drug-Induced Liver Injury in the Second Near-Infrared Window [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (46) : 15279-15287 . |
| MLA | Bai, Feicheng et al. "A NO-Responsive Ratiometric Fluorescent Nanoprobe for Monitoring Drug-Induced Liver Injury in the Second Near-Infrared Window" . | ANALYTICAL CHEMISTRY 93 . 46 (2021) : 15279-15287 . |
| APA | Bai, Feicheng , Du, Wei , Liu, Xia , Su, Lichao , Li, Zhi , Chen, Tao et al. A NO-Responsive Ratiometric Fluorescent Nanoprobe for Monitoring Drug-Induced Liver Injury in the Second Near-Infrared Window . | ANALYTICAL CHEMISTRY , 2021 , 93 (46) , 15279-15287 . |
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Cathepsin B (CTSB) is a lysosomal protease that is overexpressed in the early stage of many cancer types. Precise evaluation of CTSB expression in vivo may provide a promising method for the early diagnosis of cancers. By virtue of the high-resolution PA imaging modality, a "smart" photoacoustic (PA) probe Cypate-CBT, which can self-assemble to cypate-containing nanoparticles in response to abundant GSH and CTSB inside tumor cells, was developed for the sensitive and specific detection of CTSB activity. Compared with unmodified Cypate, our probe Cypate-CBT exhibited a 4.9-fold or 4.7-fold PA signal enhancement in CTSB-overexpressing MDA-MB-231 cancer cells or tumors, respectively, revealing intracellular accumulation of the probe after CTSB-initiated self-assembly. We expect Cypate-CBT to be employed as an effective PA imaging agent for clinical diagnosis of cancer at early stages.
Keyword ：
Cathepsin B Cathepsin B Nanoparticles Nanoparticles Photoacoustic imaging Photoacoustic imaging Self-assembly Self-assembly
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| GB/T 7714 | Wang, Chenchen , Du, Wei , Wu, Chenfan et al. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2021 , 61 (5) . |
| MLA | Wang, Chenchen et al. "Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 61 . 5 (2021) . |
| APA | Wang, Chenchen , Du, Wei , Wu, Chenfan , Dan, Shan , Sun, Miao , Zhang, Tong et al. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2021 , 61 (5) . |
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