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学者姓名：陈兆委
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Abstract ：
Bioorthogonal catalysis mediated by abiotic transition metal catalysts (TMCs) is emerging as a momentum- gathering strategy for in situ generation of therapeutics. However, the unpredictable leakage and deposition of TMCs in living systems easily lead to nonspecific exposure of catalysts and concomitant off-target prodrug activation. Herein, we propose an enzyme-gated bioorthogonal catalytic nanoreactor constructed from hyaluronic acid (HA)-coated dendritic mesoporous silica nanoparticles (DMSNs), where the latter serves as a host for robustly immobilizing organometallic Ru(II) catalysts via covalent interactions. The covalent immobilization of catalysts within the nanoscaffold effectively avoids nonspecific metal leakage under biological conditions. Importantly, the grafted HA not only acts as a "gatekeeper" preventing unintended catalyst exposure in nontargeted tissues but also acts as a ligand targeting CD44 overexpressed cancer cells. Upon receptor-mediated endocytosis into tumor cells, HA is degraded by the overexpressed hyaluronidase-1, leading to the channel opening of the nanoreactors and hence gaining the accessibility of Ru(II) complexes to prodrugs. The therapeutic potency of this enzyme-gated nanoreactor in mediating site- specific activation of caged prodrugs was systematically demonstrated both in cellular settings and in tumor-bearing murine models. This enzyme-gated strategy enhances the efficacy of localized treatment while avoiding off-target prodrug activation, paving the way for advancing bioorthogonal catalysis for disease management in a safe and effective way.
Keyword ：
bioorthogonal catalysis bioorthogonal catalysis cancer therapy cancer therapy catalyst immobilization catalyst immobilization enzyme-gated enzyme-gated prodrugs prodrugs
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| GB/T 7714 | Guo, Yuheng , Jiang, Fang , Zhu, Xiaohui et al. An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation [J]. | NANO RESEARCH , 2025 , 18 (2) . |
| MLA | Guo, Yuheng et al. "An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation" . | NANO RESEARCH 18 . 2 (2025) . |
| APA | Guo, Yuheng , Jiang, Fang , Zhu, Xiaohui , He, Wen , Song, Sijie , Shou, Xuecen et al. An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation . | NANO RESEARCH , 2025 , 18 (2) . |
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Pickering emulsions are dispersions of two immiscible liquids stabilized by surface-active colloidal nano-/microparticles. Their compartmentalized structures closely resemble the characteristics of cellular and subcellular systems, enabling the development of biomimetic microreactors that enhance catalytic processes. By enlarging interfacial areas while effectively partitioning reactants into their preferred phases, Pickering emulsion-based microreactors improve kinetic parameters and prevent unwanted interactions. The adaptability of Pickering emulsions is further augmented through modifications to the properties and composition of the particle emulsifiers, rendering them multifunctional and facilitating efficient reactions between immiscible phases, such as oil and water, especially when the emulsifiers themselves act as catalysts. This review summarizes recent advances in Pickering emulsion-based biomimetic microreactors, focusing on the versatile choice of various particles, design principles, and their applications in facilitating biphasic catalysis in a biomimetic way. We also discuss the challenges and future perspectives for further refining these microreactors for enhanced biphasic catalytic processes.
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| GB/T 7714 | Xu, Xiao , Zhou, Min , Wu, Ting et al. Pickering emulsion-based biomimetic microreactors [J]. | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) : 1290-1311 . |
| MLA | Xu, Xiao et al. "Pickering emulsion-based biomimetic microreactors" . | MATERIALS CHEMISTRY FRONTIERS 9 . 8 (2025) : 1290-1311 . |
| APA | Xu, Xiao , Zhou, Min , Wu, Ting , Chen, Zhaowei , Yang, Huanghao . Pickering emulsion-based biomimetic microreactors . | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) , 1290-1311 . |
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a significant challenge in wound infection treatment due to its antibiotic resistance and biofilm formation. To address this, we utilized Escherichia coli (Ec) as a carrier to deliver lysozyme (LYZ) and adsorb the photosensitizer indocyanine green (ICG), resulting in the Ec-LYZ-ICG multifunctional antimicrobial platform. Since both Ec and MRSA are bacteria, this platform can act as a "spy", evading the immune surveillance of MRSA and effectively penetrating infection sites. Upon exposure to 808 nm laser irradiation, Ec-LYZ-ICG utilizes the synergistic effects of photothermal therapy (PTT) and photodynamic therapy (PDT) induced by ICG, which ruptures Ec membrane and releases LYZ. The combined PTT and PDT directly damage MRSA, while LYZ further hydrolyzes and PDT directly damage MRSA, while LYZ further hydrolyzes MRSA. This strategy, with its "spy-like" camouflage and penetration abilities, overcomes MRSA's antibiotic resistance and immune evasion, providing new insights and approaches for the precise treatment of MRSA infections.
Keyword ：
engineered bacteria engineered bacteria lysozyme lysozyme MRSA infection MRSA infection photodynamic therapy photodynamic therapy photothermal therapy photothermal therapy
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| GB/T 7714 | Liu, Yana , Liu, Chuang , Chen, Qi et al. Light activated "spy" bacteria: Mediated PTT/PDT/Lysozyme hydrolysis for synergistic treatment of MRSA wound infections [J]. | NANO RESEARCH , 2025 , 18 (8) . |
| MLA | Liu, Yana et al. "Light activated "spy" bacteria: Mediated PTT/PDT/Lysozyme hydrolysis for synergistic treatment of MRSA wound infections" . | NANO RESEARCH 18 . 8 (2025) . |
| APA | Liu, Yana , Liu, Chuang , Chen, Qi , Chen, Zhaowei , Lu, Chunhua . Light activated "spy" bacteria: Mediated PTT/PDT/Lysozyme hydrolysis for synergistic treatment of MRSA wound infections . | NANO RESEARCH , 2025 , 18 (8) . |
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Perylene diimide (PDI) derivatives have emerged as promising candidates for phototherapeutic and bioimaging applications. PDI-based nanodrugs that incorporate high PDI content, possess biodegradable properties, and achieve combined therapeutic effects remain a significant challenge. In this study, we developed an amphiphilic polymer (poly(ethylene glycol)-b-poly(perylene diimide-co-disulfide)ester-b-poly(ethylene glycol), PSP) featuring PDI segments and disulfide linkers based on a polyprodrug strategy, enabling the construction of doxorubicin (DOX)-loaded nanoparticles (PSP@DOX NPs). The PSP@DOX NPs can generate hyperthermia under light irradiation due to the high content of PDI segments embedded in the PSP. The disulfide bonds in the main chain of PSP confer reduction-induced biodegradability and a controllable drug release property to the nanodrug. Additionally, the abundant carboxyl groups in PSP facilitate pH-dependent electrostatic interactions with DOX, while hydrophobic and pi-pi stacking interactions further promote self-assembly. Moreover, in vitro and in vivo experiments demonstrated that PSP@DOX NPs exhibited effective cellular uptake, enhanced tumor accumulation, significant antitumor effects, and biosafety. Therefore, PSP@DOX NPs hold great potential for combined chemotherapy and photothermal therapy in the treatment of solid tumors.
Keyword ：
combined chemotherapy/PTT combined chemotherapy/PTT DOX DOX drug delivery drug delivery nanoparticle nanoparticle perylene diimide-derivedpolymers perylene diimide-derivedpolymers
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| GB/T 7714 | Wu, Jiazhen , Hu, Xia , Chang, Yuanyuan et al. pH/Reduction/Light-Responsive Nanodrug Based on Perylene Diimide Polyprodrug for Combined Chemotherapy and Photothermal Therapy [J]. | ACS APPLIED NANO MATERIALS , 2025 , 8 (28) : 13981-13992 . |
| MLA | Wu, Jiazhen et al. "pH/Reduction/Light-Responsive Nanodrug Based on Perylene Diimide Polyprodrug for Combined Chemotherapy and Photothermal Therapy" . | ACS APPLIED NANO MATERIALS 8 . 28 (2025) : 13981-13992 . |
| APA | Wu, Jiazhen , Hu, Xia , Chang, Yuanyuan , Sun, Zeyuan , Zhou, Mingyang , Song, Sijie et al. pH/Reduction/Light-Responsive Nanodrug Based on Perylene Diimide Polyprodrug for Combined Chemotherapy and Photothermal Therapy . | ACS APPLIED NANO MATERIALS , 2025 , 8 (28) , 13981-13992 . |
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Plasma with low temperature generated at atmospheric pressure is known as cold atmospheric plasma (CAP). Owing to its unique characteristics and biological effects of inducing tumor cell death without endangering the surrounding healthy tissues, CAP is regarded as an emerging potent anticancer strategy and has been extensively investigated in preclinical research. In this review, we define the reactive species that play a major role in CAP as a novel 'drug' (termed as plasma drug) used in cancer therapy. Various methods of plasma drug use in tumor treatment were summarized, mainly including plasma drug direct delivery, carriers for plasma drug, plasma drug synergistic immunotherapy, plasma drug in combination with nanoparticle therapy, plasma drug delivery with other anti-tumor drugs, and biomedical devices assisted plasma drug delivery. Furthermore, we provide prospective on the future development of plasma drug for cancer therapy. Plasma drug has the potential to evolve into a novel class of cancer therapy with continued technology improvements and multidisciplinary research efforts, providing patients with effective and individualized treatment alternatives. © 2025 Elsevier B.V.
Keyword ：
Cell death Cell death Controlled drug delivery Controlled drug delivery Diseases Diseases Oncology Oncology Plasma applications Plasma applications Targeted drug delivery Targeted drug delivery Tumors Tumors
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| GB/T 7714 | Fu, Danni , Lin, Shiyao , Xu, Qingnan et al. Cold atmospheric plasma as a novel 'drug' for cancer therapy [J]. | Journal of Controlled Release , 2025 , 386 . |
| MLA | Fu, Danni et al. "Cold atmospheric plasma as a novel 'drug' for cancer therapy" . | Journal of Controlled Release 386 (2025) . |
| APA | Fu, Danni , Lin, Shiyao , Xu, Qingnan , Cao, Fei , Khan, Israr , Xu, Shu et al. Cold atmospheric plasma as a novel 'drug' for cancer therapy . | Journal of Controlled Release , 2025 , 386 . |
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Androgenetic alopecia (AGA) is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment, leading to cell apoptosis and eventual loss of hair follicles (HFs). Traditional therapeutic formulations, such as Minoxidil (MXD) tincture, have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness. Here, we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy. The platform combines microneedle (MN) patches loaded with MXD-encapsulated nanostructured lipid carriers (MXD-NLC-MNs) and cold atmospheric plasma (CAP). The MNs' mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells, promoting cell proliferation. Furthermore, in collaboration with MXD, the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor, leading to neoangiogenesis. Meanwhile, the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAP-generated nitric oxide (NO) to the sites of HF lesions, whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation. Consequently, the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models. This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.
Keyword ：
androgenetic alopecia androgenetic alopecia cold atmospheric plasma cold atmospheric plasma drug delivery drug delivery microneedle microneedle nanomedicine nanomedicine
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| GB/T 7714 | Chen, Hao , Tang, Xianzhe , Huang, Yueye et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia [J]. | NANO RESEARCH , 2024 , 17 (7) : 6411-6419 . |
| MLA | Chen, Hao et al. "Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia" . | NANO RESEARCH 17 . 7 (2024) : 6411-6419 . |
| APA | Chen, Hao , Tang, Xianzhe , Huang, Yueye , Chen, Chen , Yang, Yuheng , Hao, Chaojie et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia . | NANO RESEARCH , 2024 , 17 (7) , 6411-6419 . |
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Bacterial biofilm infection is a serious obstacle to clinical therapeutics. Photodynamic therapy (PDT) plays a dynamic role in combating biofilm infection by utilizing reactive oxygen species (ROS)-induced bacterial oxidation injury, showing advantages of mild side effects, spatiotemporal controllability and little drug resistance. However, superfluous glutathione (GSH) present in biofilm and bacteria corporately reduces ROS levels and seriously affects PDT efficiency. Herein, we have constructed a Cu2+-infused porphyrin metal-organic framework (MOF@Cu2+) for the enhanced photodynamic combating of biofilm infection by the maximum depletion of GSH. Our results show that the released Cu2+ from porphyrin MOF@Cu2+ could not only oxidize GSH in biofilm but also consume GSH leaked from ROS-destroyed bacteria, thus greatly weakening the antioxidant system in biofilm and bacteria and dramatically improving the ROS levels. As expected, our dual-enhanced PDT nanoplatform exhibits a strong biofilm eradication ability both in vitro and in an in vivo biofilm-infected mouse model. In addition, Cu2+ can promote biofilm-infected wound closing by provoking cell immigration, collagen sediment and angiogenesis. Besides, no apparent toxicity was detected after treatment with MOF@Cu2+. Overall, our design offers a new paradigm for photodynamic combating biofilm infection.
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| GB/T 7714 | Zhang, Yaoxin , Li, Linpei , Liu, Hui et al. Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (5) : 1317-1329 . |
| MLA | Zhang, Yaoxin et al. "Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 5 (2024) : 1317-1329 . |
| APA | Zhang, Yaoxin , Li, Linpei , Liu, Hui , Zhang, Haixia , Wei, Menghao , Zhang, Junqing et al. Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (5) , 1317-1329 . |
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Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However, traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial micro-compartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme (glucose oxidase/chloroperoxidase) and three-enzyme (invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.
Keyword ：
bacterial microcompartment bacterial microcompartment biocatalysis biocatalysis biomimetics biomimetics chemical warfare agent chemical warfare agent Pickering emulsion Pickering emulsion
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| GB/T 7714 | Xu, Xiao , Xie, Wenqi , Wu, Ting et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) : 3039-3049 . |
| MLA | Xu, Xiao et al. "Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions" . | SCIENCE CHINA-CHEMISTRY 67 . 9 (2024) : 3039-3049 . |
| APA | Xu, Xiao , Xie, Wenqi , Wu, Ting , Chen, Chen , Chen, Xiaoning , Yang, Yuheng et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) , 3039-3049 . |
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Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-mineralization of autologous tumor cells with palladium ions in microfluidic droplets, which endowed the engineered cells with both immune and catalytic functions, to establish a bioorthogonally catalytic tumor whole-cell vaccine. This vaccine showed strong inhibition both in the occurrence and recurrence of tumor by invoking the immediate antitumor immunity and building a long-term immunity.
Keyword ：
Bioorthogonal chemistry Bioorthogonal chemistry Immunotherapy Immunotherapy Microfluidics Microfluidics Palladiumnanocatalyst Palladiumnanocatalyst Self-mineralization Self-mineralization
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| GB/T 7714 | Zeng, Fei , Pan, Yongchun , Wu, Mengnan et al. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy [J]. | ACS NANO , 2024 , 18 (11) : 7923-7936 . |
| MLA | Zeng, Fei et al. "Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy" . | ACS NANO 18 . 11 (2024) : 7923-7936 . |
| APA | Zeng, Fei , Pan, Yongchun , Wu, Mengnan , Lu, Qianglan , Qin, Shurong , Gao, Yanfeng et al. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy . | ACS NANO , 2024 , 18 (11) , 7923-7936 . |
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In situ monitoring microRNA (miRNA) expression in vivo holds immense potential for directly visualizing the occurrence and progression of tumors. However, the significant barrier to developing a probe that can overcome the low abundance of miRNAs while providing an output signal with unlimited tissue penetration depth remains formidable. In this study, we developed a DNA machine-based magnetic resonance imaging nanoprobe (MRINP) for amplified detection of miR-21 in vivo. The MRINP was constructed with superparamagnetic Fe3O4 nano- particles (NPs), paramagnetic Gd-DOTA complexes, and miR-21-activated DNA machines; the DNA machine was composed of hairpin DNAzyme (HD) strands serving as the DNAzyme walker and hairpin substrate (HS) strands serving as the track. Once uptake into tumor cells, the intracellular miR-21 specifically recognized and hybridized with the HD strand, restoring the activity of DNAzyme. Subsequently, the DNAzyme walker autonomously traveled on the surface of MRINP, and each step movement of the DNAzyme walker resulted in the cleavage of its substrate strands and the ensued release of the Gd-DOTA complex-labeled oligonucleotides, turning on the T1 signal of Gd-DOTA complexes for in situ imaging of miR-21 in tumor-bearing mice. This strategy would offer a promising approach for mapping tumor-specific biomarkers in vivo with unlimited penetration depth.
Keyword ：
Biosensor Biosensor DNA machine DNA machine Magnetic resonance imaging Magnetic resonance imaging miR-21 detection miR-21 detection Tumor imaging Tumor imaging
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| GB/T 7714 | Song, Sijie , Wang, Qi , Xie, Jiangao et al. A DNA machine-based magnetic resonance imaging nanoprobe for in vivo microRNA detection [J]. | TALANTA , 2024 , 281 . |
| MLA | Song, Sijie et al. "A DNA machine-based magnetic resonance imaging nanoprobe for in vivo microRNA detection" . | TALANTA 281 (2024) . |
| APA | Song, Sijie , Wang, Qi , Xie, Jiangao , Guo, Yuheng , He, Wen , Yao, Yuhang et al. A DNA machine-based magnetic resonance imaging nanoprobe for in vivo microRNA detection . | TALANTA , 2024 , 281 . |
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