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学者姓名：郑向南
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Abstract ：
As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which is different from other regulated cell death forms morphologically, biochemically, and immunologically. Ferroptosis is regulated by iron metabolism, lipid metabolism, and antioxidant defense systems as well as various transcription factors and related signal pathways. Emerging evidence has highlighted that ferroptosis is associated with many physiological and pathological processes, including cancer, neurodegeneration diseases, cardiovascular diseases, and ischemia/reperfusion injury. Noncoding RNAs are a group of functional RNA molecules that are not translated into proteins, which can regulate gene expression in various manners. An increasing number of studies have shown that noncoding RNAs, especially miRNAs, lncRNAs, and circRNAs, can interfere with the progression of ferroptosis by modulating ferroptosis-related genes or proteins directly or indirectly. In this review, we summarize the basic mechanisms and regulations of ferroptosis and focus on the recent studies on the mechanism for different types of ncRNAs to regulate ferroptosis in different physiological and pathological conditions, which will deepen our understanding of ferroptosis regulation by noncoding RNAs and provide new insights into employing noncoding RNAs in ferroptosis-associated therapeutic strategies.
Keyword ：
circRNAs circRNAs ferroptosis ferroptosis iron metabolism iron metabolism lipid peroxidation lipid peroxidation lncRNAs lncRNAs miRNAs miRNAs ncRNAs ncRNAs
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| GB/T 7714 | Zheng, Xiangnan , Zhang, Cen . The Regulation of Ferroptosis by Noncoding RNAs [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (17) . |
| MLA | Zheng, Xiangnan 等. "The Regulation of Ferroptosis by Noncoding RNAs" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 17 (2023) . |
| APA | Zheng, Xiangnan , Zhang, Cen . The Regulation of Ferroptosis by Noncoding RNAs . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (17) . |
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Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, and immunologically distinct from other regulated cell death forms. Ferroptosis is regulated by iron metabolism, lipid metabolism, anti-oxidant defense systems, as well as various signal pathways. Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms. Emerging evidence demonstrated that hypoxia regulates ferroptosis in certain cell types and conditions. In this review, we summarize the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in physiological and pathological conditions, which may contribute to the numerous diseases therapies.
Keyword ：
ferroptosis ferroptosis hypoxia hypoxia hypoxia-inducible factors hypoxia-inducible factors iron metabolism iron metabolism lipid peroxidation lipid peroxidation
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| GB/T 7714 | Zheng, Xiangnan , Liang, Yuqiong , Zhang, Cen . Ferroptosis Regulated by Hypoxia in Cells [J]. | CELLS , 2023 , 12 (7) . |
| MLA | Zheng, Xiangnan 等. "Ferroptosis Regulated by Hypoxia in Cells" . | CELLS 12 . 7 (2023) . |
| APA | Zheng, Xiangnan , Liang, Yuqiong , Zhang, Cen . Ferroptosis Regulated by Hypoxia in Cells . | CELLS , 2023 , 12 (7) . |
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Lustrin A is the first nacre protein with specific structure and amino acid residue content that was identified in abalone; since its identification, homologs have been found in several abalone species. In this study, we isolated and cloned the complete cDNA of Lustrin A from Haliotis discus hannai, which was named Hdh-Lustrin A. Hdh-Lustrin A has characteristic cysteine- and proline-rich domains, glycine- and serine-rich domains, and a whey acidic protein (WAP)-like C-terminus. The cysteine- and praline-rich domains showed internal similarity repeats that arrayed in gene coding region, and the phylogenetic tree of these repeats indicated that the similarity of structural repetitive unit components in different abalone species, reflecting their evolutionary distance. A tissue distribution analysis showed that the mRNA level of Hdh-Lustrin A has tissue-specific expression in mantle. Under lipopolysaccharide (LPS) challenge, Hdh-Lustrin A showed a significantly increase, while it showed a more complex pattern with two peaks in the process of shell regeneration. Moreover, acidification and warming raised the expression level of Hdh-Lustrin A in shell regeneration in two different manners; acidification raised the gene expression in quick response, in contrast the long run in warming treatment. Similar pattern also has been detected in immune reaction and the thermal treatments. These results suggest that the Hdh-Lustrin A is a nacre protein, which can be distinguished by its cysteine- and proline-rich domain. It involves in shell regeneration and innate immunity in abalone, and its expression pattern during shell regeneration can be disrupted by physicochemical properties of the environment.
Keyword ：
Biomineralization Biomineralization Lustrin A Lustrin A Ocean acidification Ocean acidification Ocean warming Ocean warming
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| GB/T 7714 | Zheng, Xiangnan , Zhao, Shuxian , Lei, Shanshan et al. Cloning and characterization of a novel Lustrin A gene from Haliotis discus hannai [J]. | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY , 2020 , 240 . |
| MLA | Zheng, Xiangnan et al. "Cloning and characterization of a novel Lustrin A gene from Haliotis discus hannai" . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 240 (2020) . |
| APA | Zheng, Xiangnan , Zhao, Shuxian , Lei, Shanshan , Ma, Ruijuan , Liu, Lemian , Xie, Youping et al. Cloning and characterization of a novel Lustrin A gene from Haliotis discus hannai . | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY , 2020 , 240 . |
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Ocean warming and acidification caused by global climate change interferes with the shell growth of mollusks. In abalone Haliotis discus hannai, the microstructural changes in the shell under stress are unclear, and the effect of thermal stress on biomineralization is unknown. The lack of gene information has also hampered the study of abalone biomineralization mechanisms. In this study, the microstructure of reconstructed shell in H. discus hannai was observed to determine the effects of thermal and acidification stress on shell growth. Three nacre protein genes, Hdh-AP7, Hdh-AP24, and Hdh-perlustrin, were characterized, and their expression pattern during shell repair was measured under thermal and acidification stress and compared with those of two known biomineralization-related genes, Hdh-AP-1 and Hdh-defensin. The stress resulted in aragonite plates with corroded or irregular microstructures. The gene expression of two nacre proteins (Hdh-AP7 and Hdh-AP24), which directly induce crystal formation, were more sensitive to thermal stress than to acidification, but the expression of the regulatory nacre protein (Hdh-perlustrin) and the two known genes (Hdh-AP-1 and Hdh-defensin), which are also related to immunity, showed an interlinked, complex pattern change. We concluded that high temperature and acidification damages the shell microstructure by disturbing the expression pattern of biomineralization-related genes.
Keyword ：
Acidification Acidification Biomineralization Biomineralization Climate change Climate change Gastropods Gastropods Gene expression Gene expression Microstructure Microstructure
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| GB/T 7714 | Zheng, Xiangnan , Lei, Shanshan , Zhao, Shuxian et al. Temperature elevation and acidification damage microstructure of abalone via expression change of crystal induction genes [J]. | MARINE ENVIRONMENTAL RESEARCH , 2020 , 162 . |
| MLA | Zheng, Xiangnan et al. "Temperature elevation and acidification damage microstructure of abalone via expression change of crystal induction genes" . | MARINE ENVIRONMENTAL RESEARCH 162 (2020) . |
| APA | Zheng, Xiangnan , Lei, Shanshan , Zhao, Shuxian , Ye, Ganping , Ma, Ruijuan , Liu, Lemian et al. Temperature elevation and acidification damage microstructure of abalone via expression change of crystal induction genes . | MARINE ENVIRONMENTAL RESEARCH , 2020 , 162 . |
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本发明提供一株具有溶藻能力的假交替单胞菌及其在控制米氏凯伦藻赤潮中的应用，属于有害赤潮处理的微生物学领域。该溶藻菌命名为假交替单胞菌(Pseudoalteromonas flavipulchra) FDHY‑MQ5，已于2019年5月20日保藏于中国典型培养物保藏中心，保藏编号：CCTCC NO：M 2019371。该菌种的发酵液以体积比1%加入指数生长期的米氏凯伦藻中，24小时杀藻率为94.3‑98.2%，经发酵条件优化后，每升的菌液可产出菌粉为18‑20g，菌粉质量分数0.04%加入量在24小时处理条件下对米氏凯伦藻溶藻率为99.67‑100%。
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| GB/T 7714 | 石新国 , 陈剑锋 , 谢友坪 et al. 一株具有溶藻能力的假交替单胞菌及其对米氏凯伦藻赤潮的应用 : CN201910597126.4[P]. | 2019/7/4 . |
| MLA | 石新国 et al. "一株具有溶藻能力的假交替单胞菌及其对米氏凯伦藻赤潮的应用" : CN201910597126.4. | 2019/7/4 . |
| APA | 石新国 , 陈剑锋 , 谢友坪 , 刘乐冕 , 郑向南 , 马瑞娟 . 一株具有溶藻能力的假交替单胞菌及其对米氏凯伦藻赤潮的应用 : CN201910597126.4. | 2019/7/4 . |
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考察脉冲式添加氮源培养对耐温微藻Desmodesmus sp.F51细胞生长和细胞组成的影响。结果表明,在脉冲式添加氮源培养过程中,藻株F51的蛋白质含量由(560±16)mg/g降低至(456±17)mg/g,而碳水化合物和油脂含量则分别由(209±13)mg/g和(98±3)mg/g提高至(310±12)mg/g和(120±4)mg/g。另外,对色素和油脂的具体组成变化进行分析,发现脉冲式添加氮源培养可增强β-胡萝卜素的生物合成,以及促进α-胡萝卜素生物转化为叶黄素,同时还可发现叶黄素积累与多不饱和脂肪酸含量变化呈正相关性。而在碳水化合物的具体组成分析中,发现碳水化合物为藻株F51主要的储...
Keyword ：
叶黄素 叶黄素 微藻 微藻 流加培养 流加培养 碳水化合物 碳水化合物 细胞组成 细胞组成
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| GB/T 7714 | 谢友坪 , 赵旭蕊 , 阳需求 et al. 脉冲式添加氮源对耐温微藻Desmodesmus sp. F51细胞生长和细胞组成的影响 [J]. | 食品科学 , 2017 , 38 (14) : 64-70 . |
| MLA | 谢友坪 et al. "脉冲式添加氮源对耐温微藻Desmodesmus sp. F51细胞生长和细胞组成的影响" . | 食品科学 38 . 14 (2017) : 64-70 . |
| APA | 谢友坪 , 赵旭蕊 , 阳需求 , 卢英华 , 郑向南 , 陈剑锋 . 脉冲式添加氮源对耐温微藻Desmodesmus sp. F51细胞生长和细胞组成的影响 . | 食品科学 , 2017 , 38 (14) , 64-70 . |
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The aim of the present study was to investigate the effect of nitrate pulse feeding on the cell growth and cell composition of Desmodesmus sp. F51. Under nitrate pulse-feeding cultivation, the protein content of cells of Desmodesmus sp. F51 decreased from (560 ± 16) mg/g to (456 ± 17) mg/g, while the contents of carbohydrate and lipid increased from (209 ± 13) mg/g to (310 ± 12) mg/g and (98 ± 3) mg/g to (120 ± 4) mg/g, respectively. By investigating the changes in carotenoid, lipid and carbohydrate compositions, it appeared that nitrate pulse feeding could promote β-carotene biosynthesis and enhance the bioconversion of α-carotene to lutein. Lutein accumulation was positively associated with polyunsaturated fatty acid formation. Desmodesmus sp. F51 tended to accumulate carbohydrate as an energy storage product after 3 days of cultivation under nitrate pulse-feeding conditions, and the major accumulated monosaccharide was glucose (75.7 ± 1.4)%. Therefore, the nitrate-pulse feeding strategy is a highly promising approach to simultaneously produce lutein and carbohydrate in Desmodesmus sp. F51. © 2017, China Food Publishing Company. All right reserved.
Keyword ：
Batch cell culture Batch cell culture Biochemistry Biochemistry Carbohydrates Carbohydrates Cell growth Cell growth Cell proliferation Cell proliferation Cells Cells Cytology Cytology Feeding Feeding Glucose Glucose Growth kinetics Growth kinetics Nitrates Nitrates Polyunsaturated fatty acids Polyunsaturated fatty acids
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| GB/T 7714 | Xie, Youping , Zhao, Xurui , Yang, Xuqiu et al. Effect of Nitrate Pulse-Feeding Cultivation on Cell Growth and Cell Composition of Thermo-Tolerant Desmodesmus sp. F51 [J]. | Food Science , 2017 , 38 (14) : 64-70 . |
| MLA | Xie, Youping et al. "Effect of Nitrate Pulse-Feeding Cultivation on Cell Growth and Cell Composition of Thermo-Tolerant Desmodesmus sp. F51" . | Food Science 38 . 14 (2017) : 64-70 . |
| APA | Xie, Youping , Zhao, Xurui , Yang, Xuqiu , Lu, Yinghua , Zheng, Xiangnan , Chen, Jianfeng . Effect of Nitrate Pulse-Feeding Cultivation on Cell Growth and Cell Composition of Thermo-Tolerant Desmodesmus sp. F51 . | Food Science , 2017 , 38 (14) , 64-70 . |
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Specificity protein (Sp) belong to a transcription factor family that contains nine subgroups with essential functions in development, including skeletogenesis, tooth development, neural tube closure, and limb formation. In molluscs, functions of the Sp protein family members have not been reported in detail. In this study, we report the first Sp protein-encoding gene in Pinctada fucata. We named the translated protein Pf-Sp8/9, based on the phylogenetic development tree constructed using Sp protein sequences from six model organisms, which showed that it was a Sp8/9 homolog. Alignment of the Pf-Sp8/9 sequence with the amino acid sequences of related proteins showed that Pf-Sp8/9 had conserved domains, including three DNA-binding motifs. The tissue distribution showed that while Pf-Sp8/9 mRNA expression was detected in all tested tissues, it was particularly high in the mantle. The luciferase reporter assay results showed that Pf-Sp8/9 had the ability to activate the transcription of a number of matrix proteins. The expression pattern of Pf-Sp8/9 during P. fucata pearl sac development was similar to that of some genes that encode matrix proteins, suggesting Pf-Sp8/9 may be involved in mantle related physiological activities and biomineralization. (C) 2016 Elsevier Inc. All rights reserved.
Keyword ：
Gene expression Gene expression Mantle Mantle Pearl sac development Pearl sac development Pinctada fucata Pinctada fucata Specificity protein Specificity protein
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| GB/T 7714 | Zheng, Xiangnan , Xiang, Liang , Liang, Jian et al. Pf-Sp8/9, a novel member of the specificity protein family in Pinctada fucata, potentially participates in biomineralization [J]. | JOURNAL OF STRUCTURAL BIOLOGY , 2016 , 196 (2) : 119-126 . |
| MLA | Zheng, Xiangnan et al. "Pf-Sp8/9, a novel member of the specificity protein family in Pinctada fucata, potentially participates in biomineralization" . | JOURNAL OF STRUCTURAL BIOLOGY 196 . 2 (2016) : 119-126 . |
| APA | Zheng, Xiangnan , Xiang, Liang , Liang, Jian , Xie, Liping , Zhang, Rongqing . Pf-Sp8/9, a novel member of the specificity protein family in Pinctada fucata, potentially participates in biomineralization . | JOURNAL OF STRUCTURAL BIOLOGY , 2016 , 196 (2) , 119-126 . |
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以次品鲍鱼腹足为原料,采用酸法提取鲍鱼腹足中的胶原蛋白,对其酸溶性胶原蛋白(ASC)的单级动态间歇式提取和多级动态连续逆流提取工艺进行研究与比较.结果表明,单级动态间歇式提取鲍鱼腹足ASC的最佳条件为:1 mol/L醋酸与0.4 mol/L盐酸按1∶1 (v/v)配制提取液、料液比1∶10、提取流速40 mL/min、单次提取时间1h和提取次数2次,在此条件下ASC提取率为11.2％(以干基计),ASC浓度为1.04 mg/mL;而多级动态连续逆流提取的最佳级数为三级,此时ASC提取率可提高至16.9％(以干基计),ASC浓度为3.12 mg/mL.通过调节硫酸铵浓度为0.4 mol/L、pH为5.6对提取所得ASC进行初步纯化,经纯化后ASC纯度最高可达88.4％,回收率为89.1％.
Keyword ：
动态连续逆流 动态连续逆流 提取 提取 皱纹盘鲍腹足 皱纹盘鲍腹足 纯化 纯化 酸溶性胶原蛋白 酸溶性胶原蛋白
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| GB/T 7714 | 陈山 , 陈剑锋 , 郑向南 et al. 动态连续逆流提取鲍鱼腹足胶原蛋白的研究 [J]. | 食品工业科技 , 2016 , 37 (14) : 262-266,271 . |
| MLA | 陈山 et al. "动态连续逆流提取鲍鱼腹足胶原蛋白的研究" . | 食品工业科技 37 . 14 (2016) : 262-266,271 . |
| APA | 陈山 , 陈剑锋 , 郑向南 , 谢友坪 . 动态连续逆流提取鲍鱼腹足胶原蛋白的研究 . | 食品工业科技 , 2016 , 37 (14) , 262-266,271 . |
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本研究考察了不同光照强度和氮源匮乏培养对小球藻细胞生长及其细胞组成的影响.结果表明,随光照强度的增强,小球藻生物量产率和碳水化合物含量可显著提高,而蛋白质含量和油脂含量则呈现缓慢下降趋势;在光照强度为750 μmol·m-2·s-1时,小球藻生物量产率、蛋白质产率和碳水化合物产率达最大值,分别为935.6、509.8、256.0 mg·L-1·d-1;而光照强度为450 μmol·m-2·s-1时,小球藻油脂产率达最大值,为105.0 mg·L-1·d-1.通过氮源匮乏培养来促进小球藻碳水化合物和油脂含量的积累,发现当氮源匮乏培养时间分别为2d和4d时,小球藻碳水化合物产率和油脂产率可进一步提高至471.1 mg·L-1·d-1和150.6 mg·L-1·d-1.
Keyword ：
光照强度 光照强度 小球藻 小球藻 氮源匮乏 氮源匮乏 细胞组成 细胞组成
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| GB/T 7714 | 阳需求 , 陈剑锋 , 郑向南 et al. 光照强度和氮源匮乏培养对小球藻细胞生长和细胞组成的影响 [J]. | 食品工业科技 , 2016 , 37 (18) : 246-250 . |
| MLA | 阳需求 et al. "光照强度和氮源匮乏培养对小球藻细胞生长和细胞组成的影响" . | 食品工业科技 37 . 18 (2016) : 246-250 . |
| APA | 阳需求 , 陈剑锋 , 郑向南 , 谢友坪 . 光照强度和氮源匮乏培养对小球藻细胞生长和细胞组成的影响 . | 食品工业科技 , 2016 , 37 (18) , 246-250 . |
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