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学者姓名：郑琤
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Abstract ：
“双一流”背景下，福州大学化学实验教学中心步入了内涵式发展阶段。实验中心贯彻学校的“价值引领、知识拓展、思维训练、能力建构”四位一体育人理念，结合学校“理工结合、基础研究与应用研究相结合”的办学特色，响应学院对化学理科拔尖2.0培养计划以及各专业的新工科、新医科等发展需求，探索地方高校国家级化学实验教学示范中心建设和改革举措和方法。本文将从实验平台建设，实验教学改革，实验师资队伍建设和科普服务等方面介绍过去五年以来福州大学化学实验中心“双一流”建设的经验，突出实践作用，强化实践育人功能，切实提高实验教学内涵。
Keyword ：
创新人才培养 创新人才培养 化学实验教学中心建设与实践 化学实验教学中心建设与实践 双一流建设 双一流建设 实验教学改革 实验教学改革 科普教育 科普教育
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| GB/T 7714 | 林佳丽 , 吴舒婷 , 郑琤 et al. “双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践 [J]. | 大学化学 , 2024 , 39 (07) : 129-139 . |
| MLA | 林佳丽 et al. "“双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践" . | 大学化学 39 . 07 (2024) : 129-139 . |
| APA | 林佳丽 , 吴舒婷 , 郑琤 , 林子俺 , 魏巧华 , 郑寿添 . “双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践 . | 大学化学 , 2024 , 39 (07) , 129-139 . |
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介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究.本实验基于氧化还原反应和配位反应合成Cu(Ⅰ)配合物,采用薄层色谱法判断合成反应进程,运用配位滴定法测定其铜含量,利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度.本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作,同时体现了发光金属配合物这一科研热点,探究物质结构与性质的关系.通过本实验的实践,学生在巩固所学实验知识和实验技能的同时,训练了运用所学知识解决实际问题的综合能力,有利于学生初步建立科学的思维方式和研究能力.
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜含量分析 铜含量分析 铜(Ⅰ)配合物 铜(Ⅰ)配合物
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 [J]. | 大学化学 , 2024 , 39 (7) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究" . | 大学化学 39 . 7 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(Ⅰ)配合物的合成、铜含量分析和发光性能研究 . | 大学化学 , 2024 , 39 (7) , 322-329 . |
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介绍了一个研究型综合化学实验——具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究。本实验基于氧化还原反应和配位反应合成Cu(I)配合物，采用薄层色谱法判断合成反应进程，运用配位滴定法测定其铜含量，利用荧光光度法和荧光定量分析法测定固态荧光以及判断产品的纯度。本实验综合了无机化学、有机化学、分析化学的基础知识和实验技能以及大型仪器的学习和操作，同时体现了发光金属配合物这一科研热点，探究物质结构与性质的关系。通过本实验的实践，学生在巩固所学实验知识和实验技能的同时，训练了运用所学知识解决实际问题的综合能力，有利于学生初步建立科学的思维方式和研究能力。
Keyword ：
发光性能 发光性能 综合化学实验 综合化学实验 铜(I)配合物 铜(I)配合物 铜含量分析 铜含量分析
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| GB/T 7714 | 郑琤 , 郑诗颖 , 张艳萍 et al. 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 [J]. | 大学化学 , 2024 , 39 (07) : 322-329 . |
| MLA | 郑琤 et al. "具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验" . | 大学化学 39 . 07 (2024) : 322-329 . |
| APA | 郑琤 , 郑诗颖 , 张艳萍 , 郑寿添 , 魏巧华 . 具有异构发光变色的双核铜(I)配合物的合成、铜含量分析和发光性能研究——推荐一个综合化学实验 . | 大学化学 , 2024 , 39 (07) , 322-329 . |
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Photodynamic therapy (PDT) is a promising cancer treatment modality with advantages of minimal in-vasiveness, repeatable therapy, and mild systemic toxicity. However, the limited bioavailability of photo -sensitizer (PS), tumor hypoxia, and the presence of antiapoptotic proteins in cancer cells, has hampered the efficiency of PDT. To address these limitations, herein, we developed a hyaluronic acid (HA) based nanosystem (HA-Ce6-Hemin@DNA-Protamine NPs, HCH@DP) loaded with chlorin e6 (Ce6, as PS), hemin (as mimetic catalase) and antisense oligonucleotide (ASO) of B-cell lymphoma 2 (Bcl-2) anti-apoptosis protein via a simple electrostatic self-assembly method for enhanced PDT of hypoxic solid tumors. The HCH@DP can target deliver the PS and ASO to tumor cells via cancer cell overexpressed HA receptors (i.e., CD44 or RHAMM). The Ce6 was released from HA-ss-Ce6 (HSC conjugates) after the reaction of cleavable disulfide bond with glutathione (GSH), which recovered the fluorescence and phototoxicity of Ce6 upon laser irradiation. Meanwhile, the catalase-mimicking hemin (degradation of HA-eda-hemin by hyaluronidase) decomposed the tumor overdressed endogenous H2O2 to oxygen, which relieved tumor hypoxia and further overcome hypoxia-associated resistance of PDT. Furthermore, the inhibition of Bcl-2 expression by Bcl-2 ASO also greatly improved the cellular sensitivity to PDT. Both in vitro and in vivo results showed the tumor cell targeting ability, hypoxia relief and significantly enhanced antitumor PDT efficacy of HCH@DP for hypoxic tumor cells upon laser irradiation. Thus, by improving the target delivery of PS and ASO, relieving tumor hypoxia, and down-regulation of anti-apoptotic proteins, this HCH@DP nanosystem achieved enhanced PDT efficiency against hypoxic tumors. In general, our work provided a promising strategy to increase the utilization of key components (PS and oxygen) of PDT and the cell sensitivity to PDT by targeting co-delivery PS and oligonucleotides to tumor cells via a biocompatible HA based carrier, thereby achieving efficiently PDT treatment of hypoxic solid tumors with potential transla-tion possibility.Statement of significance The efficiency of PDT against solid tumor is severely restricted by the limited bioavailability of photo -sensitizer, tumor hypoxia, and the presence of antiapoptotic proteins in cancer cells. Herein, we have developed an activatable hyaluronic acid (HA) based nanosystem (HA-Ce6-Hemin@DNA-Protamine NPs, HCH@DP) via a simple electrostatic self-assembly method for PDT treatment of hypoxic solid tumors. The HCH@DP enabled to target co-delivery of photosensitizer and antisense oligonucleotide to tumor cells, overcoming tumor hypoxia through in situ oxygen production and improving cellular sensitivity by efficiently reducing anti-apoptosis effect of cancer cells for synergistically enhancing PDT efficiency. This work suggests a promising strategy to develop small molecule drug and oligonucleotides co-delivery nanoplatforms for efficiently PDT treatment of hypoxic solid tumor. (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keyword ：
Antisense oligonucleotide Antisense oligonucleotide Hyaluronic acid Hyaluronic acid Hypoxia Hypoxia Synergistic PDT Synergistic PDT Tumor microenvironment Tumor microenvironment
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| GB/T 7714 | Wu, Yanni , Ding, Lei , Zheng, Cheng et al. Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors [J]. | ACTA BIOMATERIALIA , 2022 , 153 : 419-430 . |
| MLA | Wu, Yanni et al. "Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors" . | ACTA BIOMATERIALIA 153 (2022) : 419-430 . |
| APA | Wu, Yanni , Ding, Lei , Zheng, Cheng , Li, Hongsheng , Wu, Ming , Sun, Yupeng et al. Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors . | ACTA BIOMATERIALIA , 2022 , 153 , 419-430 . |
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Polynucleotide kinase (PNK) is an important DNA damage repair-related enzyme and also a promising therapeutic target in various diseases. Here, we developed a dual amplified sensing strategy based on the combination of terminal deoxynucleotidyl transferase (TdT) and CRISPR-Cas12a for high selective and sensitive detection of PNK activity in cell lysates and also inhibitor screening. In this sensing system, the PNK converted the 3'-phosphate DNA to 3'-hydroxy DNA, and then the TdT catalyzed to add a long poly-adenine (poly (A)) at the 3' OH terminus DNA (as first amplified step). The produced poly (A) tail acted as activator to trigger the Cas12a trans-cleavage (non-target) activity to cleave reporter probes for fluorescence detection (as second amplified step). The dual amplified steps lead to a synergetic signal amplification effect for sensitive detection of PNK activity. The developed sensing platform enable detect PNK activity with linear range from 0 to 1 U/mL and a direct detection limit of 5 x 10(-4) U/mL. It was also successfully used for PNK inhibitor screening and PNK activity detection in cell extracts even at a single-cell level. The efficient dual amplified method can broaden the CRISPR/Cas-based sensing systems in other bio-/chem-analysis fields.
Keyword ：
CRISPR-Cas12a CRISPR-Cas12a Dephosphorylation Dephosphorylation DNA damage repair DNA damage repair Polynucleotide kinase Polynucleotide kinase Terminal deoxynucleotidyl transferase Terminal deoxynucleotidyl transferase
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| GB/T 7714 | Zhang, Xiaolong , Zheng, Cheng , Ding, Lei et al. CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 330 . |
| MLA | Zhang, Xiaolong et al. "CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity" . | SENSORS AND ACTUATORS B-CHEMICAL 330 (2021) . |
| APA | Zhang, Xiaolong , Zheng, Cheng , Ding, Lei , Wu, Yanni , Xu, Haipo , Sun, Yupeng et al. CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity . | SENSORS AND ACTUATORS B-CHEMICAL , 2021 , 330 . |
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Lithiated transition metal oxide cathode materials that combine oxygen-anion redox [O-2(-)/(O-2)(n-)] with cation redox offer substantial capacities and higher voltage than cathodes without oxygen redox, but oxygen-anion redox is usually accompanied by the formation of peroxo or superoxo species that may cause oxygen release. To clarify the relationship between the oxygen release and peroxide and superoxide dimers without the complication of transition-metal redox, we performed density functional theory calculations to study the layered Li8SnO6 cathode because it has only oxygen-anion redox during delithiation. Features with O-O distances of similar to 1.5 angstrom (corresponding to the formation of a peroxide) were observed at 75% lithium concentration, and further delithiation to 62.5% lithium concentration shortened the O-O bond distance to similar to 1.3 angstrom (corresponding to the formation of superoxide). The solely anionic oxygen redox stabilizes the delithiated structure of Li8-xSnO6, and it does not cause structural disorder or release oxygen gas. Ab initio molecular dynamics calculations in the supercell at 300 K indicate that oxygen dimerization may occur at 75% lithium concentration. On the (0001) surface with a high lithium concentration (98%), oxygen dimerization is unfavorable. The calculations by HSE06 show that oxygen redox in Li8SnO6 offers an initial voltage (vs Li/Li+) greater than 4.2 V. The GGA+U calculations indicate that the Li+-polaron in Li95Sn12O72 migrates with a migration barrier of only 0.43 eV. This work also quantifies a solely anionic oxygen redox mechanism in Li8SnO6, and it provides a deeper understanding of anionic oxygen redox in Li-excess oxide cathode materials.
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| GB/T 7714 | Luo, Ningjing , Hou, Zhufeng , Zheng, Cheng et al. Anionic Oxygen Redox in the High-Lithium Material Li8SnO6 [J]. | CHEMISTRY OF MATERIALS , 2021 , 33 (3) : 834-844 . |
| MLA | Luo, Ningjing et al. "Anionic Oxygen Redox in the High-Lithium Material Li8SnO6" . | CHEMISTRY OF MATERIALS 33 . 3 (2021) : 834-844 . |
| APA | Luo, Ningjing , Hou, Zhufeng , Zheng, Cheng , Zhang, Yongfan , Stein, Andreas , Huang, Shuping et al. Anionic Oxygen Redox in the High-Lithium Material Li8SnO6 . | CHEMISTRY OF MATERIALS , 2021 , 33 (3) , 834-844 . |
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该文以福州大学无机化学专业实验室的建设为例,介绍了以学生为本、提高实验室综合效益、加强实验室高效管理的实验室建设新思路以及具体实施策略。通过聚焦实验室硬件升级改造和实验教学环境提升,从实验室建设和实验室管理同时着手,为师生打造安全、便捷、服务优质、能够实现多层次实验教学的化学专业实验室,促进实验教学质量和实验效率的提高。
Keyword ：
一流学科 一流学科 以学生为本 以学生为本 实验室建设与管理 实验室建设与管理 无机化学实验室 无机化学实验室
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| GB/T 7714 | 郑琤 , 郭钰 , 柯子厚 et al. 探索地方高校一流化学专业实验室的建设与管理 [J]. | 实验技术与管理 , 2021 , 38 (02) : 259-264 . |
| MLA | 郑琤 et al. "探索地方高校一流化学专业实验室的建设与管理" . | 实验技术与管理 38 . 02 (2021) : 259-264 . |
| APA | 郑琤 , 郭钰 , 柯子厚 , 林佳丽 , 魏巧华 , 汤儆 . 探索地方高校一流化学专业实验室的建设与管理 . | 实验技术与管理 , 2021 , 38 (02) , 259-264 . |
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从命题思路、试题内容及特点和结果分析等3个方面对第11届全国大学生化学实验邀请赛的理论试题进行讨论分析和总结,同时对化学实验教学的改革提出几点思考和建议,以期促进高校化学实验教学的改革和创新.
Keyword ：
化学实验邀请赛 化学实验邀请赛 实验教学改革 实验教学改革 实验理论试题 实验理论试题
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| GB/T 7714 | 郑琤 , 魏巧华 , 汤儆 et al. 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 [J]. | 化学教育 , 2021 , 42 (6) : 61-64 . |
| MLA | 郑琤 et al. "从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考" . | 化学教育 42 . 6 (2021) : 61-64 . |
| APA | 郑琤 , 魏巧华 , 汤儆 , 游毅 . 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 . | 化学教育 , 2021 , 42 (6) , 61-64 . |
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Abstract ：
从命题思路、试题内容及特点和结果分析等3个方面对第11届全国大学生化学实验邀请赛的理论试题进行讨论分析和总结,同时对化学实验教学的改革提出几点思考和建议,以期促进高校化学实验教学的改革和创新。
Keyword ：
化学实验邀请赛 化学实验邀请赛 实验教学改革 实验教学改革 实验理论试题 实验理论试题
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| GB/T 7714 | 郑琤 , 魏巧华 , 汤儆 et al. 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 [J]. | 化学教育(中英文) , 2021 , 42 (06) : 61-64 . |
| MLA | 郑琤 et al. "从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考" . | 化学教育(中英文) 42 . 06 (2021) : 61-64 . |
| APA | 郑琤 , 魏巧华 , 汤儆 , 游毅 . 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 . | 化学教育(中英文) , 2021 , 42 (06) , 61-64 . |
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MoO2 is a promising anode material for lithium-ion batteries, however, the lithiation of bulk MoO2 is usually limited to addition-type reaction at room temperature, and the conversion reaction is hindered because of the sluggish kinetics. Herein, a nanocomposite of MoO2 embedded in nitrogen-doped carbon (MoO2/NC) is synthesized through the in situ thermolysis of an organic molybdenum complex MoO2(acac)(phen) (acac = acetylacetone, phen = 1,10-Phenanthroline). Owing to the fact that [MoO2](2+) can be strongly chelated by phen, the molybdenum source in the MoO2(acac)(phen) precursor is highly dispersed, leading to the formation of ultra-small MoO2 nanoparticles in the nanocomposite, which can facilitate the conversion reaction. Moreover, the NC matrix can guarantee a high electrical conductivity and effectively accommodate the volume changes triggered by the conversion reaction. Consequently, the MoO2/NC nanocomposite exhibits outstanding electrochemical properties, including large reversible capacity of 950 mA h g(-1) at 0.1 A g(-1), high-rate capability of 605 mA h g(-1) at 2 A g(-1), and excellent cycling stability over 500 cycles as an anode material for lithium-ion batteries. (C) 2021 Elsevier Inc. All rights reserved.
Keyword ：
Electrochemical properties Electrochemical properties Lithium-ion batteries Lithium-ion batteries MoO2 nanoparticles MoO2 nanoparticles Nanocomposite Nanocomposite Nitrogen-doped carbon Nitrogen-doped carbon Organic molybdenum complex derivation Organic molybdenum complex derivation
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| GB/T 7714 | Zheng, Cheng , Wu, Weixin , Deng, Qixin et al. Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance [J]. | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2021 , 592 : 33-41 . |
| MLA | Zheng, Cheng et al. "Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance" . | JOURNAL OF COLLOID AND INTERFACE SCIENCE 592 (2021) : 33-41 . |
| APA | Zheng, Cheng , Wu, Weixin , Deng, Qixin , Li, Yafeng , Wei, Mingdeng . Nanocomposite of ultra-small MoO2 embedded in nitrogen-doped carbon: In situ derivation from an organic molybdenum complex and its superior Li-Ion storage performance . | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2021 , 592 , 33-41 . |
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