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学者姓名：肖高
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Abstract ：
The use of hydrogel-based interfacial solar evaporators for desalination is a green, sustainable, and extremely concerned freshwater acquisition strategy. However, developing evaporators that are easy to manufacture, cheap, and have excellent porous structures still remains a considerable challenge. This work proposes a novel strategy for preparing a self-assembling sponge-like poly(vinyl alcohol)/graphite composite hydrogel based on the Hofmeister effect for the first time. The sponge-like hydrogel interfacial solar evaporator (PGCNG) is successfully obtained after combining with graphite. The whole process is environmental-friendly and of low-carbon free of freezing process. The PGCNG can be conventionally dried and stored. PGCNG shows impressive water storage performance and water transmission capacity, excellent steam generation performance and salt resistance. PGCNG has a high evaporation rate of 3.5 kg m-2 h-1 under 1 kW m-2 h-1 solar irradiation and PGCNG demonstrates stable evaporation performance over both 10 h of continuous brine evaporation and 30 cycles of brine evaporation. Its excellent performance and simple, scalable preparation strategy make it a valuable material for practical interface solar seawater desalination devices. This paper presents a novel and facile method for obtaining a sponge-like hydrogel with excellent pore structure, outstanding water transport and solar interfacial evaporation performance. The method is based on the Hofmeister effect, whereby the polymer nanofibers are coiled by a combination of salting and salting effects, resulting in the formation of a pore structure. image
Keyword ：
desalination desalination hofmeister effect hofmeister effect phase separation phase separation porous hydrogels porous hydrogels solar steam generation solar steam generation
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| GB/T 7714 | Yang, Mohan , Wu, Yaowei , Chen, Mengdie et al. Hofmeister Effect-Assisted Facile Fabrication of Self-Assembled Poly(Vinyl Alcohol)/Graphite Composite Sponge-Like Hydrogel for Solar Steam Generation [J]. | SMALL , 2024 . |
| MLA | Yang, Mohan et al. "Hofmeister Effect-Assisted Facile Fabrication of Self-Assembled Poly(Vinyl Alcohol)/Graphite Composite Sponge-Like Hydrogel for Solar Steam Generation" . | SMALL (2024) . |
| APA | Yang, Mohan , Wu, Yaowei , Chen, Mengdie , Wang, Yuhao , Zhang, Lei , Deng, Yingxue et al. Hofmeister Effect-Assisted Facile Fabrication of Self-Assembled Poly(Vinyl Alcohol)/Graphite Composite Sponge-Like Hydrogel for Solar Steam Generation . | SMALL , 2024 . |
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Bisdemethoxycurcumin (BDMC) is the main active ingredient that is isolated from Zingiberaceae plants, wherein it has excellent anti-tumor effects. However, insolubility in water limits its clinical application. Herein, we reported a microfluidic chip device that can load BDMC into the lipid bilayer to form BDMC thermosensitive liposome (BDMC TSL). The natural active ingredient glycyrrhizin was selected as the surfactant to improve solubility of BDMC. Particles of BDMC TSL had small size, homogenous size distribution, and enhanced cultimulative release in vitro. The anti-tumor effect of BDMC TSL on human hepatocellular carcinomas was investigated via 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method, live/dead staining, and flowcytometry. These results showed that the formulated liposome had a strong cancer cell inhibitory, and presented a dose-dependent inhibitory effect on migration. Further mechanistic studies showed that BDMC TSL combined with mild local hyperthermia could significantly upregulate B cell lymphoma 2 associated X protein levels and decrease B cell lymphoma 2 protein levels, thereby inducing cell apoptosis. The BDMC TSL that was fabricated via microfluidic device were decomposed under mild local hyperthermia, which could beneficially enhance the anti-tumor effect of raw insoluble materials and promote translation of liposome.
Keyword ：
Antitumor Antitumor Bisdemethoxycurcumin Bisdemethoxycurcumin Glycyrrhizin Glycyrrhizin Microfluidic Microfluidic Thermosensitive liposomes Thermosensitive liposomes
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| GB/T 7714 | Cao, Xia , Liu, Qi , Shi, Wenwan et al. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2023 , 641 . |
| MLA | Cao, Xia et al. "Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 641 (2023) . |
| APA | Cao, Xia , Liu, Qi , Shi, Wenwan , Liu, Kai , Deng, Tianwen , Weng, Xuedi et al. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2023 , 641 . |
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Glioma, in which a malignant tumor cell occurs in neural mesenchymal cells, has a rapid progression and poor prognosis, which is still far from desirable in clinical treatments. We developed a lab-on-a-chip (LOC) device for the rapid and efficient preparation of vitexin/indocyanine green (ICG) liposomes. Vitexin could be released from liposome to kill cancer cell, which can potentially improve the glioma therapeutic effect and reduce the treatment time through synergistic photodynamic/photothermal therapies (PDT/PTT). The vitexin/ICG liposome was fabricated via LOC and its physicochemical property and release in vitro were evaluated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and live/dead staining were used to examine the enhanced antitumor effect of vitexin/ICG liposome in cooperation with PDT/PTT, while the related mechanism was explored by flow cytometry and western blot. The results were as follows: (1) The prepared vitexin/ICG liposome was smaller in size, homogenous in particle size distribution with significant low polydispersity index (PDI), and enhanced cumulative release in vitro. (2) We found that the formulated liposome presented strong cancer cell inhibition and suppression of its migration in a dose-dependent manner. (3) Further mechanistic studies showed that liposome combined with near-infrared irradiation could significantly upregulate levels of B cell lymphoma 2-associated X (Bax) protein and decrease B cell lymphoma 2 (Bcl-2) at protein levels. The vitexin/ICG liposomes prepared based on a simple LOC platform can effectively enhance the solubility of insoluble drugs, and the combined effect of PTT/PDT can effectively increase their antitumor effect, which provides a simple and valid method for the clinical translation of liposomes.
Keyword ：
indocyanine green indocyanine green lab-on-a-chip lab-on-a-chip liposome liposome near-infrared ray near-infrared ray vitexin vitexin
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| GB/T 7714 | Cao, Xia , Liu, Qi , Adu-Frimpong, Michael et al. Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy [J]. | AAPS PHARMSCITECH , 2023 , 24 (4) . |
| MLA | Cao, Xia et al. "Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy" . | AAPS PHARMSCITECH 24 . 4 (2023) . |
| APA | Cao, Xia , Liu, Qi , Adu-Frimpong, Michael , Shi, Wenwan , Liu, Kai , Deng, Tianwen et al. Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy . | AAPS PHARMSCITECH , 2023 , 24 (4) . |
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Emodin is applied as an antitumor drug in many tumor therapies. However, its pharmacology performances are limited due to its low solubility. Herein, we fused erythrocyte and macrophage to form a hybrid membrane (EMHM) and encapsulated emodin to form hybrid membrane-coated nanoparticles. We employed glycyrrhizin to increase the solubility of emodin first and prepared the hybrid membrane nanoparticle-coated emodin and glycyrrhizin (EG@EMHM NPs) which exhibited an average particle size of 170 +/- 20 nm and encapsulation efficiency of 98.13 +/- 0.67%. The half-inhibitory concentrations (IC50) of EG@EMHM NPs were 1.166 mu g/mL, which is half of the free emodin. Based on the photosensitivity of emodin, the reactive oxygen species (ROS) results disclosed that ROS levels of the photodynamic therapy (PDT) section were higher than the normal section (P < 0.05). Compared to the normal section, PDT-mediated EG@EMHM NPs could induce an early stage of apoptosis of B16. The western blot and flow cytometry results verified that PDT-mediated EG@EMHM NPs can significantly improve the solubility of emodin and perform a remarkably antitumor effect on melanoma via BAX and BCL-2 pathway. The application of the combined chemical and PDT therapy could provide an improving target therapy for cutaneous melanoma and also may offer an idea for other insoluble components sources of traditional Chinese medicine.
Keyword ：
emodin emodin enhanced antitumor effect enhanced antitumor effect glycyrrhizin glycyrrhizin hybrid membrane hybrid membrane photodynamic therapy photodynamic therapy
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| GB/T 7714 | Cao, Xia , Deng, Tianwen , Zhu, Qin et al. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy [J]. | AAPS PHARMSCITECH , 2023 , 24 (6) . |
| MLA | Cao, Xia et al. "Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy" . | AAPS PHARMSCITECH 24 . 6 (2023) . |
| APA | Cao, Xia , Deng, Tianwen , Zhu, Qin , Wang, Jianping , Shi, Wenwan , Liu, Qi et al. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy . | AAPS PHARMSCITECH , 2023 , 24 (6) . |
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Formononetin is a flavonoid compound with anti-tumor and anti-inflammatory properties. However, its low solubility limits its clinical use. We employed microfluidic technology to prepare formononetin-loaded PLGA-PEGDA microspheres (Degradable polymer PLGA, Crosslinking agent PEGDA), which can encapsulate and release drugs in a controlled manner. We optimized and characterized the microspheres, and evaluated their antitumor effects. The microspheres had uniform size, high drug loading efficiency, high encapsulation efficiency, and stable release for 35 days. They also inhibited the proliferation, migration, and apoptosis. The antitumor mechanism involved the induction of reactive oxygen species and modulation of Bcl-2 family proteins. These findings suggested that formononetin-loaded PLGA-PEGDA microspheres, created using microfluidic technology, could be a novel drug delivery system that can overcome the limitations of formononetin and enhance its antitumor activity.
Keyword ：
anti-tumor anti-tumor formononetin formononetin lung cancer lung cancer microfluidic microfluidic microspheres microspheres
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| GB/T 7714 | Cao, Xia , Li, Qingwen , Li, Xiaoli et al. Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication [J]. | AAPS PHARMSCITECH , 2023 , 24 (8) . |
| MLA | Cao, Xia et al. "Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication" . | AAPS PHARMSCITECH 24 . 8 (2023) . |
| APA | Cao, Xia , Li, Qingwen , Li, Xiaoli , Liu, Qi , Liu, Kai , Deng, Tianwen et al. Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication . | AAPS PHARMSCITECH , 2023 , 24 (8) . |
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Synergisticadsorption and catalytic conversion of SO2 were achievedby metal-phenolic modification of waste collagenfibers at a high efficiency with industrialization potential. SO2 removal is critical to flue gas purification.However,based on performance and cost, materials under development are hardlyadequate substitutes for active carbon-based materials. Here, we engineeredbiomass-derived nanostructured carbon nanofibers integrated with highlydispersed bimetallic Ti/CoO x nanoparticlesthrough the thermal transition of metal-phenolic functionalized industrialleather wastes for synergistic SO2 adsorption and in situcatalytic conversion. The generation of surface-SO3 (2-) and peroxide species (O-2 (2-)) by Ti/CoO x achieved catalytic conversionof adsorbed SO2 into value-added liquid H2SO4, which can be discharged from porous nanofibers. This approachcan also avoid the accumulation of the adsorbed SO2, therebyachieving high desulfurization activity and a long operating lifeover 6000 min, preceding current state-of-the-art active carbon-baseddesulfurization materials. Combined with the techno-economic and carbonfootprint analysis from 36 areas in China, we demonstrated an economicallyviable and scalable solution for real-world SO2 removalon the industrial scale.
Keyword ：
adsorption adsorption biomass biomass desulfurization desulfurization heterogeneous catalysis heterogeneous catalysis metal oxide metal oxide
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| GB/T 7714 | Xiao, Gao , Xie, Qiuping , He, Yunxiang et al. Synergistic Adsorption and In Situ Catalytic Conversion of SO2 by Transformed Bimetal-Phenolic Functionalized Biomass [J]. | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2023 . |
| MLA | Xiao, Gao et al. "Synergistic Adsorption and In Situ Catalytic Conversion of SO2 by Transformed Bimetal-Phenolic Functionalized Biomass" . | ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023) . |
| APA | Xiao, Gao , Xie, Qiuping , He, Yunxiang , Huang, Xin , Richardson, Joseph J. , Dai, Manna et al. Synergistic Adsorption and In Situ Catalytic Conversion of SO2 by Transformed Bimetal-Phenolic Functionalized Biomass . | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2023 . |
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Core-shell hydrogel microcapsules have sparked great interest due to their unique characteristics and prospective applications in the medical, pharmaceutical, and cosmetic fields. However, complex synthetic procedures and expensive costs have limited their practical application. Herein, we designed and prepared several multichannel and multijunctional droplet microfluidic devices based on soft lithography for the effective synthesis of core-shell hydrogel microcapsules for different purposes. Additionally, two different cross-linking processes (ultraviolet (UV) exposure and interfacial polymerization) were used to synthesize different types of core-shell structured hydrogel microcapsules. Hydrogel microcapsules with gelatin methacryloyl (GelMA) as the core and polyacrylamide (PAM) as the thin shell were synthesized using UV cross-linking. Using an interfacial polymerization process, another core-shell structured microcapsule with GelMA as the core and Ca2+ cross-linked alginate with polyethylenimine (PEI) as the shell was constructed, and the core diameter and total droplet diameter were flexibly controlled by carving. Noteworthy, these hydrogel microcapsules exhibit stimuli-responsiveness and controlled release ability. Overall, a novel technique was developed to successfully synthesize various hydrogel microcapsules with core-shell microstructures. The hydrogel microcapsules possess a multilayered structure that facilitates the coassembly of cells and drugs, as well as the layered assembly of multiple drugs, to develop synergistic therapeutic regimens. These adaptable and controllable hydrogel microdroplets shall held great promise for multicell or multidrug administration as well as for high-throughput drug screening.
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| GB/T 7714 | Wu, Qiong , Huang, Xing , Liu, Ran et al. Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core-Shell Structures and Adjustable Core Positions [J]. | LANGMUIR , 2023 , 40 (3) : 1950-1960 . |
| MLA | Wu, Qiong et al. "Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core-Shell Structures and Adjustable Core Positions" . | LANGMUIR 40 . 3 (2023) : 1950-1960 . |
| APA | Wu, Qiong , Huang, Xing , Liu, Ran , Yang, Xinzhu , Xiao, Gao , Jiang, Nan et al. Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core-Shell Structures and Adjustable Core Positions . | LANGMUIR , 2023 , 40 (3) , 1950-1960 . |
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本发明公开了一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料电催化剂材料及其制备方法，所述纳米材料活性物质为Ce‑MOF@BT‑Cu。燃料电池催化剂目前普遍面临着，前驱体单一和合成成本高昂的问题，而商业铂碳催化剂不仅成本高且稳定性差。为克服这些问题，本发明基于金属多酚网络的独特结构，开发了一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料。该材料呈现出均匀的颗粒状结构和丰富的孔道结构，具有高电位和良好的极限电流，拥有优良的稳定性。所采用的合成方法，操作简便，成本低廉，且制备时间短，有利于实现大规模商业化生产。
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| GB/T 7714 | 肖高 , 胡钰花 . 一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用 : CN202210409833.8[P]. | 2022-04-19 00:00:00 . |
| MLA | 肖高 et al. "一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用" : CN202210409833.8. | 2022-04-19 00:00:00 . |
| APA | 肖高 , 胡钰花 . 一种铜多酚超分子网络界面修饰的稀土基有机框架负极材料的制备及应用 : CN202210409833.8. | 2022-04-19 00:00:00 . |
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本发明公开了一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球及其制备方法和应用。通过多酚网络的功能化改性手段，将Ce基金属有机框架与共价有机聚合物碳球紧密结合，得到具有优异氧化还原性能的纳米复合材料COP‑HB@CeMOF‑BT。本发明有效改善了Ce基催化剂的电化学性能，实现了稀土多酚网络与共价有机聚合物的独特协同作用。制得的纳米复合材料作为燃料电池催化剂具有高电位、优异的极限电流、优良的稳定性以及优异的甲醇耐受性等优点，应用前景广阔。
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| GB/T 7714 | 肖高 , 胡凡莹 , 刘明华 . 一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球 : CN202111230306.2[P]. | 2021-10-22 00:00:00 . |
| MLA | 肖高 et al. "一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球" : CN202111230306.2. | 2021-10-22 00:00:00 . |
| APA | 肖高 , 胡凡莹 , 刘明华 . 一种稀土多酚超分子包覆的共价有机聚合物铈基纳米碳球 : CN202111230306.2. | 2021-10-22 00:00:00 . |
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本发明公开了一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极电催化剂材料及其制备方法，所述纳米材料活性物质为Cr‑La/CCF‑BT。燃料电池催化剂目前普遍面临着，前驱体单一和合成成本高昂的问题，而商业铂碳催化剂不仅成本高且稳定性差。为克服这些问题，本发明涉及一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备，所述材料采用生物模板法，以La‑MOFs稀土金属有机框架修饰改性的废铬屑为模板和碳源，杨梅单宁作为前驱体制备连接La‑MOFs和废铬屑生物模板的桥梁分子，利用废铬屑本身天然的纤维态分级结构制备出具有天然独特形貌的La(MOFs)‑BT@Cr‑CF纳米复合材料前驱体，经高温煅烧最终形成Cr‑La/CCF‑BT。
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| GB/T 7714 | 肖高 , 胡钰花 . 一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备 : CN202210873340.X[P]. | 2022-07-21 00:00:00 . |
| MLA | 肖高 et al. "一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备" : CN202210873340.X. | 2022-07-21 00:00:00 . |
| APA | 肖高 , 胡钰花 . 一种镧基有机框架复合改性的废铬屑衍生的多孔碳纳米负极材料的制备 : CN202210873340.X. | 2022-07-21 00:00:00 . |
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