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学者姓名：程翠
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Abstract ：
The development of traditional small molecule antibiotics is becoming increasingly challenging, and they are no longer effective against the growing number of multidrug-resistant infections. Therefore, in this study, polyhexamethylene biguanide-bismuth tungstate-poly(vinylpyrrolidone) nanoparticles (PHMB-BWO-PVP NPs) were synthesized to achieve effective treatment of drug-resistant bacterial infections through the synergistic chemical/low-temperature photothermal therapy (CT/LT-PTT). PHMB was loaded on BWO-PVP NPs via electrostatic interactions to form PHMB-BWO-PVP NPs that were stable in saline, phosphate-buffered saline, and Dulbecco’s modified Eagle’s medium. The NPs had a zeta potential of +10.6 mV and a particle size of about 45 nm. Moreover, the NPs were endowed with photothermal conversion ability by BWO and chemical antimicrobial capacity by PHMB. Thus, under LT-PTT, the NPs accelerated the release of PHMB, which exhibited excellent bactericidal effects against methicillin-resistant Staphylococcus aureus and drug-resistant Escherichia coli through synergistic effects, and inhibited the formation of bacterial biofilms. Importantly, PHMB-BWO-PVP NPs can eliminate skin abscesses in mice infected with drug-resistant bacteria via synergistic CT/LT-PTT, induce the transformation of M1 macrophages to M2 macrophages, promote collagen deposition and angiogenesis, and ultimately facilitate wound tissue healing. © 2024 American Chemical Society.
Keyword ：
Antibiotics Antibiotics Controlled drug delivery Controlled drug delivery Escherichia coli Escherichia coli Synthesis (chemical) Synthesis (chemical) Targeted drug delivery Targeted drug delivery Tissue regeneration Tissue regeneration
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| GB/T 7714 | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy [J]. | ACS Applied Polymer Materials , 2024 , 6 (19) : 12059-12070 . |
| MLA | Cheng, Cui et al. "Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy" . | ACS Applied Polymer Materials 6 . 19 (2024) : 12059-12070 . |
| APA | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing , Jiang, Xiwen , Lin, Ting , Han, Xiao et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy . | ACS Applied Polymer Materials , 2024 , 6 (19) , 12059-12070 . |
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Most anticancer treatments only induce the death of ordinary cancer cells, while cancer stem cells (CSCs) in the quiescent phase of cell division are difficult to kill, which eventually leads to cancer drug resistance, metastasis, and relapse. Therefore, CSCs are also important in targeted cancer therapy. Herein, we developed dual-targeted and glutathione (GSH)-responsive novel nanoparticles (SSBPEI-DOX@siRNAs/iRGD-PEG-HA) to efficiently and specifically deliver both doxorubicin and small interfering RNA cocktails (siRNAs) (survivin siRNA, Bcl-2 siRNA and ABCG2 siRNA) to ovarian CSCs. They are fabricated via electrostatic assembly of anionic siRNAs and cationic disulfide bond crosslinking-branched polyethyleneimine-doxorubicin (SSBPEI-DOX) as a core. Interestingly, the SSBPEI-DOX could be degraded into low-cytotoxic polyethyleneimine (PEI). Because of the enrichment of glutathione reductase in the tumor microenvironment, the disulfide bond (-SS-) in SSBPEI-DOX can be specifically reduced to promote the controlled release of siRNA and doxorubicin (DOX) in the CSCs. siRNA cocktails could specifically silence three key genes in CSCs, which, in combination with the traditional chemotherapy drug DOX, induces apoptosis or necrosis of CSCs. iRGD peptides and "sheddable" hyaluronic acid (HA) wrapped around the core could mediate CSC targeting by binding with neuropilin-1 (NRP1) and CD44 to enhance delivery. In summary, the multifunctional delivery system SSBPEI-DOX@siRNAs/iRGD-PEG-HA nanoparticles displays excellent biocompatibility, accurate CSC-targeting ability, and powerful anti-CSC ability, which demonstrates its potential value in future treatments to overcome ovarian cancer metastasis and relapse. To support this work, as exhaustive search was conducted for the literature on nanoparticle drug delivery research conducted in the last 17 years (2007-2023) using PubMed, Web of Science, and Google Scholar.
Keyword ：
cancer stem cells cancer stem cells iRGD peptides iRGD peptides reduction sensitive reduction sensitive siRNAs siRNAs targeted delivery targeted delivery
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| GB/T 7714 | Chen, Li , Luo, Jinlan , Zhang, Jingyuan et al. Dual Targeted Nanoparticles for the Codelivery of Doxorubicin and siRNA Cocktails to Overcome Ovarian Cancer Stem Cells [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (14) . |
| MLA | Chen, Li et al. "Dual Targeted Nanoparticles for the Codelivery of Doxorubicin and siRNA Cocktails to Overcome Ovarian Cancer Stem Cells" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 14 (2023) . |
| APA | Chen, Li , Luo, Jinlan , Zhang, Jingyuan , Wang, Siyuan , Sun, Yang , Liu, Qinying et al. Dual Targeted Nanoparticles for the Codelivery of Doxorubicin and siRNA Cocktails to Overcome Ovarian Cancer Stem Cells . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (14) . |
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Diabetic foot (DF) is difficult to heal due to the formation of drug-resistant bacterial biofilms and dysregulation of the wound microenvironment. To solve this problem, multifunctional hydrogels were prepared by in situ or spraying with 3-aminophenylboronic acid modified oxidized chondroitin sulfate (APBA-g-OCS), polyvinyl alcohol (PVA) and black phosphorus/bismuth oxide/e-polylysine (BP/Bi2O3/e-PL) as precursors for promoting infected diabetic wounds healing. The hydrogels display multiple stimulus responsiveness, strong adhesion and rapid self-healing ability owing to the dynamic borate ester bonds, hydrogen bonds and 7C-7C conjugation crosslink points, remain synergistic chemo-photothermal antibacterial effect and anti-biofilm formation ability due to the doping of BP/ Bi2O3/e-PL into the hydrogel by dynamic imine bonds crosslinking and possess antioxidation and inflammatory chemokine adsorption ability attributing to the presence of APBA-g-OCS. Most importantly, as a result of the above functions, the hydrogels can not only respond to the wound microenvironment to conduct combined PTT and chemotherapy for efficient anti-inflammation, but also improve the wound microenvironment by scavenging ROS and regulating the expression of cytokines, thus further accelerating collagen deposition, promoting granulation tissue formation and angiogenesis, finally promoting the healing of infected wounds in diabetic rats.
Keyword ：
Combined PTT and chemotherapy Combined PTT and chemotherapy Diabetic foot Diabetic foot Inflammatory chemokine adsorption Inflammatory chemokine adsorption Multifunctional hydrogel Multifunctional hydrogel Wounds healing Wounds healing
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| GB/T 7714 | Zhang, Yuan , Chen, Wenjuan , Feng, Wenjing et al. Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation [J]. | CARBOHYDRATE POLYMERS , 2023 , 314 . |
| MLA | Zhang, Yuan et al. "Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation" . | CARBOHYDRATE POLYMERS 314 (2023) . |
| APA | Zhang, Yuan , Chen, Wenjuan , Feng, Wenjing , Fang, Wenhong , Han, Xiao , Cheng, Cui . Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation . | CARBOHYDRATE POLYMERS , 2023 , 314 . |
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This work presents an integrated photoelectrochemical, impedance and colorimetric biosensing platform for flexible detection of cancer markers based on the targeted response by combining liposome amplification stra-tegies and target-induced non-in situ formation of electronic barriers as the signal transduction modality on carbon-modified CdS photoanodes. Inspired by game theory, the carbon layer modified CdS hyperbranched structure with low impedance and high photocurrent response was firstly obtained by surface modification of CdS nanomaterials. Through a liposome-mediated enzymatic reaction amplification strategy, a large number of organic electron barriers were formed by a biocatalytic precipitation (BCP) reaction triggered by horseradish peroxidase released from cleaved liposomes after the introduction of the target molecule, thereby increasing the impedance characteristics of the photoanode as well as attenuating the photocurrent. The BCP reaction in the microplate was accompanied by a significant color change, which opened up a new window for point-of-care testing. Taking carcinoembryonic antigen (CEA) as a proof of concept, the multi-signal output sensing plat-form showed a satisfactory sensitive response to CEA with an optimal linear range of 20 pg mL-1-100 ng mL-1. The detection limit was as low as 8.4 pg mL-1. Meanwhile, with the assistance of a portable smartphone and a miniature electrochemical workstation, the electrical signal obtained was synchronized with the colorimetric signal to correct the actual target concentration in the sample, further reducing the occurrence of false reports. Importantly, this protocol provides a new idea for the sensitive detection of cancer markers and the construction of a multi-signal output platform.
Keyword ：
Carcinoembryonic antigen Carcinoembryonic antigen Multi -signal model Multi -signal model Photoelectrochemical immunoassay Photoelectrochemical immunoassay Portable device Portable device
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| GB/T 7714 | Han, Xianlin , Lin, Shujin , Cheng, Cui et al. Inspired by game theory: Multi-signal output photoelectrochemical point-of-care immunoassay based on target-triggered organic electronic barriers [J]. | ANALYTICA CHIMICA ACTA , 2023 , 1265 . |
| MLA | Han, Xianlin et al. "Inspired by game theory: Multi-signal output photoelectrochemical point-of-care immunoassay based on target-triggered organic electronic barriers" . | ANALYTICA CHIMICA ACTA 1265 (2023) . |
| APA | Han, Xianlin , Lin, Shujin , Cheng, Cui , Han, Xiao , Tang, Dianping . Inspired by game theory: Multi-signal output photoelectrochemical point-of-care immunoassay based on target-triggered organic electronic barriers . | ANALYTICA CHIMICA ACTA , 2023 , 1265 . |
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Objective: Using meta-analysis, we evaluate circulating tumor cells(CTCs) as a potential diagnostic tool for breast cancer.Methods A document search was conducted using publicly available databases up to May 2021. Specific inclusion and exclusion criteria were formulated and summarize relevant data through literature types, research types, case populations, samples, etc. Subgroup analysis of documents based on regions, enrichment methods, and detection methods. The included research projects were evaluated using DeeKs' bias, and evaluation indicators such as specificity (SPE), sensitivity (SEN), diagnosis odds ratio (DOR) were used as evaluation indicators.Results: 16 studies on the use of circulating tumor cells to diagnose breast cancer were included in our meta-analysis. Overall sensitivity value was 0.50 (95%CI:0.48-0.52), specificity value was 0.93 (95%CI:0.92- 0.95), DOR value was 33.41 (95%CI:12.47-89.51), and AUC value was 0.8129.Conclusion:bIn meta-regressions and subgroup analysis, potential heterogeneity factors were analyzed, but the source of heterogeneity is still unclear. CTCs, as a novel tumor marker, have a good diagnostic value, but its enrichment and detection methods still need to continue to be developed to improve detection accuracy. Therefore, CTCs can be used as an auxiliary means of early detection, which is helpful to the diagnosis and screening of breast cancer.
Keyword ：
breast cancer breast cancer circulating tumor cells circulating tumor cells diagnostic diagnostic liquid biopsy liquid biopsy meta-analysis meta-analysis
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| GB/T 7714 | Bai, Shiyan , Lin, Shujin , Lin, Ting et al. Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis [J]. | FRONTIERS IN ONCOLOGY , 2023 , 13 . |
| MLA | Bai, Shiyan et al. "Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis" . | FRONTIERS IN ONCOLOGY 13 (2023) . |
| APA | Bai, Shiyan , Lin, Shujin , Lin, Ting , Wang, Qiaowen , Cheng, Cui , Lin, Junru et al. Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis . | FRONTIERS IN ONCOLOGY , 2023 , 13 . |
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Clinically, systemic antibiotic therapy and traditional dressings care are not satisfactory in treating chronic diabetic ulcers (DU). Therefore, we presented sprayable antibacterial hydrogel for effective treatment of DU by using antibacterial macromolecules (quaternized chitosan, QCS, Mn approximate to 1.5 x 105), photothermal antibacterial nanoparticles (epsilon-poly-L-lysine grafted graphene quantum dots, GQDs-epsilon-PL) and miocompatible macromolecules (benzaldehyde-terminated four-arm poly(ethylene glycol), 4 arm PEG-BA) as materials. The results revealed that the hydrogel could be in situ formed in 70-89 s through dynamic imine bonds crosslinking and exhibited a pHdependent swelling ability and degradability. The hydrogel could respond to bacterial triggered acidic environment to play a synergistic effect of chemotherapy and xenon light irradiated PTT, leading to the rupture of the bacterial membrane and the inactivation of bacteria, promoting the migration and proliferation of fibroblast cell, enhancing the adhesion of platelet endothelial cell, and finally accelerating the healing of infected diabetic wound. Moreover, the hydrogel displayed self-healing, hemostatic, and biocompatible abilities, which could provide a better healing environment for wound and further promote wound healing. Hence, the multifunctional hydrogel is expected to be a potential dressing for the clinical treatment of DU.
Keyword ：
Antibacterial hydrogel Antibacterial hydrogel bacteria-triggered bacteria-triggered Infected diabetic wound healing Infected diabetic wound healing Synergistic chemo-photothermal therapy Synergistic chemo-photothermal therapy Xenon light irradiation Xenon light irradiation
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| GB/T 7714 | Cheng, Cui , Zhong, Haowei , Zhang, Yuan et al. Bacterial responsive hydrogels based on quaternized chitosan and GQDs-?-PL for chemo-photothermal synergistic anti-infection in diabetic wounds [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2022 , 210 : 377-393 . |
| MLA | Cheng, Cui et al. "Bacterial responsive hydrogels based on quaternized chitosan and GQDs-?-PL for chemo-photothermal synergistic anti-infection in diabetic wounds" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 210 (2022) : 377-393 . |
| APA | Cheng, Cui , Zhong, Haowei , Zhang, Yuan , Gao, Xiaoran , Wang, Jianmin , Liu, Jingfeng et al. Bacterial responsive hydrogels based on quaternized chitosan and GQDs-?-PL for chemo-photothermal synergistic anti-infection in diabetic wounds . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2022 , 210 , 377-393 . |
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Surface amino-rich GQDs-epsilon-PL is prepared by changing the addition amount of epsilon-PL. Then, GQDs-epsilon-PL@4-arm PEG-BA/QCS hydrogels (GQDs-epsilon-PL@Gel) are synthesized through dynamic imine bonds cross-linking. The sol can transform quickly to gel and the gelation time can be controlled by adjusting the specific gravity of the input raw materials to water. FT-IR and thermogravimetric analyses indicate the successful synthesis of GQDs-epsilon-PL and GQDs-epsilon-PL@Gel. The microstructure observation reveals that GQDs-epsilon-PL has a sheet-like structure with an average size of 65 nm, while GQDs-epsilon-PL@Gel has a porous network structure. Both GQDs-epsilon-PL and GQDs-epsilon-PL@Gel have good fluorescence stability, photothermal and cytocompatibility, and display better antibacterial effect against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa through chemical and photothermal synergistic sterilization. More importantly, GQDs-epsilon-PL@Gel can repeatedly self-heal after being damaged, which is more beneficial to provide an effective wound closure environment for wounds and to be used as wound dressings.
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| GB/T 7714 | Gao, Jia , Zhang, Yuan , Feng, Wenjing et al. GQDs-epsilon-PL and GQDs-epsilon-PL-based self-healing hydrogel: Synthesis, characterization and in vitro chemo-photothermal combined antibacterial [J]. | JOURNAL OF MATERIALS RESEARCH , 2022 , 38 (2) : 368-379 . |
| MLA | Gao, Jia et al. "GQDs-epsilon-PL and GQDs-epsilon-PL-based self-healing hydrogel: Synthesis, characterization and in vitro chemo-photothermal combined antibacterial" . | JOURNAL OF MATERIALS RESEARCH 38 . 2 (2022) : 368-379 . |
| APA | Gao, Jia , Zhang, Yuan , Feng, Wenjing , Zhang, Ying , Cheng, Cui , Han, Xiao . GQDs-epsilon-PL and GQDs-epsilon-PL-based self-healing hydrogel: Synthesis, characterization and in vitro chemo-photothermal combined antibacterial . | JOURNAL OF MATERIALS RESEARCH , 2022 , 38 (2) , 368-379 . |
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Dengue virus (DENV) is a small envelope virus of Flaviviridae that is mainly transmitted by Aedes aegypti and Aedes albopictus. It can cause dengue fever with mild clinical symptoms or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). At present, there are no specific drugs or mature vaccine products to treat DENV. microRNAs (miRNAs) are a class of important non-coding small molecular RNAs that regulate gene expression at the post-transcriptional level. It is involved in and regulates a series of important life processes, such as growth and development, cell differentiation, cell apoptosis, anti-virus, and anti-tumor. miRNAs also play important roles in interactions between host and viral genome transcriptomes. Host miRNAs can directly target the genome of the virus or regulate host factors to promote or inhibit virus replication. Understanding the expression and function of miRNAs during infection with DENV and the related signal molecules of the miRNA-mediated regulatory network will provide new insights for the development of miRNA-based therapies.
Keyword ：
dengue virus dengue virus hostpathogen interaction hostpathogen interaction microRNA microRNA signaling/signaling pathways signaling/signaling pathways virus replication virus replication
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| GB/T 7714 | Su, Yinghua , Lin, Ting , Liu, Chun et al. microRNAs, the Link Between Dengue Virus and the Host Genome [J]. | FRONTIERS IN MICROBIOLOGY , 2021 , 12 . |
| MLA | Su, Yinghua et al. "microRNAs, the Link Between Dengue Virus and the Host Genome" . | FRONTIERS IN MICROBIOLOGY 12 (2021) . |
| APA | Su, Yinghua , Lin, Ting , Liu, Chun , Cheng, Cui , Han, Xiao , Jiang, Xiwen . microRNAs, the Link Between Dengue Virus and the Host Genome . | FRONTIERS IN MICROBIOLOGY , 2021 , 12 . |
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Cyclodextrins (CDs) are a series of cyclic oligosaccharides formed by amylose under the action of CD glucosyltransferase that is produced by Bacillus. After being modified by polymerization, substitution and grafting, high molecular weight cyclodextrin polymers (pCDs) containing multiple CD units can be obtained. pCDs retain the internal hydrophobic-external hydrophilic cavity structure characteristic of CDs, while also possessing the stability of polymer. They are a class of functional polymer materials with strong development potential and have been applied in many fields. This review introduces the research progress of pCDs, including the synthesis of pCDs and their applications in analytical separation science, materials science, and biomedicine.
Keyword ：
biomedicine biomedicine cyclodextrin polymers cyclodextrin polymers materials science materials science separation science separation science synthesis synthesis
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| GB/T 7714 | Liu, Yuan , Lin, Ting , Cheng, Cui et al. Research Progress on Synthesis and Application of Cyclodextrin Polymers [J]. | MOLECULES , 2021 , 26 (4) . |
| MLA | Liu, Yuan et al. "Research Progress on Synthesis and Application of Cyclodextrin Polymers" . | MOLECULES 26 . 4 (2021) . |
| APA | Liu, Yuan , Lin, Ting , Cheng, Cui , Wang, Qiaowen , Lin, Shujin , Liu, Chun et al. Research Progress on Synthesis and Application of Cyclodextrin Polymers . | MOLECULES , 2021 , 26 (4) . |
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Photodynamic therapy (PDT) is a promising therapy due to its efficiency and accuracy. The photosensitizer is delivered to the target lesion and locally activated. Viral nanoparticles (VNPs) have been explored as delivery vehicles for PDT in recent years because of their favorable properties, including simple manufacture and good safety profile. They have great potential as drug delivery carriers in medicine. Here, we review the development of PDT photosensitizers and discuss applications of VNP-mediated photodynamic therapies and the performance of VNPs in the treatment of tumor cells and antimicrobial therapy. Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors.
Keyword ：
photodynamic therapy photodynamic therapy photosensitizer photosensitizer viral nanoparticles viral nanoparticles
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| GB/T 7714 | Lin, Shujin , Liu, Chun , Han, Xiao et al. Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2021 , 22 (4) . |
| MLA | Lin, Shujin et al. "Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 . 4 (2021) . |
| APA | Lin, Shujin , Liu, Chun , Han, Xiao , Zhong, Haowei , Cheng, Cui . Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2021 , 22 (4) . |
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