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学者姓名：王炳喜
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Abstract ：
Tumor-selective near infrared-induced photothermal therapy is a successful approach for ablation of malignant and cancerous cells. In the NIR region, tissue penetration depth in the near-infrared second region (NIR-II, 1000-1700 nm) is deeper than that of the traditional near-infrared first region (NIR-I, 700-900 nm) for the lower scattering and absorption. However, there are few photothermal conversion agents (PCAs) in the NIR-II. And these PCAs are quickly identified by the immune system and rapidly cleared by the reticuloendothelial system (RES), leading to low accumulation in tumor, which prevents further advanced clinical practice. In this work, the conjugated polymer, PBTPBFTDPP, is prepared and assembled into nanoparticles (SPN). Then, the genetically engineered cell membranes are coated on the surface of SPN to obtain the positive targeting ability (SPN-TF). The obtained SPN-TF nanoparticles exhibit an excellent photothermal conversion ability, predominant targeting efficiency, and superb photothermal therapy for anticancer both in vitro and in vivo. These works will inspire more translational work on SPN for future clinical applications.
Keyword ：
conjugated polymer conjugated polymer genetically engineered cell membrane genetically engineered cell membrane NIR-II NIR-II photothermal therapy photothermal therapy transferrin transferrin
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| GB/T 7714 | Wei, Zuwu , Xin, Fuli , Yang, Sen et al. Genetically Engineered Cell Membrane Modified Conjugated Polymer Nanoparticles for NIR-II Photothermal Therapy [J]. | ADVANCED MATERIALS INTERFACES , 2022 , 9 (21) . |
| MLA | Wei, Zuwu et al. "Genetically Engineered Cell Membrane Modified Conjugated Polymer Nanoparticles for NIR-II Photothermal Therapy" . | ADVANCED MATERIALS INTERFACES 9 . 21 (2022) . |
| APA | Wei, Zuwu , Xin, Fuli , Yang, Sen , Zhang, Cuilin , Wang, Bingxi , Xue, Fangqin et al. Genetically Engineered Cell Membrane Modified Conjugated Polymer Nanoparticles for NIR-II Photothermal Therapy . | ADVANCED MATERIALS INTERFACES , 2022 , 9 (21) . |
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Photothermal therapy (PTT), a powerful tool for non-invasive cancer treatment, has been recognized as an alternative strategy for cancer therapy in the clinic, and it is promoted by optical absorbing agents (photothermal agents) that can intensively convert near-infrared (NIR) light into thermal energy for cancer ablation. Conjugated polymer nanoparticles (CPNs) have recently attracted extensive attention owing to their excellent photothermal properties. However, the absorption of typical CPNs is mostly located in the traditional near-infrared region (NIR-I, 700-900 nm), which suffers from low tissue penetration, so the penetration depth is still limited and severely restricts their further applications. Compared with the NIR-I light, the second near-infrared window light (NIR-II, 1000-1700 nm) could efficiently enhance the tissue penetration depth, however, CPNs which absorb NIR-II region light are still especially limited and need further exploration. Here, a thieno-isoindigo derivative-based Donor-Acceptor (D-A) polymer (BTPBFDTS), which exhibited excellent absorption characteristics from the NIR-I to NIR-II window, was prepared. After formation of nanoparticles and surface functionalization, the prepared nanoparticles (NPs(BTPBFDTS)@HA NPs) exhibited obvious targeting ability, high photothermal conversion efficiency and photoacoustic imaging effects under 1064 nm irradiation. Bothin vitroandin vivostudies demonstrate that our obtained NPs(BTPBFDTS)@HA nanoparticles possess excellent PTT efficacy including extremely high cancer cell killing ability and admirable tumor elimination efficiency. Hence, this work developed a promising photothermal conversion agent based on CPNs for cancer ablation.
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| GB/T 7714 | Wei, Zuwu , Xue, Fangqin , Xin, Fuli et al. A thieno-isoindigo derivative-based conjugated polymer nanoparticle for photothermal therapy in the NIR-II bio-window [J]. | NANOSCALE , 2020 , 12 (38) : 19665-19672 . |
| MLA | Wei, Zuwu et al. "A thieno-isoindigo derivative-based conjugated polymer nanoparticle for photothermal therapy in the NIR-II bio-window" . | NANOSCALE 12 . 38 (2020) : 19665-19672 . |
| APA | Wei, Zuwu , Xue, Fangqin , Xin, Fuli , Wu, Ming , Wang, Bingxi , Zhang, Xiaolong et al. A thieno-isoindigo derivative-based conjugated polymer nanoparticle for photothermal therapy in the NIR-II bio-window . | NANOSCALE , 2020 , 12 (38) , 19665-19672 . |
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Four novel compounds (1-4) were synthesized using 2-phenyl-4H-1-benzopyran-4-one (flavone) moiety as an acceptor and phenoxazine, phenothiazine, 9,9-dimethyl-9,10-dihydroacridine, diphenylamine as donors. Their photophysical properties were studied with spectroscopic and theoretical methods. The results show that 1 and 2 exhibit good aggregation-induced emission (AIE) properties in tetrahydrofuran (THF)/water mixtures, whose maximum photoluminescence (PL) intensities are 156- and 187-fold higher than those in pure THF solutions, and can reach 256- and 506-fold higher than those in the mixtures at water fractions of 50%, respectively. 3 displays similar PL property except for obvious emission in pure THF solution. However, PL intensity of 4 decreases with an increase in water fraction, and then is enhanced with further increase in water fraction. Moreover, 4 shows high quantum yields both in toluene solution (0.61) and in solid state (0.83). It exhibits a positive sol-vatochromism. In addition, 2 possesses mechanofluorochromic transition from sky blue to yellow after grinding. It can also be applied in live-cell imaging.
Keyword ：
Aggregation-induced emission Aggregation-induced emission Donor-acceptor Donor-acceptor Flavone Flavone Mechanofluorochromism Mechanofluorochromism Quantum yields Quantum yields
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| GB/T 7714 | Lin, Yidong , Song, Yangyang , Jin, Yanqiao et al. Synthesis and photophysical properties of donor-acceptor flavone-based derivatives with good aggregation-induced emission characteristics [J]. | DYES AND PIGMENTS , 2020 , 183 . |
| MLA | Lin, Yidong et al. "Synthesis and photophysical properties of donor-acceptor flavone-based derivatives with good aggregation-induced emission characteristics" . | DYES AND PIGMENTS 183 (2020) . |
| APA | Lin, Yidong , Song, Yangyang , Jin, Yanqiao , Wang, Bingxi , Fan, Changzeng . Synthesis and photophysical properties of donor-acceptor flavone-based derivatives with good aggregation-induced emission characteristics . | DYES AND PIGMENTS , 2020 , 183 . |
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To develop high performance anion exchange membranes (AEMs), a novel bisphenol monomer bearing eight benzylmethyl groups at the outer edge of the molecule was synthesized, which after condensation polymerization with various amounts of 4,4'-dihydroxydiphenylsulfone and 4,4'-difluorobenzophenone yielded novel poly(arylene ether)s with densely located benzylmethyl groups. These benzylmethyl groups were then converted to quaternary ammonium groups by radical-initiated bromination and quatemization in tandem, leading to the emergence of densely quaternized poly(arylene ether sulfone)s (QA-PAEs) with controlled ion exchange capacities (IECs) ranging from 1.61 to 2.32 mmol g(-1). Both small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) studies revealed distinct phase separation in the QA-PAEs. The QA-PAE-40 with an IEC of 2.32 mmol g(-1) exhibited a Br- conductivity of 9.2 mS cm(-1) and a SO42- conductivity of 14.0 mS cm(-1) at room temperature, much higher than those of a control membrane with a similar IEC but without obvious phase separation. Therefore, phase separation of AEMs was validated to be advantageous for the efficient conducting of anions. The experimental results also showed that the QA-PAEs were promising AEM materials, especially for non-alkaline applications.
Keyword ：
Anion conductivity Anion conductivity Anion exchange membranes Anion exchange membranes Phase separation Phase separation Quatemization Quatemization
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| GB/T 7714 | Hu, Yuanfang , Wang, Bingxi , Li, Xiao et al. Densely quaternized poly(arylene ether)s with distinct phase separation for highly anion-conductive membranes [J]. | JOURNAL OF POWER SOURCES , 2018 , 387 : 33-42 . |
| MLA | Hu, Yuanfang et al. "Densely quaternized poly(arylene ether)s with distinct phase separation for highly anion-conductive membranes" . | JOURNAL OF POWER SOURCES 387 (2018) : 33-42 . |
| APA | Hu, Yuanfang , Wang, Bingxi , Li, Xiao , Chen, Dongyang , Zhang, Weiying . Densely quaternized poly(arylene ether)s with distinct phase separation for highly anion-conductive membranes . | JOURNAL OF POWER SOURCES , 2018 , 387 , 33-42 . |
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Four compounds (TM-1 similar to 4) based on N-(4-trifluoromethylphenyl)phenothiazine-S,S-dioxide and N-[3,5-bis(trifluoromethyl)phenyl]phenothiazine-S,S-dioxide are synthesized by Buchwald-Hartwig cross coupling reaction. The effect of different substituents in acceptors on the electronic, photophysical and electrochemical properties are studied by UVVis, fluorescence spectroscopy, cyclic voltammetry curves and theoretical calculations. The energy gaps (Delta E-ST) between singlet excited states (S1) and triplet excited states (T-1) of these compounds decrease by addition of one para-substituted -CF3 or two meta-substituted -CF3 on N-phenyl in order to enhance the electron-withdrawing capability of the acceptors. Small Delta E-ST of these compounds range from 0.09 eV to 0.18 eV. TM-2 similar to 4 exhibit thermally activated delayed fluorescence (TADF) characteristics with short delayed fluorescence lifetimes (tau(d)) within 0.69-1.16 mu s. TM-3 emits blue light with an emission wavelength of 475 nm. (C) 2016 Elsevier Ltd. All rights reserved.
Keyword ：
Delayed fluorescence lifetime Delayed fluorescence lifetime Delta E-sT Delta E-sT Sulfone Sulfone TADF TADF
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| GB/T 7714 | Lu, Zhilin , Fang, Dandan , Zheng, Yueyou et al. Preparations and photophysical properties of thermally activated delayed fluorescence materials based on N-phenyl-phenothiazine-S,S-dioxide [J]. | TETRAHEDRON , 2017 , 73 (1) : 21-29 . |
| MLA | Lu, Zhilin et al. "Preparations and photophysical properties of thermally activated delayed fluorescence materials based on N-phenyl-phenothiazine-S,S-dioxide" . | TETRAHEDRON 73 . 1 (2017) : 21-29 . |
| APA | Lu, Zhilin , Fang, Dandan , Zheng, Yueyou , Jin, Yanqiao , Wang, Bingxi . Preparations and photophysical properties of thermally activated delayed fluorescence materials based on N-phenyl-phenothiazine-S,S-dioxide . | TETRAHEDRON , 2017 , 73 (1) , 21-29 . |
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设计并合成了四种基于10-甲基-10H-吩噻嗪-5,5-二氧化物为受体(A),9,9-二甲基-9,10-二氢吖啶(DMAC)或吩噁嗪(PXZ)为给体(D)的分子内电荷转移荧光化合物1a、1b、2a和2b,并研究它们的光物理和电化学性质.结果表明:2a甲苯溶液的最大发射波长(λmax)和除氧后的荧光量子效率(Φd)分别为422 nm和0.367,而1a和1b分别为455 nm、0.083和511 nm、0.098.室温下1a和1b掺杂的PMMA薄膜的荧光寿命(τfilm)分别为5.78和20.00μs.根据77 K时的时间分辨荧光和磷光光谱得到1a和1b的最低单重态(S_1)-最低三重态(T_1...
Keyword ：
光物理性质 光物理性质 吩噻嗪 吩噻嗪 含时密度泛函理论 含时密度泛函理论 最低单重态-最低三重态的能级差 最低单重态-最低三重态的能级差 热激活延迟荧光 热激活延迟荧光 蓝光 蓝光
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| GB/T 7714 | 郑月游 , 谢琼琳 , 王炳喜 . 10-甲基-10H-吩噻嗪-5,5-二氧化物衍生物的合成及其光物理和电化学性质 [J]. | 有机化学 , 2016 , 36 (04) : 803-811 . |
| MLA | 郑月游 et al. "10-甲基-10H-吩噻嗪-5,5-二氧化物衍生物的合成及其光物理和电化学性质" . | 有机化学 36 . 04 (2016) : 803-811 . |
| APA | 郑月游 , 谢琼琳 , 王炳喜 . 10-甲基-10H-吩噻嗪-5,5-二氧化物衍生物的合成及其光物理和电化学性质 . | 有机化学 , 2016 , 36 (04) , 803-811 . |
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Based on 10-methyl-10H-phenothiazine-5,5-dioxide unit as an acceptor and 9,10-dihydro-9,9-dimethyl-acridine (DMAC) or phenoxazine (PXZ) as donors, four intramolecular charge transfer (ICT) compounds were designed and synthesized by Buchwald-Hartwig cross coupling reactions. Their ground-state geometries were optimized with density functional theory (DFT) at B3LYP level and vertical transition energies were calculated using the optimal Hartree-Fock (HF) exchange method. Resulting compounds were characterized by fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, liquid chromatography-mass (LC-MS) spectrometry and hybrid quadrupole time-of-flight mass spectrometry (QTOF). Their photophysical properties were systematically investigated. The results show that compound 2a has maximum emission wavelength (lambda(max)) of 422 nm in toluene and its oxygen-free one has photoluminescence quantum yield (PLQY) of 0.367. The lambda(max) and PLOY for 1a and 1b are 455 nm, 0.083 and 511 nm, 0.098, respectively. Transient photoluminescence decay curves for 5 wt% 1a and 1b doped in PMMA films indicate that their delayed fluorescence lifetimes are 5.78 and 20.00 mu s, respectively. According to the time-resolved fluorescence and phosphorescence spectra of 1a and 1b doped in PMMA films at 77 K, their energy gaps (Delta E-ST) between the lowest singlet state (S-1) and the lowest triplet excited state (T-1) are determined to be 0.203 and 0.177 eV, respectively, which are consistent with the theoretical values 0.232 and 0.295 eV calculated with time-dependent density functional theory (TD-DFT). As a result, la and 1b are expected to be potential thermally activated delayed fluorescence (TADF) materials. The electrochemical properties of the four compounds in dichloromethane solution were determined through cyclic voltammetry using TBAPF(6) as supporting electrolyte and ferrocene as internal standard. The HOMO energy levels of 1a, 1b, 2a and 2b are estimated to be -5.369, -5.111, -5.412 and -5.075 eV, respectively. The thermal properties of the four compounds were investigated by thermal gravimetric analysis under nitrogen atmosphere at a heating rate of 10 degrees C.min(-1) and all compounds show good thermal stability with decomposition temperatures above 420 degrees C.
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| GB/T 7714 | Zheng Yueyou , Xie Qionglin , Wang Bingxi . Synthesis and Photophysical and Electrochemical Properties of 10-Methyl-10H-phenothiazine-5,5-dioxide Derivatives [J]. | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2016 , 36 (4) : 803-811 . |
| MLA | Zheng Yueyou et al. "Synthesis and Photophysical and Electrochemical Properties of 10-Methyl-10H-phenothiazine-5,5-dioxide Derivatives" . | CHINESE JOURNAL OF ORGANIC CHEMISTRY 36 . 4 (2016) : 803-811 . |
| APA | Zheng Yueyou , Xie Qionglin , Wang Bingxi . Synthesis and Photophysical and Electrochemical Properties of 10-Methyl-10H-phenothiazine-5,5-dioxide Derivatives . | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2016 , 36 (4) , 803-811 . |
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采用TD-DFT的最优Hartree-Fock(HF)交换方法,计算以1,8-萘酰亚胺为受体(A),9,9-二甲基-9,10-二氢吖啶、吩噁嗪等为给体(D)构建的12种分子内电荷转移化合物的最低激发单重态和最低激发三重态的能级差(ΔEST),并探寻降低ΔEST的方法.结果表明:D-A型分子比相应的D-苯桥-A型分子具有更低的ΔEST.增加D与A间的扭曲二面角(空间位阻)和提高D的给电子能力能够有效地降低D-A型分子的ΔEST.计算发现4-(9,9-二甲基-9,10-二氢吖啶)-N-苯基-1,8-萘酰亚胺(4b)和4-(吩噁嗪)-N-苯基-1,8-萘酰亚胺(5b)的ΔEST分别为0.01和0.0...
Keyword ：
热激活延迟荧光 热激活延迟荧光 能级差 能级差 萘酰亚胺 萘酰亚胺 量化计算 量化计算
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| GB/T 7714 | 巫友雄 , 任泓扬 , 吴义芳 et al. 萘酰亚胺类电荷转移化合物能隙的理论研究 [J]. | 化学学报 , 2015 , 73 (01) : 53-59 . |
| MLA | 巫友雄 et al. "萘酰亚胺类电荷转移化合物能隙的理论研究" . | 化学学报 73 . 01 (2015) : 53-59 . |
| APA | 巫友雄 , 任泓扬 , 吴义芳 , 王炳喜 . 萘酰亚胺类电荷转移化合物能隙的理论研究 . | 化学学报 , 2015 , 73 (01) , 53-59 . |
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Thermally activated delayed fluorescence (TADF) materials are promising for the next generation of organic light-emitting diodes. To realize reverse intersystem crossing (RISC) effectively for TADF molecules requires basically small energy gap (Delta E-ST) between the lowest singlet (S-1) and triplet (T-1) excited states. In this work, 1,8-naphthalimide was selected as a fixed acceptor (A) because of its large rigid conjugate structure with a high radiative decay rate. Twelve naphthalimide-based intramolecular charge transfer (ICT) compounds were constructed by the conjunction of naphthalimide moiety with each of donors (D) including 9,9-dimethyl-9,10-dihydroacridine, phenoxazine, etc. Their energy gaps were calculated with the Gaussian 09 package at TD-DFT level using the optimal Hartree-Fock exchange method reported by Huang Shuping recently. The results show that D-A structure of naphthalimide-based ICT compounds has smaller Delta E-ST and longer starting fluorescence emission wavelengths (lambda) than those for corresponding D-phenyl-A type. However, strong electron donor like 9-(9H-carbazol-3-yl)-9H-carbazole (DCZ) seems to have no significant effect on Delta E-ST and lambda at high CT amount. To achieve small Delta E-ST of these naphthalimide-based ICT compounds, increasing the twisting angle between D and A, together with enhancing electron donating ability of D is found to be a practical strategy to stabilize the energy of the lowest locally-excited triplet state ((LE)-L-3) and substantially lower the energy of its lowest CT triplet excited state ((CT)-C-3). As a result, 4-(9,9-dimethyl-9,10-dihydroacridine)-N-phenyl-1,8-naphthalimide (4b) and 4-(phenoxazine)-N-phenyl-1,8-naphthalimide (5b) show small Delta E-ST of 0.01 eV and 0.02 eV, respectively. Their lambda and oscillator strengths of vertical absorption from ground state (S-0) to S-1 are 575 nm and 0.0002 for 4b, while 621 nm and 0.0025 for 5b, respectively. In addition, the lambda of compound 5b obtained from its photoluminescence curve is 600 nm, which consists with the computed one with an error of 0.07 eV. Therefore, compounds 4b and 5b can be expected to be potential reddish-orange and red TADF emitters.
Keyword ：
energy gaps energy gaps naphthalimide naphthalimide quantum chemical calculation quantum chemical calculation thermally activated delayed fluorescence thermally activated delayed fluorescence
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| GB/T 7714 | Wu Youxiong , Ren Hongyang , Wu Yifang et al. Theoretical Study of Energy Gaps for Naphthalimide-based Charge Transfer Compounds [J]. | ACTA CHIMICA SINICA , 2015 , 73 (1) : 53-59 . |
| MLA | Wu Youxiong et al. "Theoretical Study of Energy Gaps for Naphthalimide-based Charge Transfer Compounds" . | ACTA CHIMICA SINICA 73 . 1 (2015) : 53-59 . |
| APA | Wu Youxiong , Ren Hongyang , Wu Yifang , Wang Bingxi . Theoretical Study of Energy Gaps for Naphthalimide-based Charge Transfer Compounds . | ACTA CHIMICA SINICA , 2015 , 73 (1) , 53-59 . |
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在钯催化剂条件下,2-(4-溴苯基)-1-苯基-1H-苯并咪唑(PPBI-Br)和吩(噁)嗪(PXZ)反应合成新型分子PPBI-PXZ.采用核磁和质谱表征PPBI-PXZ的结构,紫外-可见光谱和荧光发射光谱探究其光物理性质,热重分析其热稳定性.量化计算结果表明:PPBI-PXZ分子的最高已占有轨道(HOMO)主要分布在供体PXZ部分,最低未占有轨道(LUMO)则分布在受体PPBI部分,供体和受体间的二面角达87.0°,电荷转移量0.891,S1态与T1态能级差计算值为0.28eV.在正己烷、甲苯、乙酸乙酯、二氯甲烷和乙腈5种极性递增的溶剂中,PPBI-PXZ在370nm附近出现吸收肩峰,其最大发射波长从419nm红移至577nm.这种显著的溶致变色现象展现了扭曲分子的分子内电荷转移(TICT)的特征.
Keyword ：
分子内扭曲电荷转移 分子内扭曲电荷转移 吩(噁)嗪 吩(噁)嗪 溶致变色 溶致变色 苯并咪唑 苯并咪唑 量化计算 量化计算
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| GB/T 7714 | 任泓扬 , 吴义芳 , 王炳喜 . 分子内电荷转移吩(噁)嗪衍生物的合成及溶致变色效应的研究 [J]. | 化工新型材料 , 2015 , 43 (7) : 137-139,142 . |
| MLA | 任泓扬 et al. "分子内电荷转移吩(噁)嗪衍生物的合成及溶致变色效应的研究" . | 化工新型材料 43 . 7 (2015) : 137-139,142 . |
| APA | 任泓扬 , 吴义芳 , 王炳喜 . 分子内电荷转移吩(噁)嗪衍生物的合成及溶致变色效应的研究 . | 化工新型材料 , 2015 , 43 (7) , 137-139,142 . |
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