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学者姓名：王建华
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本发明公开了一种负载阿霉素靶向碳点的制备及应用。本发明以荧光碳点为载体、阿霉素为抗肿瘤药物、多巴胺为支架、叶酸为靶向剂，构建了一种负载阿霉素靶向碳点。本发明所制得的碳点具有良好的荧光成像能力，并能有效释放阿霉素，对肿瘤细胞具有显著的杀伤作用。此外，肿瘤靶向分子聚乙二醇叶酸的应用可使本碳点靶向结合肿瘤细胞，从而有效实现其对肿瘤组织的生物荧光成像与靶向药物治疗的目的。
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| GB/T 7714 | 王建华 , 刘旖 , 汪少芸 . 一种负载阿霉素靶向碳点的制备及应用 : CN202111548961.2[P]. | 2021-12-17 00:00:00 . |
| MLA | 王建华 等. "一种负载阿霉素靶向碳点的制备及应用" : CN202111548961.2. | 2021-12-17 00:00:00 . |
| APA | 王建华 , 刘旖 , 汪少芸 . 一种负载阿霉素靶向碳点的制备及应用 : CN202111548961.2. | 2021-12-17 00:00:00 . |
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本发明公开了一种广谱抗菌肽CA‑1，其氨基酸序列为GLLSVLGSVAKHVLPHVVPVIAEHLWKKLFKK‑NH2。该广谱抗菌肽是结合现有的抗菌肽相关理论知识，对澳大利亚树蛙来源的天然抗菌肽Caerin1.1通过理性分子设计进行改造而得到的。抑菌实验结果表明，本发明的抗菌肽CA‑1具有广谱的抑菌效果，其对革兰氏阳性菌、革兰氏阴性菌均有很好的抑制效果，抑菌浓度可达1~8μg/ml。经圆二色谱测定，抗菌肽CA‑1在205~220nm处有负值吸收峰，在TFE溶液中可形成α螺旋结构。
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| GB/T 7714 | 汪少芸 , 韩金志 , 杨捷 et al. 一种基于理性设计策略构建的广谱抗菌肽 : CN202210098946.0[P]. | 2022-01-27 00:00:00 . |
| MLA | 汪少芸 et al. "一种基于理性设计策略构建的广谱抗菌肽" : CN202210098946.0. | 2022-01-27 00:00:00 . |
| APA | 汪少芸 , 韩金志 , 杨捷 , 武培汾 , 陈舜娴 , 陈选 et al. 一种基于理性设计策略构建的广谱抗菌肽 : CN202210098946.0. | 2022-01-27 00:00:00 . |
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本发明公开了一种明胶/碳纳米管/聚吡咯/纳米金复合柔性凝胶电极材料及其制备方法。所述制备方法包括以下步骤：采用柠檬酸钠还原氯金酸溶液制备纳米金分散液；制备碳纳米管/聚吡咯/纳米金杂化溶液；制备明胶/碳纳米管/聚吡咯/纳米金复合溶胶；低温交联制备孔洞分布均匀的明胶/碳纳米管/聚吡咯/纳米金复合凝胶；化学交联制备增强型明胶/碳纳米管/聚吡咯/纳米金复合柔性凝胶电极材料。该复合柔性凝胶电极材料具有优异的机械性能、电化学性能和透气保湿性能，同时人体佩戴舒适度良好，是一种可用于人体生理信号检测的新型柔性电极材料。
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| GB/T 7714 | 王建华 , 丁自凤 , 汪少芸 et al. 一种明胶/碳纳米管/聚吡咯/纳米金复合柔性凝胶电极材料及其制备方法 : CN202210119684.1[P]. | 2022-02-09 00:00:00 . |
| MLA | 王建华 et al. "一种明胶/碳纳米管/聚吡咯/纳米金复合柔性凝胶电极材料及其制备方法" : CN202210119684.1. | 2022-02-09 00:00:00 . |
| APA | 王建华 , 丁自凤 , 汪少芸 , 游力军 . 一种明胶/碳纳米管/聚吡咯/纳米金复合柔性凝胶电极材料及其制备方法 : CN202210119684.1. | 2022-02-09 00:00:00 . |
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For food preservation, the packaging film needs to have higher antibacterial activity in initial phase and keep longer activity. In this study, cinnamaldehyde (CA) and its sulfobutyl ether-beta-cyclodextrin inclusion complex (CA/S) were used to fabricate fish gelatin antibacterial composite films. The addition enhanced the elongation at break and light barrier property of the films. Film forming solution incorporated with CA and CA/S presented the most excellent inhibition ratio against Pseudomonas aeruginosa, which was 98.43 +/- 1.11% in initial period and still 82.97 +/- 4.55% at 72 h. Further, the packaging solution of gelatin combined CA and CA/S effectively inhibited the growth of microorganisms during preservation of grass carp slices. Especially, the total volatile salt-based nitrogen (TVB-N) did not exceed 10 mg/100 g at the end of storage, indicating that the active coating could obviously extend the shelf life of fish muscle. This work provided a promising food packaging system with antimicrobial and environmentally friendly.
Keyword ：
Cinnamaldehyde Cinnamaldehyde Film and coating Film and coating Grass carp Grass carp Inclusion complex Inclusion complex Silver carp skin gelatin Silver carp skin gelatin
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| GB/T 7714 | Wu, Jiulin , Song, Gaojie , Huang, Ruyang et al. Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation [J]. | FOOD CHEMISTRY , 2023 , 418 . |
| MLA | Wu, Jiulin et al. "Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation" . | FOOD CHEMISTRY 418 (2023) . |
| APA | Wu, Jiulin , Song, Gaojie , Huang, Ruyang , Yan, Yongyong , Li, Qingxiang , Guo, Xiaoban et al. Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation . | FOOD CHEMISTRY , 2023 , 418 . |
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Conductive hydrogel-based flexible electronics have attracted immense interest in wearable sensor, soft robot and human-machine interface. However, the application of hydrogels in flexible electronics is limited by the deterioration of mechanical and electrical properties due to freezing at low temperature and desiccation after long-term use. Meanwhile, flexible electronics based on hydrogel are usually not breathable, which has a great impact on wearing comfort and signal stability in long-term sensing. In this work, an adjustable porous gelatin/polypyrrole/reduction graphene oxide (Gel/PPy/rGO) organohydrogel with high breathability (14 g center dot cmz center dot h-1), conductivity (5.25 S/m), mechanical flexibility, anti-freezing and long-term stability is prepared via the combination method of biological fermentation and salt-out toughening crosslinking. The sensor fabricated from the prepared porous organohydrogel exhibits excellent sensing sensitivity, fast response ability, and good endurance, which monitors both weak and intense human activities effectively like finger bending, elbow bending, walking and running, and tiny pulse beating. A pressure sensor array prepared from the porous organohydrogel detects pressure variation in 2D sensitively. Furthermore, the porous organohydrogel is utilized as flexible electrodes for the accurate collection , recognition of human physiological signals (EMG, ECG) and as an interface between human and machine. (c) 2022 Elsevier Inc. All rights reserved.
Keyword ：
Flexible electrode Flexible electrode Gelatin Gelatin Permeability Permeability Porous hydrogel Porous hydrogel Sensor Sensor
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| GB/T 7714 | You, Lijun , Shi, Xinming , Cheng, Jing et al. Flexible porous Gelatin/Polypyrrole/Reduction graphene oxide organohydrogel for wearable electronics [J]. | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2022 , 625 : 197-209 . |
| MLA | You, Lijun et al. "Flexible porous Gelatin/Polypyrrole/Reduction graphene oxide organohydrogel for wearable electronics" . | JOURNAL OF COLLOID AND INTERFACE SCIENCE 625 (2022) : 197-209 . |
| APA | You, Lijun , Shi, Xinming , Cheng, Jing , Yang, Jinhao , Xiong, Caihua , Ding, Zifeng et al. Flexible porous Gelatin/Polypyrrole/Reduction graphene oxide organohydrogel for wearable electronics . | JOURNAL OF COLLOID AND INTERFACE SCIENCE , 2022 , 625 , 197-209 . |
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Supermacroporous hydrogels have attracted wide concern due to their comfort and breathability in wearable health-monitoring applications. Size controllable supermacroporous structure and excellent mechanical properties are the most important for its application. However, they are normally fabricated by the cryogelation method, which is difficult to control pore size and maintain flexibility. Here, yeast fermentationinspired gelatin hydrogels with a controllable supermacroporous structure and excellent mechanical properties were fabricated for the first time. The pore size can be controlled by adjusting the content of glucose and yeast, the ratio of glucose to yeast, fermentation time, and gelatin content during fermentation. The hydrogels demonstrated a controllable pore size range from 100 to 400 mu m and rapid swelling characteristics. The mechanical properties were maintained by soaking ammonium sulfate solution for 12 h, showing maximum tensile and compressive strains over 300 and 99%, respectively. This novel approach can be easily applied to the preparation of supermacroporous and high ductility hydrogels under mild conditions. Furthermore, conductive hydrogels combined supermacroporous structures with conductive polyaniline and reduced oxidized graphene, and silver nanowires were prepared as wearable flexible sensors. The obtained sensors maintain well-distributed porosity, breathability, and mechanical flexibility, also showing excellent conductivity of 2.4 S m(-1). Finally, the sensors were successfully applied to detect physiological signals and human-computer interaction.
Keyword ：
controllable controllable fermentation fermentation gelatin gelatin hydrogels hydrogels supermacropores supermacropores wearable fl exible sensors wearable fl exible sensors
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| GB/T 7714 | Cheng, Jing , You, Lijun , Cai, Xixi et al. Fermentation-Inspired Gelatin Hydrogels with a Controllable Supermacroporous Structure and High Ductility for Wearable Flexible Sensors [J]. | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (23) : 26338-26349 . |
| MLA | Cheng, Jing et al. "Fermentation-Inspired Gelatin Hydrogels with a Controllable Supermacroporous Structure and High Ductility for Wearable Flexible Sensors" . | ACS APPLIED MATERIALS & INTERFACES 14 . 23 (2022) : 26338-26349 . |
| APA | Cheng, Jing , You, Lijun , Cai, Xixi , Yang, Jinhao , Chen, Huimin , Shi, Xinming et al. Fermentation-Inspired Gelatin Hydrogels with a Controllable Supermacroporous Structure and High Ductility for Wearable Flexible Sensors . | ACS APPLIED MATERIALS & INTERFACES , 2022 , 14 (23) , 26338-26349 . |
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Polysaccharide hydrogels are widely applied as wound dressings for skin wound repair due to their good biocompatibility and ability to regulate microenvironments. However, hydrogel application can result in skin wetting that can easily cause wound infections. Herein, a polysaccharide-based antibacterial hydrogel that can promote skin wound repair is prepared by a one-pot method. In this study, tannic acid (TA) is oxidized and cross-linked with carboxymethyl chitosan (CMCS) through a Schiff base reaction to form the macromolecule CMCS-TA. Carboxymethyl cellulose (CMC) cross-links more easily with CMCS-TA than CMCS when utilizing the cross-linking agent carbondiimide hydrochloride (EDC). EDC has no cytotoxicity after hydrolysis and the hydrogel prepared by EDC cross-linking has a low swelling rate. Due to the in situ reduction of Ag particles, the CMC/CMCS-TA/Ag hydrogel exhibits good antibacterial properties against E. coli and S. aureus. Cytocompatibility tests and histological analysis indicate that the antibacterial hydrogel has good biocompatibility and can promote wound repair in a rat infection model. Therefore, the polysaccharide-based hydrogel can be a promising wound dressing for skin wound repair.
Keyword ：
antibacterial hydrogels antibacterial hydrogels natural polysaccharides natural polysaccharides one-pot preparation one-pot preparation skin skin tannic acid tannic acid wound repair wound repair
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| GB/T 7714 | Xu, Gan , Geng, Yusheng , Hu, Le et al. One-Pot Preparation of Polysaccharide-Based Antibacterial Hydrogel for Skin Wound Repair [J]. | MACROMOLECULAR MATERIALS AND ENGINEERING , 2022 , 307 (3) . |
| MLA | Xu, Gan et al. "One-Pot Preparation of Polysaccharide-Based Antibacterial Hydrogel for Skin Wound Repair" . | MACROMOLECULAR MATERIALS AND ENGINEERING 307 . 3 (2022) . |
| APA | Xu, Gan , Geng, Yusheng , Hu, Le , Wang, Jianhua , Pan, PanPan , Chen, Jingdi . One-Pot Preparation of Polysaccharide-Based Antibacterial Hydrogel for Skin Wound Repair . | MACROMOLECULAR MATERIALS AND ENGINEERING , 2022 , 307 (3) . |
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The accurate and real-time monitoring of human physiological signals such as electromyography (EMG) and electrocardiogram (ECG) is of great significance. New composite flexible conductive organohydrogels, GCPP-Au, composed of gelatin (Gel), carboxylated carbon nanotubes (C-MWCNTs), polypyrrole (PPy), and gold nanoparticles (AuNPs) were fabricated. The GCPP-Au composite flexible conductive organohydrogels possessed excellent mechanical properties, electrochemical properties, and ultrahigh permeability. Its elongation at break was 253%, fracture strength was 1.52 MPa, conductivity was 2.33 S m(-1), and sensitivity was high. Due to the regulation of PVP, GCPP-Au presented uniform pore distribution and high permeability. The average pore size was 103.8 mu m, water vapor transmission (WVT) and water vapor permeability (WVP) were 126.21 g h(-1) m(-2) and 244.44 x 10(-7) g m(-1) Pa-1 h(-1), respectively, which significantly improved the wear comfort. GCPP-Au presented high strain transfer sensitivity and can be used as a wearable device for motion monitoring. At the same time, it could be applied to the sensing site of the array pressure sensor to simulate the 'electronic skin'. The GCPP-Au electrode accurately monitored human physiological signals (EMG and ECG) in real-time and realized gesture recognition. Human-computer interaction was carried out including making arm and wrist-integrated sensors to control the Russian square movement. The highly breathable GCPP-Au electrode prepared in this work has broad application prospects in flexible wearable electronic devices.
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| GB/T 7714 | Wang, Jianhua , Ding, Zifeng , Yang, Jinhao et al. Preparation and applications of flexible conductive organohydrogels with ultrahigh gas permeability [J]. | JOURNAL OF MATERIALS CHEMISTRY C , 2022 , 11 (2) : 554-573 . |
| MLA | Wang, Jianhua et al. "Preparation and applications of flexible conductive organohydrogels with ultrahigh gas permeability" . | JOURNAL OF MATERIALS CHEMISTRY C 11 . 2 (2022) : 554-573 . |
| APA | Wang, Jianhua , Ding, Zifeng , Yang, Jinhao , Cheng, Jing , Huang, Chenguang , Xiong, Caihua et al. Preparation and applications of flexible conductive organohydrogels with ultrahigh gas permeability . | JOURNAL OF MATERIALS CHEMISTRY C , 2022 , 11 (2) , 554-573 . |
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Osteoarthritis disease can easily lead to articular cartilage degeneration and subchondral bone damage, so the demand for suitable articular substitutes is gradually increasing. In order to simulate the complex environment of different layers in natural joint, we fabricate the continuous one-phase gradient scaffold. In the study, CS (chitosan) was modified with SH (sodium hyaluronate) and GO (graphene oxide) to form the whole scaffold. nHAP (Nano-hydroxyapatite) was in situ generated with gradient distribution in the scaffold. Continuous interface can better imitate the combination style of cartilage and subchondral bone at joint. The diverseness of scaffold's different layer in water absorption/retention rate and mechanical property is similar to the difference of articular cartilage and subchondral bone. Meanwhile, the cell experiments demonstrated that the bionic scaffold can well promote the proliferation of bone marrow mesenchymal stem cell. Articular defect model further confirmed that the scaffold can better induce articular regeneration. Herein, the prepared scaffold might be an excellent candidate for endogenous articular repair.
Keyword ：
Articular repair Articular repair Continuous scaffold Continuous scaffold Nano hydroxyapatite Nano hydroxyapatite Osteoarthritis disease Osteoarthritis disease
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| GB/T 7714 | Xu, Gan , Zhao, Yao , Geng, Yusheng et al. Nano-hybrid gradient scaffold for articular repair [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 . |
| MLA | Xu, Gan et al. "Nano-hybrid gradient scaffold for articular repair" . | COLLOIDS AND SURFACES B-BIOINTERFACES 208 (2021) . |
| APA | Xu, Gan , Zhao, Yao , Geng, Yusheng , Cao, Shujun , Pan, Panpan , Wang, Jianhua et al. Nano-hybrid gradient scaffold for articular repair . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2021 , 208 . |
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The rapid growth of the abalone industry has brought a great burden to the environment because of their inedible shells. Aiming at environmental and resource sustainability, porous microspheres of carbonate-substituted hydroxyapatite (HAP) were prepared by a hydrothermal method using abalone shells; then, they were further used as a carrier for doxorubicin (DOX) in a drug delivery system. The porous HAP microspheres were approximately 6 mu m in size with a considerable specific surface area and average pore size (128.6659 cm(2)/g and 9.064 nm, respectively), which ensured excellent drug-handling capacity (95.542%). In addition, the pH responsiveness of the drug release system was favorable for effective in vivo drug release in an acidic tumor microenvironment. Moreover, the drug-loaded microspheres could effectively induce apoptosis of MCF-7 cells but were less cytotoxic to MC3T3-E1 cells. Because of its good biocompatibility, high drug loading capacity and controlled drug release property, the porous microspheres prepared in this experiment have potential application value in drug delivery and tumor therapy; furthermore, they make full use of abalone shells, providing environmental sustainability.
Keyword ：
Abalone shell recycling Abalone shell recycling Drug delivery Drug delivery Environmental sustainability Environmental sustainability Hydrothermal Hydrothermal Hydroxyapatite microsphere Hydroxyapatite microsphere
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| GB/T 7714 | Huang, Hao , Du, Mingzu , Chen, Jingdi et al. Preparation and characterization of abalone shells derived biological mesoporous hydroxyapatite microspheres for drug delivery [J]. | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2020 , 113 . |
| MLA | Huang, Hao et al. "Preparation and characterization of abalone shells derived biological mesoporous hydroxyapatite microspheres for drug delivery" . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 113 (2020) . |
| APA | Huang, Hao , Du, Mingzu , Chen, Jingdi , Zhong, Shengnan , Wang, Jianhua . Preparation and characterization of abalone shells derived biological mesoporous hydroxyapatite microspheres for drug delivery . | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS , 2020 , 113 . |
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