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学者姓名：朱春玲
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本发明公开了一种多功能、多靶点抗阿尔兹海默症(AD)的纳米治疗剂及其制备方法和应用。所述纳米治疗剂为Tf‑Fe2+‑Que NPs，由Tf和Fe2+及Que按一定配比通过自组装形成，其中Tf能够通过受体介导的方式促进颗粒靶向穿透BBB，Fe2+‑Que复合物能够提供光热效应以及多靶点抗AD的疗效。本发明所制备的纳米治疗剂，不仅能够协同受体介导转运和光热效应显著提升BBB穿透功能，而且具有结合化学治疗和光热治疗协同促进Aβ降解的效果，以及通过清除ROS、抑制BACE1活性等多靶点途径治疗AD的性能。所述纳米治疗剂制备方法简单，原料易得且生物安全性高，治疗功能多样化，具备多靶点抗AD的潜质。
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| GB/T 7714 | 朱春玲 , 杨宇恒 , 陈兴禹 . 一种多功能、多靶点抗阿尔兹海默症的纳米治疗剂及其制备方法和应用 : CN202210509778.X[P]. | 2022-05-11 00:00:00 . |
| MLA | 朱春玲 等. "一种多功能、多靶点抗阿尔兹海默症的纳米治疗剂及其制备方法和应用" : CN202210509778.X. | 2022-05-11 00:00:00 . |
| APA | 朱春玲 , 杨宇恒 , 陈兴禹 . 一种多功能、多靶点抗阿尔兹海默症的纳米治疗剂及其制备方法和应用 : CN202210509778.X. | 2022-05-11 00:00:00 . |
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Exploring multi-target drugs (MTDs) is a prevalent method against Alzheimer's disease (AD). However, the current developed MTDs based on the "framework combination" technique or using flavonoids have not realized better healing effects owing to a complex metabolic process and low bioavailability. Here, we propose an alternative strategy to develop self-assembled nanoparticles (NPs) as MTDs using 9-fluorenylmethyloxycarbonyl-tryptophan (Fmoc-Trp), quercetin (Que), and Fe2+ as building blocks through coordination and electrostatic interaction to generate Fmoc-Trp-Fe2+-Que (FTFQ) NPs. Whether in cell or in vivo, FTFQ NPs exhibited considerable biocompatibility attributing to the inherent biological affinity of assembly units. By combining the advantages of assemble approach and nanostructures, the obtained FTFQ NPs greatly enhanced the bioavailability of Que and displayed synergistic therapeutic effects through reducing A beta aggregation in direct/indirect means and eliminating the toxicity induced by ROS and A beta oligomer/fibrils. Furthermore, FTFQ NPs could obviously restore the AD zebrafish's mobility and stimulus response ability. More importantly, developing self-assembly NPs as MTDs could be an efficient and general method to promote other novel MTDs by extending the assemble units to other drugs, peptides, and metal ions. Based on above benefits, these self-assembled NPs could be as potential MTDs and show great promising application in AD treatment.
Keyword ：
Alzheimer's disease Alzheimer's disease multi-target drugs (MTDs) multi-target drugs (MTDs) quercetin (Que) quercetin (Que) self-assembled nanoparticles (NPs) self-assembled nanoparticles (NPs)
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| GB/T 7714 | Zhu, Chunling , Yang, Yuheng , Li, Xiaowen et al. Develop potential multi-target drugs by self-assembly of quercetin with amino acids and metal ion to achieve significant efficacy in anti-Alzheimer's disease [J]. | NANO RESEARCH , 2022 , 15 (6) : 5173-5182 . |
| MLA | Zhu, Chunling et al. "Develop potential multi-target drugs by self-assembly of quercetin with amino acids and metal ion to achieve significant efficacy in anti-Alzheimer's disease" . | NANO RESEARCH 15 . 6 (2022) : 5173-5182 . |
| APA | Zhu, Chunling , Yang, Yuheng , Li, Xiaowen , Chen, Xingyu , Lin, Xucong , Wu, Xiaoping . Develop potential multi-target drugs by self-assembly of quercetin with amino acids and metal ion to achieve significant efficacy in anti-Alzheimer's disease . | NANO RESEARCH , 2022 , 15 (6) , 5173-5182 . |
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In order to effectively avoid the side effects induced by multiple components and tedious synthesis process, a simple therapy system based on one material to simultaneously realize both photothermal therapy (PIT) and photodynamic therapy (PDT) under single laser irradiation will promote the overall phototherapeutic efficiency and make the PTT/PDT system easier to operate. Here, by using transferrin (Tf) as protein template, ultrasmall CuS@transferrin nanodots (CuS@Tf NDs) were successfully synthesized through a facile one-pot protein-based biomineralization method. The obtained CuS@Tf NDs exhibited not only excellent photothermal conversion ability (34.4%) but also high photoactivated formation of reactive oxygen species (ROS) upon 980 nm near-infrared (NIR) irradiation. By loading the drug doxorubicin (DOX) to CuS@Tf NDs, a synergistic therapy system with multiple therapeutic effects combined PTT, PDT, chemotherapy (CT) and tumor targeting properties could be perfectly implemented together by CuS@Tf-DOX NDs without any complicated post-modification process. Results from the in vitro cell experiments confirmed that these CuS@Tf-DOX NDs could produce excellent effect on cancer cells with 88.5% cell inhibition rate. In comparison with the complicated systems based on "multiplecomponents-in-one" strategy, this therapy system based on one single material but possess multifunctional purpose is easy to operate and more suitable for clinical applications.
Keyword ：
Biomineralization method Biomineralization method CuS@Tf nanodots CuS@Tf nanodots PTT/PDT synergistic system PTT/PDT synergistic system Transferrin Transferrin
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| GB/T 7714 | Zhu, Chunling , Yin, Xiuhui , Li, Xiaowen et al. Construction of synergistic therapy system with multiple therapeutic effects based on CuS@Tf nanodots [J]. | JOURNAL OF INORGANIC BIOCHEMISTRY , 2020 , 209 . |
| MLA | Zhu, Chunling et al. "Construction of synergistic therapy system with multiple therapeutic effects based on CuS@Tf nanodots" . | JOURNAL OF INORGANIC BIOCHEMISTRY 209 (2020) . |
| APA | Zhu, Chunling , Yin, Xiuhui , Li, Xiaowen , Wang, Yuexue . Construction of synergistic therapy system with multiple therapeutic effects based on CuS@Tf nanodots . | JOURNAL OF INORGANIC BIOCHEMISTRY , 2020 , 209 . |
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Nanotheranostic agents that integrate diagnostic and therapeutic components into one single ultrasmall nanoparticle hold great promise in cancer imaging and therapy, but their synthesis still remains challenging. Here, Ag2Se@BSA-RGD quantum dots (QDs) were successfully synthesized in an aqueous phase by using bovine serum albumin (BSA) as both the template and dispersant and coupled with the tumor targeting molecule Arg-Gly-Asp (RGD). The prepared Ag2Se@BSA-RGD QDs exhibited fascinating properties such as small size (2.46 nm), high biocompatibility, excellent stability in a cell medium, high cellular uptake efficiency, high fluorescence quantum yield, strong photoacoustic signals and promising photothermal conversion efficiency, providing great potential for applications in synchronous imaging and synergetic therapy. Furthermore, by loading DOX into these QDs, an all-in-one theranostic platform by integrating fluorescence/photoacoustic imaging and targeted chemo/photothermal therapy was successfully established in this study.
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| GB/T 7714 | Yin, Xiuhui , Li, Xianglong , Zhu, Chunling et al. Integration of fluorescence/photoacoustic imaging and targeted chemo/photothermal therapy with Ag2Se@BSA-RGD nanodots [J]. | NEW JOURNAL OF CHEMISTRY , 2020 , 44 (12) : 4850-4857 . |
| MLA | Yin, Xiuhui et al. "Integration of fluorescence/photoacoustic imaging and targeted chemo/photothermal therapy with Ag2Se@BSA-RGD nanodots" . | NEW JOURNAL OF CHEMISTRY 44 . 12 (2020) : 4850-4857 . |
| APA | Yin, Xiuhui , Li, Xianglong , Zhu, Chunling , Lin, Xucong , Xie, Zenghong . Integration of fluorescence/photoacoustic imaging and targeted chemo/photothermal therapy with Ag2Se@BSA-RGD nanodots . | NEW JOURNAL OF CHEMISTRY , 2020 , 44 (12) , 4850-4857 . |
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To achieve the clinical application of photothermal nanomaterials in tumor treatment, developing photothermal therapeutic agents with a strong photothermal therapeutic effect, good photostability and rapid clearance or dissociation abilities are urgently desired. Herein, epigallocatechin gallate-iron coordination nanocomplexes with high photothermal conversion capability, magnetic resonance (MR)/photoacoustic (PA) imaging ability and rapid degradation ability under high GSH condition were prepared. (abbreviated as EGCG-Fe/PVP NCs). The EGCG-Fe/PVP NCs were composed through a coordination reaction between Fe3+ and EGCG upon the protection of polyvinyl pyrrolidone (PVP). For its application in the biomedical field, using electronegativity from the polyhydroxy characteristics of EGCG, these complexes were controlled to cap the pores of the DOX-loaded and aminated mesoporous silica nanoparticles via electrostatic attraction to form a multimodal imaging-guided combined chemo and photothermal therapy nanoplatform (abbreviated as MDEF NPs). The prepared MDEF NPs exhibit high drug loading efficiency and favorable pH-dependent drug release capacity. In vitro cytotoxicity data showed that MDEF NPs in the laser exposure group exhibited stronger cytotoxicity than other groups. Therefore, this work may expand the application of MSNs and EGCG-Fe/PVP NCs in the biological field.
Keyword ：
Chemo-photothermal therapy Chemo-photothermal therapy Drug delivery Drug delivery EGCG-Fe EGCG-Fe Mesoporous silica nanoparticles Mesoporous silica nanoparticles Multimodal imaging Multimodal imaging PVP nanocomplexes PVP nanocomplexes
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| GB/T 7714 | Li, Xianglong , Luo, Kai , Lin, Xucong et al. Multifunctional Ultra-Small Nanocomplexes Capping Mesoporous Silica Nanoparticles for Multimodal Imaging and Chemo-Photothermal Therapy [J]. | CHEMNANOMAT , 2019 , 5 (9) : 1115-1122 . |
| MLA | Li, Xianglong et al. "Multifunctional Ultra-Small Nanocomplexes Capping Mesoporous Silica Nanoparticles for Multimodal Imaging and Chemo-Photothermal Therapy" . | CHEMNANOMAT 5 . 9 (2019) : 1115-1122 . |
| APA | Li, Xianglong , Luo, Kai , Lin, Xucong , Zhu, Chunling . Multifunctional Ultra-Small Nanocomplexes Capping Mesoporous Silica Nanoparticles for Multimodal Imaging and Chemo-Photothermal Therapy . | CHEMNANOMAT , 2019 , 5 (9) , 1115-1122 . |
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A direct immersion solid-phase microextraction (DI-SPME) approach for gas chromatography-mass spectrometry (GC-MS) based on hybrid fiber coating of ionic liquid and polyhedral oligomeric silsesquioxane (POSS) is presented. To fabricate the task-specific coating for the enrichment of polycyclic aromatic hydrocarbons (PAHs), 1-butyl-3-vinylimidazolium bist(trifluoromethyl)sulfonyl]imide (IL) and POSS were rapidly photoinitiated copolymerized within 5 min on a stainless steel fiber. The high efficient extraction of target analytes can be attributed to a combined result of multiple interactions including the strong C-F center dot center dot center dot H-C pseudohydrogen bonding, pi-pi stacking, hydrophobic force, and molecular sieve effect. A wide linear range (0.04-400 ng L-1) with low detection limits in the range of 0.004 and 0.5 ng L-1 were obtained for PAHs by GC-MS. The applicability of this coupling method was successfully demonstrated by the analysis of trace PAHs in real river water and soil samples, with satisfied recoveries (84.2-108.6%) and relative standard deviations (<8.1%). Compared to the other commercial fiber-based SPME methods, the IL/POSS hybrid coating-based SPME is much cheaper, thermally stable and capable of eliminating possible deleterious effects as well. (C) 2019 Elsevier B.V. All rights reserved.
Keyword ：
Ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating Ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating Photo-initiated polymerization Photo-initiated polymerization Polycyclic aromatic hydrocarbons Polycyclic aromatic hydrocarbons Solid-phase microextraction Solid-phase microextraction Stainless steel fiber Stainless steel fiber
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| GB/T 7714 | Zhang, Ning , Su, Lishen , Man, Suning et al. Task-specific solid-phase microextraction based on ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating for sensitive analysis of polycyclic aromatic hydrocarbons by gas chromatography-mass spectrometry [J]. | JOURNAL OF CHROMATOGRAPHY A , 2019 , 1598 : 49-57 . |
| MLA | Zhang, Ning et al. "Task-specific solid-phase microextraction based on ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating for sensitive analysis of polycyclic aromatic hydrocarbons by gas chromatography-mass spectrometry" . | JOURNAL OF CHROMATOGRAPHY A 1598 (2019) : 49-57 . |
| APA | Zhang, Ning , Su, Lishen , Man, Suning , Lei, Xiaoyun , Huang, Ting , Zhu, Chunling et al. Task-specific solid-phase microextraction based on ionic liquid/polyhedral oligomeric silsesquioxane hybrid coating for sensitive analysis of polycyclic aromatic hydrocarbons by gas chromatography-mass spectrometry . | JOURNAL OF CHROMATOGRAPHY A , 2019 , 1598 , 49-57 . |
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Recently, due to their properties of high surface-to-volume ratio, easy penetration of the blood-brain barrier and easily modified surfaces, nanoparticles (NPs) have been recognized as promising inhibitors for Alzheimer's disease (AD) diagnosis and therapy. However, to achieve clinical application, the design and synthesis of specific NPs with good biocompatibility and degradability still are the main focus of research. In this paper, EGCG-Fe(III)/PVP (EFPP) NPs with ultra-small size and good biocompatibility were first fabricated by the coordination reaction between Fe3+, EGCG and PVP. The obtained EFPP NPs exhibited effective influence on the inhibition of A beta 40 fibrillation and disaggregation of existing A beta 40 fibrils. The inhibitory effect was mainly derived from the synergistic effect of the weak hydrophobicity from PVP and antioxidant activity of EGCG. With the advantages of easy synthesis, high stability in simulated body fluid, high performance towards the antifibrillation of A beta 40 and biodegradability, it is reasonable to consider that the as-prepared EFPP NPs have good application prospects in the treatment of AD.
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| GB/T 7714 | Liu, Zexiu , Li, Xianglong , Wu, Xiaoping et al. A dual-inhibitor system for the effective antifibrillation of A beta 40 peptides by biodegradable EGCG-Fe(iii)/PVP nanoparticles [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2019 , 7 (8) : 1292-1299 . |
| MLA | Liu, Zexiu et al. "A dual-inhibitor system for the effective antifibrillation of A beta 40 peptides by biodegradable EGCG-Fe(iii)/PVP nanoparticles" . | JOURNAL OF MATERIALS CHEMISTRY B 7 . 8 (2019) : 1292-1299 . |
| APA | Liu, Zexiu , Li, Xianglong , Wu, Xiaoping , Zhu, Chunling . A dual-inhibitor system for the effective antifibrillation of A beta 40 peptides by biodegradable EGCG-Fe(iii)/PVP nanoparticles . | JOURNAL OF MATERIALS CHEMISTRY B , 2019 , 7 (8) , 1292-1299 . |
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Ag2Se quantum dots (QDs) with near-infrared (NIR) fluorescence have been widely utilized in NIR fluorescence imaging in vivo because of their narrow bulk band gap and excellent biocompatibility. However, most of synthesis methods for Ag2Se QDs are expensive and the reactants are toxic. Herein, a new protein-templated biomimetic synthesis approach is proposed for the preparation of Ag2Se QDs by employing bovine serum albumin (BSA) as a template and dispersant. The BSA-templated Ag2Se QDs (Ag2Se@BSA QDs) showed NIR fluorescence with high fluorescence quantum yield (approximate to 21.2 %), excellent biocompatibility and good dispersibility in different media. Moreover, the obtained Ag2Se@BSA QDs exhibited remarkable photothermal conversion (approximate to 27.8 %), which could be used in photothermal therapy. As a model application in biomedicine, the Ag2Se@BSA QDs were used as "gatekeepers" to cap mesoporous silica nanoparticles (MSNs) by means of electrostatic interaction. By taking the advantages of NIR fluorescence and photothermal property of Ag2Se@BSA QDs, the obtained MSN-DOX-Ag2Se nanoparticles (MDA NPs) were employed as a nanoplatform for combined chemo-photothermal therapy. Compared with free DOX and MDA NPs without NIR laser, the laser-treated MDA NPs exhibited lower cell viability in vitro, implying that Ag2Se@BSA QDs are highly promising photothermal agents and the MDA NPs are potential carriers for chemo-photothermal therapy.
Keyword ：
biomimetic synthesis biomimetic synthesis chemo-photothermal therapy chemo-photothermal therapy drug delivery drug delivery near-infrared fluorescence near-infrared fluorescence quantum dots quantum dots silver selenide silver selenide
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| GB/T 7714 | Li, Xianglong , Liu, Zexiu , Luo, Kai et al. Biomimetic Synthesis of Ag2Se Quantum Dots with Enhanced Photothermal Properties and as "Gatekeepers" to Cap Mesoporous Silica Nanoparticles for Chemo-Photothermal Therapy [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2019 , 14 (1) : 155-161 . |
| MLA | Li, Xianglong et al. "Biomimetic Synthesis of Ag2Se Quantum Dots with Enhanced Photothermal Properties and as "Gatekeepers" to Cap Mesoporous Silica Nanoparticles for Chemo-Photothermal Therapy" . | CHEMISTRY-AN ASIAN JOURNAL 14 . 1 (2019) : 155-161 . |
| APA | Li, Xianglong , Liu, Zexiu , Luo, Kai , Yin, Xiuhui , Lin, Xucong , Zhu, Chunling . Biomimetic Synthesis of Ag2Se Quantum Dots with Enhanced Photothermal Properties and as "Gatekeepers" to Cap Mesoporous Silica Nanoparticles for Chemo-Photothermal Therapy . | CHEMISTRY-AN ASIAN JOURNAL , 2019 , 14 (1) , 155-161 . |
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In this paper, the W18O49 nanospheres (W18O49 NSs) with diameter about 100 nm have been found to exhibit intrinsic peroxidase-like activity, which can catalytically oxidize 3,3', 5,5'-tetramethylbenzidine (TMB) by H2O2 to produce a color reaction. Different from the catalytic behavior of the Fe3O4 particles, the possible catalysis mechanism was notably dependent on the surface oxygen vacancies (SOVs) abundant in W18O49 NSs, which served as important catalytic sites. Moreover, due to the speciality with high surface area (136.13 m(2) g(-1)) and negative potential (-54.8 mV), the obtained W18O49 NSs could be used as efficient peroxidase mimetic to remove the dye pollutant methylene blue (MB) in the assistance of H2O2. And the degradation efficiency of MB could be achieved above 91% with 50 mu g mL(-1) W18O49 NSs.
Keyword ：
Environmental mitigation application Environmental mitigation application Nanostructured catalysts Nanostructured catalysts Peroxidase-like activity Peroxidase-like activity Surface oxygen vacancies Surface oxygen vacancies W18O49 nanospheres W18O49 nanospheres
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| GB/T 7714 | Zhu, Chunling , Zheng, Shaoqiu , Cao, Ting et al. Surface oxygen vacancies induced peroxidase-like activity for W18O49 nanospheres and their application in degradation of methylene blue [J]. | JOURNAL OF NANOPARTICLE RESEARCH , 2018 , 20 (7) . |
| MLA | Zhu, Chunling et al. "Surface oxygen vacancies induced peroxidase-like activity for W18O49 nanospheres and their application in degradation of methylene blue" . | JOURNAL OF NANOPARTICLE RESEARCH 20 . 7 (2018) . |
| APA | Zhu, Chunling , Zheng, Shaoqiu , Cao, Ting , Lin, Chenchen , Xie, Zenghong . Surface oxygen vacancies induced peroxidase-like activity for W18O49 nanospheres and their application in degradation of methylene blue . | JOURNAL OF NANOPARTICLE RESEARCH , 2018 , 20 (7) . |
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本发明属于纳米材料制备和催化应用领域，具体涉及一种葡萄干面包式的金‑二氧化硅纳米催化剂及其制备和应用，所述的纳米催化剂为Au‑SiO2‑TA‑Fe组成的葡萄干面包式形貌的纳米复合颗粒。所述的催化剂是由Au的前驱物溶液与二氧化硅‑多酚金属纳米颗粒混合反应而制得的Au‑SiO2‑TA‑Fe纳米复合颗粒，复合颗粒粒径为80‑100 nm，Au在复合颗粒中的含量为2.07~2.51 wt%，Au的粒径为2~5 nm。该方法无需使用任何有机溶剂、特殊的仪器或强还原性试剂，仅利用硅羟基及多酚羟基即可原位还原获得单分散的Au纳米颗粒，合成方法绿色环保，简单易行。所制备的Au‑SiO2‑TA‑Fe复合颗粒可应用于催化及生物医学等领域。
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| GB/T 7714 | 朱春玲 , 郑少秋 , 谢增鸿 et al. 一种葡萄干面包式金-二氧化硅纳米催化剂及其制备和应用 : CN201810019063.X[P]. | 2018/1/9 . |
| MLA | 朱春玲 et al. "一种葡萄干面包式金-二氧化硅纳米催化剂及其制备和应用" : CN201810019063.X. | 2018/1/9 . |
| APA | 朱春玲 , 郑少秋 , 谢增鸿 , 林旭聪 . 一种葡萄干面包式金-二氧化硅纳米催化剂及其制备和应用 : CN201810019063.X. | 2018/1/9 . |
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