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学者姓名：唐点平
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Abstract ：
With increasing public awareness of healthcare, the demand for early screening of cancer biomarkers has grown substantially. Nanozymes, with their unique catalytic and sensing properties, have emerged as promising alternatives in this field. Herein, a cascade catalytic system was developed by integrating natural glucose oxidase with oxygen vacancy-rich trimetallic oxide nanozymes. Through specific immunorecognition, efficient conversion of biological signals into measurable outputs was achieved, enabling the construction of a dual-mode colorimetric and photothermal sensing platform for the sensitive detection of carcinoembryonic antigens. Density functional theory calculations revealed that the trimetallic synergistic strategy effectively modulates the distribution of active sites and electronic structures. The presence of abundant oxygen vacancies and a multilayered stacked morphology further enhanced the peroxidase-like activity and substrate activation capability. Under optimized conditions, the photothermal mode exhibited a broad linear range from 0.05 to 50 ng mL-1, while the colorimetric mode showed a sensitive response from 0.015 to 100 ng mL-1, with corresponding detection limits of 14.2 and 9.7 pg mL-1, respectively. This work demonstrates that the synergy between multimetallic components and oxygen vacancies can significantly enhance artificial enzyme performance, offering a robust sensing platform with dual-signal output. The strategy not only shows excellent applicability in real sample analysis but also provides a new avenue for high-throughput and multidimensional bioanalytical applications.
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| GB/T 7714 | Wang, Haiyang , Wu, Di , Lao, Shuqun et al. Three-Metal Oxide Hollow Lamellar Cube and Oxygen Vacancy Engineering: Construction of a Dual-Mode Sensing Platform and Collaborative Detection Mechanism [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (36) : 19926-19933 . |
| MLA | Wang, Haiyang et al. "Three-Metal Oxide Hollow Lamellar Cube and Oxygen Vacancy Engineering: Construction of a Dual-Mode Sensing Platform and Collaborative Detection Mechanism" . | ANALYTICAL CHEMISTRY 97 . 36 (2025) : 19926-19933 . |
| APA | Wang, Haiyang , Wu, Di , Lao, Shuqun , Tang, Dianping . Three-Metal Oxide Hollow Lamellar Cube and Oxygen Vacancy Engineering: Construction of a Dual-Mode Sensing Platform and Collaborative Detection Mechanism . | ANALYTICAL CHEMISTRY , 2025 , 97 (36) , 19926-19933 . |
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Development of accurate analytical protocols for cancer biomarkers is used for the initial prescreening of malignant tumors, disease surveillance, and efficacy assessment with significant clinical benefits. In this work, we reported a liposome-mediated signal-off photoelectrochemical (PEC) immunoassay for the sensitive detection of carcinoembryonic antigen (CEA) using ternary transition metal sulfide CuS/ZnCdS as the photoactive material. Good photocurrents were acquired on the basis of specific oxidation reaction of dopamine on the CuS/ZnCdS. The energy band relationship of CuS/ZnCdS was determined, and the wellmatched oxidation potential of dopamine was verified. To achieve accurate recovery of low-abundance CEA, systematic PEC evaluation from human serum samples was performed by combining with classical immunoreaction and liposome-induced dopamine amplification strategy with high stability and selectivity. Under optimum conditions, PEC immunoassay displayed good photocurrent responses toward target CEA with a dynamic linear range of 0.1-50 ng/mL with a detection limit of 31.6 pg/mL. Importantly, this system by combining with a discussion of energy level matching between semiconductor energy bands and small-molecules opens a new horizon for development of high-efficient PEC immunoassays. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Carcinoembryonic antigen Carcinoembryonic antigen Liposome labelling Liposome labelling Photoelectrochemical immunoassay Photoelectrochemical immunoassay Signal amplification Signal amplification Ternary transition metal sulfides Ternary transition metal sulfides
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| GB/T 7714 | Tian, Shuo , Chen, Shuyun , Wang, Yunsen et al. Liposomal photoelectrochemical immunoassay for low-abundance proteins with ternary transition metal sulfides for signal amplification [J]. | CHINESE CHEMICAL LETTERS , 2025 , 36 (7) . |
| MLA | Tian, Shuo et al. "Liposomal photoelectrochemical immunoassay for low-abundance proteins with ternary transition metal sulfides for signal amplification" . | CHINESE CHEMICAL LETTERS 36 . 7 (2025) . |
| APA | Tian, Shuo , Chen, Shuyun , Wang, Yunsen , Tang, Dianping . Liposomal photoelectrochemical immunoassay for low-abundance proteins with ternary transition metal sulfides for signal amplification . | CHINESE CHEMICAL LETTERS , 2025 , 36 (7) . |
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The development of rapid and sensitive CA19–9 (carbohydrate antigen 19–9) analytical methods for early screening of potential patients, especially in clinical situations, is important for controlling the progression of pancreatic cancer. Herein, a new photoelectrochemical (PEC) immunoassay has been devised for the ultrasensitive detection of CA19–9 using gold nanoparticle-modified ultrathin ZnIn2S4 nanosheets (Au-UZNS) as the photoactive substrate. Notably, the alkaline phosphatase (ALP) labeled on the detection antibody (ALP-dAb) serves as the signal amplifier that catalyzes the production of large amounts of ascorbic acid (AA) after the sandwiched immunoreaction. The generated AA is an outstanding electron donor, thereby improving the intensity of the photoactive substrate. Under the optimized parameters, the Au-UZNS-based PEC immunosensor displays an excellent response to CA19–9 ranging from 0.01 to 500 U mL −1 with a limit of detection (LOD) of 4.7 mU mL −1. Generally, the CA19–9 levels in the serum of high-risk pancreatic cancer patients range from 120 to 400 U mL−1, while the levels in normal humans range from 0 to 40 U mL−1. Therefore, the exceptionally low LOD value of the proposed method is sufficient to meet the threshold for clinical detection and holds significant potential for further application. © 2025 Elsevier B.V.
Keyword ：
Au-ZnIn2S4 heterojunction Au-ZnIn2S4 heterojunction Carbohydrate antigen 19–9 Carbohydrate antigen 19–9 Enzyme-amplified photoelectrochemical immunoassay Enzyme-amplified photoelectrochemical immunoassay Photoactive materials Photoactive materials Split-type screening mode Split-type screening mode
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| GB/T 7714 | Tian, S. , Lin, J. , Chen, W. et al. Enzyme-amplified split-type photoelectrochemical immunoassay for quantitative monitoring of carbohydrate antigen 19–9 (CA19–9) based on Au-ZnIn2S4 heterojunction [J]. | Microchemical Journal , 2025 , 216 . |
| MLA | Tian, S. et al. "Enzyme-amplified split-type photoelectrochemical immunoassay for quantitative monitoring of carbohydrate antigen 19–9 (CA19–9) based on Au-ZnIn2S4 heterojunction" . | Microchemical Journal 216 (2025) . |
| APA | Tian, S. , Lin, J. , Chen, W. , Tang, D. , Ou, Y. . Enzyme-amplified split-type photoelectrochemical immunoassay for quantitative monitoring of carbohydrate antigen 19–9 (CA19–9) based on Au-ZnIn2S4 heterojunction . | Microchemical Journal , 2025 , 216 . |
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Hydrogel wound dressing has significant advantages in wound treatment. It can shorten the time of wound healing, control the process of wound healing, and effectively promote the healing of damaged tissues in a hydrated environment. Sodium alginate (SA) is a commonly used hydrogel wound dressing material, which can quickly form a three-dimensional network structure hydrogel in a relatively mild environment, but the mechanical properties and stability of a single SA hydrogel are poor. The composite hydrogel prepared by mixing SA with other substances can not only exert the performance of a single substance but also improve the mechanical properties, stability and adsorption of the hydrogel and has a wider application prospect in the field of sustained release control of bioactive substances. Natural polymers have been widely used in the preparation of hemostatic and wound healing materials due to their excellent biocompatibility, degradability, viscoelasticity and easy processing. This paper introduces the research progress of composite hydrogels prepared by SA and natural polymers in mechanical properties, antibacterial, anti-inflammatory, tissue repair and sustained release control of bioactive substances, and provides a theoretical basis for the application of SA-based composite hydrogels in wound dressings.
Keyword ：
cellulose cellulose chitosan chitosan composite hydrogel composite hydrogel hyaluronic acid hyaluronic acid Sodium alginate Sodium alginate wound dressing, gelatin wound dressing, gelatin
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| GB/T 7714 | Zhou, Fengchao , Deng, Shibin , Lin, Guorong et al. Research Progress of Wound Dressing Based on Sodium Alginate Composite Hydrogel [J]. | CURRENT MEDICINAL CHEMISTRY , 2025 . |
| MLA | Zhou, Fengchao et al. "Research Progress of Wound Dressing Based on Sodium Alginate Composite Hydrogel" . | CURRENT MEDICINAL CHEMISTRY (2025) . |
| APA | Zhou, Fengchao , Deng, Shibin , Lin, Guorong , Shen, Jiandong , Tang, Dianping . Research Progress of Wound Dressing Based on Sodium Alginate Composite Hydrogel . | CURRENT MEDICINAL CHEMISTRY , 2025 . |
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Colorimetric immunoassays based on the nanozymes offer amazing potentials in the fields of quick detection. However, the subjective nature of their visual interpretation, as well as the interference of ambient factors on color development findings, severely limit the objectivity and accuracy of quantitative analysis. To overcome these constraints, we developed a photothermal-electrochemical immunoassay by using Co3O4@MnCo2O4 core-shell nanozymes that leverage the multifunctional properties of the chromogenic substrate 3,3 ',5,5 '-tetramethylbenzidine (TMB). This design synergistically enhances both electrocatalytic and photothermal activities, enabling highly sensitive dual-mode detection of alpha-fetoprotein (AFP). The photothermal mode achieved a detection range of 0.1-100 ng mL-1 with a limit of detection (LOD) of 60 pg mL-1, while the electrochemical mode offered a range of 0.01-50 ng mL-1 and a lower LOD of 6.2 pg mL-1. The immunoassay integrates rapid screening, accurate quantification and cross-validation functions, breaking through the bottleneck of single-mode detection and providing a new highly sensitive and reliable solution for clinical tumor marker detection.
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| GB/T 7714 | Chen, Shuyun , Wang, Yunsen , Tian, Shuo et al. Core-Shell Bimetallic Nanozyme-Enabled Synergistic Photothermal-Electrochemical Amplification for Ultrasensitive Immunoassay [J]. | ANALYTICAL CHEMISTRY , 2025 . |
| MLA | Chen, Shuyun et al. "Core-Shell Bimetallic Nanozyme-Enabled Synergistic Photothermal-Electrochemical Amplification for Ultrasensitive Immunoassay" . | ANALYTICAL CHEMISTRY (2025) . |
| APA | Chen, Shuyun , Wang, Yunsen , Tian, Shuo , Tang, Dianping . Core-Shell Bimetallic Nanozyme-Enabled Synergistic Photothermal-Electrochemical Amplification for Ultrasensitive Immunoassay . | ANALYTICAL CHEMISTRY , 2025 . |
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Accurate and rapid identification of expired and spoiled food is crucial for food conservation, reducing resource wastage, and preventing food poisoning. This paper presents a portable electrochemical sensing platform supported by a miniature electrochemical workstation and an intelligent pH recognition system, enabling detection of L-lactic acid (L-LA) in food products without enzyme involvement. The system was based on a Cu2O@CuO multifaceted extended spatial hexapod structure. The synthesized Cu2O@CuO was characterized by a welldefined multifaceted structure. Significant enzyme-free catalysis was exhibited, and pH responses dominated by anthocyanins were identified through an intelligent image acquisition system. Additionally, we developed an electrochemical detection device for pH assistance during target testing, addressing the limitations of current electrochemical sensors' complex signal acquisition components using 3D-printed fabrication techniques and smartphones. The proposed multifunctional electrochemical workbench based on Cu2O@CuO was found to offer a preferable linear detection range of 0.1-1000 mu M for L-LA, with a low detection limit of 0.027 mu M. The visualization of pH determination was introduced as a novel approach for developing advanced electrochemical workbenches. In conclusion, pH-assisted portable electrochemical detection systems hold great potential for immediate food safety identification, particularly in resource-limited areas, facilitating prompt diagnosis and ensuring food safety.
Keyword ：
3D-printed device 3D-printed device Electrochemical detection Electrochemical detection Enzyme-free catalysis Enzyme-free catalysis Food quality evaluation Food quality evaluation Visualization Visualization
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| GB/T 7714 | Wu, Di , Wei, Qiaohua , Yu, Zhichao et al. Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition [J]. | FOOD CHEMISTRY , 2025 , 465 . |
| MLA | Wu, Di et al. "Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition" . | FOOD CHEMISTRY 465 (2025) . |
| APA | Wu, Di , Wei, Qiaohua , Yu, Zhichao , Gao, Yuan , Knopp, Dietmar , Tang, Dianping . Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition . | FOOD CHEMISTRY , 2025 , 465 . |
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The judicious utilization of antibiotics has established a robust bulwark for human health. However, their improper usage has engendered deleterious ramifications on the environment, underscoring the imperative for developing efficacious and cost-effective detection and degradation platforms. This study presents a sulfur-modified iron-cobalt bimetallic single-atom nitrogen-doped carbon catalyst (S-FeCo-NC) with a noncopper active center. In contrast to conventional laccase, which utilizes copper as its active center, the S-FeCo-NC catalyst exhibits multiple enzyme activities, including laccase-like, peroxidase-like, and catalase-like functions, with iron and cobalt serving as the active centers. As a proof of concept, the combined laccase-like and catalase-like functions of S-FeCo-NC were used as independent signal outputs, while a multienzyme cascade dual-mode assay system was designed for the rapid detection of tetracycline (TC) in combination with peroxidase-like enzymes. In this system, oxygen directly participated in the catalytic process of laccase-like as an electron acceptor, while catalase-like peroxidase efficiently catalyzed the production of O2 from H2O2. The elevated concentration of O2 offered a unique advantage for the increased catalytic activity of the laccase-like enzyme, which outputs visually resolved colorimetric signals using stable 4-aminopyridine with oxidized TC. Furthermore, the peroxidase-like activity of S-FeCo-NC catalyzed the generation of OH radicals with strong oxidative properties, and these radicals carried out effective oxidative decomposition of TC. The signal output of the response of the catalytic process was performed using differential pulse cyclic voltammetry, which further improved the sensitivity and accuracy of the detection. The experimental findings demonstrate that the detection system exhibits a favorable response signal to TC within the range of 0.005-500 mu M, with its detection range reaching 0.5-500 and 0.005-1.00 mu M, respectively, and the detection limit is as low as 0.22 mu M and 1.68 nM, respectively. This cascade dual-mode detection system, based on multienzyme activity, has been shown to significantly enhance the catalytic activity of laccase, while also demonstrating stability in a lower detection range. This suggests that it may offer a novel approach for the sensitive detection and degradation of environmental pollutants.
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| GB/T 7714 | Wang, Yunsen , Tian, Shuo , Chen, Shuyun et al. S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (13) : 7526-7535 . |
| MLA | Wang, Yunsen et al. "S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay" . | ANALYTICAL CHEMISTRY 97 . 13 (2025) : 7526-7535 . |
| APA | Wang, Yunsen , Tian, Shuo , Chen, Shuyun , Li, Meijin , Tang, Dianping . S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay . | ANALYTICAL CHEMISTRY , 2025 , 97 (13) , 7526-7535 . |
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Photocurrent-polarity conversion strategies are typically realized by constructing complex photovoltaic electrodes or changing the relevant conditions, but most involve poor photogenerated carrier transfer efficiency and cumbersome experimental steps. To this end, a photoelectrochemical (PEC) biosensor by utilizing ascorbic acid (AA)-induced photocurrent-polarity-switching was proposed for the detection of carcinoembryonic antigen (CEA). Under light excitation, the electron donor AA was oxidized by the photogenerated holes of photoactive material Co-NC/CdS, resulting in the conversion of cathodic photocurrent to the anodic direction. In the presence of the target CEA, alkaline phosphatase (ALP) was introduced into the microplates by the sandwiched immunoreaction, which then catalyzed the production of AA from ascorbic acid-2-phosphate (AAP). Finally, the catalytic product AA was transferred onto Co-NC/CdS-modified screen-printed carbon electrode, thus activating photocurrent-polarity-switching platform. The anodic photocurrent values gradually increased with increasing CEA concentration in the range of 0.02-80 ng mL(-1) and reached a limit of detection (LOD) of 8.47 pg mL(-1) (S/N = 3). In addition, the results of actual sample detection prove the reliability of the constructed PEC biosensor. Importantly, this work relies on a mobile smartphone wireless Bluetooth device coupled with the PEC biosensor for immediate detection, providing another idea for detecting CEA in clinical diagnosis.
Keyword ：
Carcinoembryonic antigen Carcinoembryonic antigen Photocurrent-polarity-switching Photocurrent-polarity-switching Photoelectrochemical immunoassay Photoelectrochemical immunoassay Point-of-care Point-of-care Wireless bluetooth Wireless bluetooth
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| GB/T 7714 | Wang, Xin , Wang, Haiyang , Wan, Xinyu et al. Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching [J]. | BIOSENSORS & BIOELECTRONICS , 2025 , 267 . |
| MLA | Wang, Xin et al. "Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching" . | BIOSENSORS & BIOELECTRONICS 267 (2025) . |
| APA | Wang, Xin , Wang, Haiyang , Wan, Xinyu , Wei, Qiaohua , Zeng, Yongyi , Tang, Dianping . Smartphone-based point-of-care photoelectrochemical immunoassay coupling with ascorbic acid-triggered photocurrent-polarity conversion switching . | BIOSENSORS & BIOELECTRONICS , 2025 , 267 . |
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Crystal facet engineering is a pivotal strategy to design high-performance photoelectrodes and suppress electron and hole complexation, thus enhancing photoelectrochemical (PEC) activity through carrier enrichment at specific crystal facets. However, there is still a lack of systematic resolution on the intrinsic principles of crystal facet tuning energy band structure and the specific adsorption of signaling molecules. In this work, a multidimensional synergistic optimization strategy was proposed to achieve precise prediction and targeted crystal facet design of photoelectrodes by establishing a quantitative structure-activity relationship (QSAR) model of "crystal configuration-molecular recognition-carrier transport". A three-dimensional hierarchical TiO2 nanoflower (3D HTNF) photoelectrode dominated by the {110} facet exhibited a significant positive photocurrent toward uric acid (UA). Integrated with a microelectromechanical system (MEMS), a miniaturized self-powered PEC biosensor provided an innovative solution for high-throughput, noninvasive UA monitoring in saliva and displayed a linear range of 0.01-50 mu M with a detection limit of 8.76 nM. In addition, the advantages of photoelectrodes in light harvesting, charge separation and migration, molecular adsorption, and surface reactions were verified by density functional theory (DFT) calculations to reveal the path selectivity and carrier transport mechanisms of the photo-oxidation reactions on specific crystal surfaces. This study elucidates the interplay mechanism of the crystal surface tuning energy band structure and the interfacial kinetics of response. The program can be extended to precisely detect biomarkers in complex biological matrices, promoting the leapfrog development of noninvasive health monitoring technology.
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| GB/T 7714 | Tian, Shuo , Yu, Zhichao , Wang, Yunsen et al. Crystal Facet Engineering Modulated Electron Transfer Mechanisms: A Self-Powered Photoelectrochemical Sensing Platform for Noninvasive Detection of Uric Acid [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (17) : 9518-9526 . |
| MLA | Tian, Shuo et al. "Crystal Facet Engineering Modulated Electron Transfer Mechanisms: A Self-Powered Photoelectrochemical Sensing Platform for Noninvasive Detection of Uric Acid" . | ANALYTICAL CHEMISTRY 97 . 17 (2025) : 9518-9526 . |
| APA | Tian, Shuo , Yu, Zhichao , Wang, Yunsen , Chen, Shuyun , Li, Meijin , Tang, Dianping . Crystal Facet Engineering Modulated Electron Transfer Mechanisms: A Self-Powered Photoelectrochemical Sensing Platform for Noninvasive Detection of Uric Acid . | ANALYTICAL CHEMISTRY , 2025 , 97 (17) , 9518-9526 . |
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The rise of antibiotic-resistant bacteria poses a serious global health threat, highlighting the urgent need for novel strategies beyond conventional antibiotic therapies. This study explores the potential of microbe-imprinted polymers (MIPs) as innovative, pathogen-specific affinity agents. Utilizing microbial surface-initiated polymerization, MIPs are in-situ synthesized on the surface of target microbes, creating flexible heteropolymers that precisely replicate microbial surface structures. This method exhibits high affinity (KD = 2.7x108 CFU/mL for E. coli) and selectivity at the strain level. MIPs offer significant advantages over traditional antibodies, including greater stability, cost-effectiveness, and a broader spectrum of binding capabilities, making them effective for identifying and targeting various microbial strains, including unidentified or drug-resistant variants. Moreover, their favorable biocompatibility and functional resilience in diverse environments position MIPs as promising candidates for rapid pathogen detection and therapeutic applications. This research paves the way for advanced biomimetic materials in microbe-specific diagnostics and combating infections, addressing the critical need for effective tools in antibiotic resistance surveillance.
Keyword ：
Affinity Affinity Antibiotic resistance Antibiotic resistance Antibody mimics Antibody mimics Microbe-imprinted polymers Microbe-imprinted polymers Microbial recognition Microbial recognition
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| GB/T 7714 | Wu, Yuanzi , Zhou, Kaiqiang , Li, Wenhui et al. Microbe-imprinted polymers for rapid drug-resistant bacteria recognition [J]. | CHEMICAL ENGINEERING JOURNAL , 2025 , 512 . |
| MLA | Wu, Yuanzi et al. "Microbe-imprinted polymers for rapid drug-resistant bacteria recognition" . | CHEMICAL ENGINEERING JOURNAL 512 (2025) . |
| APA | Wu, Yuanzi , Zhou, Kaiqiang , Li, Wenhui , Huan, Min , Yu, Zhichao , Yan, Fen et al. Microbe-imprinted polymers for rapid drug-resistant bacteria recognition . | CHEMICAL ENGINEERING JOURNAL , 2025 , 512 . |
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