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学者姓名：林子俺
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Abstract ：
手性物质在生物学、药理学和化学反应等领域都扮演着重要角色.手性材料在应用时一般只有一种构型可表现出正面效果,因此手性分离十分重要.框架材料结构多样,易于修饰,用作色谱固定相时可实现手性物质的高效分离.本文综述了框架材料固定相用于手性分离的最新研究进展,并提出了框架材料固定相存在的问题和应用前景.
Keyword ：
共价有机框架 共价有机框架 氢键有机框架 氢键有机框架 色谱手性分离 色谱手性分离 金属有机框架材料 金属有机框架材料
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| GB/T 7714 | 张秋婷 , 吴帆 , 刘锦 et al. 框架材料色谱固定相及手性分离 [J]. | 大学化学 , 2025 , 40 (4) : 291-298 . |
| MLA | 张秋婷 et al. "框架材料色谱固定相及手性分离" . | 大学化学 40 . 4 (2025) : 291-298 . |
| APA | 张秋婷 , 吴帆 , 刘锦 , 林子俺 . 框架材料色谱固定相及手性分离 . | 大学化学 , 2025 , 40 (4) , 291-298 . |
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随着工业的发展,重金属及放射性物质的污染加剧,同时对稀有金属的需求上升,因此对金属进行分离富集非常必要.共价有机框架材料(COFs)具有比表面积大、孔隙率高、结晶度高和孔径可调等特点,在金属分离富集领域展现出巨大潜力.通过结合特定官能团,能够提高COFs对某些金属离子的选择性,COFs材料稳定的共价键连接方式也增强了其在恶劣环境中的稳定性.鉴于此,该文对近年来COFs在金属分离富集中的应用进行了综述,重点对COFs的不同连接方式,及其在贵金属、重金属、稀土元素和放射性元素中的分离富集以及吸附机理进行介绍.最后对COFs在金属分离富集中存在的挑战进行分析,并对未来的研究趋势进行了展望.
Keyword ：
共价有机框架 共价有机框架 分离 分离 富集 富集 金属 金属
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| GB/T 7714 | 李松涛 , 董少锋 , 林月琳 et al. 共价有机框架材料在金属分离富集中的应用 [J]. | 分析测试学报 , 2025 , 44 (1) : 51-60 . |
| MLA | 李松涛 et al. "共价有机框架材料在金属分离富集中的应用" . | 分析测试学报 44 . 1 (2025) : 51-60 . |
| APA | 李松涛 , 董少锋 , 林月琳 , 孙颖 , 林子俺 . 共价有机框架材料在金属分离富集中的应用 . | 分析测试学报 , 2025 , 44 (1) , 51-60 . |
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Covalent organic frameworks (COFs) have demonstrated great potential in chromatographic separation because of unique structure and superior performance. Herein, single-crystal three-dimensional (3D) COFs with regular morphology, good monodispersity and high specific surface area, were used as a stationary phase for high-performance liquid chromatography (HPLC). The single-crystal 3D COFs packed column not only exhibits high efficiency in separating hydrophobic molecules involving substituted benzenes, halogenated benzenes, halogenated nitrobenzenes, aromatic amines, aromatic hydrocarbons (PAHs) and phthalate esters (PAEs), but also achieves baseline separation of acenaphthene and acenaphthylene with similar physical and chemical properties as well as environmental pollutants, which cannot be quickly separated on commercial C18 column and a polycrystalline 3D COFs packed column. Especially, the column efficiency of 17303-24255 plates/m was obtained for PAEs, and the resolution values for acenaphthene and acenaphthylene, and carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZEP) were 1.7 and 2.2, respectively. This successful application not only confirmed the great potential of the singlecrystal 3D COFs in HPLC separation of the organic molecules, but also facilitates the application of COFs in separation science. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
frameworks frameworks High-performance liquid chromatography High-performance liquid chromatography Separation Separation Single-crystal 3D covalent organic Single-crystal 3D covalent organic Stationary phase Stationary phase
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| GB/T 7714 | Zhang, Qiuting , Wu, Fan , Liu, Jin et al. Facile synthesis of single-crystal 3D covalent organic frameworks as stationary phases for high-performance liquid chromatographic separation [J]. | CHINESE CHEMICAL LETTERS , 2025 , 36 (8) . |
| MLA | Zhang, Qiuting et al. "Facile synthesis of single-crystal 3D covalent organic frameworks as stationary phases for high-performance liquid chromatographic separation" . | CHINESE CHEMICAL LETTERS 36 . 8 (2025) . |
| APA | Zhang, Qiuting , Wu, Fan , Liu, Jin , Su, Hang , Zhong, Yanhui , Lin, Zian . Facile synthesis of single-crystal 3D covalent organic frameworks as stationary phases for high-performance liquid chromatographic separation . | CHINESE CHEMICAL LETTERS , 2025 , 36 (8) . |
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Imidacloprid (IMI), a neonicotinoid insecticide extensively applied in agriculture, is among the most frequently detected pesticides in food. However, the long-term impact of chronic dietary exposure to environmentally relevant IMI doses on kidney health has not been fully elucidated, particularly regarding its nephrotoxic mechanisms. To address this gap, chronic exposure to IMI was administered to mice through supplementation of their feed with environmentally relevant doses (approximately 100 and 1000 mu g/kg/day) for 24 weeks to investigate its nephrotoxicity and underlying mechanisms. Toxicological analysis revealed that chronic IMI exposure led to renal dysfunction, histopathological alterations, and excessive apoptosis in mice. Mechanistic investigations suggested that IMI might inhibit AMP-activated protein kinase (AMPK) activity through both direct and indirect pathways. Direct inhibition occurred through the binding of IMI and its metabolites to AMPK, reducing its phosphorylation activity. Indirect inhibition involved excessive production of reactive oxygen species, which suppressed AMPK phosphorylation, leading to sustained purine metabolism dysregulation in the renal system. Consequently, the kidneys showed an aggravated redox imbalance, heightened inflammatory states, and increased cellular apoptosis. The results of this study are intended to raise awareness of pesticide use and food safety among agricultural workers and consumers.
Keyword ：
dietary exposure dietary exposure environmentallyrelevant dose environmentallyrelevant dose imidacloprid imidacloprid inhibition of AMPKprotein activity inhibition of AMPKprotein activity purine metabolism purine metabolism renal injury renal injury
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| GB/T 7714 | Xie, Wen , Zhang, Yajing , He, Yu et al. Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation [J]. | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2025 , 59 (36) : 19160-19171 . |
| MLA | Xie, Wen et al. "Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation" . | ENVIRONMENTAL SCIENCE & TECHNOLOGY 59 . 36 (2025) : 19160-19171 . |
| APA | Xie, Wen , Zhang, Yajing , He, Yu , Su, Hang , Zhang, Jinni , Chen, Canrong et al. Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation . | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2025 , 59 (36) , 19160-19171 . |
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Triphenyl phosphate (TPHP) is an emerging endocrine-disrupting chemical that has been widely used as a flame retardant. Although the neurotoxicity of TPHP to aquatic animals had been highlighted in previous studies, its effects on mammals, particularly at environmentally relevant doses (ERDs), have remained largely unknown. In this study, a 28-week mouse model was established to investigate the potential neurotoxicity induced by ERDs of TPHP (0.89 and 9.19 mu g/kg/day). The mechanisms underlying gut-brain axis communication were explored using behavioral tests, 16S rRNA sequencing, and multiomics analysis. The results demonstrated that chronic exposure to an ERD of TPHP (9.19 mu g/kg/day) significantly reduced the abundance of Lactobacillus in the gut microbiota of mice and led to an increase in pro-inflammatory bacterium. These alterations activated the NF-kappa B signaling pathway in the prefrontal cortex, resulting in the accumulation of quinolinic acid and glutamate. Ultimately, these changes induced anxiety- and depression-like behaviors in mice. This study provides novel insights into the indirect neurotoxic effects of TPHP exposure at ERDs in mammals and emphasizes the need for more stringent regulatory policies regarding the use of TPHP.
Keyword ：
Gut microbiota Gut microbiota Metabolomics Metabolomics Neurotoxicity Neurotoxicity Transcriptomics Transcriptomics Triphenyl phosphate Triphenyl phosphate
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| GB/T 7714 | Dan, Akang , Yuan, Jiahao , Xie, Peisi et al. Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis [J]. | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2025 , 59 (27) : 13671-13682 . |
| MLA | Dan, Akang et al. "Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis" . | ENVIRONMENTAL SCIENCE & TECHNOLOGY 59 . 27 (2025) : 13671-13682 . |
| APA | Dan, Akang , Yuan, Jiahao , Xie, Peisi , Chen, Jing , Chen, Canrong , Lin, Zian et al. Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis . | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2025 , 59 (27) , 13671-13682 . |
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Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) holds great promise for the rapid and sensitive detection of biomolecules, but its precise detection of small molecule metabolites is hindered by severe background interference from the organic matrix in the low molecular weight range. To address this issue, nanomaterials have commonly been utilized as substrates in LDI-MS. Among them, covalent organic frameworks (COFs), known for their unique optical absorption and structural properties, have garnered significant attention. Despite these advantages, their low ionization efficiency remains a challenge. Herein, a composite material of COF-S@Au nanoparticles (NPs), by incorporating Au NPs into a sulfur-functionalized COF (COF-S) through postsynthetic modification, was designed and adopted as substrates. This hybrid material leverages the synergistic effects of COF-S and Au NPs to improve the desorption/ionization efficiency and minimize background interference. The COF-S@Au NPs demonstrated a 5-16-fold improvement in MS signals of small biomolecules along with a clean background and excellent resistance to salt and protein interference. Their corresponding limits of detection (LODs) were achieved at similar to pmol. Furthermore, the COF-S@Au NPs were applied to analyze metabolites in a triclosan (TCS)-exposed mouse model, successfully identifying 10 differential metabolites associated with TCS toxicity. This work provides a foundation for developing advanced LDI-MS materials for high-performance metabolic analysis and offers valuable insights into TCS metabolic toxicity with potential applications in environmental toxicology.
Keyword ：
gold-modified covalent organic frameworks gold-modified covalent organic frameworks LDI-MS LDI-MS metabolic analysis metabolic analysis smallmolecule smallmolecule triclosan exposure triclosan exposure
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| GB/T 7714 | Jin, Yingxue , Chen, Jiajing , Xie, Wen et al. Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (4) : 7056-7065 . |
| MLA | Jin, Yingxue et al. "Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure" . | ACS APPLIED MATERIALS & INTERFACES 17 . 4 (2025) : 7056-7065 . |
| APA | Jin, Yingxue , Chen, Jiajing , Xie, Wen , Zhang, Jinni , Yan, Jingjing , Chen, Canrong et al. Gold-Modified Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry for Analysis of Metabolites Induced by Triclosan Exposure . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (4) , 7056-7065 . |
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The discharge of oily wastewater poses a serious threat to human health and the ecological environment. The development of effective oil-water separation techniques is critical to addressing this issue. Herein, a side-chain engineering strategy was proposed to construct nanoscale covalent organic frameworks (COFs) decorated stainless steel nets (SSN) with tunable wettability (SSN@COFs-C) via the introduction of three distinct lengths of alkyl chains. The nanoscale COFs particles were uniformly distributed on the SSN substrate, resulting in a hierarchical surface structure that significantly enhanced the material's hydrophobicity. Unlike conventional approaches, COFs provide a robust and tunable platform to address challenges in achieving durable superhydrophobic surfaces and overcome key development barriers such as stability and reusability. The SSN@COFs-C exhibited high hydrophobicity (water contact angle of 151.1-157.3 degrees) and self-cleaning properties. The optimal composite was capable of separating immiscible oil/water mixtures with a flux of 6079 L m-2 h-1 and exhibited an oil/water separation efficiency exceeding 99.0%. Moreover, it effectively separated surfactant-stabilized water-in-oil emulsions with a separation efficiency greater than 99% and retained their performance after multiple reused cycles. This work provides insight into the fabrication and application of nanoscale hydrophobic oil-water separation composites.
Keyword ：
adjustable hydrophobicity adjustable hydrophobicity covalent organic frameworks covalent organic frameworks emulsionseparation emulsionseparation oil/waterseparation oil/waterseparation side-chain engineering side-chain engineering stainless steel net stainless steel net
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| GB/T 7714 | Dong, Jinghan , Dong, Shaofeng , Ye, Zhi et al. Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation [J]. | ACS APPLIED NANO MATERIALS , 2025 , 8 (5) : 2299-2309 . |
| MLA | Dong, Jinghan et al. "Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation" . | ACS APPLIED NANO MATERIALS 8 . 5 (2025) : 2299-2309 . |
| APA | Dong, Jinghan , Dong, Shaofeng , Ye, Zhi , Li, Songtao , Lin, Zian . Superhydrophobic Nanoporous Covalent Organic Frameworks Decorated on Stainless Steel Nets for Oil/Water Separation . | ACS APPLIED NANO MATERIALS , 2025 , 8 (5) , 2299-2309 . |
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RationalPeople are widely exposed to parabens in their daily life, but parabens are endocrine disrupting chemicals that pose a threat to human health. Therefore, establishing a rapid screening method to enhance monitoring of parabens is necessary. Herein, a covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method was established to screen parabens in personal care products (PCPs).MethodsTAPB-TFPB-COF nanofilm was synthesized on indium tin oxide (ITO) glass and used as LDI-MS substrates. To observe the practicability of TAPB-TFPB-COF nanofilm-assisted LDI-MS, the results of this method for analyzing small molecules such as parabens, estrogens, and bisphenols were compared with those of the conventional organic matrix 9-aminoacridine (9-AA), and the reproducibility and detection limit were further verified. Finally, the method was applied to screen parabens in PCPs.ResultsTAPB-TFPB-COF nanofilm-assisted LDI-MS analyzed small molecules such as parabens, estrogens, and bisphenols with higher mass spectral signals and cleaner mass spectral backgrounds compared with 9-AA. Meanwhile, the method analyzed methylparaben (MeP) with high reproducibility (RSD = 6.96%) and low detection limit (1.64 mu M) and performed well for rapid screening of parabens in PCPs.ConclusionTAPB-TFPB-COF nanofilm-assisted LDI-MS for analyzing small molecules such as parabens, estrogens, and amino acids offered the advantages of rapid analysis, a clean background, and good reproducibility. The method was successfully applied to detecting parabens in PCPs, demonstrating the practical utility of LDI-MS based on TAPB-TFPB-COF nanofilm for analyzing parabens in complex samples.
Keyword ：
covalent organic framework nanofilms covalent organic framework nanofilms endocrine disrupting chemicals endocrine disrupting chemicals laser desorption ionization mass spectrometry laser desorption ionization mass spectrometry parabens parabens personal care products personal care products
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| GB/T 7714 | Zheng, Wenjun , Yan, Jingjing , Jin, Yingxue et al. Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products [J]. | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (7) . |
| MLA | Zheng, Wenjun et al. "Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products" . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY 39 . 7 (2025) . |
| APA | Zheng, Wenjun , Yan, Jingjing , Jin, Yingxue , Lin, Zian , Cai, Zongwei . Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products . | RAPID COMMUNICATIONS IN MASS SPECTROMETRY , 2025 , 39 (7) . |
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Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) has been regarded as one of the prominent techniques in small molecule analysis, which employs nanostructured materials as substrates to replace conventional organic matrices for laser absorption and analyte desorption/ionization. The rational design and development of nanostructured substrates, particularly metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs), are crucial for enhancing SALDI-MS performance. This review aims to cover the latest developments (within 5 years) in nanostructured substrates in SALDI-MS, including carbon- and silicon-based materials, metals and their oxide materials, MOFs, COFs, and other materials. The key design parameters that affect the SALDI-MS efficiency of these nanomaterials in small molecule analysis, such as pore size, surface area, and functional groups, are also discussed. Furthermore, the applications of SALDI-MS in various fields are reviewed. Lastly, the challenges and prospects for future research on the design of nano- structured substrates for SALDI-MS in small molecule analysis are discussed.
Keyword ：
Applications Applications mass spectrometry mass spectrometry Nanomaterials Nanomaterials Small molecule Small molecule Surface-assisted laser desorption/ionization Surface-assisted laser desorption/ionization
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| GB/T 7714 | Jin, Yingxue , Yan, Jingjing , Cai, Zongwei et al. Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 183 . |
| MLA | Jin, Yingxue et al. "Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 183 (2025) . |
| APA | Jin, Yingxue , Yan, Jingjing , Cai, Zongwei , Lin, Zian . Advances in nanomaterials for surface-assisted laser desorption ionization mass spectrometry: Applications in small molecule analysis over the past five years . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2025 , 183 . |
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Phenolic compounds are a kind of persistent organic pollutants (POPs), which are always a threat to human and environment due to their strong toxicity and low biodegradability. Therefore, developing a reliable method to simultaneously detect phenolic pollutants is of great importance to environmental safety and human health. Herein, we combined the advantages of metal organic frameworks (MOFs) and covalent organic frameworks (COFs) to prepare two cyclic trinuclear unit-based metal covalent organic framework (MCOFs, denoted as Cu3- TDH COF and Cu3-BDU COF) with large specific surface area, good stability and excellent laccase-like activity. Their oxidative degradation ability toward phenolic pollutants was verified, and a dual-channel nanozyme sensor array based on Cu3-TDH COF and Cu3-BDU COF was constructed for the identification of six phenolic pollutants. Notably, the sensor array can accurately distinguish between different concentrations of phenolic pollutants and different types of phenolic pollutants at the same concentration, even at levels as low as 1 mu M. Moreover, three real water samples (rainwater, tap water and wastewater) and 18 unknown samples were also distinguished and differentiated by the sensor array. This study opens up a potential avenue for the design of MCOFs-based nanozyme sensor arrays to simultaneously realize identification and detection of multiple phenolic pollutants.
Keyword ：
Catalytic oxidation Catalytic oxidation Laccase-like nanozymes Laccase-like nanozymes Metal covalent organic frameworks Metal covalent organic frameworks Phenolic pollutants Phenolic pollutants Sensor array Sensor array
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| GB/T 7714 | Liu, Jin , Hu, Cong , Meng, Xiaoyan et al. Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants [J]. | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 487 . |
| MLA | Liu, Jin et al. "Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants" . | JOURNAL OF HAZARDOUS MATERIALS 487 (2025) . |
| APA | Liu, Jin , Hu, Cong , Meng, Xiaoyan , Sun, Ying , Zhao, Bo , Lin, Zian . Metal covalent organic frameworks-based laccase-like nanozyme for oxidative degradation and identification of phenolic pollutants . | JOURNAL OF HAZARDOUS MATERIALS , 2025 , 487 . |
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