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学者姓名：林子俺
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Abstract ：
Development of metal-free nanozymes has raised concern for their extensive applications in photocatalysis and sensing fields. As novel metal-free nanomaterials, covalent organic frameworks (COFs) have engendered intense interest in the construction of nanozymes due to their structural controllability and molecular functionality. The formation of the molecular arrangement by embedding orderly donor-acceptors (D-A) linked in the framework topology to modulate material properties for highly efficient enzyme mimicking activity is of importance but challenging. Here, a strong D-A type of COF was designed and synthesized by integrating electron donor units (pyrene) and electron acceptor units (phenanthroline), named Py-PD COF. Using experiments and theoretical calculations, the introduction of a phenanthroline ring endowed the Py-PD COF with a narrowed band gap, and efficient charge transfer and separation. Further, the Py-PD COF exhibited a superior light-responsive oxidase-mimicking characteristic under visible light irradiation, which could catalyze the oxidation of 3,3 ',5,5-tetramethylbenzidine (TMB) and give the corresponding evolution of color. The nanoenzymatic activity of the Py-PD COF was light-regulated, which offers a fascinating advantage because of its high efficiency and spatial controllability. Based on previously mentioned characteristics, an "on-off" sensing platform for the colorimetric analysis of isoniazid (INH) could be constructed with a good linear relationship (2-100 mu M) and a low limit of detection (1.26 mu M). This research shows that not only is Py-PD COF an environmentally friendly compound for the colorimetric detection of INH, but it is also capable of providing the interesting D-A type COF-based material for designing an excellent nanozyme. We fabricated phenanthroline-functionalized donor-acceptor covalent organic frameworks (Py-PD COF) and showed their roles in enhancing nanozymes' activity. The Py-PD COF could be used as a robust colorimetric probe for detection of isoniazid.
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| GB/T 7714 | Li, Guorong , Yang, Yixin , Chen, Wenjie et al. Phenanthroline-functionalized donor-acceptor covalent organic frameworks as photo-responsive nanozymes for visual colorimetric detection of isoniazid [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (18) : 4502-4508 . |
| MLA | Li, Guorong et al. "Phenanthroline-functionalized donor-acceptor covalent organic frameworks as photo-responsive nanozymes for visual colorimetric detection of isoniazid" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 18 (2024) : 4502-4508 . |
| APA | Li, Guorong , Yang, Yixin , Chen, Wenjie , Song, Zhiping , Shi, Jiale , Wang, Bingqing et al. Phenanthroline-functionalized donor-acceptor covalent organic frameworks as photo-responsive nanozymes for visual colorimetric detection of isoniazid . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (18) , 4502-4508 . |
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Cancer cell spheroids (CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the spatial distribution of endogenous compounds ( e.g. , lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization (MALDI-2) and trapped ion mobility spectrometry (TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Cancer cell spheroids Cancer cell spheroids (MALDI) (MALDI) Mass spectrometry imaging Mass spectrometry imaging Matrix-assisted laser desorption/ionization Matrix-assisted laser desorption/ionization Trapped ion mobility spectrometry Trapped ion mobility spectrometry
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| GB/T 7714 | Chen, Jing , Xie, Peisi , Wu, Pengfei et al. MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (4) . |
| MLA | Chen, Jing et al. "MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids" . | CHINESE CHEMICAL LETTERS 35 . 4 (2024) . |
| APA | Chen, Jing , Xie, Peisi , Wu, Pengfei , He, Yu , Lin, Zian , Cai, Zongwei . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids . | CHINESE CHEMICAL LETTERS , 2024 , 35 (4) . |
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Targeted construction of new covalent organic frameworks (COFs) with specific purposes and rationalities to build colorimetric assay platform for environmental pollutant monitoring have attracted increasing interest. However, it is still challenging due to lack of available coordination sites inside COFs pores and only a slight bonding ability for anchoring metal. In this work, a two-dimensional (2D) COFs (termed as Tz-COF) with high crystallinity, excellent chemical stability, and abundant sulfur coordination in its skeletons was synthesized and used for the confined growth of Au NPs. It was found that the Au NPs showed significant dispersibility for the support of Tz-COF. The proposed Tz-COF@Au NPs possessed outstanding Hg 2 + -activated peroxidase-like activity benefited from physicochemical properties of gold amalgam and synergistic effect between COFs and Au NPs to oxidize chromogenic substrate. Based on highly efficient activity and distinctive color evolution, the strategy for detecting Hg 2 + was developed and successfully applied to determine the content of Hg 2 + in real environmental samples. This work manifests that a potential strategy to establish a colorimetric assay platform for environmental pollutant monitoring based on the targeted manufacturing of novel COFs with specific functions. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Au nanoparticles Au nanoparticles Covalent organic frameworks Covalent organic frameworks Hg2+-activated peroxidase-like activity Hg2+-activated peroxidase-like activity Sulfur coordination Sulfur coordination Thiazole Thiazole
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| GB/T 7714 | Li, Guorong , Wu, Yijing , Zhong, Chao et al. Pre designe d covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(II) [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
| MLA | Li, Guorong et al. "Pre designe d covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(II)" . | CHINESE CHEMICAL LETTERS 35 . 5 (2024) . |
| APA | Li, Guorong , Wu, Yijing , Zhong, Chao , Yang, Yixin , Lin, Zian . Pre designe d covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(II) . | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
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Frequent oil spills cause substantial economic losses and pose a significant threat to human life. Urgent measures must be taken to develop a highly effective approach to mitigating oil spills and minimizing their potential consequences. Herein, we synthesized MS@COFs-F, fluorinated covalent organic framework-decorated superhydrophobic sponges, to clean up crude oil spills efficiently. The synthesis method involved a simple and effective room-temperature approach, utilizing 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) as the amine monomer and binding it with three aldehyde monomers of varying fluoride content. The MS@COFs-F with the highest fluorine content, known as MS@COFs-F4, exhibited low surface energy, superhydrophobicity (water contact angle of 155.7 degrees), a large specific surface area of 180 m(2)/g, and exceptional chemical, mechanical, and thermal stability. MS@COFs-F4 demonstrated remarkable effectiveness in adsorbing crude oils and organic solvents of diverse viscosities, exhibiting an adsorption capacity between 68.5 and 125.9 g/g, achieving an oil-water separation efficiency exceeding 97.0 %. Additionally, MS@COFs-F4 showcased self-cleaning and flame-retardant properties, further enhancing its suitability for real-world applications. MS@COFs-F4 holds the potential to offer a novel, safe, and effective approach in addressing oil spill incidents.
Keyword ：
Fluorinated covalent organic framework Fluorinated covalent organic framework Oil spill cleanup Oil spill cleanup Room-temperature synthesis Room-temperature synthesis Superhydrophobicity Superhydrophobicity Superhydrophobic sponges Superhydrophobic sponges
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| GB/T 7714 | Dong, Jinghan , Zheng, Wenjun , Yang, Yixin et al. Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup [J]. | SEPARATION AND PURIFICATION TECHNOLOGY , 2024 , 344 . |
| MLA | Dong, Jinghan et al. "Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup" . | SEPARATION AND PURIFICATION TECHNOLOGY 344 (2024) . |
| APA | Dong, Jinghan , Zheng, Wenjun , Yang, Yixin , Dong, Shaofeng , Li, Songtao , Zhong, Yanhui et al. Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup . | SEPARATION AND PURIFICATION TECHNOLOGY , 2024 , 344 . |
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Saccharides are a sort of ubiquitous and vital molecules within the whole life. However, the application of saccharides analysis with matrix -assisted laser desorption/ionization mass spectrometry (MALDI-MS) is restricted by their low ionization efficiency and the instability of the sialic acid fraction. Derivatization strategy based on nonreductive amination provides a good solution, however, this is often time consuming and may result in sample loss due to removal of excessive derivatization reagents. Herein, hydralazine (HZN) was utilized as a reactive matrix for labeling reducing saccharides directly on MALDI target which eliminated tedious sample preparation and avoided sample loss. After optimization, effective and reproducible on-MALDI-target derivatization of neutral and acidic saccharides was achieved in both positive and negative modes. Compared with 2,5-dihydroxybenzoic acid (DHB) and 9-aminoacridine (9 -AA), HZN improved the detection sensitivity of reducing saccharides and provided more abundant fragment ions in MS/MS analysis. Moreover, 26 kinds of neutral glycans and 5 kinds of sialic glycans were identified from ovalbumin (OVA) and bovine fetuin, respectively. Combined with the statistical models, this strategy could be used to distinguish and predict samples of 6 brands of beer, and discriminate 2 kinds of beer fermentation modes. In addition, HZN was applied for quantitative analysis of glucose in urine samples, and the obtained urine glucose concentrations of diabetic patients were consistent with the clinical test results, showing the potential of qualitative and quantitative analysis of reducing saccharides in complex samples. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Hydralazine Hydralazine On-MALDI-target derivatization On-MALDI-target derivatization Reactive matrix Reactive matrix Saccharides Saccharides
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| GB/T 7714 | Ouyang, Dan , Huang, Huan , He, Yanting et al. Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
| MLA | Ouyang, Dan et al. "Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides" . | CHINESE CHEMICAL LETTERS 35 . 5 (2024) . |
| APA | Ouyang, Dan , Huang, Huan , He, Yanting , Chen, Jiajing , Lin, Jiali , Chen, Zhuling et al. Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides . | CHINESE CHEMICAL LETTERS , 2024 , 35 (5) . |
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Solid-phase microextraction (SPME) coupled with electrospray ionization mass spectrometry (ESI-MS) was developed for rapid and sensitive determination of endogenous androgens. The SPME probe is coated with covalent organic frameworks (COFs) synthesized by reacting 1,3,5-tri(4-aminophenyl)benzene (TPB) with 2,5-dioctyloxybenzaldehyde (C8PDA). This COFs-SPME probe offers several advantages, including enhanced extraction efficiency and stability. The analytical method exhibited wide linearity (0.1-100.0 mu g L-1), low limits of detection (0.03-0.07 mu g L-1), high enrichment factors (37-154), and satisfactory relative standard deviations (RSDs) for both within one probe (4.0-14.8%) and between different probes (3.4-12.7%). These remarkable performance characteristics highlight the reliability and precision of the COFs-SPME-ESI-MS method. The developed method was successfully applied to detect five kinds of endogenous androgens in female serum samples, indicating that the developed analytical method has great potential for application in preliminary clinical diagnosis.
Keyword ：
Androgens Androgens Covalent organic frameworks Covalent organic frameworks Electrospray ionization mass spectrometry Electrospray ionization mass spectrometry Solid-phase microextraction Solid-phase microextraction
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| GB/T 7714 | Li, Heming , Tu, Yuxin , Xie, Wen et al. In situ fabrication of covalent organic frameworks on solid-phase microextraction probes coupled with electrospray ionization mass spectrometry for enrichment and determination of androgens in biosamples [J]. | MICROCHIMICA ACTA , 2024 , 191 (5) . |
| MLA | Li, Heming et al. "In situ fabrication of covalent organic frameworks on solid-phase microextraction probes coupled with electrospray ionization mass spectrometry for enrichment and determination of androgens in biosamples" . | MICROCHIMICA ACTA 191 . 5 (2024) . |
| APA | Li, Heming , Tu, Yuxin , Xie, Wen , Shi, Xinye , Zhang, Qiuting , Lin, Juan et al. In situ fabrication of covalent organic frameworks on solid-phase microextraction probes coupled with electrospray ionization mass spectrometry for enrichment and determination of androgens in biosamples . | MICROCHIMICA ACTA , 2024 , 191 (5) . |
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在教育部不断推进新课程标准的背景下,本文介绍了一项面向本科生仪器分析课程的综合性教学实验,旨在通过实践提高学生在材料制备和仪器使用方面的技能.该实验通过"一锅法"制备了一种基于共价有机框架的核壳结构固定相材料(SiO2@COFTTA-DHTA),并对其进行了详细的理化表征.随后,采用高效液相色谱技术对该材料的色谱性能进行了评估.整个实验流程包括了材料合成、表征、色谱保留行为研究和色谱分离性能测试.该实验不仅加深了学生对于功能材料性质及其应用的理解,而且提高了他们的实验设计和批判性思维能力.通过理论科学与实验教学的结合,该实验不仅能够培养学生的科研兴趣,还可以锻炼实验操作能力、创新思维和实践能力,同时增强学生的社会责任感和历史使命感,实现实验教学的全方位育人目标.
Keyword ：
共价有机框架 共价有机框架 核壳结构 核壳结构 综合性实验 综合性实验 色谱固定相 色谱固定相
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| GB/T 7714 | 刘锦 , 田文锠 , 吴帆 et al. 本科生综合实验:基于共价有机框架的核壳型固定相的制备及色谱性能评价 [J]. | 色谱 , 2024 , 42 (10) : 1006-1012 . |
| MLA | 刘锦 et al. "本科生综合实验:基于共价有机框架的核壳型固定相的制备及色谱性能评价" . | 色谱 42 . 10 (2024) : 1006-1012 . |
| APA | 刘锦 , 田文锠 , 吴帆 , 张秋婷 , 钟燕辉 , 林子俺 . 本科生综合实验:基于共价有机框架的核壳型固定相的制备及色谱性能评价 . | 色谱 , 2024 , 42 (10) , 1006-1012 . |
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“双一流”背景下，福州大学化学实验教学中心步入了内涵式发展阶段。实验中心贯彻学校的“价值引领、知识拓展、思维训练、能力建构”四位一体育人理念，结合学校“理工结合、基础研究与应用研究相结合”的办学特色，响应学院对化学理科拔尖2.0培养计划以及各专业的新工科、新医科等发展需求，探索地方高校国家级化学实验教学示范中心建设和改革举措和方法。本文将从实验平台建设，实验教学改革，实验师资队伍建设和科普服务等方面介绍过去五年以来福州大学化学实验中心“双一流”建设的经验，突出实践作用，强化实践育人功能，切实提高实验教学内涵。
Keyword ：
创新人才培养 创新人才培养 化学实验教学中心建设与实践 化学实验教学中心建设与实践 双一流建设 双一流建设 实验教学改革 实验教学改革 科普教育 科普教育
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| GB/T 7714 | 林佳丽 , 吴舒婷 , 郑琤 et al. “双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践 [J]. | 大学化学 , 2024 , 39 (07) : 129-139 . |
| MLA | 林佳丽 et al. "“双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践" . | 大学化学 39 . 07 (2024) : 129-139 . |
| APA | 林佳丽 , 吴舒婷 , 郑琤 , 林子俺 , 魏巧华 , 郑寿添 . “双一流”背景下地方高校国家级化学实验教学示范中心的建设与实践 . | 大学化学 , 2024 , 39 (07) , 129-139 . |
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Significant impairment of pulmonary function has been demonstrated through long-term exposure to neonicotinoid insecticides, such as imidacloprid (IMI). However, the underlying mechanisms of lung injury induced by IMI remain unclear. In this study, a mouse model of IMI-induced pulmonary injury was established, and the toxicity and lung damage were assessed through mouse body weight, organ index, hematological parameters, and histopathological analysis of lung tissues. Furthermore, metabolomics and transcriptomics techniques were employed to explore the mechanistic aspects. Results from the toxicity assessments indicated that mouse body weight was significantly reduced by IMI, organ index was disturbed, and hematological parameters were disrupted, resulting in pulmonary injury. The mechanistic experimental results indicate that the differences in metabolites and gene expression in mouse lungs could be altered by IMI. Validation of the results through combined analysis of metabolomics and transcriptomics revealed that the mechanism by which IMI induces lung injury in mice might be associated with the activation of the TLR4 receptor, thereby activating the PI3K/AKT/ NF- kappa B signaling pathway to induce inflammation in mouse lungs. This study provided valuable insights into the mechanisms underlying IMI-induced pulmonary damage, potentially contributing to the development of safer pest control strategies. The knowledge gained served as a robust scientific foundation for the prevention and treatment of IMI-related pulmonary injuries.
Keyword ：
Imidacloprid Imidacloprid Lung injury Lung injury Metabolomics Metabolomics Multi-omics integrated analysis Multi-omics integrated analysis Transcriptomics Transcriptomics
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| GB/T 7714 | Xie, Wen , Chen, Canrong , Li, Heming et al. Imidacloprid-induced lung injury in mice: Activation of the PI3K/AKT/ NF- κB signaling pathway via TLR4 receptor engagement [J]. | SCIENCE OF THE TOTAL ENVIRONMENT , 2024 , 931 . |
| MLA | Xie, Wen et al. "Imidacloprid-induced lung injury in mice: Activation of the PI3K/AKT/ NF- κB signaling pathway via TLR4 receptor engagement" . | SCIENCE OF THE TOTAL ENVIRONMENT 931 (2024) . |
| APA | Xie, Wen , Chen, Canrong , Li, Heming , Tu, Yuxin , Zhong, Yanhui , Lin, Zian et al. Imidacloprid-induced lung injury in mice: Activation of the PI3K/AKT/ NF- κB signaling pathway via TLR4 receptor engagement . | SCIENCE OF THE TOTAL ENVIRONMENT , 2024 , 931 . |
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Sunitinib, N-desmethyl imatinib, dasatinib, imatinib, and bosutinib are tyrosine kinase inhibitors (TKIs) that are commonly employed in the treatment of a multitude of cancers. However, the inappropriate concentrations of TKIs can result in ineffective treatment or the emergence of multiple adverse effects. Consequently, the development of a rapid and sensitive analytical method for TKIs is of paramount importance for the safe administration of drugs. In this work, solid-phase microextraction (SPME) probe combined with an electrospray ionization mass spectrometry (ESI-MS) coupling platform was constructed for rapid and sensitive determination of TKIs. The covalent organic frameworks (COFs) coated SPME probe was made of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and 2,5-dibutoxyterephthalaldehyde (DBTA) by in-situ layer-by-layer chemical bonding synthesis strategy. The TAPT-DBTA-SPME probe exhibited several advantageous properties which rendered it suitable for the enrichment of TKIs. Under the optimal conditions, the developed analytical method demonstrated a broad linear range (0.05–500.00 µg/L), a low limit of detection (0.02 µg/L) and a high enrichment factor (51–203) for TKIs. The developed analytical method was successfully applied to a pharmacokinetic study of TKIs in mouse plasma and tissue matrix, demonstrating that the proposed analytical method has promise for clinical applications and metabolic monitoring. © 2024 Elsevier B.V.
Keyword ：
Covalent organic frameworks Covalent organic frameworks Electrospray ionization mass spectrometry Electrospray ionization mass spectrometry Solid-phase microextraction Solid-phase microextraction Tyrosine kinase inhibitors Tyrosine kinase inhibitors
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| GB/T 7714 | Li, H. , Shi, X. , Su, H. et al. Layer-by-layer fabrication of covalent organic frameworks on stainless steel needles as solid-phase microextraction probe coupled with electrospray ionization mass spectrometry for enrichment and determination of tyrosine kinase inhibitors in biosamples [J]. | Journal of Chromatography A , 2024 , 1733 . |
| MLA | Li, H. et al. "Layer-by-layer fabrication of covalent organic frameworks on stainless steel needles as solid-phase microextraction probe coupled with electrospray ionization mass spectrometry for enrichment and determination of tyrosine kinase inhibitors in biosamples" . | Journal of Chromatography A 1733 (2024) . |
| APA | Li, H. , Shi, X. , Su, H. , Wang, S. , Lin, J. , Lin, Z. et al. Layer-by-layer fabrication of covalent organic frameworks on stainless steel needles as solid-phase microextraction probe coupled with electrospray ionization mass spectrometry for enrichment and determination of tyrosine kinase inhibitors in biosamples . | Journal of Chromatography A , 2024 , 1733 . |
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