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学者姓名：杨黄浩
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Abstract ：
Signal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis. However, existing STAT3 inhibitors have suffered from drawbacks including poor efficacy, limited specificity, and undesirable off-target effects, due to the challenging nature of identifying active sites or allosteric regulatory pockets on STAT3 amenable to small-molecule inhibition. In response to these obstacles, we utilize the innovative proteolysis targeting chimera (PROTAC) technology to create a highly specific decoy-targeted protein degradation system for STAT3 protein, termed D-PROTAC. This system fuses DNA decoy that targets STAT3 with an E3 ligase ligand, utilizing a click chemistry approach. Experimental results demonstrate that D-PROTAC efficiently mediates the degradation of the STAT3 protein across various cancer cell types, leading to the downregulation of crucial downstream STAT3 targets, inhibiting tumor cell growth, triggering cell cycle arrest and apoptosis, and suppressing tumor immune evasion. Furthermore, D-PROTAC is capable of achieving significant tumor suppression in xenograft models. Overall, our research validates that D-PROTAC can successfully target and eliminate the "undruggable" STAT3, showcasing specificity and potent antitumor effects. This strategy will suggest a promising avenue for the development of targeted therapies against the critical functions of STAT3 in human cancers and potentially other diseases.
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| GB/T 7714 | Li, Shiqing , Wang, Xin , Huang, Jiabao et al. Decoy-PROTAC for specific degradation of "Undruggable" STAT3 transcription factor [J]. | CELL DEATH & DISEASE , 2025 , 16 (1) . |
| MLA | Li, Shiqing et al. "Decoy-PROTAC for specific degradation of "Undruggable" STAT3 transcription factor" . | CELL DEATH & DISEASE 16 . 1 (2025) . |
| APA | Li, Shiqing , Wang, Xin , Huang, Jiabao , Cao, Xiuping , Liu, Yana , Bai, Shiyan et al. Decoy-PROTAC for specific degradation of "Undruggable" STAT3 transcription factor . | CELL DEATH & DISEASE , 2025 , 16 (1) . |
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Following publication of this article, the authors realized there was an inadvertent error in Fig. 3I that needed correction. In Fig. 3I, the image of the Control group was mistakenly used due to initial mislabeling. The correct image of the Control group is provided in the corrected Fig. 3I below. This inadvertent error did not impact the conclusions of the article. The original article has been corrected. © The Author(s) 2025.
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| GB/T 7714 | Li, S. , Wang, X. , Huang, J. et al. Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor (Cell Death & Disease, (2025), 16, 1, (197), 10.1038/s41419-025-07535-x) [未知]. |
| MLA | Li, S. et al. "Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor (Cell Death & Disease, (2025), 16, 1, (197), 10.1038/s41419-025-07535-x)" [未知]. |
| APA | Li, S. , Wang, X. , Huang, J. , Cao, X. , Liu, Y. , Bai, S. et al. Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor (Cell Death & Disease, (2025), 16, 1, (197), 10.1038/s41419-025-07535-x) [未知]. |
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Osteosarcoma (OS) is a highly aggressive and lethal malignant tumor with a 5-year overall survival rate of less than 20%, while its post-operative recovery remains suboptimal due to persistent inflammatory responses, incomplete clearance of residual tumor cells, and insufficient repair of tumor-induced large bone defects. Herein, a self-adaptive multi-functional RPSH hydrogel is successfully prepared by integrating a self-assembled 1-bromoacetyl-3,3-dinitroazetidine (RRx-001)/indocyanine green (ICG)@diselenide nanoparticle (R/I@SeNP) into a dual-network polyacrylamide/sodium alginate/hyaluronic acid (PAAm/SA/HA) hydrogel matrix. Initially, high molecular weight HA effectively suppresses the NF-kappa B pathway and induces macrophage polarization toward the M2 phenotype within 24 h, thereby reversing inflammatory microenvironments following OS resection. Then, dual-responsive R/I@SeNP enables a multi-modal anti-cancer approach by up-regulating levels of reactive oxygen/nitrogen species and generating RSeH or the immune checkpoint inhibitor RSeO(OH) with a tumor growth inhibition rate of 72.84% +/- 6.75% at three weeks post-surgery. Remarkably, the RPSH hydrogel promotes substantial new-bone formation and achieves a bone volume/total tissue volume (BV/TV) ratio of 59.03% +/- 9.41% following eight weeks of implantation by regulating the osteogenic-osteoclastic balance, demonstrating its sustained ability to create microenvironments favorable for bone regeneration. This self-adaptive hydrogel-based strategy offers promising insights and potential benefits for improving post-operative OS therapy.
Keyword ：
inflammation resolution inflammation resolution multi-modal tumor inhibition multi-modal tumor inhibition osteogenesis osteogenesis osteosarcoma treatment osteosarcoma treatment self-adaptive hydrogel self-adaptive hydrogel
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| GB/T 7714 | Lin, Hairong , Jin, Xinmeng , Cao, Yang et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
| MLA | Lin, Hairong et al. "Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction" . | ADVANCED FUNCTIONAL MATERIALS (2025) . |
| APA | Lin, Hairong , Jin, Xinmeng , Cao, Yang , Ruan, Renjie , Liu, Changhua , Huang, Shandeng et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction . | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
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Next-generation sequencing (NGS) technologies have achieved remarkable success in both biological research and clinical applications. However, in recent years, performance improvements have slowed due to fundamental limitations imposed by Poiseuille fluid dynamics in flow cells, which we overcome using Couette flow. Here we show NGS by roll-to-roll fluidics (r2r-fl), a cost-effective approach compatible with flexible biochip sizes. r2r-fl is a practical implementation of plane Couette flow, with up to 85-fold lower reagent consumption (US$0.16 per gigabase pair), rinsing times under 2 s and a reduction in paired-end 100-base pair sequencing turnaround from days to less than 12 h. The method maintains over 99.9% precision and 99.3% sensitivity of single nucleotide polymorphisms in the human genome, 99.9% mapping rate for Escherichia coli, and minimal nucleotide substitutions, deletions or insertions in the severe acute respiratory syndrome coronavirus 2 alpha strain. By lowering cost and time, r2r-fl enables rapid, scalable NGS for pathogen detection, cancer diagnostics and genetic disease profiling.
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| GB/T 7714 | Qin, Yanzhe , Koehler, Stephan A. , Ling, Yunyan et al. Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics [J]. | NATURE METHODS , 2025 , 22 (8) . |
| MLA | Qin, Yanzhe et al. "Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics" . | NATURE METHODS 22 . 8 (2025) . |
| APA | Qin, Yanzhe , Koehler, Stephan A. , Ling, Yunyan , Yu, Shiqiang , Zhang, Yongjie , Luo, Jie et al. Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics . | NATURE METHODS , 2025 , 22 (8) . |
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Precise control over the release of light energy, distinct from conventional thermal energy management, poses significant challenges in luminescent technologies. This study pioneers organic above-room-temperature thermoluminescent materials using radical pairs as energy storage centers (ESCs), enabling controlled light energy release from multi-hour afterglows to microsecond-scale explosive bursts, accelerating the energy release rate by up to 1.8 x 108 times. Notably, the unique transannular interactions between sulfur and oxygen in thianthrene oxides facilitate a thermally driven back electron transfer (BET) process based on radical pairs, central to the energy storage and release mechanism. Due to this BET process, these materials precisely modulate luminescence and exhibit robust stability, maintaining luminescence for 4 h in boiling water and storing energy in air for over six months. These findings advance organic thermoluminescence, highlight the significance of BET processes in various domains, and set new performance benchmarks for luminescent materials under extreme conditions.
Keyword ：
back electron transfer back electron transfer high-temperature stability high-temperature stability organic thermoluminescence organic thermoluminescence persistent luminescence persistent luminescence radical pairs radical pairs X-ray imaging X-ray imaging
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| GB/T 7714 | Wang, Yunsheng , Wang, Liwei , Li, Aisen et al. Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow [J]. | ADVANCED MATERIALS , 2025 . |
| MLA | Wang, Yunsheng et al. "Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow" . | ADVANCED MATERIALS (2025) . |
| APA | Wang, Yunsheng , Wang, Liwei , Li, Aisen , Li, Nan , Cao, Yalei , Wang, Xiaoze et al. Organic Thermoluminescence Driven by Electron Back Transfer: Microsecond Explosive Emission to Persistent Multi-Hour Afterglow . | ADVANCED MATERIALS , 2025 . |
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RNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species-dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu+)-containing disulfide assembled siRNA (Gu+-siRNA), demonstrating remarkable species independence and efficient systemic gene silencing across different plant species. Our results indicate that this approach effectively utilizes the plant vascular system to deliver siRNA, enabling long-distance gene silencing across both monocot and dicot plants, such as rice and Arabidopsis. By applying this method, we successfully targeted and silenced key genes like STM, WER, MYB23, GD1, EIL1, and EIL2, which regulate plant development and enhance salt tolerance. This delivery system significantly expands the application of RNAi technology across different plants, serving as a valuable tool for advancing agricultural biotechnology, enhancing crop resistance, and improving agricultural productivity, while aligning with global goals for sustainable food production and crop improvement.
Keyword ：
long-distance movement long-distance movement nanoparticle nanoparticle RNA interference RNA interference systematically deliver systematically deliver thiolated thiolated
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| GB/T 7714 | Lin, Shujin , Zhang, Qian , Bai, Shiyan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles [J]. | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) : 1165-1177 . |
| MLA | Lin, Shujin et al. "Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles" . | PLANT BIOTECHNOLOGY JOURNAL 23 . 4 (2025) : 1165-1177 . |
| APA | Lin, Shujin , Zhang, Qian , Bai, Shiyan , Yang, Liwen , Qin, Guannan , Wang, Liyuan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles . | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) , 1165-1177 . |
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Ischemic stroke, a leading cause of global mortality and disability, faces therapeutic limitations due to the narrow time window and restricted efficacy of current interventions such as thrombolysis and thrombectomy. Recent advancements highlight exosomes-nanoscale extracellular vesicles-as promising therapeutic agents owing to their ability to cross the blood-brain barrier (BBB) and mediate intercellular communication. This review summarizes the biological characteristics of exosomes, their roles in neuroprotection, neuroregeneration, and angiogenesis following ischemic stroke, and emerging strategies utilizing engineered exosome-based nanoparticles for targeted therapy. Despite exosomes showing significant advantages in the treatment of ischemic stroke, their clinical transformation still faces challenges, including the standardized production of exosomes, the clarification of biological distribution mechanisms, and the assessment of immunogenicity and safety. Overcoming these challenges, exosomes are expected to become a safe and efficient therapeutic means for ischemic stroke.
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| GB/T 7714 | Shen, Meilin , Zhu, Yan , Chen, Qi et al. Unlocking the therapeutic potential of exosomes for ischemic stroke [J]. | BIOMATERIALS SCIENCE , 2025 . |
| MLA | Shen, Meilin et al. "Unlocking the therapeutic potential of exosomes for ischemic stroke" . | BIOMATERIALS SCIENCE (2025) . |
| APA | Shen, Meilin , Zhu, Yan , Chen, Qi , Yang, Huanghao . Unlocking the therapeutic potential of exosomes for ischemic stroke . | BIOMATERIALS SCIENCE , 2025 . |
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Proteolysis-targeting chimeras (PROTACs) are dual-functional molecules composed of a protein of interest (POI) ligand and an E3 ligase ligand connected by a linker, which can recruit POI and E3 ligases simultaneously, thereby inducing the degradation of POI and showing great potential in disease treatment. A challenge in developing PROTACs is the design of linkers and the modification of ligands to establish a multifunctional platform that enhances degradation efficiency and antitumor activity. As a programmable and modifiable nanomaterial, DNA tetrahedron can precisely assemble and selectively recognize molecules and flexibly adjust the distance between molecules, making them ideal linkers. Herein, we developed a multivalent PROTAC based on a DNA tetrahedron, named AS-TD2-PRO. Using DNA tetrahedron as a linker, we combined modules targeting tumor cells, recognizing E3 ligases, and multiple POI together. We took the undruggable target protein signal transducer and activator of transcription 3 (STAT3), associated with the etiology and progression in a variety of malignant tumors, as an example in this study. AS-TD2-PRO with two STAT3 recognition modules demonstrated good potential in enhancing tumor-specific targeting and degradation efficiency compared to traditional bivalent PROTACs. Furthermore, in a mouse tumor model, the superior therapeutic activity of AS-TD2-PRO was observed. Overall, DNA tetrahedron-driven multivalent PROTACs both serve as a proof of principle for multifunctional PROTAC design and introduce a promising avenue for cancer treatment strategies.
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| GB/T 7714 | Li, Shiqing , Zeng, Tao , Wu, Zhixing et al. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (2) : 2168-2181 . |
| MLA | Li, Shiqing et al. "DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 147 . 2 (2025) : 2168-2181 . |
| APA | Li, Shiqing , Zeng, Tao , Wu, Zhixing , Huang, Jiabao , Cao, Xiuping , Liu, Yana et al. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2025 , 147 (2) , 2168-2181 . |
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Bioorthogonal catalysis mediated by abiotic transition metal catalysts (TMCs) is emerging as a momentum- gathering strategy for in situ generation of therapeutics. However, the unpredictable leakage and deposition of TMCs in living systems easily lead to nonspecific exposure of catalysts and concomitant off-target prodrug activation. Herein, we propose an enzyme-gated bioorthogonal catalytic nanoreactor constructed from hyaluronic acid (HA)-coated dendritic mesoporous silica nanoparticles (DMSNs), where the latter serves as a host for robustly immobilizing organometallic Ru(II) catalysts via covalent interactions. The covalent immobilization of catalysts within the nanoscaffold effectively avoids nonspecific metal leakage under biological conditions. Importantly, the grafted HA not only acts as a "gatekeeper" preventing unintended catalyst exposure in nontargeted tissues but also acts as a ligand targeting CD44 overexpressed cancer cells. Upon receptor-mediated endocytosis into tumor cells, HA is degraded by the overexpressed hyaluronidase-1, leading to the channel opening of the nanoreactors and hence gaining the accessibility of Ru(II) complexes to prodrugs. The therapeutic potency of this enzyme-gated nanoreactor in mediating site- specific activation of caged prodrugs was systematically demonstrated both in cellular settings and in tumor-bearing murine models. This enzyme-gated strategy enhances the efficacy of localized treatment while avoiding off-target prodrug activation, paving the way for advancing bioorthogonal catalysis for disease management in a safe and effective way.
Keyword ：
bioorthogonal catalysis bioorthogonal catalysis cancer therapy cancer therapy catalyst immobilization catalyst immobilization enzyme-gated enzyme-gated prodrugs prodrugs
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| GB/T 7714 | Guo, Yuheng , Jiang, Fang , Zhu, Xiaohui et al. An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation [J]. | NANO RESEARCH , 2025 , 18 (2) . |
| MLA | Guo, Yuheng et al. "An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation" . | NANO RESEARCH 18 . 2 (2025) . |
| APA | Guo, Yuheng , Jiang, Fang , Zhu, Xiaohui , He, Wen , Song, Sijie , Shou, Xuecen et al. An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation . | NANO RESEARCH , 2025 , 18 (2) . |
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Healing of chronic wounds becomes a global health issue due to increasing incidence and associated burdens, and therefore promoting tissue-remodeling and monitoring wound-status visually are of particular significance. Herein, an electronic-skin patch (TENG-gel) composed by polydimethylsiloxane/polytetrafluoroethylene film, eutectic gallium-indium (E-GaIn), and quaternary chitosan/polyacrylamide/sodium alginate@molybdenum disulfide (MoS2) nanosheet (H-QPS@MoS2) composite hydrogel is assembled layer-by-layer. First, the TENG-gel realizes multimodal antibacterial by integrating peroxidase-like activity, photothermal therapy, and nano-knife effect, which eliminates both Gram-positive/negative bacteria with killing ratio of above 95%. Besides, electrical stimulation generated from the TENG-gel promotes migration of fibroblasts after an incubation of 48 h by activating signaling pathways, and meanwhile accelerates vascularization by secreting different growth factors of CD31, VEGF, and TGF-beta. Through providing an ideal microenvironment for tissue repair, the TENG-gel achieves 1.6-fold new hair follicles and 2.4-fold collagen deposition compared with those of the control group. More interestingly, dual temperature-/strain-sensing performance enables the TENG-gel with capability of monitoring wound status or reminding external danger signals in real-time dependent on variational electrical signals. Overall, unique advantages of such smart electronic-skin patch provide a personalized medicine strategy for realizing tissue reconstruction and monitoring synchronously.
Keyword ：
chronic wounds chronic wounds MoS2 nanosheets MoS2 nanosheets multimodal antibacterial multimodal antibacterial real-time monitoring real-time monitoring wireless self-powered wireless self-powered
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| GB/T 7714 | Liu, Wanling , Ye, Juncheng , Wang, Yanlang et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) . |
| MLA | Liu, Wanling et al. "Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds" . | ADVANCED FUNCTIONAL MATERIALS 35 . 22 (2025) . |
| APA | Liu, Wanling , Ye, Juncheng , Wang, Yanlang , Xu, Xiaobo , Gao, Yujie , Liu, Kangyu et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds . | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) . |
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