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学者姓名：杨黄浩
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Abstract ：
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification or functionalization has emerged as a promising approach. These tailored nanovaccines not only enhance antigen presentation, but also effectively modulate immunosuppression within the tumor microenvironment. Specifically, they are distinguished by their diverse sizes, shapes, charges, structures, and unique physicochemical properties, along with targeting ligands. These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells. This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications, offering insights into their future development and role in cancer immunotherapy.
Keyword ：
Customized structure Customized structure Enhanced cancer immunotherapy Enhanced cancer immunotherapy Nanovaccines Nanovaccines Prophylactic and therapeutic applications Prophylactic and therapeutic applications Tailored-ligand Tailored-ligand
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| GB/T 7714 | Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang et al. Engineering customized nanovaccines for enhanced cancer immunotherapy [J]. | BIOACTIVE MATERIALS , 2024 , 36 : 330-357 . |
| MLA | Guo, Jinyu et al. "Engineering customized nanovaccines for enhanced cancer immunotherapy" . | BIOACTIVE MATERIALS 36 (2024) : 330-357 . |
| APA | Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang , Qiu, Ting , Zhang, Jin , Yang, Huanghao . Engineering customized nanovaccines for enhanced cancer immunotherapy . | BIOACTIVE MATERIALS , 2024 , 36 , 330-357 . |
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It remains a challenge to use a single probe to simultaneously detect extracellular pH fluctuations and specifically recognize cancer cells for precise drug delivery. Here, we engineered a tetrahedral framework nucleic acid-based logic nanoprobe (isgc8-tFNA) on live cell membranes for simultaneously monitoring extracellular pH and targeted drug delivery. Isgc8-tFNA was anchored stably on the cell surface through three cholesterol molecules inserting into the bilayer of the cell membrane. Once responding to the acidic tumor microenvironment, isgc8-tFNA formed an i-motif structure, leading to turn-on FRET signals for monitoring changes of extracellular pH. The nanoprobe exhibited a narrow pH-response window and excellent reversibility. Moreover, the nanoprobe could execute logic identification on the cell surface for precise drug delivery. Only if both in the acidic microenvironment and aptamer-targeting marker are present on the cell surface, the sgc8-ASO-chimera strand, carrying an antisense oligonucleotide drug, was released from the nanoprobe and entered into targeted cancer cells for gene silence. Additionally, the in situ drug release facilitated the uptake of drugs mediated by the interaction between sgc8 aptamer and membrane proteins, resulting in enhanced inhibition of cancer cell migration and proliferation. This logic nanoprobe will provide inspiration for designing smart devices for diagnosis of pH-related diseases and targeted drug delivery.
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| GB/T 7714 | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi et al. Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (8) : 3462-3469 . |
| MLA | Chen, Wanzhen et al. "Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery" . | ANALYTICAL CHEMISTRY 96 . 8 (2024) : 3462-3469 . |
| APA | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi , Chen, Lanlan , Yang, Huanghao . Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery . | ANALYTICAL CHEMISTRY , 2024 , 96 (8) , 3462-3469 . |
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Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.
Keyword ：
bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy
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| GB/T 7714 | Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 . |
| MLA | Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 . |
| APA | Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 . |
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The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging. However, scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge. In this study, we report an efficient method to synthesize ligand-free, lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method. The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration. Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators. We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method, a spatial resolution of 24.9 lp/mm for X-ray imaging. Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.
Keyword ：
Afterglow Afterglow Microscintillators Microscintillators NaLuF4:Tb3+ NaLuF4:Tb3+ X-ray detector X-ray detector X-ray luminescence imaging X-ray luminescence imaging
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| GB/T 7714 | Jiang, Hao , Chen, Qihao , Wang, Hongyu et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
| MLA | Jiang, Hao et al. "Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging" . | CHINESE CHEMICAL LETTERS 35 . 3 (2024) . |
| APA | Jiang, Hao , Chen, Qihao , Wang, Hongyu , Wu, Tingting , Gong, Jianwei , Zhang, Zhenzhen et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging . | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
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Metal nanoclusters (MNCs) can be synthesized with atomically precise structures and molecule formulae due to the rapid development of nanocluster science in recent decades. The ultrasmall size range (normally < 2 nm) endows MNCs with plenty of molecular-like properties, among which photoluminescent properties have aroused extensive attention. Tracing the research and development processes of luminescent nanoclusters, various photoluminescent analysis and characterization methods play a significant role in elucidating luminescent mechanism and analyzing luminescent properties. In this review, it is aimed to systematically summarize the normally used photoluminescent characterizations in MNCs including basic parameters and methods, such as excitation/emission wavelength, quantum yield, and lifetime. For each key parameter, first its definition and meaning is introduced and then the relevant characterization methods including measuring principles and the revelation of luminescent properties from the collected data are discussed. Then, it is discussed in details how to explore the luminescent mechanism of MNCs and construct NC-based applications based on the measured data. By means of these characterization strategies, the luminescent properties of MNCs and NC-based designs can be explained quantitatively and qualitatively. Hence, this review is expected to provide clear guidance for researchers to characterize luminescent MNCs and better understand the luminescent mechanism from the measured results.
Keyword ：
luminescent properties luminescent properties metal nanoclusters metal nanoclusters photoluminescence photoluminescence photoluminescent characterization photoluminescent characterization photoluminescent lifetime photoluminescent lifetime
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| GB/T 7714 | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang et al. Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications [J]. | ADVANCED MATERIALS , 2024 , 36 (25) . |
| MLA | Lin, Hongbin et al. "Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications" . | ADVANCED MATERIALS 36 . 25 (2024) . |
| APA | Lin, Hongbin , Song, Xiaorong , Chai, Osburg Jin Huang , Yao, Qiaofeng , Yang, Huanghao , Xie, Jianping . Photoluminescent Characterization of Metal Nanoclusters: Basic Parameters, Methods, and Applications . | ADVANCED MATERIALS , 2024 , 36 (25) . |
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Long-lasting radioluminescence scintillators have recently attracted substantial attention from both research and industrial communities, primarily due to their distinctive capabilities of converting and storing X-ray energy. However, determination of energy-conversion kinetics in these nanocrystals remains unexplored. Here we present a strategy to probe and unveil energy-funneling kinetics in NaLuF4:Mn2+/Gd3+ nanocrystal sublattices through Gd3+-driven microenvironment engineering and Mn2+-mediated radioluminescence profiling. Our photophysical studies reveal effective control of energy-funneling kinetics and demonstrate the tunability of electron trap depth ranging from 0.66 to 0.96 eV, with the corresponding trap density varying between 2.38x105 and 1.34x107 cm-3. This enables controlled release of captured electrons over durations spanning from seconds to 30 days. It allows tailorable emission wavelength within the range of 520-580 nm and fine-tuning of thermally-stimulated temperature between 313-403 K. We further utilize these scintillators to fabricate high-density, large-area scintillation screens that exhibit a 6-fold improvement in X-ray sensitivity, 22 lp/mm high-resolution X-ray imaging, and a 30-day-long optical memory. This enables high-contrast imaging of injured mice through fast thermally-stimulated radioluminescence readout. These findings offer new insights into the correlation of radioluminescence dynamics with energy-funneling kinetics, thereby contributing to the advancement of high-energy nanophotonic applications. Energy-funneling kinetics in NaLuF4: Mn2+/Gd3+ nanocrystals were explored through precise microenvironment engineering within nanocrystal sublattices. The resulting tailorable radioluminescence afterglow enabled high-sensitivity, high-resolution X-ray imaging with an ultralong optical memory. image
Keyword ：
Electronic traps Electronic traps Energy funneling Energy funneling Nanocrystal scintillators Nanocrystal scintillators Radioluminescence afterglow Radioluminescence afterglow X-ray imaging X-ray imaging
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| GB/T 7714 | Wu, Qinxia , Xu, Xinqi , Li, Xiaokun et al. Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (25) . |
| MLA | Wu, Qinxia et al. "Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 25 (2024) . |
| APA | Wu, Qinxia , Xu, Xinqi , Li, Xiaokun , Jiang, Hao , Qin, Xian , Hong, Zhongzhu et al. Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (25) . |
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Photodynamic therapy (PDT) as an emerging therapeutic method has drawn much attention in the treatment field for cancer. Photosensitizer, which can convert photon energy into cytotoxic species under light irradiation, is the core component in PDT. The design of photosensitizers still faces problems of light absorption, targeting, penetration and oxygen dependence. With the rapid progress of material science, various photosensitizers have been developed to produce cytotoxic species for treatment of tumor with high selectivity, safety, and noninvasiveness. Besides, the applications of photosensitizers have been expanded to diverse cancer treatments such as drug release, optogenetics and immune checkpoint blockade. In this review, we summarize the recent advances of photosensitizers in various therapeutic methods for cancer. Prevailing challenges and further prospects associated with photosensitizers are also discussed. Explore the groundbreaking realm of cancer therapy with our comprehensive study on the mechanism and applications of photosensitizer-mediated light-controlled cancer therapy. Uncover the intricate workings and diverse applications of this innovative approach, clarify the future of targeted and controlled cancer treatment. image
Keyword ：
Drug Delivery Drug Delivery Optogenetics Optogenetics Photodynamic Therapy Photodynamic Therapy Photosensitizer Photosensitizer X-rays X-rays
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| GB/T 7714 | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen et al. Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
| MLA | Chen, Minle et al. "Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy" . | CHEMISTRY-AN ASIAN JOURNAL 19 . 11 (2024) . |
| APA | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen , Chen, Qiushui , Yang, Huanghao . Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy . | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
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X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程,在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景.相较于传统的紫外激发光,X射线对生物组织具有高穿透性且不会触发生物体的自荧光,可实现深组织、无背景、高灵敏的生物分析.近年来,基于纳米闪烁体的X射线发光在生物光子学领域中得到广泛研究,促进了 X射线发光在分析化学和生物医学中的应用.本文首先对闪烁体的X射线发光机理进行了概述,接着重点介绍了纳米闪烁体作为光学探针在生物分子测量与疾病治疗中的研究进展,包括生物传感、活体成像和光动力治疗等,最后讨论了该领域存在的一些挑战和可能的解决方案.
Keyword ：
X射线发光 X射线发光 光学探针 光学探针 生物分析 生物分析 纳米闪烁体 纳米闪烁体
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| GB/T 7714 | 徐新奇 , 张珍珍 , 陈小丰 et al. 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 [J]. | 化学通报（印刷版） , 2024 , 87 (9) : 1009-1019 . |
| MLA | 徐新奇 et al. "基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展" . | 化学通报（印刷版） 87 . 9 (2024) : 1009-1019 . |
| APA | 徐新奇 , 张珍珍 , 陈小丰 , 陈秋水 , 杨黄浩 . 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 . | 化学通报（印刷版） , 2024 , 87 (9) , 1009-1019 . |
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Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine, which remains a major challenge for effective anti-tumor. Herein, we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation pathway. To achieve active tumor accumulation in vivo, disulfide-based nanoparticles are modified with folic acid units (FA-DBNPs). It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway, which facilitates transcellular transportation and tumor penetration both in vitro and in vivo. Besides, FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization, indicating that the GSH level in tumor tissues regulates the penetration depth of FA-DBNPs. Benefiting from these advantages, FA-DBNPs showed potent anti-tumor activity in mouse models, leading to the significant regression of tumors. The current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.
Keyword ：
deep penetration deep penetration solid tumor solid tumor thiol-mediated pathway thiol-mediated pathway transcellular transportation transcellular transportation
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| GB/T 7714 | Zhang, Junjie , Sun, Weican , Wang, Xing et al. Thiol-mediated transportation pathway: an approach for improving tumor penetration of nanomedicines in vivo [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (1) : 383-389 . |
| MLA | Zhang, Junjie et al. "Thiol-mediated transportation pathway: an approach for improving tumor penetration of nanomedicines in vivo" . | SCIENCE CHINA-CHEMISTRY 67 . 1 (2024) : 383-389 . |
| APA | Zhang, Junjie , Sun, Weican , Wang, Xing , Chen, Senyan , Li, Jingying , Yang, Huanghao . Thiol-mediated transportation pathway: an approach for improving tumor penetration of nanomedicines in vivo . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (1) , 383-389 . |
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Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand as the leading causes of irreversible vision impairment and blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to the presence of complex ocular barriers and elimination mechanisms. Over time, various approaches have been developed to fabricate drug delivery systems for improving retinal therapy including virus vectors, lipid nanoparticles, and polymers. However, conventional nanocarriers encounter issues related to the controllability, efficiency, and safety in the retina. Therefore, the development of smart nanocarriers for effective or more invasive long-term treatment remains a desirable goal. Recently, approaches have surfaced for the intelligent design of nanocarriers, leveraging specific responses to external or internal triggers and enabling multiple functions for retinal therapy such as topical administration, prolonged drug release, and site-specific drug delivery. This Review provides an overview of prevalent retinal pathologies and related pharmacotherapies to enhance the understanding of retinal diseases. It also surveys recent developments and strategies employed in the intelligent design of nanocarriers for retinal disease. Finally, the challenges of smart nanocarriers in potential clinical retinal therapeutic applications are discussed to inspire the next generation of smart nanocarriers.
Keyword ：
ophthalmology ophthalmology posteriorsegment drug delivery posteriorsegment drug delivery retinal disease retinal disease smart nanocarriers smart nanocarriers stimuli-response stimuli-response
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| GB/T 7714 | Liu, Shuya , Yan, Zhike , Huang, Zixiang et al. Smart Nanocarriers for the Treatment of Retinal Diseases [J]. | ACS APPLIED BIO MATERIALS , 2024 , 7 (4) : 2070-2085 . |
| MLA | Liu, Shuya et al. "Smart Nanocarriers for the Treatment of Retinal Diseases" . | ACS APPLIED BIO MATERIALS 7 . 4 (2024) : 2070-2085 . |
| APA | Liu, Shuya , Yan, Zhike , Huang, Zixiang , Yang, Huanghao , Li, Jingying . Smart Nanocarriers for the Treatment of Retinal Diseases . | ACS APPLIED BIO MATERIALS , 2024 , 7 (4) , 2070-2085 . |
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