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学者姓名：陈杰林
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Abstract ：
Crystals are materials in which atoms, ions, or molecules are arranged in a periodic and ordered three-dimensional structure. Among novel crystalline nanomaterials, self-assembled DNA crystals form via the base-pair complementarity of DNA molecules. Unlike traditional ionic or metallic crystals, self-assembled DNA crystals offer high programmability, enabling the design of addressable frameworks with tunable pore sizes for host-guest interactions and further functionalization through interfacial chemical modifications. Over the past 15 years, research interest in DNA nanotechnology and DNA self-assembled nanomaterials has surged. This review provides a comprehensive overview of the design principles, regulation, and functionalization of self-assembled DNA crystals for applications in molecular recognition, catalysis, and photonic crystals, while also addressing their emerging challenges within the broader context of nucleic acid chemistry and structural DNA nanotechnology.
Keyword ：
DNA crystallography DNA crystallography DNA nanotechnology DNA nanotechnology framework nucleic acid framework nucleic acid self-assembled DNA crystal self-assembled DNA crystal
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| GB/T 7714 | Li, Ziyu , Li, Mingqiang , Liu, Xiaoguo et al. Design, regulation, and functionalization of self-assembled DNA crystals [J]. | NANO RESEARCH , 2025 , 18 (7) . |
| MLA | Li, Ziyu et al. "Design, regulation, and functionalization of self-assembled DNA crystals" . | NANO RESEARCH 18 . 7 (2025) . |
| APA | Li, Ziyu , Li, Mingqiang , Liu, Xiaoguo , Chen, Jielin . Design, regulation, and functionalization of self-assembled DNA crystals . | NANO RESEARCH , 2025 , 18 (7) . |
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Abstract ：
DNA hybridization and assembly processes are governed by the concerted effects of Watson-Crick pairing and base-stacking interactions. While sequence engineering and chemical modifications have been extensively exploited to regulate DNA hybridization processes and complex structural assembly of DNA, here we demonstrate the use of locked nucleic acid (LNA) modifications to finely tune base-stacking interactions, which are yet to be explored in DNA assembly processes, to program the growth of self-assembled DNA crystals. We find that sticky-end LNA modifications decrease base-pair spacing and enhance base-stacking energy, which synergistically improves interstrand affinity and accelerates hybridization rate constants, as revealed by strand displacement kinetics, molecular dynamics simulations, and small-angle X-ray scattering analysis. This LNA-based base-stacking engineering strategy can finely tune base-stacking energy landscapes to drive anisotropic growth and morphological control in self-assembled DNA crystal. We further establish a quantitative framework for probing structure-energy relationships in base-stacking interactions, which not only paves the way for better control of structural DNA nanotechnology but also provides mechanistic insights for developing dynamic DNA nanosystems.
Keyword ：
Crystallization Crystallization DNA crystal DNA crystal DNA nanotechnology DNA nanotechnology Locked nucleic acid Locked nucleic acid Nucleobase chemical modification Nucleobase chemical modification
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| GB/T 7714 | Chen, Jielin , Li, Mingqiang , Li, Ziyu et al. Locked Nucleic Acid Modification for Base-Stacking Engineering of Self-Assembled DNA Crystals [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (39) . |
| MLA | Chen, Jielin et al. "Locked Nucleic Acid Modification for Base-Stacking Engineering of Self-Assembled DNA Crystals" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 39 (2025) . |
| APA | Chen, Jielin , Li, Mingqiang , Li, Ziyu , Tang, Yuqing , Zhang, Hanwei , Cheng, Jianing et al. Locked Nucleic Acid Modification for Base-Stacking Engineering of Self-Assembled DNA Crystals . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (39) . |
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