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学者姓名：周晓雷
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Abstract ：
Diabetic wounds complicated by bacterial infections present a significant clinical challenge, and cause a great burden to the world's health care systems. Infections by bacteria, especially drug-resistant bacteria, is the major underlying factor leading to diabetic wounds. Here, we synthesized a series of fluoroborane dipyrrole compounds that can be activated under ambient light conditions, and identified one compound with potent antibacterial action. The compound has a maximum absorption wavelength of 538 nm, close to the maximum emission wavelength of sunlight, making it particularly suitable for incorporation into transparent antimicrobial patches. We fabricated such a patch and evaluated its therapeutic potential in a murine model of diabetic wounds infected with drug-resistant bacteria. The experimental results showed that the patch not only eradicates drug-resistant bacterial strains but also promoted wound healing under ambient light. Furthermore, the compound exhibited a high level of biosafety. This work developed an effective and safe method to combat bacterial skin infections associated with diabetic wounds.
Keyword ：
Antimicrobial photodynamic therapy Antimicrobial photodynamic therapy BODIPY BODIPY Diabetic wounds Diabetic wounds Drug-resistant bacteria Drug-resistant bacteria Photosensitizer Photosensitizer Transparent patches Transparent patches
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| GB/T 7714 | Deng, Lina , Chen, Zheng , Jiang, Libin et al. Treatment of diabetic infection wounds using novel fluoroborane dipyrrole-coated transparent patch [J]. | BIOORGANIC CHEMISTRY , 2025 , 163 . |
| MLA | Deng, Lina et al. "Treatment of diabetic infection wounds using novel fluoroborane dipyrrole-coated transparent patch" . | BIOORGANIC CHEMISTRY 163 (2025) . |
| APA | Deng, Lina , Chen, Zheng , Jiang, Libin , Jing, Qian , Wang, Shuai , Yang, De-Chao et al. Treatment of diabetic infection wounds using novel fluoroborane dipyrrole-coated transparent patch . | BIOORGANIC CHEMISTRY , 2025 , 163 . |
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Abstract ：
Lysosomes are promising therapeutic targets for cancer therapy due to their essential function and increased vulnerability in cancer cells. Herein, we report a new category of cationic photosensitizers (compounds 1-3) containing a quaternary ammonium group. These photosensitizers exhibited selective uptake on cancer cells (about three times compared to the normal cells), lysosome-specific localization (Pearson's coefficients greater than 0.85), remarkable phototoxicity (IC50 are in the range of dozens of nM), and at the same time, favorable biosafety. Mechanically, these tumor-targeting photosensitizers function as light-controlled "bombs", inducing lysosomal membrane permeabilization (LMP), ultimately resulting in apoptosis of cancer cells. In vivo, compound 1 (a representative of these novel photosensitizers) accumulated predominantly in and visualized tumors implanted on mice. Upon exposure to near-infrared light irradiation (50 J/cm2), the compound effectively ablated the tumor at a low dose of 2 mg/kg. Our results demonstrate a novel class of photosensitizers showing potential for integrated cancer diagnosis and photodynamic treatment.
Keyword ：
Lysosomal membrane permeabilization Lysosomal membrane permeabilization Photodynamic therapy Photodynamic therapy Phthalocyanine Phthalocyanine Tumor-targeting Tumor-targeting
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| GB/T 7714 | Li, Jiahui , Wang, Guodong , Mai, Yuhan et al. Lysosome-localization and tumor-targeting of novel photosensitizers enhance the ablation of cancer [J]. | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2024 , 261 . |
| MLA | Li, Jiahui et al. "Lysosome-localization and tumor-targeting of novel photosensitizers enhance the ablation of cancer" . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 261 (2024) . |
| APA | Li, Jiahui , Wang, Guodong , Mai, Yuhan , Zhang, Wei , Zhao, Hailong , Zhou, Yang et al. Lysosome-localization and tumor-targeting of novel photosensitizers enhance the ablation of cancer . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2024 , 261 . |
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