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学者姓名：林振宇
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Abstract ：
A colorimetric and photothermal dual readout biosensor for Flap endonuclease 1 (FEN1) quantification was developed on the basis of target-prevented gold nanoparticles (AuNPs) aggregation. The exposed 5 & PRIME;-flap of double-flap DNA substrate modified on SAMBs was firstly cleaved by FEN1. Large amount of cleaved 5 & PRIME;-flap remained in the supernatant after simple magnetic separation, which can adsorb on the surface of AuNPs and effectively prevent the dispersed AuNPs from aggregation under high ionic concentration, accompanied with the color changing of the system, which can be recognized by nake eyes easily. The absorption intensity at 528 nm shows a good linear relationship with the increasing FEN1 concentration from 5.0 x 10-3 to 3.1 x 10-2 U & mu;L-1 with a LOD of 1.6 x 10-3 U & mu;L-1 (S/N = 3). Given the aggregated AuNPs have higher photothermal effect than that of the dispersed AuNPs, the target-prevented AuNPs aggregation avoids a sharp increase of temperature for the system under the laser radiation. The temperature change is linearly correlated with the FEN1 concentration in the range of 3.1 x 10-3-6.1 x 10-2 U & mu;L-1 with a LOD of 1.1 x 10-3 U & mu;L-1. The whole detection process can be completed within 1 h. The proposed system had been applied to detect FEN1 concentration in serum samples with satisfied results, which can be applied in resource-limited area easily and quickly.
Keyword ：
Colorimetric Colorimetric Flap endonuclease 1 Flap endonuclease 1 Gold nanoparticles aggregation Gold nanoparticles aggregation Photothermal effect Photothermal effect
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| GB/T 7714 | Li, Xianghui , Yang, Xiulin , Zhuo, Shuangmu et al. Colorimetric and photothermal dual readout biosensor for flap endonuclease 1 based on target-prevented gold nanoparticles aggregation [J]. | TALANTA , 2024 , 266 . |
| MLA | Li, Xianghui et al. "Colorimetric and photothermal dual readout biosensor for flap endonuclease 1 based on target-prevented gold nanoparticles aggregation" . | TALANTA 266 (2024) . |
| APA | Li, Xianghui , Yang, Xiulin , Zhuo, Shuangmu , Lin, Zhenyu , Chen, Jianxin . Colorimetric and photothermal dual readout biosensor for flap endonuclease 1 based on target-prevented gold nanoparticles aggregation . | TALANTA , 2024 , 266 . |
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Changes in the charge density on the inner surface of the microchannel can modulate the ion concentration at the tip, thus causing changes in the resistance of the system. In this study, this property is adopted to construct a portable sensor using a multimeter and aflatoxin B1 (AFB1) is used as the model target. Initially, the cDNA/aptamer complex is modified in the microchannel. The inner microchannel surface's charge density is then altered by the recognition of the target, leading to a change in the system's resistance, which can be conveniently monitored using a multimeter. Critical parameters influencing the performance of the system are optimized. Under optimum conditions, the resistance is linearly related to the logarithm of AFB1 concentration in the range of 100 fM-10 nM and the detection limit is 46 fM (S/N = 3). The resistive measurement is separated from the recognition reaction of the target, reducing the matrix interference during the detection process. This sensor boasts high sensitivity and specificity coupled with commendable reproducibility and stability. It is applied to assay the AFB1 content successfully in an actual sample of corn. Moreover, this approach is cost-effective, user-friendly, and highly accurate.
Keyword ：
aflatoxin B1 aflatoxin B1 microchannel microchannel portablesensor portablesensor resistance resistance surface charge density surface charge density
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| GB/T 7714 | Cai, Huabin , Huang, Yanling , Lin, Yue et al. Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout [J]. | ACS SENSORS , 2024 , 9 (1) : 494-501 . |
| MLA | Cai, Huabin et al. "Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout" . | ACS SENSORS 9 . 1 (2024) : 494-501 . |
| APA | Cai, Huabin , Huang, Yanling , Lin, Yue , Luo, Fang , Chen, Lifen , Guo, Longhua et al. Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout . | ACS SENSORS , 2024 , 9 (1) , 494-501 . |
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将具有丰富微孔的ZIF-8金属有机框架和电化学技术对金属离子的富集作用与微流控器件对溶液流动的可控性相结合,构建了一种新型传感器,实现了高通量、实时和快速检测环境中的多种金属离子污染物.研制的ZIF-8-Nafion/ITO 基微流控电化学传感器对Cd2+,Pb2+及Hg2+离子在0.1～100 μmol/L的浓度范围内具有良好的线性关系,检出限分别为 0.055,0.0025及0.0016 μmol/L(S/N=3).该微流控芯片对于样品的需求量少,可降低对能源的消耗;同时由聚二甲基硅氧烷拓印的微流控器件还有望实现柔性电极的功能,对便携式电化学柔性器件在生物和环境样品的集成化和自动化检测具有重要意义.
Keyword ：
微流控 微流控 电化学传感器 电化学传感器 重金属检测 重金属检测 金属有机框架 金属有机框架
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| GB/T 7714 | 陈晓萍 , 王旭潭 , 刘宁 et al. MOFs基微流控电化学芯片对多种重金属离子的实时在线检测 [J]. | 高等学校化学学报 , 2024 , 45 (2) : 23-32 . |
| MLA | 陈晓萍 et al. "MOFs基微流控电化学芯片对多种重金属离子的实时在线检测" . | 高等学校化学学报 45 . 2 (2024) : 23-32 . |
| APA | 陈晓萍 , 王旭潭 , 刘宁 , 汪庆祥 , 倪建聪 , 杨伟强 et al. MOFs基微流控电化学芯片对多种重金属离子的实时在线检测 . | 高等学校化学学报 , 2024 , 45 (2) , 23-32 . |
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The chemical enhancement of semiconductor-based surface-enhanced Raman scattering (SERS) substrates is an exciting hot topic. Herein, a simple hydrothermal method is developed to prepare molybdenum disulfide (MoS2), which can be easily exfoliated into monolayer nanosheets (MoS(2)NSs) by sonication, even in the absence of any surfactant. The obtained MoS(2)NSs contain two types of defects, namely, one caused by the incorporation of Mo atoms of high valence states and one caused by the incorporation of S-2(2-). The density of the two types of defects can be easily tuned by controlling the ratio of Na2S and Na2MoO4 in the raw materials. The unique properties and the clear surface make the obtained MoS(2)NSs ideal models to investigate the effect of defects on the SERS activity of MoS2. It is found that the SERS activity of the obtained MoS(2)NSs increases dramatically with the defects caused by Mo atoms of high valence states, while it first increases and then decreases with the increase of defects caused by S-2(2-). On the basis, MoS(2)NSs with high SERS activity and a low detection limit of 5.0 x 10(-9) mol/L toward crystal violet (CV) are obtained. Moreover, the mechanism of defects affecting the SERS activity of MoS(2)NSs is revealed. The defects on one hand provide a large amount of dangling bonds that can combine CV molecules to form MoS2NS-CV complex and on the other hand provide extensive induced local dipoles and enhance the overall SERS spectrum of CV.
Keyword ：
chemical enhancement chemical enhancement crystal violet crystal violet defects defects molybdenum disulfidenanosheets molybdenum disulfidenanosheets surface-enhanced Raman scattering surface-enhanced Raman scattering
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| GB/T 7714 | Fu, Xiaolong , Wu, Huiying , Liu, Zhihong et al. MoS2 Nanosheets as Substrates for SERS-Based Sensing [J]. | ACS APPLIED NANO MATERIALS , 2024 , 7 (4) : 3988-3996 . |
| MLA | Fu, Xiaolong et al. "MoS2 Nanosheets as Substrates for SERS-Based Sensing" . | ACS APPLIED NANO MATERIALS 7 . 4 (2024) : 3988-3996 . |
| APA | Fu, Xiaolong , Wu, Huiying , Liu, Zhihong , Wang, Pengzhao , Rong, Jiefeng , Fu, Fengfu et al. MoS2 Nanosheets as Substrates for SERS-Based Sensing . | ACS APPLIED NANO MATERIALS , 2024 , 7 (4) , 3988-3996 . |
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The control of nanoparticle morphology can effectively change their properties. Adjusting the aggregation state of bovine serum albumin-coated gold nanoclusters (BSA-Au NCs) can regulate the enzyme-mimicking catalytic activity. Hyaluronic acid (HA) induces the aggregation of BSA-Au NCs, leading to the shielding of the catalytic active sites and a decrease in activity; this feature has been utilized to design a multicolor biosensor for hyaluronidase (HAase). The presence of HAase can hydrolyze the glycosidic bonds in HA, causing the aggregated BSA-Au NCs to disperse and express their catalytic activity, which in turn catalyzes the etching of Au nanobipyramids (Au-NBPs) in the presence of 3,3 ',5,5 ' -tetramethylbenzidine (TMB), resulting in a morphological transition from bipyramidal to ellipsoidal and spherical shapes, while the solution displays a variety of colors. Visual recognition of these multicolor changes establishes a relationship between the enzyme activity and color. Based on the controlled aggregation and dispersion of BSA-Au NCs and the etching of Au-NBPs, a simple multicolor HAase biosensor was designed. The proposed biosensor shows a linear response to HAase concentrations in the range of 5-80 U/mL, with clear color changes under optimized conditions. The limit of detection (LOD) of the sensor was determined to be 1.98 U/mL (LOD = 3s/k). This method successfully applies the changing of enzyme-mimicking catalytic activity nanoparticles for colorimetric analysis detection.
Keyword ：
aggregation statemodulation aggregation statemodulation Au nanocluster Au nanocluster hyaluronidase hyaluronidase multicolor multicolor nanozymes nanozymes
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| GB/T 7714 | Tian, Mengjian , Lin, Cuiying , Lin, Yue et al. Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State [J]. | ACS APPLIED NANO MATERIALS , 2024 , 7 (5) : 5620-5627 . |
| MLA | Tian, Mengjian et al. "Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State" . | ACS APPLIED NANO MATERIALS 7 . 5 (2024) : 5620-5627 . |
| APA | Tian, Mengjian , Lin, Cuiying , Lin, Yue , Luo, Fang , Qiu, Bin , Wang, Jian et al. Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State . | ACS APPLIED NANO MATERIALS , 2024 , 7 (5) , 5620-5627 . |
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A series of novel phosphors, specifically Eu3+-doped and Eu3+/M+ co-doped (M = Li+, Na+, K+) SrLaNaTeO6, were synthesized via a high-temperature solid-state process. The luminous properties and thermal stability of these phosphors were thoroughly investigated. When subjected to the appropriate excitation wavelengths (395 and 465 nm), all phosphors demonstrate a pronounced red light emission, corresponding to the D-5(0)-> F-7(2) transition of Eu3+. The researchers found that the most effective concentration of Eu3+ doping in the Sr1-xLaNaTeO6:xEu(3+) phosphor was discovered to be x = 0.25. It was shown that excessive doping leads to concentration quenching, which can be attributed to the energy transfer interaction between Eu3+ ions. The incorporation of Li+, Na+, and K+ as charge compensation ions in conjunction with Eu3+ in Sr0.75LaNaTeO6:0.25Eu(3+) phosphor leads to a notable enhancement in light intensity. Notably, the phosphor co-doped with Na+ exhibits the highest luminous intensity among the alkali metal charge compensation ions. The near proximity of the ion radius of the charge compensation ion Na+ to that of Sr2+ in the host facilitates the occupation of the Na (+) ion in the Sr2+ lattice location. Sodium ions (Na+) have the ability to counteract the positive defects resulting from the substitution of europium ions (Eu3+) with strontium ions (Sr2+), hence maintaining charge neutrality. Additionally, it should be noted that Sr0.5LaNaTeO6:0.25Eu(3+),0.25Na(+) phosphor exhibits a remarkable quantum yield of 71.26 % and lacks thermal quenching. These characteristics suggest that this particular phosphor holds promising potential for utilization in developing white-light-emitting diodes.
Keyword ：
Alkali metal charge compensation Alkali metal charge compensation Luminescence enhancement Luminescence enhancement Negative thermal quenching Negative thermal quenching Sr1-xLaNaTeO6:xEu(3+) Sr1-xLaNaTeO6:xEu(3+)
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| GB/T 7714 | Ruan, Fangyi , Fan, Guodong , Li, Nan et al. Charge compensation effect of alkali metal ions on luminescence enhancement and negative thermal quenching of Sr1-xLaNaTeO6:xEu3+ red phosphors [J]. | CERAMICS INTERNATIONAL , 2024 , 50 (8) : 12866-12876 . |
| MLA | Ruan, Fangyi et al. "Charge compensation effect of alkali metal ions on luminescence enhancement and negative thermal quenching of Sr1-xLaNaTeO6:xEu3+ red phosphors" . | CERAMICS INTERNATIONAL 50 . 8 (2024) : 12866-12876 . |
| APA | Ruan, Fangyi , Fan, Guodong , Li, Nan , Zhou, Jianfeng , Li, Ying , Fan, Di et al. Charge compensation effect of alkali metal ions on luminescence enhancement and negative thermal quenching of Sr1-xLaNaTeO6:xEu3+ red phosphors . | CERAMICS INTERNATIONAL , 2024 , 50 (8) , 12866-12876 . |
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Halide perovskites have emerged as a highly promising class of photoelectric materials. However, the application of lead-based perovskites has been hindered by their toxicity and relatively weak stability. In this work, a composite material comprising a lead-free perovskite cesium copper iodide (CsCu2I3) nanocrystal and a metal-organic framework (MOF-801) has been synthesized through an in situ growth approach. The resulting composite material, denoted as CsCu2I3/MOF-801, demonstrates outstanding stability and exceptional optoelectronic characteristics. MOF-801 may serve a dual role by acting as a protective barrier between CsCu2I3 nanocrystals and the external environment, as well as promoting the efficient transfer of photogenerated charge carriers, thereby mitigating their recombination. Consequently, CsCu2I3/MOF-801 demonstrates its utility by providing both stability and a notably high initial photocurrent. Leveraging the inherent reactivity between H2S and the composite material, which results in the formation of Cu2S and structural alteration, an exceptionally sensitive photoelectrochemical sensor for H2S detection has been designed. This sensor exhibits a linear detection range spanning from 0.005 to 100 mu M with a remarkable detection limit of 1.67 nM, rendering it highly suitable for precise quantification of H2S in rat brains. This eco-friendly sensor significantly broadens the application horizon of perovskite materials and lays a robust foundation for their future commercialization.
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| GB/T 7714 | Mao, Mengfan , Zu, Yexin , Zhang, Yating et al. Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (10) : 4290-4298 . |
| MLA | Mao, Mengfan et al. "Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite" . | ANALYTICAL CHEMISTRY 96 . 10 (2024) : 4290-4298 . |
| APA | Mao, Mengfan , Zu, Yexin , Zhang, Yating , Qiu, Yongzhen , Lin, Yue , Luo, Fang et al. Photoelectrochemical Sensor for H2S Based on a Lead-Free Perovskite/Metal-Organic Framework Composite . | ANALYTICAL CHEMISTRY , 2024 , 96 (10) , 4290-4298 . |
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Circulating cell-free DNA (cfDNA) is known to be an attractive biomarker for liquid biopsy. In this work, a rapid and sensitive biosensor was achieved for cfDNA detection based on CRISPR-associated nuclease 12a (CRISPRCas12a) and single nanoparticle dark-field microscopy (DFM) imaging. The biosensor employed gold nanoparticles (AuNPs) as signal source, DFM as readout system, and Meanshift algorithms as the image processing systems, respectively. The presence or absence of cfDNA caused the different existing states (monomer or aggregated state) of AuNPs. AuNPs monomers could be effectively distinguished from the aggregated ones under DFM since the AuNPs aggregation could induced the green-to-yellow or green-to-red changing of scattering color. The monomer ratio easily obtained by Meanshift and partial least-square (PLS) algorithms was used for quantitative analysis. Using this strategy, breast cancer gene-1 (BRCA-1), a representative of cfDNA biomarker for breast cancer could be measured with high sensitivity in 40 min and has a low detection limit of 0.081 fM. It is hoped that this nucleic acid amplification-free sensor could be also utilized to detect other nucleic acid biomarkers, and thus, provides a novel strategy for biomedical image analysis.
Keyword ：
CfDNA CfDNA CRISPR/Cas12a CRISPR/Cas12a Dark -field microscopy imaging Dark -field microscopy imaging Gold nanoparticle Gold nanoparticle
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| GB/T 7714 | Li, Xianghui , Yang, Xiulin , Pan, Zhipeng et al. Nucleic acid amplification-free biosensor for sensitive and specific cfDNA detection based on CRISPR-Cas12a and single nanoparticle dark-field microscopy (DFM) imaging [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 406 . |
| MLA | Li, Xianghui et al. "Nucleic acid amplification-free biosensor for sensitive and specific cfDNA detection based on CRISPR-Cas12a and single nanoparticle dark-field microscopy (DFM) imaging" . | SENSORS AND ACTUATORS B-CHEMICAL 406 (2024) . |
| APA | Li, Xianghui , Yang, Xiulin , Pan, Zhipeng , Zhuo, Shuangmu , Lin, Zhenyu , Chen, Jianxin . Nucleic acid amplification-free biosensor for sensitive and specific cfDNA detection based on CRISPR-Cas12a and single nanoparticle dark-field microscopy (DFM) imaging . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 406 . |
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Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HCMSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.91 %), for combination therapy of UC. The microspheres were successfully engineered, retaining the antioxidative and anti-inflammatory activities of parental CUR and demonstrating excellent biocompatibility and controlled release properties, notably triggered by alpha-amylase, facilitating targeted drug delivery to inflamed sites. In a mouse UC model induced by dextran sulfate sodium, the microspheres effectively accumulated in inflamed colons and both HC-MSs and DHC-MSs exhibited superior therapeutic efficacy in alleviating UC symptoms compared to free DEX. Moreover, mechanistic exploration uncovered the multifaceted therapeutic mechanisms of these formulations, encompassing anti-inflammatory actions, mitigation of spleen enlargement, and modulation of gut microbiota composition. These findings underscore the potential of HC-MSs and DHC-MSs as promising formulations for UC, with implications for advancing treatment modalities for various inflammatory bowel disorders.
Keyword ：
Anti-inflammatory Anti-inflammatory Curcumin Curcumin Gut microbiota Gut microbiota Microspheres Microspheres Oral delivery Oral delivery Ulcerative colitis Ulcerative colitis
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| GB/T 7714 | Huang, Da , Wang, Yongming , Xu, Chenlan et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
| MLA | Huang, Da et al. "Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 266 (2024) . |
| APA | Huang, Da , Wang, Yongming , Xu, Chenlan , Zou, Minglang , Ming, Yangcan , Luo, Fang et al. Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 266 . |
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Surface-enhanced Raman scattering (SERS) has great potential in biological analysis due to its specificity, sensitivity, and non-invasive nature. However, effectively extracting Raman information and avoiding spectral overlapping from biological background interference remain major challenges. In this study, we developed a background-free SERS nanosensor consisting of gold nanobipyramids (Au NBPs) core-Prussian blue (PB) shell (Au NBPs@PB), for endogenous H2S detection. The PB shell degraded quickly upon contact with endogenous H2S, generating a unique Raman signal response in the Raman silent region (1800-2800 cm(-1)). By taking advantage of the high SERS-activity of Au NBPs and H2S-triggered spectral changes of PB, these SERS nanosensors effectively minimize potential biological interferences. The nanosensor exhibits a detection range of 2.0 mu M to 250 mu M and a limit of detection (LOD) of 0.34 mu M, with good reproducibility and minimal interference. We successfully applied this background-free SERS platform to monitor endogenous H2S concentrations in human serum samples with satisfied results.
Keyword ：
background-free background-free H2S H2S Prussian blue Prussian blue Raman silent region Raman silent region SERS SERS
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| GB/T 7714 | Chen, Jiaming , Cheng, Lingjun , Yang, Yuanyuan et al. Background-Free SERS Nanosensor for Endogenous Hydrogen Sulfide Detection Based on Prussian Blue-Coated Gold Nanobipyramids [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (12) : 14467-14473 . |
| MLA | Chen, Jiaming et al. "Background-Free SERS Nanosensor for Endogenous Hydrogen Sulfide Detection Based on Prussian Blue-Coated Gold Nanobipyramids" . | ACS APPLIED MATERIALS & INTERFACES 16 . 12 (2024) : 14467-14473 . |
| APA | Chen, Jiaming , Cheng, Lingjun , Yang, Yuanyuan , Liu, Yating , Su, Canping , He, Yinghao et al. Background-Free SERS Nanosensor for Endogenous Hydrogen Sulfide Detection Based on Prussian Blue-Coated Gold Nanobipyramids . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (12) , 14467-14473 . |
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