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学者姓名：汤云东
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Abstract ：
磁粒子成像(MPI)利用检测装置感应可视场内不同位置处磁纳米粒子(MNPs)的非线性磁化响应,并基于所获得的检测信号重建MNPs浓度分布.该文基于激励与接收线圈磁场强度对检测信号的影响,论证了X-space和投影重建成像算法中MPI检测装置磁场均匀性的重要性,继而提出一种由具有较高磁场均匀性的正方形亥姆霍兹线圈所构成的改进开放式检测装置.此外,在零磁场点和零磁场线扫描移动两种情况下,基于不同装置下均匀分布MNPs所获得的检测信号,评估了两种传统开放式检测装置和所提改进装置的检测效果.研究结果表明,所提改进开放式装置的检测结果相比两种传统开放式装置显著接近理想情况,进而也证实了检测装置磁场均匀性的重要性.此外,该文还发现在改进装置基础上采用二次谐波检测方法相较于三次谐波检测,可获得更佳的检测效果.
Keyword ：
开放式检测装置 开放式检测装置 检测信号 检测信号 正方形亥姆霍兹线圈 正方形亥姆霍兹线圈 磁场均匀性 磁场均匀性 磁粒子成像 磁粒子成像
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| GB/T 7714 | 汤云东 , 丁宇彬 , 金涛 . 考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法 [J]. | 电工技术学报 , 2025 , 40 (6) : 1718-1728 . |
| MLA | 汤云东 等. "考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法" . | 电工技术学报 40 . 6 (2025) : 1718-1728 . |
| APA | 汤云东 , 丁宇彬 , 金涛 . 考虑磁场均匀性优化的开放式磁粒子成像检测装置改进方法 . | 电工技术学报 , 2025 , 40 (6) , 1718-1728 . |
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Although deep convolutional neural network (CNN) has been widely used in the breast cancer detection based on thermal imaging technology, this scenario still did not receive enough attention in the mobile devices with limited resource. In addition, there still exists challenge on how to assist front view thermal imaging by side one during breast cancer detection. This study proposes a multi-input lightweight CNN named Multi-light Net in order to achieve more accurate early detection for breast cancer, which combines the thermal image from multiple perspectives with the lightweight CNN on the basis of model performance and scale. In addition, a new weighted label smoothing regularization (WLSR) is proposed for the Multi-light Net with the purpose of increasing the network's generalization ability and classification accuracy. The experimental results demonstrate that the proposed approach by combining front view with side view can achieve more significant results than the common one using only front view during breast cancer detection, and the proposed Multi-light Net also exhibits an excellent performance with respect to the currently popular lightweight CNN. Furthermore, the proposed WLSR loss function can also lead to both faster convergence rate and more stable training process during network training and ultimately higher diagnostic accuracy for breast cancer.
Keyword ：
Breast cancer Breast cancer CNN CNN Lightweight Lightweight Multi-input Multi-input Thermography Thermography
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| GB/T 7714 | Tang, Yundong , Zhou, Depei , Flesch, Rodolfo C. C. et al. A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography [J]. | EXPERT SYSTEMS WITH APPLICATIONS , 2025 , 263 . |
| MLA | Tang, Yundong et al. "A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography" . | EXPERT SYSTEMS WITH APPLICATIONS 263 (2025) . |
| APA | Tang, Yundong , Zhou, Depei , Flesch, Rodolfo C. C. , Jin, Tao . A multi-input lightweight convolutional neural network for breast cancer detection considering infrared thermography . | EXPERT SYSTEMS WITH APPLICATIONS , 2025 , 263 . |
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Magnetic nanoparticles (MNPs) used for magnetic hyperthermia can not only damage tumor cells after elevating to a specific temperature but also provide the temperature required for thermosensitive liposomes (TSL) to release doxorubicin (DOX). MNPs injected into tumor will generate heat under an alternating magnetic field, so the MNPs distribution can determine temperature distribution and further affect the DOX concentration used for tumor therapy. This study proposes an asynchronous injection strategy for this combination therapy in order to improve the DOX concentration value for drug therapy, in which the MNPs are injected into tumor after a certain lagging of TSL injection in order to increase the TSL concentration inside tumor. In addition, the evaluation of treatment effect for this combination therapy is implemented by considering two different MNPs concentration distributions and two biological heat transfer models. The simulation results demonstrate that the treatment effect for combination therapy can be significantly improved after considering the proposed asynchronous injection strategy, which can mainly attribute to the improvement of DOX concentration. The DOX concentration difference during therapy is generally relevant to both the lagging time of different injections and the local temperature distribution due to MNPs concentration distribution.
Keyword ：
Heat transfer Heat transfer Heat transfer model Heat transfer model Magnetic hyperthermia Magnetic hyperthermia Targeted drug delivery Targeted drug delivery Temperature-sensitive liposomes Temperature-sensitive liposomes
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| GB/T 7714 | Tang, Yundong , Zhu, Jiajia , Flesch, Rodolfo C. C. et al. Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome [J]. | JOURNAL OF THERMAL BIOLOGY , 2025 , 127 . |
| MLA | Tang, Yundong et al. "Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome" . | JOURNAL OF THERMAL BIOLOGY 127 (2025) . |
| APA | Tang, Yundong , Zhu, Jiajia , Flesch, Rodolfo C. C. , Jin, Tao . Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome . | JOURNAL OF THERMAL BIOLOGY , 2025 , 127 . |
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Abstract ：
In view of the problem of too idealized modeling for magnetic nanoparticles，a variety of monodisperse and polydisperse magnetic nanoparticles (MNPs) distributions were constructed for a proposed tumor model．On this basis，the treatment temperature for the proposed model was predicted by solving the biological heat transfer equation after taking the power consumption of MNPs as the input，and the therapeutic effect differences due to different dispersed MNPs during magnetic hyperthermia were further investigated． In addition，a fuzzy adaptive proportional-integral-differential control system for magnetic hyperthermia was constructed after considering a more real distribution for polydisperse MNPs． This system can accurately control the treatment temperature within a critical value (46°C) by temperature feedback during magnetic hyperthermia，which solves the problem that the local temperature of target area is difficult to stabilize at the optimal safe treatment temperature due to the inhomogeneous distribution and polydispersity of MNPs．The simulation results demonstrate that the treatment effect can be improved by increasing the aggregation degree of MNPs size and the uniformity of MNPs distribution in the tumor area under the same treatment conditions．Furthermore，the control system proposed can significantly improve the treatment effect by quickly stabilizing the maximum temperature to an optimal value，46°C． © 2024 Huazhong University of Science and Technology. All rights reserved.
Keyword ：
Adaptive control systems Adaptive control systems Heat transfer Heat transfer Hyperthermia therapy Hyperthermia therapy Particle size Particle size Particle size analysis Particle size analysis Polydispersity Polydispersity Proportional control systems Proportional control systems Tumors Tumors Two term control systems Two term control systems
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| GB/T 7714 | Tang, Yundong , Chen, Ming , Jin, Tao . Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion [J]. | Journal of Huazhong University of Science and Technology (Natural Science Edition) , 2024 , 52 (3) : 65-71 . |
| MLA | Tang, Yundong et al. "Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion" . | Journal of Huazhong University of Science and Technology (Natural Science Edition) 52 . 3 (2024) : 65-71 . |
| APA | Tang, Yundong , Chen, Ming , Jin, Tao . Evaluation and optimization for temperature distribution in magnetic hyperthermia considering particle dispersion . | Journal of Huazhong University of Science and Technology (Natural Science Edition) , 2024 , 52 (3) , 65-71 . |
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The combination therapy of magnetic hyperthermia and thermosensitive liposomes (TSL) is an emerging and effective cancer treatment method. The heat generation of magnetic nanoparticles (MNPs) due to an external alternating magnetic field can not only directly damage tumor cells, but also serves as a triggering factor for the release of doxorubicin from TSL. The aim of this study is to investigate the effects in the degree of tumor cell damage of two proposed injection strategies that consider intravenous administration. Since both MNPs and TSL enter the tumor region intravenously, this study establishes a biological geometric model based on an experiment-based vascular distribution. Furthermore, this study derives the flow velocity of interstitial fluid after coupling the pressure distribution inside blood vessels and the pressure distribution of interstitial fluid, which then provides the convective velocity for the calculation of subsequent nanoparticle concentration. Different injection strategies for the proposed approach are evaluated by drug delivery result, temperature distribution, and tumor cell damage. Simulation results demonstrate that the proposed delayed injection strategy after optimization can not only result in a wider distribution for MNPs and TSL due to the sufficient diffusion time, but also improves the distribution of the temperature and drug concentration fields for the overall efficacy of combination therapy.
Keyword ：
44.05.+e 44.05.+e 44.10.+i 44.10.+i 87.85.J- 87.85.J- injection strategy injection strategy intravenous injection intravenous injection magnetic hyperthermia magnetic hyperthermia temperature-sensitive liposomes temperature-sensitive liposomes
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| GB/T 7714 | Zhu, Jiajia , Tang, Yundong , Flesch, Rodolfo C. C. et al. Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes [J]. | CHINESE PHYSICS B , 2024 , 33 (12) . |
| MLA | Zhu, Jiajia et al. "Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes" . | CHINESE PHYSICS B 33 . 12 (2024) . |
| APA | Zhu, Jiajia , Tang, Yundong , Flesch, Rodolfo C. C. , Jin, Tao . Effect of different injection strategies considering intravenous injection on combination therapy of magnetic hyperthermia and thermosensitive liposomes . | CHINESE PHYSICS B , 2024 , 33 (12) . |
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Magnetic hyperthermia regulates the therapeutic temperature within a specific range to damage malignant cells after exposing the magnetic nanoparticles inside tumor tissue to an alternating magnetic field. The therapeutic temperature of living tissues can be generally predicted using Pennes' bio-heat equation after ignoring both the inhomogeneity of biological structure and the microstructural responses. Although various of the bio-heat transfer models proposed in literature fix these shortages, there is still a lack of a comprehensive report on investigating the discrepancy for different models when applied in the magnetic hyperthermia context. This study compares four different bio-heat equations in terms of the therapeutic temperature distribution and the heat-induced damage situation for a proposed geometric model, which is established based on computed tomography images of a tumor bearing mouse. The therapeutic temperature is also used as an index to evaluate the effect of two key relaxation times for the phase lag behavior on bio-heat transfer. Moreover, this work evaluates the effects of two blood perfusion rates on both the treatment temperature and the cumulative equivalent heating minutes at 43 degrees C. Numerical analysis results reveal that relaxation times for phase-lag behavior as well as the porosity for living tissues directly affect the therapeutic temperature variation and ultimately the thermal damage for the malignant tissue during magnetic hyperthermia. The dual-phase-lag equation can be converted into Pennes' equation and simple-phase-lag equation when relaxation times meet specific conditions during the process of heat transfer. In addition, different blood perfusion rates can result in an amplitude discrepancy for treatment temperature, but this parameter does not change the characteristics of thermal propagation during therapy.
Keyword ：
Bio-heat transfer Bio-heat transfer Blood perfusion rate Blood perfusion rate Magnetic hyperthermia Magnetic hyperthermia Phase lag behavior Phase lag behavior Therapeutic temperature Therapeutic temperature
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| GB/T 7714 | Tang, Yundong , Wang, Yuesheng , Flesch, Rodolfo C. C. et al. Influence of different heat transfer models on therapeutic temperature prediction and heat-induced damage during magnetic hyperthermia [J]. | JOURNAL OF THERMAL BIOLOGY , 2023 , 118 . |
| MLA | Tang, Yundong et al. "Influence of different heat transfer models on therapeutic temperature prediction and heat-induced damage during magnetic hyperthermia" . | JOURNAL OF THERMAL BIOLOGY 118 (2023) . |
| APA | Tang, Yundong , Wang, Yuesheng , Flesch, Rodolfo C. C. , Jin, Tao . Influence of different heat transfer models on therapeutic temperature prediction and heat-induced damage during magnetic hyperthermia . | JOURNAL OF THERMAL BIOLOGY , 2023 , 118 . |
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Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia. The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region. This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia, in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration. The nanofluid flow behavior is illustrated by two different theoretical models in this study, which are Navier-Stokes equation inside syringe needle and modified Darcy's law inside bio-tissue. The diffusion behavior after nanofluid injection is expressed by a modified convection-diffusion equation. A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study, in which all bio-tissues are assumed to be deformable porous media. Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure, deformation degree, and interstitial flow velocity during the injection process, all of which then drop sharply with the distance away from the injection center. In addition to the bio-tissue deformation due to injection behavior, the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.
Keyword ：
heat transfer heat transfer mass transfer mass transfer thermal apoptosis analysis thermal apoptosis analysis tissue deformation tissue deformation
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| GB/T 7714 | Tang, Yundong , Zou, Jian , Flesch, Rodolfo C. C. et al. Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia [J]. | CHINESE PHYSICS B , 2023 , 32 (3) . |
| MLA | Tang, Yundong et al. "Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia" . | CHINESE PHYSICS B 32 . 3 (2023) . |
| APA | Tang, Yundong , Zou, Jian , Flesch, Rodolfo C. C. , Jin, Tao . Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia . | CHINESE PHYSICS B , 2023 , 32 (3) . |
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Abstract ：
Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanopar-ticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia.The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region.This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia,in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration.The nanofluid flow behavior is illustrated by two different theoretical models in this study,which are Navier-Stokes equation inside syringe needle and modified Darcy's law inside bio-tissue.The diffusion behavior after nanofluid injection is expressed by a modified convection-diffusion equation.A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study,in which all bio-tissues are assumed to be deformable porous media.Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure,deformation degree,and interstitial flow velocity during the injection process,all of which then drop sharply with the distance away from the injection center.In addition to the bio-tissue deformation due to injection behavior,the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.
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| GB/T 7714 | Yundong Tang , Jian Zou , Rodolfo C.C.Flesch et al. Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia [J]. | 中国物理B（英文版） , 2023 , 32 (3) : 375-384 . |
| MLA | Yundong Tang et al. "Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia" . | 中国物理B（英文版） 32 . 3 (2023) : 375-384 . |
| APA | Yundong Tang , Jian Zou , Rodolfo C.C.Flesch , Tao Jin . Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia . | 中国物理B（英文版） , 2023 , 32 (3) , 375-384 . |
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本发明提出一种用于加热磁纳米粒子的高频时谐磁场产生电路，采用电源模块经过Buck斩波调功模块控制后为全桥电路模块供电；采用锁相环模块自动跟踪经信号调理模块处理后输入的电压信号并输出与该信号同频率的方波信号；采用光耦隔离模块对所述锁相环模块输入的方波信号进行光耦隔离后，再将经过隔离后的方波信号输入到全桥电路模块作为其驱动信号；所述全桥电路模块在驱动信号的作用下驱动串联谐振逆变电路模块产生正弦波信号，以通过绕有线圈的锰锌铁氧体磁环制成的电感其磁环气隙中间产生与正弦波信号同频率的交变磁场。能够解决现有技术的磁场产生装置频率不高，加热磁纳米粒子效果不好的问题。
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| GB/T 7714 | 汤云东 , 陈泓霖 , 苏航 et al. 用于加热磁纳米粒子的高频时谐磁场产生电路 : CN202111324379.8[P]. | 2021-11-10 00:00:00 . |
| MLA | 汤云东 et al. "用于加热磁纳米粒子的高频时谐磁场产生电路" : CN202111324379.8. | 2021-11-10 00:00:00 . |
| APA | 汤云东 , 陈泓霖 , 苏航 , 邹建 , 陈鸣 , 王跃升 . 用于加热磁纳米粒子的高频时谐磁场产生电路 : CN202111324379.8. | 2021-11-10 00:00:00 . |
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该文研究了两种常见亥姆霍兹线圈产生磁场的均匀性,并根据装置线圈所产生磁场作用下的生物组织治疗温度分布分析了磁场均匀性对治疗效果的影响.其中,文中的磁纳米粒子(MNPs)以磁流体形式注射进肿瘤区域并假定以注射点为中心呈现高斯分布.该文在多种约束条件下应用改进粒子群算法优化了磁场的频率和强度、磁纳米粒子粒径,以及磁纳米粒子体积分数等参数,而涉及的约束条件包括治疗最高安全温度、治疗磁场安全范围上限、MNPs粒径范围,以及MNPs产热有效条件等.同时,该文以累积等效分钟数来评估圆形和正方形亥姆霍兹线圈及理想磁场在不同血液灌注率下的细胞热损伤程度.研究结果表明,正方形亥姆霍兹线圈相比于圆形线圈能产生更大范围的匀强磁场,这使其磁热疗效果更接近于理想磁场情况.同时,考虑温度依赖的血液灌注率相比定值情况具有更高的治疗温度.
Keyword ：
亥姆霍兹线圈 亥姆霍兹线圈 温度场 温度场 磁场 磁场 磁热疗 磁热疗 粒子群优化算法 粒子群优化算法 血液灌注率 血液灌注率
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| GB/T 7714 | 汤云东 , 丁宇彬 , 金涛 . 基于亥姆霍兹线圈装置的磁热疗优化方法 [J]. | 电工技术学报 , 2023 , 38 (5) : 1248-1260 . |
| MLA | 汤云东 et al. "基于亥姆霍兹线圈装置的磁热疗优化方法" . | 电工技术学报 38 . 5 (2023) : 1248-1260 . |
| APA | 汤云东 , 丁宇彬 , 金涛 . 基于亥姆霍兹线圈装置的磁热疗优化方法 . | 电工技术学报 , 2023 , 38 (5) , 1248-1260 . |
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