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学者姓名：姚宇航
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Abstract ：
Control of phosphate capture and release is vital in environmental, biological, and pharmaceutical contexts. However, the binding of trivalent phosphate (PO43-) in water is exceptionally difficult due to its high hydration energy. Based on the anion coordination chemistry of phosphate, in this study, four charge-neutral tripodal hexaurea receptors (L1-L4), which were equipped with morpholine and polyethylene glycol terminal groups to enhance their solubility in water, were synthesized to enable the pH-triggered phosphate binding and release in aqueous solutions. Encouragingly, the receptors were found to bind PO43- anion in a 1 : 1 ratio via hydrogen bonds in 100 % water solutions, with L1 exhibiting the highest binding constant (1.2x103 M-1). These represent the first neutral anion ligands to bind phosphate in 100 % water and demonstrate the potential for phosphate capture and release in water through pH-triggered mechanisms, mimicking native phosphate binding proteins. Furthermore, L1 can also bind multiple bioavailable phosphate species, which may serve as model systems for probing and modulating phosphate homeostasis in biological and biomedical researches. A biomimetic charge-neutral anion receptor for reversible binding and release of highly hydrated phosphate in water image
Keyword ：
Anion Coordination Chemistry Anion Coordination Chemistry Hydrogen Bond Hydrogen Bond Phosphate Binding in Water Phosphate Binding in Water Water-Soluble Anion Receptors Water-Soluble Anion Receptors
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| GB/T 7714 | He, Maolin , Yao, Yuhang , Yang, Zihe et al. Biomimetic Charge-Neutral Anion Receptors for Reversible Binding and Release of Highly Hydrated Phosphate in Water [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (33) . |
| MLA | He, Maolin et al. "Biomimetic Charge-Neutral Anion Receptors for Reversible Binding and Release of Highly Hydrated Phosphate in Water" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 33 (2024) . |
| APA | He, Maolin , Yao, Yuhang , Yang, Zihe , Li, Boyang , Wang, Ji , Wang, Yanchao et al. Biomimetic Charge-Neutral Anion Receptors for Reversible Binding and Release of Highly Hydrated Phosphate in Water . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (33) . |
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