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学者姓名：陈琪
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Abstract ：
In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood-brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug delivery systems have been widely studied and applied to the study of cerebral ischemic diseases due to their favorable biocompatibility, high efficiency, strong specificity, and specific targeting ability. In this paper, we briefly describe the pathological process of reperfusion injuries in strokes and focus on the therapeutic research progress of nano-drug delivery systems in ischemic strokes, aiming to provide certain references to understand the progress of research on nano-drug delivery systems (NDDSs).
Keyword ：
blood-brain barrier blood-brain barrier ischemic stroke ischemic stroke nano-drug delivery system nano-drug delivery system nanoparticles nanoparticles
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| GB/T 7714 | Zhang, Jiajie , Chen, Zhong , Chen, Qi . Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke [J]. | MOLECULES , 2024 , 29 (8) . |
| MLA | Zhang, Jiajie 等. "Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke" . | MOLECULES 29 . 8 (2024) . |
| APA | Zhang, Jiajie , Chen, Zhong , Chen, Qi . Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke . | MOLECULES , 2024 , 29 (8) . |
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Abstract ：
Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy. This is accomplished not by enhancing the delivery of PD-1 blockade to enhance the effect of immunotherapy, but by introducing bacterial photothermal therapy to promote greater involvement of M1 cells in the immune response. After reaching glioma, the bacteria further target glioma cells and M2 phenotype macrophages selectively, enabling precise photothermal conversion for lysing tumor cells and M2 phenotype macrophages, which thereby enhances the positive feedback loop of cancer cells-M1 macrophages-T cells. Collectively, the bacteria synergized with PD-1 blockade strategy may be the key to overcoming the immunosuppressive glioma microenvironment and improving the outcome of immunotherapy toward glioma. Porphyromonas gingivalis (Pg) synergized with PD-1 blockade strategy is reported. After reaching glioma, the customized bacteria can target glioma cells and M2 phenotype macrophages selectively, receive and convert light into heat for lysing tumor cells and M2 phenotype macrophages, thereby enhancing the positive feedback loop of cancer cells-M1 macrophages-T cells. image
Keyword ：
anti-PD-1 anti-PD-1 cancer immunotherapy cancer immunotherapy customized bacteria customized bacteria glioma glioma tumor microenvironment tumor microenvironment
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| GB/T 7714 | Chen, Qi , Zheng, Yuyi , Chen, Xiaojie et al. Bacteria Synergized with PD-1 Blockade Enhance Positive Feedback Loop of Cancer Cells-M1 Macrophages-T Cells in Glioma [J]. | ADVANCED SCIENCE , 2024 , 11 (20) . |
| MLA | Chen, Qi et al. "Bacteria Synergized with PD-1 Blockade Enhance Positive Feedback Loop of Cancer Cells-M1 Macrophages-T Cells in Glioma" . | ADVANCED SCIENCE 11 . 20 (2024) . |
| APA | Chen, Qi , Zheng, Yuyi , Chen, Xiaojie , Xing, Yuan , Zhang, Jiajie , Yan, Xinyi et al. Bacteria Synergized with PD-1 Blockade Enhance Positive Feedback Loop of Cancer Cells-M1 Macrophages-T Cells in Glioma . | ADVANCED SCIENCE , 2024 , 11 (20) . |
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Abstract ：
With the rapid development of drug delivery systems, extracellular vesicles (EVs) have emerged as promising stars for improving targeting abilities and realizing effective delivery. Numerous studies have shown when compared to conventional strategies in targeted drug delivery (TDD), EVs-based strategies have several distinguished advantages besides targeting, such as participating in cell-to-cell communications and immune response, showing high biocompatibility and stability, penetrating through biological barriers, etc. In this review, we mainly focus on the mass production of EVs including the challenges and strategies for scaling up EVs production in a cost-effective and reproducible manner, the loading and active targeting methods, and examples of EVs as vehicles for TDD in consideration of potential safety and regulatory issues associated. We also conclude and discuss the rigor and reproducibility of EVs production, the current research status of the application of EVs-based strategies to targeted drug delivery, clinical conversion prospects, and existing chances and challenges.
Keyword ：
carrier carrier drug delivery system drug delivery system Extracellular vesicles Extracellular vesicles nanoparticle nanoparticle
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| GB/T 7714 | Chen, Qi , Zheng, Yuyi , Jiang, Xuhong et al. Nature's carriers: leveraging extracellular vesicles for targeted drug delivery [J]. | DRUG DELIVERY , 2024 , 31 (1) . |
| MLA | Chen, Qi et al. "Nature's carriers: leveraging extracellular vesicles for targeted drug delivery" . | DRUG DELIVERY 31 . 1 (2024) . |
| APA | Chen, Qi , Zheng, Yuyi , Jiang, Xuhong , Wang, Yi , Chen, Zhong , Wu, Di . Nature's carriers: leveraging extracellular vesicles for targeted drug delivery . | DRUG DELIVERY , 2024 , 31 (1) . |
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Abstract ：
Glioma is the most common primary intracranial tumor, which is formed by the malignant transformation of glial cells in the brain and spinal cord. It has the characteristics of high incidence, high recurrence rate, high mortality and low cure rate. The treatments for glioma include surgical removal, chemotherapy and radiotherapy. Due to the obstruction of the biological barrier of brain tissue, it is difficult to achieve the desired therapeutic effects. To address the limitations imposed by the brain’s natural barriers and enhance the treatment efficacy, researchers have effectively used brain-targeted drug delivery systems (DDSs) in glioma therapy. Polyamidoamine (PAMAM) dendrimers, as branched macromolecular architectures, represent promising candidates for studies in glioma therapy. This review focuses on PAMAM-based DDSs in the treatment of glioma, highlighting their physicochemical characteristics, structural properties as well as an overview of the toxicity and safety profiles. © 2024 by the authors.
Keyword ：
brain-targeted brain-targeted drug delivery system drug delivery system glioma glioma PAMAM dendrimers PAMAM dendrimers
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| GB/T 7714 | Yan, X. , Chen, Q. . Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy [J]. | Polymers , 2024 , 16 (14) . |
| MLA | Yan, X. et al. "Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy" . | Polymers 16 . 14 (2024) . |
| APA | Yan, X. , Chen, Q. . Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy . | Polymers , 2024 , 16 (14) . |
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