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学者姓名：张珍珍
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Abstract ：
The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension imaging. However, scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a challenge. In this study, we report an efficient method to synthesize ligand-free, lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal method. The as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without deterioration. Monte Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the microscintillators. We employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method, a spatial resolution of 24.9 lp/mm for X-ray imaging. Our study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.
Keyword ：
Afterglow Afterglow Microscintillators Microscintillators NaLuF4:Tb3+ NaLuF4:Tb3+ X-ray detector X-ray detector X-ray luminescence imaging X-ray luminescence imaging
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| GB/T 7714 | Jiang, Hao , Chen, Qihao , Wang, Hongyu et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
| MLA | Jiang, Hao et al. "Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging" . | CHINESE CHEMICAL LETTERS 35 . 3 (2024) . |
| APA | Jiang, Hao , Chen, Qihao , Wang, Hongyu , Wu, Tingting , Gong, Jianwei , Zhang, Zhenzhen et al. Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging . | CHINESE CHEMICAL LETTERS , 2024 , 35 (3) . |
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Photodynamic therapy (PDT) as an emerging therapeutic method has drawn much attention in the treatment field for cancer. Photosensitizer, which can convert photon energy into cytotoxic species under light irradiation, is the core component in PDT. The design of photosensitizers still faces problems of light absorption, targeting, penetration and oxygen dependence. With the rapid progress of material science, various photosensitizers have been developed to produce cytotoxic species for treatment of tumor with high selectivity, safety, and noninvasiveness. Besides, the applications of photosensitizers have been expanded to diverse cancer treatments such as drug release, optogenetics and immune checkpoint blockade. In this review, we summarize the recent advances of photosensitizers in various therapeutic methods for cancer. Prevailing challenges and further prospects associated with photosensitizers are also discussed. Explore the groundbreaking realm of cancer therapy with our comprehensive study on the mechanism and applications of photosensitizer-mediated light-controlled cancer therapy. Uncover the intricate workings and diverse applications of this innovative approach, clarify the future of targeted and controlled cancer treatment. image
Keyword ：
Drug Delivery Drug Delivery Optogenetics Optogenetics Photodynamic Therapy Photodynamic Therapy Photosensitizer Photosensitizer X-rays X-rays
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| GB/T 7714 | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen et al. Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
| MLA | Chen, Minle et al. "Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy" . | CHEMISTRY-AN ASIAN JOURNAL 19 . 11 (2024) . |
| APA | Chen, Minle , Zhu, Qianru , Zhang, Zhenzhen , Chen, Qiushui , Yang, Huanghao . Recent Advances in Photosensitizer Materials for Light-Mediated Tumor Therapy . | CHEMISTRY-AN ASIAN JOURNAL , 2024 , 19 (11) . |
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X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程,在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景.相较于传统的紫外激发光,X射线对生物组织具有高穿透性且不会触发生物体的自荧光,可实现深组织、无背景、高灵敏的生物分析.近年来,基于纳米闪烁体的X射线发光在生物光子学领域中得到广泛研究,促进了 X射线发光在分析化学和生物医学中的应用.本文首先对闪烁体的X射线发光机理进行了概述,接着重点介绍了纳米闪烁体作为光学探针在生物分子测量与疾病治疗中的研究进展,包括生物传感、活体成像和光动力治疗等,最后讨论了该领域存在的一些挑战和可能的解决方案.
Keyword ：
X射线发光 X射线发光 光学探针 光学探针 生物分析 生物分析 纳米闪烁体 纳米闪烁体
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| GB/T 7714 | 徐新奇 , 张珍珍 , 陈小丰 et al. 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 [J]. | 化学通报（印刷版） , 2024 , 87 (9) : 1009-1019 . |
| MLA | 徐新奇 et al. "基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展" . | 化学通报（印刷版） 87 . 9 (2024) : 1009-1019 . |
| APA | 徐新奇 , 张珍珍 , 陈小丰 , 陈秋水 , 杨黄浩 . 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 . | 化学通报（印刷版） , 2024 , 87 (9) , 1009-1019 . |
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由于X射线的高穿透性,X射线成像技术被广泛应用于医学诊断、工业无损探伤、安全检查和航空航天等领域。闪烁体材料作为X射线成像装备的核心部件,可以将高能射线转化为低能光子被光电探测器接收,决定了X射线成像装备的成像质量和制作成本。然而,传统的闪烁体材料大多存在制备工艺复杂、生产成本高以及发光性能可调性差等诸多问题,限制了它们的进一步应用。因此,开发合成工艺简单、发光性能优异、制作成本低的新型闪烁体材料具有重要的科学意义。基于此,我们设计了一系列高效X射线闪烁体,实现了高分辨率和高灵敏度的X射线成像应用。首先,设计了具有丰富浅缺陷的Cs_2ZrCl_6:Te闪烁体,实现了X射线图像的室温读取与低温擦除。实验发现,Cs_2ZrCl_6:Te的热释发光峰是目前报道的材料中最接近室温的,是延时X射线成像的理想材料。通过热释光曲线对比、理论计算等手段,证明Cs_2ZrCl_6:Te的余辉发光主要来源于X射线诱导的Frenkel缺陷。通过Cs_2ZrCl_6:Te与PDMS混合,可以制备成均匀的薄膜,实现了可低温擦除且无残影的时间延迟X射线成像。此外,我们还设计了NaLuF_4:Tb和NaLuF_4:Tb/Yb微米闪烁体:其中,NaLuF_4:Tb微米闪烁体在X射线停止激发30天后仍可以发出余辉,实现了超长时间记忆式X射线成像;在NaLuF_4:Tb/Yb微米闪烁体中,Yb~(3+)的加入可以完全淬灭NaLuF_4:Tb的余辉发光,实现了快速的动态X射线摄影。
Keyword ：
X射线成像 X射线成像 稀土 稀土 钙钛矿 钙钛矿 闪烁体 闪烁体
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| GB/T 7714 | 张珍珍 . 金属卤化物闪烁体的X射线成像研究 [C] //第4届分子科学博士后学术年会 . 2024 . |
| MLA | 张珍珍 . "金属卤化物闪烁体的X射线成像研究" 第4届分子科学博士后学术年会 . (2024) . |
| APA | 张珍珍 . 金属卤化物闪烁体的X射线成像研究 第4届分子科学博士后学术年会 . (2024) . |
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The growing demands for X-ray imaging applications impose diverse and stringent requirements on advanced X-ray detectors. Among these, flexibility stands out as the most expected characteristic for next-generation X-ray detectors. Flexible X-ray detectors can spatially conform to nonflat surfaces, substantially improving the imaging resolution, reducing the X-ray exposure dosage, and enabling extended application opportunities that are hardly achievable by conventional rigid flat-panel detectors. Over the past years, indirect- and direct-conversion flexible X-ray detectors have made marvelous achievements. In particular, microscale and nanoscale engineering technologies play a pivotal role in defining the optical, electrical, and mechanical properties of flexible X-ray detectors. In this Perspective, we spotlight recent landmark advancements in flexible X-ray detectors from the aspects of micro/nano engineering strategies, which are broadly categorized into two prevailing modalities: materials-in-substrate and materials-on-substrate. We also discuss existing challenges hindering the development of flexible X-ray detectors, as well as prospective research opportunities to mitigate these issues. © 2024 American Chemical Society.
Keyword ：
Carrier concentration Carrier concentration II-VI semiconductors II-VI semiconductors Particle detectors Particle detectors Photons Photons Scintillation counters Scintillation counters Semiconductor detectors Semiconductor detectors X ray analysis X ray analysis X ray cameras X ray cameras X ray detectors X ray detectors X ray laboratories X ray laboratories
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| GB/T 7714 | Ou, Xiangyu , Hong, Zhongzhu , Wu, Qinxia et al. Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors [J]. | ACS Nano , 2024 , 18 (40) : 27126-27137 . |
| MLA | Ou, Xiangyu et al. "Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors" . | ACS Nano 18 . 40 (2024) : 27126-27137 . |
| APA | Ou, Xiangyu , Hong, Zhongzhu , Wu, Qinxia , Chen, Xiaofeng , Xie, Lili , Zhang, Zhenzhen et al. Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors . | ACS Nano , 2024 , 18 (40) , 27126-27137 . |
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Abstract ：
X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程，在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景。相较于传统的紫外激发光，X射线对生物组织具有高穿透性且不会触发生物体的自荧光，可实现深组织、无背景、高灵敏的生物分析。近年来，基于纳米闪烁体的X射线发光在生物光子学领域中得到广泛研究，促进了X射线发光在分析化学和生物医学中的应用。本文首先对闪烁体的X射线发光机理进行了概述，接着重点介绍了纳米闪烁体作为光学探针在生物分子测量与疾病治疗中的研究进展，包括生物传感、活体成像和光动力治疗等，最后讨论了该领域存在的一些挑战和可能的解决方案。
Keyword ：
X射线发光 X射线发光 光学探针 光学探针 生物分析 生物分析 纳米闪烁体 纳米闪烁体
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| GB/T 7714 | 徐新奇 , 张珍珍 , 陈小丰 et al. 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 [J]. | 化学通报 , 2024 , 87 (09) : 1009-1019 . |
| MLA | 徐新奇 et al. "基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展" . | 化学通报 87 . 09 (2024) : 1009-1019 . |
| APA | 徐新奇 , 张珍珍 , 陈小丰 , 陈秋水 , 杨黄浩 . 基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 . | 化学通报 , 2024 , 87 (09) , 1009-1019 . |
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Abstract ：
X-ray imaging plays an increasingly crucial role in clinical radiography, industrial inspection, and military applications. However, current X-ray imaging technologies have difficulty in protecting against information leakage caused by brute force attacks via trial-and-error. Here high-confidentiality X-ray imaging encryption by fabricating ultralong radioluminescence memory films composed of lanthanide-activated nanoscintillators (NaLuF4: Gd3+ or Ce3+) with imperceptible purely-ultraviolet (UV) emission is reported. Mechanistic investigations unveil that ultralong X-ray memory is attributed to the long-lived trapping of thermalized charge carriers within Frenkel defect states and subsequent slow release in the form of imperceptible radioluminescence. The encrypted X-ray imaging can be securely stored in the memory film for more than 7 days and optically decoded by perovskite nanocrystal. Importantly, this encryption strategy can protect X-ray imaging information against brute force trial-and-error attacks through the perception of lifetime change in the persistent radioluminescence. It is further demonstrated that the as-fabricated flexible memory film enables achieving of 3D X-ray imaging encryption of curved objects with a high spatial resolution of 20 lp/mm and excellent recyclability. This study provides valuable insights into the fundamental understanding of X-ray-to-UV conversion in nanocrystal lattices and opens up a new avenue toward the development of high-confidential 3D X-ray imaging encryption technologies. Existing X-ray imaging technologies have difficulty in protecting against information leakage from brute force attacks through trial and error. In this study, high-confidential 3D X-ray imaging encryption is achieved by fabricating ultralong imperceptible radioluminescence memory films.image
Keyword ：
information encryption information encryption lanthanide nanoscintillators lanthanide nanoscintillators perovskite nanocrystals perovskite nanocrystals radioluminescence memory radioluminescence memory X-ray imaging X-ray imaging
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| GB/T 7714 | Yang, Zhijian , Zhang, Peng , Chen, Xiaofeng et al. High-Confidentiality X-Ray Imaging Encryption Using Prolonged Imperceptible Radioluminescence Memory Scintillators [J]. | ADVANCED MATERIALS , 2023 , 35 (52) . |
| MLA | Yang, Zhijian et al. "High-Confidentiality X-Ray Imaging Encryption Using Prolonged Imperceptible Radioluminescence Memory Scintillators" . | ADVANCED MATERIALS 35 . 52 (2023) . |
| APA | Yang, Zhijian , Zhang, Peng , Chen, Xiaofeng , Hong, Zhongzhu , Gong, Jianwei , Ou, Xiangyu et al. High-Confidentiality X-Ray Imaging Encryption Using Prolonged Imperceptible Radioluminescence Memory Scintillators . | ADVANCED MATERIALS , 2023 , 35 (52) . |
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