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学者姓名：姚爱芳
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Abstract ：
Antimicrobial peptides (AMPs) that exert multiple functions are considered promising candidates to combat the bacterial drug resistance crisis. Nowadays, targeted peptide modification has been widely recognised to improve biological activity and make up for deficiencies in clinical applications such as toxicity. In this study, a helix-loop peptide was isolated and identified from the skin secretion of the Wuyi torrent frog Amolops wuyiensis, namely, ranatuerin-2-AW (R2AW) (GFMDTAKNVAKNVAATLLDKLKCKITGGC). Target modifications were made to R2AW to study the structure-activity relationships and to optimise its bioactivities. Five analogues were progressively designed via residue substitution and truncation and the antibacterial and anticancer activities were evaluated. We found that the serine-substitution and cyclic-domain-deletion products showed similar antibacterial activity to the natural peptide R2AW, implying that the disulphide bridge and Rana box were dispensable for the antibacterial activity of ranatuerin-2 peptides. Notably, the cationicity- and hydrophobicity-enhanced variant, [Lys(4,19), Leu(20)]R2AW(1-22)-NH2, exhibited significantly optimised antibacterial and anticancer activities. Additionally, it killed bacteria by membrane disruption at a highly efficient rate. Moreover, [Lys(4,19), Leu(20)]R2AW(1-22)-NH2 exerted potential in vivo efficacy in a methicillin-resistant Staphylococcus aureus (MRSA)-infected waxworm model. Overall, this study demonstrated some rational design ideas for optimising the dual antibacterial and anticancer activities of ranatuerin-2 peptides and it proposes [Lys(4,19), Leu(20)]R2AW(1-22)-NH2 as an appealing candidate for therapeutic development.
Keyword ：
antimicrobial peptides (AMPs) antimicrobial peptides (AMPs) drug optimisation drug optimisation multidrug-resistant bacteria multidrug-resistant bacteria peptide design peptide design ranatuerin ranatuerin
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| GB/T 7714 | Yao, Aifang , Liu, Tianxing , Cai, Yuhai et al. Progressive Design of a Ranatuerin-2 Peptide from Amolops wuyiensis: Enhancement of Bioactivity and In Vivo Efficacy [J]. | ANTIBIOTICS-BASEL , 2024 , 13 (1) . |
| MLA | Yao, Aifang et al. "Progressive Design of a Ranatuerin-2 Peptide from Amolops wuyiensis: Enhancement of Bioactivity and In Vivo Efficacy" . | ANTIBIOTICS-BASEL 13 . 1 (2024) . |
| APA | Yao, Aifang , Liu, Tianxing , Cai, Yuhai , Zhou, Siqi , Chen, Xiaoling , Zhou, Mei et al. Progressive Design of a Ranatuerin-2 Peptide from Amolops wuyiensis: Enhancement of Bioactivity and In Vivo Efficacy . | ANTIBIOTICS-BASEL , 2024 , 13 (1) . |
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Abstract ：
Conductive hydrogels have emerged as fascinating materials for flexible electronics because of their integrated conductivity, mechanical flexibility, and the possibility to introduce several smart functions. However, the swelling of hydrogels in aqueous environments significantly reduces their applicability where contact with water is unavoidable. In this study, a physically cross-linked composite hydrogel is proposed, that is transparent, highly stretchable, anti-swelling, capable of autonomous self-healing, adhesive, and anti-freezing. The hydrogel is synthesized through a simple one-step photopolymerization in a novel deep eutectic solvent (DES)/water system. Dynamic physical interactions, including hydrophobic interaction, hydrogen bonding, and electrostatic interactions, confer remarkable transparency (92%), self-healing capability (up to 94%), good adhesion to a wide array of substrates (91 to 199 kPa), high toughness (1.46 MJ m−3), excellent elongation at break (up to 2064%), and resistance to swelling in water (equilibrium swelling ratio of 3% in water for 30 days) even in solutions at different pH (pH 1–11), and in other solvents. The incorporation of a DES contributes to exceptional anti-freezing performance. The transparent sensor achieves multifunctional sensing and human motion detection with high sensitivity and stability. Notably, the sensor demonstrates information transmission underwater through stretching and pressing, showcasing its immense potential in underwater flexible devices. © 2024 The Author(s). Advanced Functional Materials published by Wiley-VCH GmbH.
Keyword ：
conductive hydrogels conductive hydrogels flexible electronics flexible electronics self-healing self-healing swelling-resistant swelling-resistant underwater sensing underwater sensing
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| GB/T 7714 | Zhang, Z. , Yao, A. , Raffa, P. . Transparent, Highly Stretchable, Self-Healing, Adhesive, Freezing-Tolerant, and Swelling-Resistant Multifunctional Hydrogels for Underwater Motion Detection and Information Transmission [J]. | Advanced Functional Materials , 2024 . |
| MLA | Zhang, Z. et al. "Transparent, Highly Stretchable, Self-Healing, Adhesive, Freezing-Tolerant, and Swelling-Resistant Multifunctional Hydrogels for Underwater Motion Detection and Information Transmission" . | Advanced Functional Materials (2024) . |
| APA | Zhang, Z. , Yao, A. , Raffa, P. . Transparent, Highly Stretchable, Self-Healing, Adhesive, Freezing-Tolerant, and Swelling-Resistant Multifunctional Hydrogels for Underwater Motion Detection and Information Transmission . | Advanced Functional Materials , 2024 . |
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Antimicrobial peptides have gradually attracted interest as promising alternatives to conventional agents to control the worldwide health threats posed by antibiotic resistance and cancer. Crabrolin is a tridecapeptide extracted from the venom of the European hornet (Vespa crabro). Its antibacterial and anticancer potentials have been underrated compared to other peptides discovered from natural resources. Herein, a series of analogs were designed based on the template sequence of crabrolin to study its structure-activity relationship and enhance the drug's potential by changing the number, type, and distribution of charged residues. The cationicity-enhanced derivatives were shown to have improved antibacterial and anticancer activities with a lower toxicity. Notably, the double-arginine-modified product, crabrolin-TR, possessed a potent capacity against Pseudomonas aeruginosa(minimum inhibitory concentration (MIC) = 4 mu M), which was around thirty times stronger than the parent peptide (MIC = 128 mu M). Furthermore, crabrolin-TR showed an in vivo treatment efficacy in a Klebsiella-pneumoniae-infected waxworm model and was non-toxic under its maximum MBC value (MIC = 8 mu M), indicating its therapeutic potency and better selectivity. Overall, we rationally designed functional peptides by progressively increasing the number and distribution of charged residues, demonstrating new insights for developing therapeutic molecules from natural resources with enhanced properties, and proposed crabrolin-TR as an appealing antibacterial and anticancer agent candidate for development
Keyword ：
anti-infective materials anti-infective materials antimicrobial peptides antimicrobial peptides bacterial biofilms bacterial biofilms cancer cancer crabrolin crabrolin Galleria mellonella Galleria mellonella peptide design peptide design Vespa crabro Vespa crabro
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| GB/T 7714 | Yao, Aifang , Ma, Yingxue , Sun, Ruize et al. A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (19) . |
| MLA | Yao, Aifang et al. "A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 19 (2023) . |
| APA | Yao, Aifang , Ma, Yingxue , Sun, Ruize , Zou, Wanchen , Chen, Xiaoling , Zhou, Mei et al. A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (19) . |
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