Query：
学者姓名：何聿
Refining：
Year
Type
Indexed by
Source
Complex
Co-
Language
Clean All
Abstract ：
Cancer cell spheroids (CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the spatial distribution of endogenous compounds ( e.g. , lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization (MALDI-2) and trapped ion mobility spectrometry (TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Cancer cell spheroids Cancer cell spheroids (MALDI) (MALDI) Mass spectrometry imaging Mass spectrometry imaging Matrix-assisted laser desorption/ionization Matrix-assisted laser desorption/ionization Trapped ion mobility spectrometry Trapped ion mobility spectrometry
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Jing , Xie, Peisi , Wu, Pengfei et al. MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (4) . |
| MLA | Chen, Jing et al. "MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids" . | CHINESE CHEMICAL LETTERS 35 . 4 (2024) . |
| APA | Chen, Jing , Xie, Peisi , Wu, Pengfei , He, Yu , Lin, Zian , Cai, Zongwei . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids . | CHINESE CHEMICAL LETTERS , 2024 , 35 (4) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Frequent oil spills cause substantial economic losses and pose a significant threat to human life. Urgent measures must be taken to develop a highly effective approach to mitigating oil spills and minimizing their potential consequences. Herein, we synthesized MS@COFs-F, fluorinated covalent organic framework-decorated superhydrophobic sponges, to clean up crude oil spills efficiently. The synthesis method involved a simple and effective room-temperature approach, utilizing 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) as the amine monomer and binding it with three aldehyde monomers of varying fluoride content. The MS@COFs-F with the highest fluorine content, known as MS@COFs-F4, exhibited low surface energy, superhydrophobicity (water contact angle of 155.7 degrees), a large specific surface area of 180 m(2)/g, and exceptional chemical, mechanical, and thermal stability. MS@COFs-F4 demonstrated remarkable effectiveness in adsorbing crude oils and organic solvents of diverse viscosities, exhibiting an adsorption capacity between 68.5 and 125.9 g/g, achieving an oil-water separation efficiency exceeding 97.0 %. Additionally, MS@COFs-F4 showcased self-cleaning and flame-retardant properties, further enhancing its suitability for real-world applications. MS@COFs-F4 holds the potential to offer a novel, safe, and effective approach in addressing oil spill incidents.
Keyword ：
Fluorinated covalent organic framework Fluorinated covalent organic framework Oil spill cleanup Oil spill cleanup Room-temperature synthesis Room-temperature synthesis Superhydrophobicity Superhydrophobicity Superhydrophobic sponges Superhydrophobic sponges
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Dong, Jinghan , Zheng, Wenjun , Yang, Yixin et al. Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup [J]. | SEPARATION AND PURIFICATION TECHNOLOGY , 2024 , 344 . |
| MLA | Dong, Jinghan et al. "Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup" . | SEPARATION AND PURIFICATION TECHNOLOGY 344 (2024) . |
| APA | Dong, Jinghan , Zheng, Wenjun , Yang, Yixin , Dong, Shaofeng , Li, Songtao , Zhong, Yanhui et al. Room-temperature synthesis of fluorinated covalent organic framework decorated superhydrophobic sponges for highly efficient crude oil spill cleanup . | SEPARATION AND PURIFICATION TECHNOLOGY , 2024 , 344 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Long-lasting radioluminescence scintillators have recently attracted substantial attention from both research and industrial communities, primarily due to their distinctive capabilities of converting and storing X-ray energy. However, determination of energy-conversion kinetics in these nanocrystals remains unexplored. Here we present a strategy to probe and unveil energy-funneling kinetics in NaLuF4:Mn2+/Gd3+ nanocrystal sublattices through Gd3+-driven microenvironment engineering and Mn2+-mediated radioluminescence profiling. Our photophysical studies reveal effective control of energy-funneling kinetics and demonstrate the tunability of electron trap depth ranging from 0.66 to 0.96 eV, with the corresponding trap density varying between 2.38x105 and 1.34x107 cm-3. This enables controlled release of captured electrons over durations spanning from seconds to 30 days. It allows tailorable emission wavelength within the range of 520-580 nm and fine-tuning of thermally-stimulated temperature between 313-403 K. We further utilize these scintillators to fabricate high-density, large-area scintillation screens that exhibit a 6-fold improvement in X-ray sensitivity, 22 lp/mm high-resolution X-ray imaging, and a 30-day-long optical memory. This enables high-contrast imaging of injured mice through fast thermally-stimulated radioluminescence readout. These findings offer new insights into the correlation of radioluminescence dynamics with energy-funneling kinetics, thereby contributing to the advancement of high-energy nanophotonic applications. Energy-funneling kinetics in NaLuF4: Mn2+/Gd3+ nanocrystals were explored through precise microenvironment engineering within nanocrystal sublattices. The resulting tailorable radioluminescence afterglow enabled high-sensitivity, high-resolution X-ray imaging with an ultralong optical memory. image
Keyword ：
Electronic traps Electronic traps Energy funneling Energy funneling Nanocrystal scintillators Nanocrystal scintillators Radioluminescence afterglow Radioluminescence afterglow X-ray imaging X-ray imaging
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Qinxia , Xu, Xinqi , Li, Xiaokun et al. Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (25) . |
| MLA | Wu, Qinxia et al. "Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 25 (2024) . |
| APA | Wu, Qinxia , Xu, Xinqi , Li, Xiaokun , Jiang, Hao , Qin, Xian , Hong, Zhongzhu et al. Probing Energy-Funneling Kinetics in Nanocrystal Sublattices for Superior X-Ray Imaging . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (25) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The growing demands for X-ray imaging applications impose diverse and stringent requirements on advanced X-ray detectors. Among these, flexibility stands out as the most expected characteristic for next-generation X-ray detectors. Flexible X-ray detectors can spatially conform to nonflat surfaces, substantially improving the imaging resolution, reducing the X-ray exposure dosage, and enabling extended application opportunities that are hardly achievable by conventional rigid flat-panel detectors. Over the past years, indirect- and direct-conversion flexible X-ray detectors have made marvelous achievements. In particular, microscale and nanoscale engineering technologies play a pivotal role in defining the optical, electrical, and mechanical properties of flexible X-ray detectors. In this Perspective, we spotlight recent landmark advancements in flexible X-ray detectors from the aspects of micro/nano engineering strategies, which are broadly categorized into two prevailing modalities: materials-in-substrate and materials-on-substrate. We also discuss existing challenges hindering the development of flexible X-ray detectors, as well as prospective research opportunities to mitigate these issues. © 2024 American Chemical Society.
Keyword ：
Carrier concentration Carrier concentration II-VI semiconductors II-VI semiconductors Particle detectors Particle detectors Photons Photons Scintillation counters Scintillation counters Semiconductor detectors Semiconductor detectors X ray analysis X ray analysis X ray cameras X ray cameras X ray detectors X ray detectors X ray laboratories X ray laboratories
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Ou, Xiangyu , Hong, Zhongzhu , Wu, Qinxia et al. Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors [J]. | ACS Nano , 2024 , 18 (40) : 27126-27137 . |
| MLA | Ou, Xiangyu et al. "Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors" . | ACS Nano 18 . 40 (2024) : 27126-27137 . |
| APA | Ou, Xiangyu , Hong, Zhongzhu , Wu, Qinxia , Chen, Xiaofeng , Xie, Lili , Zhang, Zhenzhen et al. Micro/Nano Engineering Advances Next-Generation Flexible X-ray Detectors . | ACS Nano , 2024 , 18 (40) , 27126-27137 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Qinxia , Zheng, Qianyu , He, Yu et al. Emerging Nanoagents for Medical X-ray Imaging [J]. | ANALYTICAL CHEMISTRY , 2023 , 95 (1) : 33-48 . |
| MLA | Wu, Qinxia et al. "Emerging Nanoagents for Medical X-ray Imaging" . | ANALYTICAL CHEMISTRY 95 . 1 (2023) : 33-48 . |
| APA | Wu, Qinxia , Zheng, Qianyu , He, Yu , Chen, Qiushui , Yang, Huanghao . Emerging Nanoagents for Medical X-ray Imaging . | ANALYTICAL CHEMISTRY , 2023 , 95 (1) , 33-48 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
N-nitrosodiethylamine (NDEA) is a disinfection by-product (DBP) and is classified as a probable carcinogen by the International Agency for Research on Cancer. Its concentration is lower but its toxicity is higher than other DBPs. Designing a new adsorbent with a high adsorption effect on low concentrations of NDEA instead of traditional materials will be useful. To the best of our knowledge, this is the first study to investigate metal -organic frameworks (MOFs) for the adsorption of NDEA. Two novel Al-based MOFs were synthesized by modifying MIL-96 with amino and thiol groups. Their adsorption performances at low concentrations of NDEA in water were compared using adsorption kinetics and isotherm models. It was observed that MIL-96 modified with thiol groups (MIL-96-M) followed the Langmuir and pseudo-second-order models and exhibited the best adsorption performance. Owing to the well-matched pore size and hydrophobicity, the Langmuir adsorption capacity of MIL-96-M for NDEA was achieved at 1004.71 mu g/g. The parameters of the adsorption performance were investigated using the Box-Behnken response surface methodology, and on the basis of which, the per-formance under different conditions was predicted. The experimental data suggested that the increase in tem-perature and time was beneficial for the adsorption performance, whereas an increase in dosage was not beneficial. It was identified that the adsorption mechanism between MIL-96-M and NDEA involves van der Waals forces, electrostatic interactions, and nucleophilic reactions by characterization and density functional theory (DFT).
Keyword ：
Adsorption Adsorption Amino-functionalized Amino-functionalized MIL-96 MIL-96 NDEA NDEA Thiol-functionalized Thiol-functionalized
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yao, Ning , Chen, Jinfeng , Feng, Ren et al. Mechanistic insight into the adsorption of low concentrations of N-nitrosodiethylamine in water by functional MIL-96: Experiments and theoretical calculations [J]. | CHEMICAL ENGINEERING JOURNAL , 2023 , 451 . |
| MLA | Yao, Ning et al. "Mechanistic insight into the adsorption of low concentrations of N-nitrosodiethylamine in water by functional MIL-96: Experiments and theoretical calculations" . | CHEMICAL ENGINEERING JOURNAL 451 (2023) . |
| APA | Yao, Ning , Chen, Jinfeng , Feng, Ren , Liu, Zhipeng , He, Yu , Jiang, Zhuwu . Mechanistic insight into the adsorption of low concentrations of N-nitrosodiethylamine in water by functional MIL-96: Experiments and theoretical calculations . | CHEMICAL ENGINEERING JOURNAL , 2023 , 451 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The detection of emerging contaminants (ECs) and understanding their ecotoxicity has brought new challenges to water pollution control. Triclosan (TCS), as an emerging contaminant, is a commonly used antibacterial agent widely present in the environment. Microdialysis (MD), as a sampling technique, can overcome some of the deficiencies of traditional approaches to sampling, using sources such as blood, urine, tissue, and target organs, in terms of invasiveness, time from collection to analysis, and possible changes during sample preparation. In this study, we coupled MD with analysis using UHPLC-QTOF/MS to identify the endogenous metabolites in the liver as biomarkers of the exposure of living crucian carp to TCS. The identified biomarkers were then quantified using UHPLC-MS/MS to continuously monitor the effect of TCS on endogenous metabolites in the liver of living crucian carp, which contributes to a better understanding of the toxicological effect of TCS. The experimental results demonstrated that TCS exposure interfered with the metabolic pathways of amino acids (l-isoleucine and l-histidine), purines (xanthine and hypoxanthine), and small nerve molecules (acetylcholine and choline).
Keyword ：
Endogenous metabolites Endogenous metabolites Microdialysis Microdialysis Statistical analysis Statistical analysis UHPLC-MS/MS UHPLC-MS/MS UHPLC-QTOF/MS UHPLC-QTOF/MS
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Huang, Bowen , Ong, Adabelle , Wang, Wenli et al. Application of microdialysis combined with UHPLC-QTOF/MS to screen for endogenous metabolites in aquatic organisms as biomarkers of exposure to an emerging contaminant, triclosan [J]. | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2023 , 415 (8) : 1571-1581 . |
| MLA | Huang, Bowen et al. "Application of microdialysis combined with UHPLC-QTOF/MS to screen for endogenous metabolites in aquatic organisms as biomarkers of exposure to an emerging contaminant, triclosan" . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY 415 . 8 (2023) : 1571-1581 . |
| APA | Huang, Bowen , Ong, Adabelle , Wang, Wenli , He, Yu , Xiao, Yongjun . Application of microdialysis combined with UHPLC-QTOF/MS to screen for endogenous metabolites in aquatic organisms as biomarkers of exposure to an emerging contaminant, triclosan . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2023 , 415 (8) , 1571-1581 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Development of adsorbent materials for highly efficient iodine capture is high demand from the perspective of ecological environment and human health. Herein, the two kinds of thiophene-based covalent organic frameworks (COFs) with different morphologies were synthesized by solvothermal reaction using thieno[3,2-b]thiophene-2,5-dicarbaldehyde (TT) as the aldehyde monomer and tri(4-aminophenyl)benzene (PB) or tris(4-aminophenyl)amine (PA) as the amino monomer (denoted as PB-TT COF and PA-TT COF) and the as-prepared two heteroatoms-rich COFs possessed many excellent properties, including high thermal stability and abundant binding sites. Among them, PB-TT COF exhibited ultra-high iodine uptake up to 5.97 g/g in vapor, surpassing most of adsorbents previously reported, which was ascribed to its high specific surface (1305.3 m(2)/g). Interestingly, PA-TT COF with low specific surface (48.6 m(2)/g) showed good adsorption ability for iodine in cyclohexane solution with uptake value of 750 mg/g, which was 2.38 times higher than that obtained with PB-TT COF due to its unique sheet-like morphology. Besides, the two COFs possessed good reusability, high selectivity and iodine retention ability. Based on experimental results, the adsorption mechanisms of both COFs were studied, revealing that iodine was captured by the physical-chemical adsorption. Furthermore, the both COFs showed excellent adsorption ability in real radioactive seawater treated safely, demonstrating their great potential in real environment. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Adsorption mechanisms Adsorption mechanisms Iodine Iodine Morphology Morphology Radioactive seawater Radioactive seawater Thiophene-based covalent organic frameworks Thiophene-based covalent organic frameworks
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yan, Xi , Yang, Yixin , Li, Guorong et al. Thiophene-based covalent organic frameworks for highly efficient iodine capture [J]. | CHINESE CHEMICAL LETTERS , 2023 , 34 (1) . |
| MLA | Yan, Xi et al. "Thiophene-based covalent organic frameworks for highly efficient iodine capture" . | CHINESE CHEMICAL LETTERS 34 . 1 (2023) . |
| APA | Yan, Xi , Yang, Yixin , Li, Guorong , Zhang, Jianhua , He, Yu , Wang, Ran et al. Thiophene-based covalent organic frameworks for highly efficient iodine capture . | CHINESE CHEMICAL LETTERS , 2023 , 34 (1) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Triclosan (TCS), an antimicrobial compound, is knownto have potentialendocrine-disruptive properties, but the underlying toxic mechanismsat the metabolic level are not well understood. Here, we applied metabolomicsand lipidomics combined with mass spectrometry imaging (MSI) to unveilthe mechanisms of the enhanced growth of MCF-7 breast cancer cellspheroids (CCS) exposed to TCS. To obtain a wide coverage of metabolitesand lipids by using MSI, we used techniques of matrix-assisted laserdesorption/ionization (MALDI) and MALDI coupled with laser-postionization.The results showed that TCS and TCS sulfate penetrated into the entirearea at 0-3 h and both localized in the inner area at 6 h.After 24 h, a portion of two compounds was released from CCS. Omicdata indicated that TCS exposure induced alterations via several pathways,including energy metabolism and biosynthesis of glycerophospholipidsand glycerolipids. Further MSI data revealed that the enhancementof energy supply in the peripheral area and the increase of energystorage in the inner area might contribute to the enhanced growthof MCF-7 breast CCS exposed to TCS. This study highlights the importanceof integrating metabolite distributions and metabolic profiles toreveal the novel mechanisms of TCS-triggered endocrine disruptingeffects. Minimal research exists onexploring the mechanisms of triclosan-inducedendocrine disrupting effects at metabolic levels. This study fillsthis gap by using a triclosan-exposed breast cancer cell spheroidmodel.
Keyword ：
breast cancer cell spheroids breast cancer cell spheroids enhancedgrowth enhancedgrowth mass spectrometryimaging mass spectrometryimaging metabolites and lipids metabolites and lipids triclosan triclosan
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Jing , Xie, Peisi , Wu, Pengfei et al. Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan [J]. | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2023 , 57 (29) : 10542-10553 . |
| MLA | Chen, Jing et al. "Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan" . | ENVIRONMENTAL SCIENCE & TECHNOLOGY 57 . 29 (2023) : 10542-10553 . |
| APA | Chen, Jing , Xie, Peisi , Wu, Pengfei , Lin, Zian , He, Yu , Cai, Zongwei . Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan . | ENVIRONMENTAL SCIENCE & TECHNOLOGY , 2023 , 57 (29) , 10542-10553 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Qinxia , Zheng, Qianyu , He, Yu et al. Emerging Nanoagents for Medical X-ray Imaging [J]. | ANALYTICAL CHEMISTRY , 2023 , 95 (1) : 33-48 . |
| MLA | Wu, Qinxia et al. "Emerging Nanoagents for Medical X-ray Imaging" . | ANALYTICAL CHEMISTRY 95 . 1 (2023) : 33-48 . |
| APA | Wu, Qinxia , Zheng, Qianyu , He, Yu , Chen, Qiushui , Yang, Huanghao . Emerging Nanoagents for Medical X-ray Imaging . | ANALYTICAL CHEMISTRY , 2023 , 95 (1) , 33-48 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
