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学者姓名：杨丽聪
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Abstract ：
A beta aggregation-related neuroinflammation and imbalance of brain glucose homeostasis play important roles in the pathological process of Alzheimer's disease (AD). Chlorogenic acid (CGA) is one of the most common dietary polyphenols with neuroprotective effects. However, due to the low bioavailability of CGA, its application dose is usually high in vivo. In our previous study, the spherical selenium nanoparticles act as drug carriers to improve the bioactivity of resveratrol. Here, the brain-targeting peptide (TGN peptide) and CGA were used to prepare a new flowerlike selenium nanocluster (TGN-CGA@SeNCs) for enhancing the bioavailability of CGA. After decoration on selenium nanoclusters, the solubility and stability of CGA was obviously increased. Oral administration of a low dose of CGA (80 mg/kg/body weight) only slightly inhibited A beta aggregate-related neuroinflammation and glucose homeostasis disorder in the brain. Moreover, CGA showed less effect on increasing the diversity and richness of gut microbiota. At the same concentration, the CGA-modified selenium nanocluster (CGA@SeNCs) and TGN-CGA@SeNCs showed better function in ameliorating the gut microbiota disorder. Especially, TGN-CGA@SeNCs significantly increased the relative abundance of Turicibacter, Colidextribacter, Ruminococcus, Alloprevotella, and Alistipes against oxidative stress, inflammation, and glucose homeostasis imbalance. Notably, only TGN-CGA@SeNCs can transport through the blood-brain barrier (BBB), and TGN-CGA@SeNCs showed better effects than CGA@SeNCs in regulating A beta aggregation and improving brain glucose homeostasis. These results broadened the application of TGN-CGA@SeNCs, effectively improving the bioactivity of CGA, which also lowers the CGA dose for preventing AD progression.
Keyword ：
A ? aggregation A ? aggregation Alzheimer?s disease Alzheimer?s disease chlorogenic acid chlorogenic acid gut microbiota gut microbiota nanoselenium nanoselenium    
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| GB/T 7714 | Li, Zhiwei , Zheng, Guodong , Wang, Na et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) : 2883-2897 . |
| MLA | Li, Zhiwei et al. "A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71 . 6 (2023) : 2883-2897 . |
| APA | Li, Zhiwei , Zheng, Guodong , Wang, Na , Liang, Hanji , Li, Changjiang , Wang, Yabin et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) , 2883-2897 . |
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Abstract ：
The pathology of Alzheimer's disease (AD) is highly correlated with obesity-induced insulin resistance. Resveratrol (Res) is a natural phenol that demonstrates a neuroprotective effect, but the bioactivity of Res is low in vivo. Here, chitosan (CS) was cross-linked with sodium tripolyphosphate (TPP) to encapsulate low water solubility Res. Next, a brain-targeted peptide (TG: TGNYKALHPHNG) was modified on the surface of Res-loaded CS/TPP nanoparticles (TG-Res-CS/TPP-NPs) to specifically deliver Res to the brain. Morris water maze results indicated that cognitive impairments were ameliorated by TG-Res-CS/TPP-NPs in obesity-related AD mice. Obesity-related insulin resistance promotes Tau phosphorylation and A beta aggregation in the brain. Administration of TG-Res-CS/TPP-NPs alleviated lipid deposition-induced insulin resistance and decreased the level of phos-phorylated Tau and A beta aggregation via the JNK/AKT/GSK3 beta pathway. Additionally, TG-Res-CS/TPP-NPs transported across blood-brain barrier which in turn increased glucose transporter expression levels, antioxi-dant enzyme activity and inhibited microglial cell activation. Thus, TG-Res-CS/TPP-NPs were more effective than Res-CS/TPP-NPs at regulating glucose homeostasis, oxidative stress and neuroinflammation in the brain. Moreover, inflammatory, lipid metabolism and oxidative stress-related gut microbiota including Helicobacter, Colidextribacter, Anaerotruncus, Parasutterella, Allobaculum, Alloprevotella, Alistipes, Bifidobacterium and Candida-tus_Saccharimonas were also regulated by TG-Res-CS/TPP-NPs. This work indicates the potential use of TG-Res-CS/TPP-NPs for the delivery of Res.
Keyword ：
Alzheimer?s disease Alzheimer?s disease Blood brain barrier Blood brain barrier Brain delivery Brain delivery Chitosan nanoparticles Chitosan nanoparticles Gut microbiota Gut microbiota Insulin resistance Insulin resistance
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| GB/T 7714 | Yang, Licong , Wang, Yabin , Li, Zhiwei et al. Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease [J]. | CARBOHYDRATE POLYMERS , 2023 , 310 . |
| MLA | Yang, Licong et al. "Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease" . | CARBOHYDRATE POLYMERS 310 (2023) . |
| APA | Yang, Licong , Wang, Yabin , Li, Zhiwei , Wu, Xiaohua , Mei, Jingtao , Zheng, Guodong . Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer?s disease . | CARBOHYDRATE POLYMERS , 2023 , 310 . |
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Abstract ：
A beta aggregation-related neuroinflammation and imbalance of brain glucose homeostasis play important roles in the pathological process of Alzheimer's disease (AD). Chlorogenic acid (CGA) is one of the most common dietary polyphenols with neuroprotective effects. However, due to the low bioavailability of CGA, its application dose is usually high in vivo. In our previous study, the spherical selenium nanoparticles act as drug carriers to improve the bioactivity of resveratrol. Here, the brain-targeting peptide (TGN peptide) and CGA were used to prepare a new flowerlike selenium nanocluster (TGN-CGA@SeNCs) for enhancing the bioavailability of CGA. After decoration on selenium nanoclusters, the solubility and stability of CGA was obviously increased. Oral administration of a low dose of CGA (80 mg/kg/body weight) only slightly inhibited A beta aggregate-related neuroinflammation and glucose homeostasis disorder in the brain. Moreover, CGA showed less effect on increasing the diversity and richness of gut microbiota. At the same concentration, the CGA-modified selenium nanocluster (CGA@SeNCs) and TGN-CGA@SeNCs showed better function in ameliorating the gut microbiota disorder. Especially, TGN-CGA@SeNCs significantly increased the relative abundance of Turicibacter, Colidextribacter, Ruminococcus, Alloprevotella, and Alistipes against oxidative stress, inflammation, and glucose homeostasis imbalance. Notably, only TGN-CGA@SeNCs can transport through the blood-brain barrier (BBB), and TGN-CGA@SeNCs showed better effects than CGA@SeNCs in regulating A beta aggregation and improving brain glucose homeostasis. These results broadened the application of TGN-CGA@SeNCs, effectively improving the bioactivity of CGA, which also lowers the CGA dose for preventing AD progression.
Keyword ：
A ? aggregation A ? aggregation Alzheimer?s disease Alzheimer?s disease chlorogenic acid chlorogenic acid gut microbiota gut microbiota nanoselenium nanoselenium    
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| GB/T 7714 | Li, Zhiwei , Zheng, Guodong , Wang, Na et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice [J]. | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) : 2883-2897 . |
| MLA | Li, Zhiwei et al. "A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice" . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71 . 6 (2023) : 2883-2897 . |
| APA | Li, Zhiwei , Zheng, Guodong , Wang, Na , Liang, Hanji , Li, Changjiang , Wang, Yabin et al. A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice . | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 2023 , 71 (6) , 2883-2897 . |
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Abstract ：
食品中常见多酚成分及维生素C在体内外容易被氧化,性质极不稳定,影响其生物活性.前期研究中通过纳米硒(selenium nanparticles,SeNPs)负载维生素C并提高多酚类物质的生物活性,然而这些纳米硒的体内稳定性仍是未知的.该实验选取绿原酸纳米硒(CGA@SeNPs)、没食子酸纳米硒(GA@SeNPs)及维生素C纳米硒(VC@SeNPs)作为研究对象,测定不同pH下纳米硒粒径变化,胃肠液消化前后DPPH自由基和ABTS阳离子自由基清除率及表面修饰剂保留量,评估不同表面修饰纳米硒在胃肠环境中稳定性.结果表明:3种不同表面修饰纳米硒在酸性和中性条件下稳定,碱性条件下不稳定;经胃肠消化后,CGA@SeNPs结构和含量最稳定;未消化前,CGA@SeNPs对DPPH自由基和ABTS阳离子自由基抗氧化活性最好;经胃消化后,CGA@SeNPs对DPPH自由基抗氧化活性最好,VC@SeNPs对ABTS阳离子自由基抗氧化活性最好;经肠消化后GA@SeNPs对DPPH自由基抗氧化活性最好,CGA@SeNPs对ABTS阳离子自由基抗氧化活性最好.综上,CGA@SeNPs在胃肠道消化中稳定性和抗氧化活性最好.
Keyword ：
不同表面修饰纳米硒 不同表面修饰纳米硒 抗氧化活性 抗氧化活性 稳定性 稳定性 胃肠道消化 胃肠道消化
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| GB/T 7714 | 王亚彬 , 黎志伟 , 李长江 et al. 不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化 [J]. | 食品与发酵工业 , 2023 , 49 (1) : 53-59 . |
| MLA | 王亚彬 et al. "不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化" . | 食品与发酵工业 49 . 1 (2023) : 53-59 . |
| APA | 王亚彬 , 黎志伟 , 李长江 , 戴雅琪 , 何芬芳 , 郑国栋 et al. 不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化 . | 食品与发酵工业 , 2023 , 49 (1) , 53-59 . |
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Abstract ：
Resveratrol (Res) is a common natural polyphenol that inhibits inflammation and oxidative stress in Alzheimer's disease (AD). However, the absorption efficiency and in vivo bioactivity of Res are poor. High fat diet-induced metabolic disorders, including obesity and insulin resistance, can promote AD-related beta-amyloid (A beta) aggrega-tion, Tau protein phosphorylation and neurotoxicity. Gut microbiota play a role in modulating metabolic syn-drome and cognitive impairment. Herein, flower-like Res-loaded selenium nanoparticles/chitosan nanoparticles (Res@SeNPs@Res-CS-NPs) with higher loading capacity (64 %) were prepared to regulate gut microbiota in cases of AD with metabolic disorder. The nano-flowers could restore gut microbiota homeostasis to reduce lipopolysaccharide (LPS) formation and LPS-induced neuroinflammation. Additionally, Res@SeNPs@Res-CS-NPs can prevent lipid deposition and insulin resistance by decreasing Firmicutes levels and increasing Bacteroidetes levels in the gut, further inhibiting A beta aggregation and Tau protein phosphorylation through the JNK/AKT/ GSK3 beta signaling pathway. Moreover, Res@SeNPs@Res-CS-NPs treatment was able to regulate the relative levels of gut microbiota associated with oxidative stress, inflammation and lipid deposition, including Entercoccus, Colidextribacter, Rikenella, Ruminococcus, Candidatus_Saccharimonas, Alloprevotella and Lachnospiraceae_UCG-006. Overall, Res@SeNPs@Res-CS-NPs significantly enhances cognitive ability in AD mice with metabolic disorder, highlighting their potential for preventing cognitive impairments in AD.
Keyword ：
Alzheimer?s disease Alzheimer?s disease Gut microbiota Gut microbiota Resveratrol modified selenium nanoparticles Resveratrol modified selenium nanoparticles
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| GB/T 7714 | Yang, Licong , Wang, Yabin , Zheng, Guodong et al. Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2023 , 239 . |
| MLA | Yang, Licong et al. "Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 239 (2023) . |
| APA | Yang, Licong , Wang, Yabin , Zheng, Guodong , Li, Zhiwei , Mei, Jingtao . Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer?s disease . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2023 , 239 . |
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The deposition of amyloid beta (A beta) is a conventional pathological hallmark of Alzheimer's disease (AD). Consequently, the inhibition of A beta aggregation combined with the disaggregation of A beta fibrils is an important therapeutic method for AD treatment. In this study, a gold nanoparticle-decorated porous metal organic framework MIL-101(Fe) (AuNPs@PEG@MIL-101) was created as an A beta inhibitor. The high positively charged MIL-101 induced a high number of A beta(40) to be absorbed or aggregated on the surface of nanoparticles. In addition, AuNPs improved the surface property of MIL-101, causing it to uniformly bind A beta monomers and A beta fibrils. Thus, this framework can efficiently suppress extracellular A beta monomer fibrillation and disrupt the preformed A beta fibers. AuNPs@PEG@MIL-101 also decreases intracellular A beta(40) aggregation and the amount of A beta(40) immobilized on the cell membrane, thus protecting PC12 cells from A beta(40)-induced microtubular defects and cell membrane damage. In summary, AuNPs@PEG@MIL-101 shows great potential for application in AD therapy.
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| GB/T 7714 | Yang, Licong , Chen, Yutong , Jia, Zhi et al. Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (20) : 4453-4463 . |
| MLA | Yang, Licong et al. "Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity" . | JOURNAL OF MATERIALS CHEMISTRY B 11 . 20 (2023) : 4453-4463 . |
| APA | Yang, Licong , Chen, Yutong , Jia, Zhi , Yuan, Xiaoyu , Liu, Jie . Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity . | JOURNAL OF MATERIALS CHEMISTRY B , 2023 , 11 (20) , 4453-4463 . |
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Abstract ：
Common polyphenols and vitamin C in food are particularly unstable. They are easily oxidized in vivo and in vitro, which will affect their biological activity. In previous studies, selenium nanoparticles (SeNPs) were used to load and improve the biological activity of polyphenols. However, the in vivo stability of these SeNPs is still unknown. Selenium nanoparticles were loaded with chlorogenic acid nano selenium (CGA@SeNPs), gallic acid-modified selenium nanoparticles (GA@SeNPs), and vitamin C-modified nano selenium (VC@SeNPs)were taken as the research subjects. To evaluate the stability of nano selenium with different surface modifications in the gastrointestinal environment, the particle size changes of three surface-modified SeNPs at different pH, the scavenging rates of DPPH free radicals and ABTS cationic radicals before and after gastrointestinal digestion, and the retention of surface modifiers were measured by simulated gastric digestion. Results showed that three surfaces modified SeNPs were stable under acidic and neutral conditions but unstable under alkaline conditions. After gastrointestinal digestion, the structure and content of CGA@SeNPs were the most stable. Before digestion, CGA@SeNPs had the best antioxidant activity of DPPH free radicals and ABTS cationic radicals. After gastric digestion, CGA@SeNPs had the best antioxidant activity against DPPH free radicals, and the optimum antioxidant activity of ABTS cationic radical was VC@SeNPs. After intestinal digestion, GA@SeNPs had the optimum antioxidant activity against DPPH free radicals. The antioxidant activity of ABTS cationic free radical of CGA@SeNPs was at the top. To sum up, CGA@SeNPs have the best stability and antioxidant activity in gastrointestinal digestion. © 2023 The Author(s).
Keyword ：
antioxidant activity antioxidant activity gastrointestinal digestion gastrointestinal digestion nano selenium with different surface modification nano selenium with different surface modification stability stability
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| GB/T 7714 | Wang, Y. , Li, Z. , Li, C. et al. Changes of stability and antioxidant activity of different surface-modified selenium nanoparticles in simulated gastrointestinal digestion; [不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化] [J]. | Food and Fermentation Industries , 2023 , 49 (1) : 53-59 . |
| MLA | Wang, Y. et al. "Changes of stability and antioxidant activity of different surface-modified selenium nanoparticles in simulated gastrointestinal digestion; [不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化]" . | Food and Fermentation Industries 49 . 1 (2023) : 53-59 . |
| APA | Wang, Y. , Li, Z. , Li, C. , Dai, Y. , He, F. , Zheng, G. et al. Changes of stability and antioxidant activity of different surface-modified selenium nanoparticles in simulated gastrointestinal digestion; [不同表面修饰纳米硒在模拟胃肠消化中稳定性及抗氧化活性变化] . | Food and Fermentation Industries , 2023 , 49 (1) , 53-59 . |
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Smilax china L. is used not only as a kind of traditional Chinese herbal medicinal ingredients with various pharmacological properties, but also as food in certain parts of China. However, it is by far still unclear whether Smilax china L. polyphenols (SCP), as important bioactive constituents in Smilax china L., have effects on inflammatory bowel diseases (IBD). This study investigated the impact of SCP on the dextran sulfate sodium (DSS)-induced IBD and gut microbiota in mice. SCP treatments ameliorated typical symptoms of IBD as what was reflected through suppressing body weight loss, colonic shortening, intestinal barrier damage, and increasing intestinal disease activity index. SCP treatments simultaneously decreased the release of proinflammatory cytokines and oxidative stress, as well as promoted the release of anti-inflammatory factors. Furthermore, SCP ameliorated the ecological imbalance of gut microbiota and regulated the key bacteria associated with IBD (including Akkermansiaceae, Ruminococcaceae, Acidaminococcaceae, Muribaculaceae, and Anaeroplasmataceae). In general, SCP may improve DSS-induced IBD in mice by regulating inflammatory factors, inhibiting oxidative stress, reducing intestinal tissue damage, and regulating the ecological imbalance of intestinal microbiota. Thus, SCP might serve as a potential therapeutic agent against the inflammation-driven diseases.
Keyword ：
Dextran Sulfate Sodium Dextran Sulfate Sodium Gut Microbiota Gut Microbiota Inflammatory Bowel Diseases Inflammatory Bowel Diseases Polyphenols Polyphenols Smilax china L Smilax china L
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| GB/T 7714 | Xu, Meng , Xue, Hui , Qiao, Gaoxiang et al. Regulating the Imbalance of Gut Microbiota by Smilax china L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases [J]. | AMERICAN JOURNAL OF CHINESE MEDICINE , 2022 , 50 (02) : 553-568 . |
| MLA | Xu, Meng et al. "Regulating the Imbalance of Gut Microbiota by Smilax china L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases" . | AMERICAN JOURNAL OF CHINESE MEDICINE 50 . 02 (2022) : 553-568 . |
| APA | Xu, Meng , Xue, Hui , Qiao, Gaoxiang , Liao, Mingfu , Kong, Li , Zhang, Qingfeng et al. Regulating the Imbalance of Gut Microbiota by Smilax china L. Polyphenols to Alleviate Dextran Sulfate Sodium-induced Inflammatory Bowel Diseases . | AMERICAN JOURNAL OF CHINESE MEDICINE , 2022 , 50 (02) , 553-568 . |
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Neuroinflammation plays a critical role in Alzheimer's disease (AD). However, it is still unknown if neuroinflammation can be effectively treated using selenium nanoparticles (SeNPs) with different surface modifications. In this study, SeNPs were coated with dihydromyricetin (DMY), a natural polyphenol, to obtain DMY@SeNPs. Given that DMY@SeNPs are unstable under physiological conditions, they were decorated step-by-step with chitosan (CS/DMY@SeNPs) and with the blood brain barrier (BBB) targeting peptide Tg (TGNYKALHPHNG) to yield Tg-CS/ DMY@SeNPs, which significantly reduced the aggregation of A beta and improved the anti-inflammatory effects of SeNPs in vitro. The mechanisms of CS/DMY@SeNPs and Tg-CS/DMY@SeNPs on regulating neuroinflammation are different. Only Tg-CS/DMY@SeNPs can cross the BBB; therefore, Tg-CS/DMY@SeNPs more successfully inhibited A beta aggregation and reduced inflammatory cytokine secretion via the NF-kappa B pathway in the brain of APP/PS1 mice compared to CS/DMY@SeNPs. Furthermore, both types of nanoparticles, however, were able to repair the gut barrier and regulate the population of inflammatory-related gut microbiota such as Bifidobacterium, Dubosiella, and Desulfovibrio. Of note, the relative abundance of Gordonibacter was only enhanced by Tg-CS/DMY@SeNPs, thereby downregulating the protein expression of the NLRP3 inflammasome and the concentrations of serum inflammatory factors. This demonstrates that Tg-CS/DMY@SeNPs ameliorate neuroinflammation through the gut microbiota-NLRP3 inflammasome-brain axis. Overall, our data suggest that Tg-CS/DMY@SeNPs are an ideal drug candidate for AD treatment.
Keyword ：
Alzheimer's disease Alzheimer's disease gut microbiota gut microbiota NLRP3 inflammasome NLRP3 inflammasome selenium nanoparticles selenium nanoparticles surface modifications surface modifications
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| GB/T 7714 | Yang, Licong , Cui, Yanan , Liang, Hanji et al. Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice [J]. | ACS APPLIED MATERIALS & INTERFACES , 2022 . |
| MLA | Yang, Licong et al. "Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice" . | ACS APPLIED MATERIALS & INTERFACES (2022) . |
| APA | Yang, Licong , Cui, Yanan , Liang, Hanji , Li, Zhiwei , Wang, Na , Wang, Yabin et al. Multifunctional Selenium Nanoparticles with Different Surface Modifications Ameliorate Neuroinflammation through the Gut Microbiota-NLRP3 Inflammasome-Brain Axis in APP/PS1 Mice . | ACS APPLIED MATERIALS & INTERFACES , 2022 . |
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The aim of this study is to investigate the molecular mechanism of Smilax china L. polyphenols (SCLPs) in enhancing lipid metabolism and stimulating browning to reduce lipid accumulation in 3T3-L1 adipocytes. SCLP treatment obviously decreased lipid content in a dose-dependent manner (10-40 mu g/mL) in adipocytes. SCLP treatment cooperated with noradrenalin to increase lipolysis. SCLPs reduced the gene expressions of C/EBP alpha and Ap2 and enhanced the expressions of ACO, CPT, pHSL/HSL, ATGL, and PKA in adipocytes. Furthermore, SCLPs increased mRNA and protein expressions of brown adipocyte-specific factors (UCP-1, PRDM16, PGC-1 alpha, and PPAR gamma) and mRNA expressions of beige adipocyte-specific markers (CD137, Tbx1, and Tmem26) in 3T3-L1 adipocytes, as well as mitochondrial biogenesis genes (Nrf1 and Tfam). In addition, according to the immunofluorescence staining, the mitochondria number was increased by SCLP. Moreover, beta 3-AR or AMPK agonist synergistic SCLPs enhanced the expressions of UCP-1, PRDM16, and PGC-1 alpha. While beta 3-AR or AMPK antagonist significantly decreased the expressions of these brown adipocyte-specific factors, SCLP treatment inhibited the effect of antagonist to improve the expression of UCP-1, PRDM16, and PGC-1 alpha. These results indicated that SCLPs may regulate lipid metabolism and stimulate browning via the beta 3-AR/AMPK alpha signaling pathway. Thus, SCLPs likely have potential therapeutic effects on obesity.
Keyword ：
3T3-L1 Adipocytes 3T3-L1 Adipocytes Fat Browning Fat Browning Lipid Metabolism Lipid Metabolism Smilax china L. Polyphenols Smilax china L. Polyphenols
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| GB/T 7714 | Kong, Li , Xu, Meng , Yang, Licong et al. Smilax china Polyphenols Stimulate Browning via beta 3-Adrenergic Receptor/AMP-Activated Protein Kinase alpha Signaling Pathway in 3T3-L1 Adipocytes [J]. | AMERICAN JOURNAL OF CHINESE MEDICINE , 2022 , 50 (05) : 1315-1329 . |
| MLA | Kong, Li et al. "Smilax china Polyphenols Stimulate Browning via beta 3-Adrenergic Receptor/AMP-Activated Protein Kinase alpha Signaling Pathway in 3T3-L1 Adipocytes" . | AMERICAN JOURNAL OF CHINESE MEDICINE 50 . 05 (2022) : 1315-1329 . |
| APA | Kong, Li , Xu, Meng , Yang, Licong , Liu, Shanshan , Zheng, Guodong . Smilax china Polyphenols Stimulate Browning via beta 3-Adrenergic Receptor/AMP-Activated Protein Kinase alpha Signaling Pathway in 3T3-L1 Adipocytes . | AMERICAN JOURNAL OF CHINESE MEDICINE , 2022 , 50 (05) , 1315-1329 . |
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