Supply　chain　alliance　cooperation　is　of　great　significance　to　optimize　resource　allocation　and　improve　profits,　but　the　impact　of　resource　allocation　efficiency　on　profits　has　not　been　quantitatively　studied,　and　the　profit　loss　caused　by　resource　allocation　inefficiency　has　not　been　attention　and　improved.　Therefore,　based　on　hybrid　network　DEA,　this　paper　proposes　a　new　method　to　measure　resource　allocation　efficiency　from　the　perspective　of　profit,　which　quantifies　the　profit　loss　caused　by　resource　allocation　inefficiency　for　the　first　time.　To　reduce　profit　loss,　multi-output　and　multi-input　technical　bias　method　(MMTB)　is　proposed　to　guide　the　rearrangement　of　upstream　and　downstream　structures　in　supply　chain　alliances,　so　as　to　accurately　find　structural　rearrangement　plan　under　profit　maximization,　and　then　realize　the　adjustment　of　profit　loss.　On　this　basis,　a　new　classification　method　of　profit　loss　(adjustable　profit　loss　and　unadjusted　profit　loss)　and　a　new　efficiency　measurement　method　(profit　adjustable　efficiency)　are　proposed.　Finally,　we　analyze　the　data　of　25　supply　chains　in　resin　producing　companies　to　verify　our　proposed　method.　The　resulting　resource　allocation　inefficiency　is　compared　with　the　classical　method.　©　2025　Elsevier　Ltd