Immune　checkpoint　blockade　(ICB)　holds　broad　application　prospects　in　tumor　treatment.　However,　the　poor　immunogenicity　and　the　adaptive　resistance　cells　severely　limit　the　clinical　efficacy.　Immunogenic　cell　death　(ICD)　can　sensitize　the　cells　which　were　initially　lower　responsive　to　ICB.　Based　on　this,　we　reported　a　metal　coordination　co-assembly　nanocomposite　(SIF　NPs),　which　can　enhance　cancer　immunotherapy　by　strengthening　ICD　induction　through　inducing　ferroptosis-photo-chemo.　The　SIF　NPs　possess　excellent　biocompatibility　and　stability,　and　exhibit　good　PTT　and　PDT　effects　both　in　vitro　and　in　vivo.　The　SIF　NPs　disrupt　redox　homeostasis　and　induce　ferroptosis　by　consuming　glutathione　(GSH),　downregulating　the　expression　of　solute　carrier　family　7　member　11　(SLC7A11)　and　glutathione　peroxidase　4　(GPX4),　and　enhancing　the　generation　of　lipid　hydroperoxides　(LPO).　Importantly,　SIF　NPs　trigger　an　ICD　cascade　via　inducing　the　cell　death,　thus　enhancing　the　immunogenicity　of　tumors.　In　a　tumor-bearing　mice　model,　the　synergistic‌　therapy　of　SIF　NPs　and　anti-PD-L1　antibody　demonstrated　a　powerful　inhibition　effectiveness　on　bilateral　tumors　and　instigated　a　long-time　immune　memory　effect.　This　study　indicates　that　the　combined　treatment　of　ferroptosis-photo-chemo　and　immunotherapy　possess　promising　application　prospects.　©　2025　Elsevier　B.V.