Glioblastoma　(GBM)　remains　a　formidable　challenge　in　oncology,　characterized　by　high　recurrence　rates　and　mortality.　While　temozolomide　(TMZ)　is　the　primary　chemotherapeutic　agent　for　GBM,　its　efficacy　is　limited.　This　study　introduces　a　novel　approach　combining　photothermal　therapy　(PTT)　and　chemotherapy　using　a　mesoporous　polydopamine　nanocarrier　with　a　unique　bowl-like　nanostructure,　co-loaded　with　indocyanine　green　(ICG)　and　TMZ　(MPDA@ICG/TMZ).　Our　in　vitro　experiments　demonstrate　that　this　innovative　nanotherapeutic　exhibits　an　impressive　photothermal　conversion　efficiency　(η　=　43.88%).　The　distinctive　bowl-shaped　morphology　significantly　enhances　tumor　cellular　uptake　compared　to　conventional　mesoporous　nanospheres.　Moreover,　hyperthermia　induced　by　808　nm　laser　irradiation　amplifies　TMZ’s　cytotoxicity,　resulting　in　a　mere　17.2%　cell　survival　rate.　Remarkably,　MPDA@ICG/TMZ　displays　strong　tumor-targeting　capabilities　in　GBM-bearing　nude　Balb/C　mice,　leveraging　the　enhanced　permeability　and　retention　(EPR)　effect.　This　targeting　is　distinctly　visualized　through　fluorescent　imaging　in　the　second　near-infrared　window　(1000–1700　nm).　The　combined　treatment　approach　leads　to　complete　tumor　cell　eradication　both　in　vitro　and　in　vivo　under　808　nm　laser　illumination.　This　research　underscores　the　potential　of　MPDA@ICG/TMZ　as　a　powerful　nanoplatform　for　combined　chemotherapy　and　PTT　in　clinical　applications,　offering　a　promising　new　direction　in　GBM　treatment.　(Figure　presented.)　©　Science　China　Press　2025.