The　existing　research　results　of　high-rise　base-isolation　structures　without　considering　high-order　effects　may　have　serious　safety　risks.　Thusly,　revealed　is　the　working　mechanism　of　the　coupling　between　the　high-order　effect　and　the　lift-off　sway　of　the　high-rise　foundation　isolation　structure.　A　simulated　seismic　shaking　table　test　is　carried　out,　a　finite　element　model　is　established,　and　the　simulation　results　are　compared　with　the　test　results　to　obtain　the　seismic　response　of　the　high-rise　foundation　isolation　structure.　Based　on　the　results　of　seismic　response　analysis,　a　targeted　vibration　control　target　is　formulated　and　the　corresponding　vibration　control　scheme　is　put　forward.　Finally,　engineering　suggestions　are　proposed.　The　results　show　that:　Compared　with　not　considering　the　high-order　effect,　the　high-order　effect　can　significantly　enhance　the　lift-off　sway　effect,　and　the　isolation　support　is　easier　to　enter　the　tension　state.　The　limit　value　of　the　tensile　seismic　influence　coefficient　of　the　isolation　support　decreases,　and　the　overall　overturning　trend　of　the　structure　is　advanced.　Different　from　the　linear　elastic　state　of　the　superstructure　without　considering　the　high-order　effect,　the　high-order　effect　causes　obvious　abrupt　change　at　the　high　position　of　the　superstructure.　Under　the　combined　effect　of　the　high-order　effect　and　the　lift-off　sway　effect,　the　seismic　response　of　the　isolation　layer　is　amplified　by　about　40%　compared　with　that　without　considering　the　high-order　effect.　Under　different　seismic　conditions,　the　tensile　stress　of　the　isolation　layer　does　not　meet　relevant　regulatory　requirements.　Under　the　action　of　rare　earthquakes,　the　isolation　layer　and　the　abrupt　region　of　the　superstructure　may　cause　serious　damage,　and　the　structure　may　overturn　under　the　action　of　rare　earthquakes.　Two　vibration　control　schemes　are　also　proposed,　the　base-TMD　hybrid　isolation　scheme　and　the　base-tension-TMD　joint　control　scheme,　to　eliminate　the　high-order　effect　of　high　position　mutation　and,　to　reduce　the　seismic　response　of　the　isolation　layer　to　40%~70%　of　the　original　structure,　effectively　to　suppress　the　lift-off　sway　effect,　and　to　ensure　the　safety　of　this　type　of　structure　under　the　action　of　earthquakes.　©　2025,　Tsinghua　University.　All　rights　reserved.